Cephalexin (BioDeep_00000419369)
Main id: BioDeep_00000002201
natural product
代谢物信息卡片
Cephalexin - Dark Web Drugs
化学式: C16H17N3O4S (347.09397220000005)
中文名称: 头孢氨苄
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O
InChI: InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
描述信息
A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3534
- KEGG: C06895
- KEGGdrug: D00263
- PubChem: 27447
- DrugBank: DB00567
- ChEMBL: CHEMBL1727
- MeSH: Cephalexin
- CAS: 15686-71-2
- CAS: 34632-04-7
- MoNA: CCMSLIB00005434461
- MoNA: CCMSLIB00005434462
- MoNA: CCMSLIB00005434463
- MoNA: CCMSLIB00005434464
- MoNA: CCMSLIB00005434465
- MetaboLights: MTBLC3534
- PubChem: 9112
- NIKKAJI: J3.133J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pascaline Sanga, Haitham Saad Al-Mashriqi, Jing Xiao, Jia Chen, Hongdeng Qiu. Streamlined fabrication of AuPtRh trimetallic nanoparticles supported on Ti3C2MXene for enhanced photocatalytic activity in cephalosporins degradation.
Journal of colloid and interface science.
2024 Mar; 658(?):188-198. doi:
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Journal of bioscience and bioengineering.
2022 Nov; 134(5):471-476. doi:
10.1016/j.jbiosc.2022.08.003. [PMID: 36151004] - M Hamdi Abdulkareem, I Abbas Abood, M Munis Dakheel. Antimicrobial Resistance of Tannin Extract against E. coli Isolates from Sheep.
Archives of Razi Institute.
2022 Apr; 77(2):697-701. doi:
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Environmental science and pollution research international.
2021 Dec; 28(47):67822-67832. doi:
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International journal of clinical pharmacology and therapeutics.
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The Journal of infection.
2021 08; 83(2):182-189. doi:
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Journal of veterinary pharmacology and therapeutics.
2011 Aug; 34(4):397-402. doi:
10.1111/j.1365-2885.2010.01232.x. [PMID: 20950353] - Tanja Ilić, Sanda Gračan, Adela Arapović, Vesna Capkun, Mirna Subat-Dežulović, Marijan Saraga. Changes in bacterial resistance patterns in children with urinary tract infections on antimicrobial prophylaxis at University Hospital in Split.
Medical science monitor : international medical journal of experimental and clinical research.
2011 Jul; 17(7):CR355-61. doi:
10.12659/msm.881845. [PMID: 21709628] - Alexandra Christine Helena Frankland Sawaya, Ildenize Barbosa da Silva Cunha, Maria Cristina Marcucci. Analytical methods applied to diverse types of Brazilian propolis.
Chemistry Central journal.
2011 Jun; 5(1):27. doi:
10.1186/1752-153x-5-27. [PMID: 21631940] - Cliodna A M McNulty, Gemma M Lasseter, André Charlett, Andy Lovering, Rebecca Howell-Jones, Alasdair Macgowan, Mike Thomas. Does laboratory antibiotic susceptibility reporting influence primary care prescribing in urinary tract infection and other infections?.
The Journal of antimicrobial chemotherapy.
2011 Jun; 66(6):1396-404. doi:
10.1093/jac/dkr088. [PMID: 21398297] - Zofia Wańkowicz, Anna Grzywacz, Marek Saracyn, Henryk Zieliński. Multiple renal abscesses leading to nephrectomy of the solitary kidney in a young female with type 1 diabetes and history of recurrent urinary tract infections.
Archives of medical science : AMS.
2011 Apr; 7(2):349-52. doi:
10.5114/aoms.2011.22091. [PMID: 22291780] - N Mori, Y Shimomukai, T Yokooji, M Ishiguro, Y Kamio, T Murakami. Modulation in concentrative nucleoside transporters-mediated intestinal absorption of mizoribine, an immunosuppressive agent, in lipopolysaccharide-treated rats.
Die Pharmazie.
2011 Mar; 66(3):207-11. doi:
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European journal of pediatrics.
2011 Mar; 170(3):347-50. doi:
10.1007/s00431-010-1297-1. [PMID: 20853007] - Praveen Rishi, Simran Preet, Prabhjot Kaur. Effect of L. plantarum cell-free extract and co-trimoxazole against Salmonella Typhimurium: a possible adjunct therapy.
Annals of clinical microbiology and antimicrobials.
2011 Feb; 10(?):9. doi:
10.1186/1476-0711-10-9. [PMID: 21352573] - Wipawadee Sianglum, Potjanee Srimanote, Wijit Wonglumsom, Kanokwan Kittiniyom, Supayang P Voravuthikunchai. Proteome analyses of cellular proteins in methicillin-resistant Staphylococcus aureus treated with rhodomyrtone, a novel antibiotic candidate.
PloS one.
2011 Feb; 6(2):e16628. doi:
10.1371/journal.pone.0016628. [PMID: 21326597] - Ziaaedin Ghorashi, Sona Ghorashi, Hassan Soltani-Ahari, Nariman Nezami. Demographic features and antibiotic resistance among children hospitalized for urinary tract infection in northwest Iran.
Infection and drug resistance.
2011; 4(?):171-6. doi:
10.2147/idr.s24171. [PMID: 22114509] - Iman K Behiry, Emad A Abada, Entsar A Ahmed, Rania S Labeeb. Enteropathogenic Escherichia coli associated with diarrhea in children in Cairo, Egypt.
TheScientificWorldJournal.
2011; 11(?):2613-9. doi:
10.1100/2011/485381. [PMID: 22262949] - Sang-Wook Han, Malinee Sriariyanun, Sang-Won Lee, Manoj Sharma, Ofir Bahar, Zachary Bower, Pamela C Ronald. Small protein-mediated quorum sensing in a Gram-negative bacterium.
PloS one.
2011; 6(12):e29192. doi:
10.1371/journal.pone.0029192. [PMID: 22174954] - S Saeidnia, Ar Gohari, N Mokhber-Dezfuli, F Kiuchi. A review on phytochemistry and medicinal properties of the genus Achillea.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2011; 19(3):173-86. doi:
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Drug metabolism and pharmacokinetics.
2011; 26(1):87-93. doi:
10.2133/dmpk.dmpk-10-rg-039. [PMID: 21084767] - Anna-Maria Nässl, Isabel Rubio-Aliaga, Manuela Sailer, Hannelore Daniel. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet.
PloS one.
2011; 6(10):e26407. doi:
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International journal of general medicine.
2011; 4(?):333-43. doi:
10.2147/ijgm.s11767. [PMID: 21674026] - Rose McGready, Vanaporn Wuthiekanun, Elizabeth A Ashley, Saw Oo Tan, Mupawjay Pimanpanarak, Samuel Jacher Viladpai-Nguen, Wilarat Jesadapanpong, Stuart D Blacksell, Stephane Proux, Nicholas P Day, Pratap Singhasivanon, Nicholas J White, François Nosten, Sharon J Peacock. Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings.
The American journal of tropical medicine and hygiene.
2010 Dec; 83(6):1322-9. doi:
10.4269/ajtmh.2010.10-0332. [PMID: 21118943] - Hong-Qi Chen, Jun Yang, Min Zhang, Yu-Kun Zhou, Tong-Yi Shen, Zhao-Xin Chu, Ming Zhang, Xiao-Min Hang, Yan-Qun Jiang, Huan-Long Qin. Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice.
American journal of physiology. Gastrointestinal and liver physiology.
2010 Dec; 299(6):G1287-97. doi:
10.1152/ajpgi.00196.2010. [PMID: 20884889] - Mark G Papich, Jennifer L Davis, Amanda M Floerchinger. Pharmacokinetics, protein binding, and tissue distribution of orally administered cefpodoxime proxetil and cephalexin in dogs.
American journal of veterinary research.
2010 Dec; 71(12):1484-91. doi:
10.2460/ajvr.71.12.1484. [PMID: 21118001] - Fernando Antonini, Cassiano Costa Silva Pereira, Eduardo Varela Parente, Fabiano Goulart Azambuja. Management of osteonecrosis of the jaws in patients with history of bisphosphonates therapy.
The Journal of craniofacial surgery.
2010 Nov; 21(6):1962-6. doi:
10.1097/scs.0b013e3181f4ee4e. [PMID: 21119470] - Aftab S Chishti, Erich C Maul, Rubén J Nazario, Jeffrey S Bennett, Stefan G Kiessling. A guideline for the inpatient care of children with pyelonephritis.
Annals of Saudi medicine.
2010 Sep; 30(5):341-9. doi:
10.4103/0256-4947.68549. [PMID: 20716830] - Shingo Watanabe, Masahiro Tsuda, Tomohiro Terada, Toshiya Katsura, Ken-Ichi Inui. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice.
The Journal of pharmacology and experimental therapeutics.
2010 Aug; 334(2):651-6. doi:
10.1124/jpet.110.169433. [PMID: 20484555] - Ya-Wen He, Ji'en Wu, Jae-Soon Cha, Lian-Hui Zhang. Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production.
BMC microbiology.
2010 Jul; 10(?):187. doi:
10.1186/1471-2180-10-187. [PMID: 20615263] - Shilpa Arora, Pushpa Devi, Usha Arora, Bimla Devi. Prevalence of Methicillin-resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Hospital in Northern India.
Journal of laboratory physicians.
2010 Jul; 2(2):78-81. doi:
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Journal of clinical pathology.
2010 Jul; 63(7):652-4. doi:
10.1136/jcp.2009.074617. [PMID: 20501451] - Michael Pennick. Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine.
Neuropsychiatric disease and treatment.
2010 Jun; 6(?):317-27. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2010 Jun; 38(6):930-8. doi:
10.1124/dmd.110.032060. [PMID: 20219852] - Adenike Adedayo O Ogunshe, Abosede Oyeyemi Fawole, Victoria Abosede Ajayi. Microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy.
The Pan African medical journal.
2010 May; 5(?):12. doi:
10.4314/pamj.v5i1.56188. [PMID: 21293739] - Alex Avdeef, Kin Y Tam. How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?.
Journal of medicinal chemistry.
2010 May; 53(9):3566-84. doi:
10.1021/jm901846t. [PMID: 20373811] - Amélie Leclerc, Anthony C G Abrams-Ogg, Stephen A Kruth, Dorothee Bienzle. Effects of lithium carbonate on carboplatin-induced thrombocytopenia in dogs.
American journal of veterinary research.
2010 May; 71(5):555-63. doi:
10.2460/ajvr.71.5.555. [PMID: 20433382] - Sreyashi Sarkar, Arnab Pramanik, Anindita Mitra, Joydeep Mukherjee. Bioprocessing data for the production of marine enzymes.
Marine drugs.
2010 Apr; 8(4):1323-72. doi:
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Emerging infectious diseases.
2010 Mar; 16(3):521-3. doi:
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BMC complementary and alternative medicine.
2010 Feb; 10(?):9. doi:
10.1186/1472-6882-10-9. [PMID: 20187978] - Vesna Stojanović, Biljana Milosević. [Resistence of Escherichia coli, the most frequent cause of urinary tract infection in children, to antibiotics].
Medicinski pregled.
2010 Jan; 63(1-2):109-12. doi:
10.2298/mpns1002109s. [PMID: 20873320] - A R Gohari, S Saeidnia, K Mollazadeh, N Yassa, M Malmir, A R Shahverdi. Isolation of a new quinic acid derivative and its antibacterial modulating activity.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2010; 18(1):69-73. doi:
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Journal of natural medicines.
2010 Jan; 64(1):55-62. doi:
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Sensors (Basel, Switzerland).
2010; 10(8):7323-46. doi:
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