Dimethylsulfide (BioDeep_00000004314)
Secondary id: BioDeep_00000866906, BioDeep_00001867648
human metabolite Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
化学式: C2H6S (62.019)
中文名称: 二甲基硫醚, 二甲基硫
谱图信息:
最多检出来源 Homo sapiens(blood) 92.31%
分子结构信息
SMILES: CSC
InChI: InChI=1S/C2H6S/c1-3-2/h1-2H3
描述信息
Dimethylsulfide is the predominant volatile sulfur compound (VSC) in breadth malodor, a metabolite of suplatast tosilate (a dimethylsulphonium compound for the treatment of asthma) in patients that regularly take that medication. (PMID 14628896). Dimethylsulfide is a sulfur containing organic chemical compound with a disagreeable odor. In vapor form it is produced by cooking of certain vegetables, notably corn and cabbage, and seafood. It is also an indication of bacterial infection in malt production and brewing. It is a breakdown product of dimethylsulfoniopropionate, and is also produced by the bacterial metabolism of methanethiol. Dimethylsulfide in concentrated liquid form is insoluble and a flammable. This is a microbial metabolite that can be found in Bradyrhizobium, Cyanothece, Escherichia, Pseudomonas and Rhizobiaceae (PMID:25807229).
Dimethyl sulfide (DMS) or methylthiomethane is an organosulfur compound with the formula (CH3)2S. Dimethyl sulfide is a water-insoluble flammable liquid that boils at 37 °C (99 °F) and has a characteristic disagreeable odor. It is a component of the smell produced from cooking of certain vegetables, notably maize, cabbage, beetroot and seafoods. It is also an indication of bacterial infection in malt production and brewing. It is a breakdown product of dimethylsulfoniopropionate (DMSP), and is also produced by the bacterial metabolism of methanethiol. Dimethyl sulfide is found in many foods, some of which are soft-necked garlic, chives, spearmint, and potato.
同义名列表
28 个代谢物同义名
Dimethyl sulfoxide(reduced); Dimethyl sulfide (natural); Methylthiomethyl radical; (METHYLsulphanyl)methane; (METHYLsulfanyl)methane; Dimethyl monosulfide; Dimethyl thioether; Methyl monosulfide; Methanethiomethane; Dimethyl sulphide; Methylthiomethane; Methyl thioether; Dimethylsulphide; dimethyl sulfide; Methyl sulphide; Dimethylsulfide; Thiobis-methane; Dimethylsulfid; Methyl sulfide; 2-Thiopropane; 2-Thiapropane; Reduced-dmso; Thiopropane; [SMe2]; dms; MSM; Dimethyl sulfide; Dimethyl sulfide
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:17437
- KEGG: C00580
- PubChem: 1068
- HMDB: HMDB0002303
- ChEMBL: CHEMBL15580
- Wikipedia: Dimethyl_sulfide
- MetaCyc: CPD-7670
- KNApSAcK: C00053130
- foodb: FDB003591
- chemspider: 1039
- CAS: 31533-72-9
- CAS: 75-18-3
- PMhub: MS000016495
- PubChem: 3859
- PDB-CCD: MSM
- 3DMET: B00138
- NIKKAJI: J1.443E
- RefMet: Dimethylsulfide
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-379
- KNApSAcK: 17437
分类词条
相关代谢途径
Reactome(0)
BioCyc(9)
- superpathway of dimethylsulfone degradation
- dimethyl sulfide degradation I
- dimethyl sulfide degradation II (oxidation)
- dimethyl sulfoxide degradation
- dimethyl sulfide degradation III (oxidation)
- hydrogen to dimethyl sulfoxide electron transfer
- formate to dimethyl sulfoxide electron transfer
- NADH to dimethyl sulfoxide electron transfer
- respiration (anaerobic)-- electron acceptors reaction list
PlantCyc(0)
代谢反应
65 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(61)
- folate transformations I:
NAD+ + a tetrahydrofolate + gly ⟶ CO2 + NADH + a 5,10-methylenetetrahydrofolate + ammonium
- dimethylsulfoniopropanoate degradation II (cleavage):
DMSP-CoA + H2O ⟶ 3-hydroxypropanoate + H+ + coenzyme A + dimethyl sulfide
- dimethylsulfoniopropanoate degradation I (cleavage):
DMSP ⟶ H+ + acrylate + dimethyl sulfide
- superpathway of dimethylsulfoniopropanoate degradation:
DMSP ⟶ H+ + acrylate + dimethyl sulfide
- dimethyl sulfoxide degradation:
H+ + NADH + dimethyl sulfoxide ⟶ H2O + NAD+ + dimethyl sulfide
- dimethyl sulfide biosynthesis from methionine:
SAM + methanethiol ⟶ H+ + SAH + dimethyl sulfide
- methanogenesis from dimethylsulfide:
H+ + a [Co(I) methanethiol-specific corrinoid protein] + dimethyl sulfide ⟶ a [methyl-Co(III) methanethiol-specific corrinoid protein] + methanethiol
- superpathway of dimethylsulfone degradation:
H+ + NADH + O2 + dimethyl sulfide ⟶ H2O + NAD+ + formaldehyde + methanethiol
- folate transformations I:
a tetrahydrofolate + trimethyl sulfonium ⟶ H+ + a 5-methyltetrahydrofolate + dimethyl sulfide
- dimethyl sulfide degradation I:
H+ + NADH + O2 + dimethyl sulfide ⟶ H2O + NAD+ + formaldehyde + methanethiol
- dimethyl sulfide degradation III (oxidation):
H2O + an oxidized cytochrome c2 + dimethyl sulfide ⟶ H+ + a reduced cytochrome c2 + dimethyl sulfoxide
- dimethyl sulfide degradation II (oxidation):
H+ + NADPH + O2 + dimethyl sulfide ⟶ H2O + NADP+ + dimethyl sulfoxide
- hydrogen to dimethyl sulfoxide electron transfer:
H2O + MQ + dimethyl sulfide ⟶ MQH2 + dimethyl sulfoxide
- formate to dimethyl sulfoxide electron transfer:
H2O + MQ + dimethyl sulfide ⟶ MQH2 + dimethyl sulfoxide
- NADH to dimethyl sulfoxide electron transfer:
H2O + MQ + dimethyl sulfide ⟶ MQH2 + dimethyl sulfoxide
- hydrogen to dimethyl sulfoxide electron transfer:
H2O + MQ + dimethyl sulfide ⟶ MQH2 + dimethyl sulfoxide
- formate to dimethyl sulfoxide electron transfer:
H+ + MQ + formate ⟶ CO2 + H+ + MQH2
- NADH to dimethyl sulfoxide electron transfer:
H2O + MQ + dimethyl sulfide ⟶ MQH2 + dimethyl sulfoxide
- folate transformations:
NAD+ + a tetrahydrofolate + gly ⟶ CO2 + NADH + a 5,10-methylenetetrahydrofolate + ammonium
- formate to dimethyl sulfoxide electron transfer:
H+ + MQ + formate ⟶ CO2 + H+ + MQH2
- folate transformations I:
NAD+ + a tetrahydrofolate + gly ⟶ CO2 + NADH + a 5,10-methylenetetrahydrofolate + ammonium
- formate to dimethyl sulfoxide electron transfer:
H+ + MQ + formate ⟶ CO2 + H+ + MQH2
- NADH to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- folate transformations I:
NAD+ + a tetrahydrofolate + gly ⟶ CO2 + NADH + a 5,10-methylenetetrahydrofolate + ammonium
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + H+ + NADH + ammonia
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
- dimethyl sulfoxide degradation:
H+ + NADH + dimethyl sulfoxide ⟶ H2O + NAD+ + dimethyl sulfide
- folate transformations I:
10-formyl-tetrahydrofolate + H2O ⟶ H+ + formate + tetrahydrofolate
- formate to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- formate to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- dimethyl sulfoxide degradation:
H+ + NADH + dimethyl sulfoxide ⟶ H2O + NAD+ + dimethyl sulfide
- folate transformations I:
10-formyl-tetrahydrofolate + H2O ⟶ H+ + formate + tetrahydrofolate
- folate transformations I:
10-formyl-tetrahydrofolate + H2O ⟶ H+ + formate + tetrahydrofolate
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations I:
a tetrahydrofolate + trimethyl sulfonium ⟶ H+ + a 5-methyltetrahydrofolate + dimethyl sulfide
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydropteroyl mono-L-glutamate + CO2 + H+ + NADH + ammonia
- folate transformations:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia
- respiration (anaerobic)-- electron acceptors reaction list:
nitrite ⟶ ammonia
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations:
H+ + NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + NADH + ammonia
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
- formate to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- NADH to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- formate to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- NADH to dimethyl sulfoxide electron transfer:
MQH2 + dimethyl sulfoxide ⟶ H2O + MQ + dimethyl sulfide
- folate transformations:
5,10-methylene-THF + NADP+ ⟶ 5,10-methenyltetrahydrofolate + NADPH
- formate to dimethyl sulfoxide electron transfer:
H+ + MQ + formate ⟶ CO2 + H+ + MQH2
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + H+ + NADH + ammonia
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + H+ + NADH + ammonia
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + H+ + NADH + ammonia
- folate transformations I:
NAD+ + gly + tetrahydrofolate ⟶ 5,10-methylenetetrahydrofolate + CO2 + H+ + NADH + ammonia
- folate transformations I:
ATP + formate + tetrahydrofolate ⟶ 10-formyl-tetrahydrofolate + ADP + phosphate
- folate transformations I:
ATP + formate + tetrahydrofolate ⟶ 10-formyl-tetrahydrofolate + ADP + phosphate
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
- folate transformations I:
H2O + a 10-formyltetrahydrofolate ⟶ H+ + a tetrahydrofolate + formate
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
- folate transformations I:
ATP + a tetrahydrofolate + formate ⟶ ADP + a 10-formyltetrahydrofolate + phosphate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(2)
- dimethylsulfoniopropanoate degradation I (cleavage):
DMSP ⟶ H+ + acrylate + dimethyl sulfide
- dimethylsulfoniopropanoate degradation I (cleavage):
DMSP ⟶ H+ + acrylate + dimethyl sulfide
COVID-19 Disease Map(0)
PathBank(2)
- Dimethyl Sulfoxide Electron Transfer:
Dimethyl sulfoxide + Electron + Hydrogen Ion + Menaquinol 8 ⟶ Dimethylsulfide + Hydrogen Ion + Water + menaquinone-8
- Dimethyl Sulfoxide Electron Transfer:
Dimethyl sulfoxide + Electron + Hydrogen Ion + Menaquinol 8 ⟶ Dimethylsulfide + Hydrogen Ion + Water + menaquinone-8
PharmGKB(0)
12 个相关的物种来源信息
- 4681 - Allium ampeloprasum: 10.1080/10412905.1991.9697935
- 4682 - Allium sativum: 10.1021/JF00059A033
- 991028 - Biflustra perfragilis: 10.1016/0305-1978(92)90046-G
- 13443 - Coffea arabica: 10.1021/JF60160A010
- 9606 - Homo sapiens: -
- 29780 - Mangifera indica: 10.1016/0031-9422(88)80124-9
- 138667 - Monostroma nitidum: 10.1271/BBB1961.53.2587
- 4043 - Petroselinum crispum: 10.1016/S0031-9422(00)80682-2
- 74632 - Rosa gallica: 10.1271/BBB1961.51.3421
- 4463 - Sauromatum venosum: 10.1016/S0031-9422(00)94756-3
- 3641 - Theobroma cacao: 10.1021/JF60160A011
- 39416 - Tuber melanosporum: 10.1021/JF00077A031
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Linfeng Wei, Jiyan Liu, Xingwang Hou, Weifang Chen, Yue Feng, Wenqian Kong, Yinyin Tang, Chuanji Zhong, Shuyan Zhang, Tian Wang, Ganghui Zhao, Suning Jiao, Guibin Jiang. Rice Seedlings and Microorganisms Mediate Biotransformation of Se in CdSe/ZnS Quantum Dots to Volatile Alkyl Selenides.
Environmental science & technology.
2023 Dec; 57(48):20261-20271. doi:
10.1021/acs.est.3c07094
. [PMID: 37992251] - Kathryn L Van Alstyne, Jennifer K Butler, Neal Smith. Airborne dimethyl sulfide (DMS) cues dimethylsulfoniopropionate (DMSP) increases in the intertidal green alga Ulva fenestrata.
Scientific reports.
2023 Mar; 13(1):4298. doi:
10.1038/s41598-023-30881-9
. [PMID: 36922620] - Xiaoting Zhai, Jing Wang, Hui Wang, Manman Xue, Xin Yao, Mengru Li, Jieyao Yu, Liang Zhang, Xiaochun Wan. Formation of dimethyl sulfide from the decomposition of S-methylmethionine in tea (Camellia sinensis) during manufacturing process and infusion brewing.
Food research international (Ottawa, Ont.).
2022 12; 162(Pt B):112106. doi:
10.1016/j.foodres.2022.112106
. [PMID: 36461406] - Pei Yu, Yini Yang, Jinyuan Sun, Xiao Jia, Chang Zheng, Qi Zhou, Fenghong Huang. Identification of volatile sulfur-containing compounds and the precursor of dimethyl sulfide in cold-pressed rapeseed oil by GC-SCD and UPLC-MS/MS.
Food chemistry.
2022 Jan; 367(?):130741. doi:
10.1016/j.foodchem.2021.130741
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Nature microbiology.
2021 11; 6(11):1357-1366. doi:
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Chemosphere.
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eLife.
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Chemosphere.
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PloS one.
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Nature genetics.
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Plant molecular biology.
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Trends in plant science.
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Environmental monitoring and assessment.
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ACS chemical biology.
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Journal of food science.
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Environmental science & technology.
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Science (New York, N.Y.).
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The Analyst.
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Biochemistry.
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Journal of clinical periodontology.
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Proceedings of the National Academy of Sciences of the United States of America.
2014 Mar; 111(11):4157-61. doi:
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Journal of chromatography. A.
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PloS one.
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Rapid communications in mass spectrometry : RCM.
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Bioresource technology.
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Chemosphere.
2013 Jul; 92(6):725-30. doi:
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Phytochemistry.
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