Nitrite (BioDeep_00000004379)

 

Secondary id: BioDeep_00001867951

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Nitrosyl hydroxide

化学式: HNO2 (47.0007)
中文名称: 亚硝酸
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 49.62%

分子结构信息

SMILES: N(=O)O
InChI: InChI=1S/HNO2/c2-1-3/h(H,2,3)

描述信息

Nitrite is a nitrite compound is either a salt or an ester of nitrous acid. Sodium nitrite is used for the curing of meat because it prevents bacterial growth and, in a reaction with the meats myoglobin, gives the product a desirable dark red color. Nitrite can be reduced to nitric oxide or ammonia by many species of bacteria. Under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. Several mechanisms for nitrite conversion to NO have been described including enzymatic reduction by xanthine oxidoreductase, the mitochondria, and NO synthase (NOS), as well as nonenzymatic acidic disproportionation. -- Wikipedia.
A nitrite compound is either a salt or an ester of nitrous acid. Sodium nitrite is used for the curing of meat because it prevents bacterial growth and, in a reaction with the meats myoglobin, gives the product a desirable dark red color. Nitrite can be reduced to nitric oxide or ammonia by many species of bacteria.

同义名列表

6 个代谢物同义名

Nitrosyl hydroxide; Acid, nitrous; NITROUS ACID; [NO(OH)]; Nitrite; HNO2



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(1)

代谢反应

142 个相关的代谢反应过程信息。

Reactome(3)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(138)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, CA2, ELANE, ENDOV, PMP2
Peripheral membrane protein 2 ACHE, LPL
Nucleus 4 ACHE, ALB, PMP2, UNG
cytosol 6 ALB, CA2, ELANE, LIPE, MB, PMP2
phagocytic vesicle 1 ELANE
centrosome 1 ALB
nucleoplasm 2 FAM20C, UNG
Cell membrane 4 ACHE, CA2, LIPE, LPL
Golgi apparatus membrane 1 FAM20C
Synapse 1 ACHE
cell surface 4 ACHE, ELANE, LPL, SDC2
Golgi apparatus 3 ACHE, ALB, FAM20C
Golgi membrane 2 FAM20C, INS
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 1 LIPE
Lysosome 2 GALNS, IDUA
plasma membrane 8 ACHE, CA2, F2, HSPG2, IFNLR1, LPL, SDC2, SERPINC1
Membrane 5 ACHE, HSPG2, IFNLR1, LIPE, SDC2
caveola 1 LIPE
extracellular exosome 12 ALB, CA2, ELANE, F2, FAM20C, GALNS, HSPG2, IDUA, LYZ, MB, PMP2, SERPINC1
endoplasmic reticulum 2 ALB, FAM20C
extracellular space 10 ACHE, ALB, ELANE, F2, FAM20C, HSPG2, INS, LPL, LYZ, SERPINC1
lysosomal lumen 4 GALNS, HSPG2, IDUA, SDC2
perinuclear region of cytoplasm 1 ACHE
mitochondrion 1 UNG
protein-containing complex 1 ALB
Single-pass type I membrane protein 3 HSPG2, IFNLR1, SDC2
Secreted 7 ACHE, ALB, F2, FAM20C, HSPG2, INS, LPL
extracellular region 10 ACHE, ALB, ELANE, F2, GALNS, HSPG2, INS, LPL, LYZ, SERPINC1
Single-pass membrane protein 1 HSPG2
Extracellular side 2 ACHE, LPL
anchoring junction 1 ALB
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 1 LPL
very-low-density lipoprotein particle 1 LPL
nucleolus 1 ENDOV
sarcoplasm 1 MB
apical part of cell 1 CA2
Single-pass type II membrane protein 1 FAM20C
focal adhesion 1 HSPG2
basement membrane 2 ACHE, HSPG2
collagen-containing extracellular matrix 5 ELANE, F2, HSPG2, SDC2, SERPINC1
secretory granule 1 ELANE
ciliary basal body 1 ALB
centriole 1 ALB
Secreted, extracellular space 1 SERPINC1
plasma membrane protein complex 1 HSPG2
Nucleus, nucleolus 1 ENDOV
spindle pole 1 ALB
blood microparticle 3 ALB, F2, SERPINC1
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cytoplasm, Stress granule 1 ENDOV
cytoplasmic stress granule 1 ENDOV
side of membrane 1 ACHE
myelin sheath 2 CA2, PMP2
[Isoform 1]: Cytoplasm 1 ENDOV
secretory granule lumen 1 INS
Golgi lumen 4 F2, HSPG2, INS, SDC2
endoplasmic reticulum lumen 6 ALB, F2, FAM20C, INS, SDC2, SERPINC1
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 ALB
specific granule lumen 2 ELANE, LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 3 ELANE, GALNS, LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
synaptic cleft 1 ACHE
Cytoplasmic vesicle, phagosome 1 ELANE
[Isoform 7]: Cytoplasm 1 ENDOV
Cytoplasm, sarcoplasm 1 MB
catalytic complex 1 LPL
[Isoform 6]: Cytoplasm 1 ENDOV
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Siddharth Seshan, Johann Poinapen, Marcel H Zandvoort, Jules B van Lier, Zoran Kapelan. Limitations of a biokinetic model to predict the seasonal variations of nitrous oxide emissions from a full-scale wastewater treatment plant. The Science of the total environment. 2024 Mar; 917(?):170370. doi: 10.1016/j.scitotenv.2024.170370. [PMID: 38280609]
  • Reun-Ping Goh, Xing-Yun Xie, Ya-Chi Lin, Hao-Wen Cheng, Joseph A J Raja, Shyi-Dong Yeh. Rapid selection of potyviral cross-protection effective mutants from the local lesion host after nitrous acid mutagenesis. Molecular plant pathology. 2023 08; 24(8):973-988. doi: 10.1111/mpp.13346. [PMID: 37158451]
  • Yunju Zhang, Meilian Zhao, Yongguo Liu, Yuxi Sun. The influence of a single water molecule on the reaction of BrO + HONO. Journal of molecular graphics & modelling. 2022 11; 116(?):108261. doi: 10.1016/j.jmgm.2022.108261. [PMID: 35926333]
  • Alexandra Maria Kratz, Stefanie Maier, Jens Weber, Minsu Kim, Giacomo Mele, Laura Gargiulo, Anna Lena Leifke, Maria Prass, Raeid M M Abed, Yafang Cheng, Hang Su, Ulrich Pöschl, Bettina Weber. Reactive Nitrogen Hotspots Related to Microscale Heterogeneity in Biological Soil Crusts. Environmental science & technology. 2022 08; 56(16):11865-11877. doi: 10.1021/acs.est.2c02207. [PMID: 35929951]
  • Umeo Takahama, Sachiko Hirota. Further slowing down of hydrolysis of amylose heated with black soybean extract by treating with nitrite under gastric conditions. Scientific reports. 2022 08; 12(1):13212. doi: 10.1038/s41598-022-17476-6. [PMID: 35918428]
  • Aurélie Marion, Julien Morin, Elena Ormeño, Sylvie Dupouyet, Barbara D'Anna, Séverine Boiry, Henri Wortham. Nitrous acid production and uptake by Zea mays plants in growth chambers in the presence of nitrogen dioxide. The Science of the total environment. 2022 Feb; 806(Pt 2):150696. doi: 10.1016/j.scitotenv.2021.150696. [PMID: 34597576]
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  • Aurélie Marion, Julien Morin, Adrien Gandolfo, Elena Ormeño, Barbara D'Anna, Henri Wortham. Nitrous acid formation on Zea mays leaves by heterogeneous reaction of nitrogen dioxide in the laboratory. Environmental research. 2021 02; 193(?):110543. doi: 10.1016/j.envres.2020.110543. [PMID: 33253704]
  • Yongchun Liu, Shuangying Ni, Tao Jiang, Shubin Xing, Yusheng Zhang, Xiaolei Bao, Zeming Feng, Xiaolong Fan, Liang Zhang, Haibo Feng. Influence of Chinese New Year overlapping COVID-19 lockdown on HONO sources in Shijiazhuang. The Science of the total environment. 2020 Nov; 745(?):141025. doi: 10.1016/j.scitotenv.2020.141025. [PMID: 32738691]
  • Haoran Duan, Shuhong Gao, Xuan Li, Nur Hafizah Ab Hamid, Guangming Jiang, Min Zheng, Xue Bai, Philip L Bond, Xuanyu Lu, Mariella M Chislett, Shihu Hu, Liu Ye, Zhiguo Yuan. Improving wastewater management using free nitrous acid (FNA). Water research. 2020 Mar; 171(?):115382. doi: 10.1016/j.watres.2019.115382. [PMID: 31855696]
  • Moo Joon Shim, Tae Yoon Jung, Dong Hyck Yoon, Yun Mo Yang, Jannatul Rumky, Yi Yong Yoon. HNO2 treatment of sludge: An alternative way of sludge usage as fertilizer. Journal of environmental management. 2020 Mar; 258(?):110016. doi: 10.1016/j.jenvman.2019.110016. [PMID: 31929058]
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  • Jia Zhang, Cheng Yang, Chuanxia Chen, Xiurong Yang. Determination of nitrite and glucose in water and human urine with light-up chromogenic response based on the expeditious oxidation of 3,3',5,5'-tetramethylbenzidine by peroxynitrous acid. The Analyst. 2013 Apr; 138(8):2398-404. doi: 10.1039/c3an00080j. [PMID: 23463362]
  • J Claros, E Jiménez, D Aguado, J Ferrer, A Seco, J Serralta. Effect of pH and HNO2 concentration on the activity of ammonia-oxidizing bacteria in a partial nitritation reactor. Water science and technology : a journal of the International Association on Water Pollution Research. 2013; 67(11):2587-94. doi: 10.2166/wst.2013.132. [PMID: 23752393]
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