All-trans-13,14-dihydroretinol (BioDeep_00000004261)

 

Secondary id: BioDeep_00001872133

human metabolite Endogenous


代谢物信息卡片


(4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-4,6,8-trien-1-ol

化学式: C20H32O (288.2453)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 35.94%

分子结构信息

SMILES: C1(CCCC(C)=C1/C=C/C(/C)=C/C=C/C(C)CCO)(C)C
InChI: InChI=1S/C20H32O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-12,17,21H,7,10,13-15H2,1-5H3/b9-6+,12-11+,16-8+

描述信息

All-trans-13,14-dihydroretinol is involved in the retinol metabolism pathway. In this pathway, all-trans-13,14-dihydroretinol and an acceptor molecule is reversibly converted to retinol (vitamin A) plus reduced acceptor via the enzyme all-trans-retinol 13,14-reductase (EC 1.3.99.23). (KEGG) [HMDB]
All-trans-13,14-dihydroretinol is involved in the retinol metabolism pathway. In this pathway, all-trans-13,14-dihydroretinol and an acceptor molecule is reversibly converted to retinol (vitamin A) plus reduced acceptor via the enzyme all-trans-retinol 13,14-reductase (EC 1.3.99.23). (KEGG).
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

6 个代谢物同义名

(4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-4,6,8-trien-1-ol; 13,14-Dihydro-all-trans-retinol; all-trans-13,14-dihydroretinol; 11,12-cis-13,14-Dihydroretinol; 13,14-Dihydro-retinol; 13,14-dihydroretinol



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

16 个相关的代谢反应过程信息。

Reactome(6)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(9)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALDH1A2, CRABP1, MLXIPL, PPARG, RARG, RBP1, RXRG, SMAD3, VDR, VEGFA
Peripheral membrane protein 3 ACADVL, HSD17B6, RETSAT
Endoplasmic reticulum membrane 2 CYP26A1, RETSAT
Nucleus 10 CRABP1, HOXA1, MLXIPL, PPARG, RARG, RBP1, RXRG, SMAD3, VDR, VEGFA
cytosol 8 ALDH1A2, BCO1, CRABP1, MLXIPL, PPARG, RBP1, SMAD3, VDR
mitochondrial membrane 1 ACADVL
nucleoplasm 8 ACADVL, MLXIPL, PPARG, RARG, RBP1, RXRG, SMAD3, VDR
RNA polymerase II transcription regulator complex 3 PPARG, RXRG, VDR
Early endosome membrane 1 HSD17B6
cell surface 2 BMP2, VEGFA
glutamatergic synapse 1 RBP1
Golgi apparatus 1 VEGFA
Golgi membrane 1 INS
mitochondrial inner membrane 1 ACADVL
Cytoplasm, cytosol 1 BCO1
plasma membrane 3 BMP2, RBP1, SMAD3
Membrane 3 RARG, RETSAT, VEGFA
extracellular exosome 1 RBP4
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, VEGFA
extracellular space 4 BMP2, INS, RBP4, VEGFA
perinuclear region of cytoplasm 2 ALDH1A2, PPARG
adherens junction 1 VEGFA
mitochondrion 3 ACADVL, BCO2, RBP1
intracellular membrane-bounded organelle 3 BMP2, HSD17B6, PPARG
Microsome membrane 2 CYP26A1, HSD17B6
Secreted 4 BMP2, INS, RBP4, VEGFA
extracellular region 4 BMP2, INS, RBP4, VEGFA
mitochondrial matrix 2 ACADVL, BCO2
transcription regulator complex 3 MLXIPL, RARG, SMAD3
nuclear membrane 1 RETSAT
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 ACADVL
Mitochondrion inner membrane 1 ACADVL
extracellular matrix 1 VEGFA
mitochondrial nucleoid 1 ACADVL
secretory granule 1 VEGFA
nuclear inner membrane 1 SMAD3
nuclear outer membrane 1 RETSAT
receptor complex 3 PPARG, SMAD3, VDR
chromatin 7 HOXA1, MLXIPL, PPARG, RARG, RXRG, SMAD3, VDR
Endomembrane system 1 RETSAT
endosome lumen 1 INS
Lipid droplet 1 RBP1
cell body 1 RBP1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transcription repressor complex 1 RBP1
platelet alpha granule lumen 1 VEGFA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calyx of Held 1 RBP1
heteromeric SMAD protein complex 1 SMAD3
SMAD protein complex 1 SMAD3
Sin3-type complex 1 RBP1
BMP receptor complex 1 BMP2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform 2]: Mitochondrion inner membrane 1 ACADVL


文献列表

  • Xianru Xia, Xiandong Li, Fei Xie, Guolin Yuan, Dongliang Cheng, Chunyan Peng. Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry. Annals of translational medicine. 2022 Feb; 10(3):133. doi: 10.21037/atm-22-118. [PMID: 35284547]
  • Wojciech Krężel, Aurea Rivas, Monika Szklenar, Marion Ciancia, Rosana Alvarez, Angel R de Lera, Ralph Rühl. Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13030925. [PMID: 33809241]
  • Alexander R Moise, Glenn P Lobo, Bernadette Erokwu, David L Wilson, David Peck, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Chris A Flask, Angel R de Lera, Johannes von Lintig, Krzysztof Palczewski. Increased adiposity in the retinol saturase-knockout mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Apr; 24(4):1261-70. doi: 10.1096/fj.09-147207. [PMID: 19940255]
  • Alexander R Moise, Andrea Isken, Marta Domínguez, Angel R de Lera, Johannes von Lintig, Krzysztof Palczewski. Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry. 2007 Feb; 46(7):1811-20. doi: 10.1021/bi062147u. [PMID: 17253779]
  • Alexander R Moise, Vladimir Kuksa, Yoshikazu Imanishi, Krzysztof Palczewski. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. The Journal of biological chemistry. 2004 Nov; 279(48):50230-42. doi: 10.1074/jbc.m409130200. [PMID: 15358783]