ethosuximide (BioDeep_00000415943)

Main id: BioDeep_00000006513

 


代谢物信息卡片


ethosuximide

化学式: C7H11NO2 (141.0789746)
中文名称: 乙琥胺
谱图信息: 最多检出来源 Homo sapiens(urine) 8.77%

分子结构信息

SMILES: CCC1(CC(=O)NC1=O)C
InChI: InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

描述信息

N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

1 个代谢物同义名

ethosuximide



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Léonore Diezi, Kim Dao, Vincent Jullien, Caroline Roussel-Maupetit, Ingrid Burton, Pascal André, Carine Bardinet, Laura E Rothuizen, Haithem Chtioui, Maria A Manso-Silvan, Catherine Guittet, Françoise Brunner-Ferber, Francois Vandenhende, Catherine Chiron, Luc-André Granier, Thierry Buclin. An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup. Pharmacology research & perspectives. 2023 02; 11(1):e01032. doi: 10.1002/prp2.1032. [PMID: 36537292]
  • Ramzi Shawahna, Lina Zaid. Concentrations of antiseizure medications in breast milk of lactating women with epilepsy: A systematic review with qualitative synthesis. Seizure. 2022 May; 98(?):57-70. doi: 10.1016/j.seizure.2022.03.017. [PMID: 35427849]
  • Sahar M El-Haggar, Sahar K Hegazy, Sherief M Abd-Elsalam, Mostafa M Bahaa. Open-label pilot study of ethosuximide as adjunctive therapy for relieving abdominal pain related to Irritable Bowel Syndrome. Journal of clinical pharmacy and therapeutics. 2022 Mar; 47(3):306-312. doi: 10.1111/jcpt.13556. [PMID: 34726293]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • María Eva González-Trujano, Gerardo Contreras-Murillo, Claudia Andrea López-Najera, Fernando Josué Hidalgo-Flores, Andrés Navarrete-Castro, Concepción Gamboa Sánchez, Víctor Manuel Magdaleno-Madrigal. Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats. Journal of ethnopharmacology. 2021 Jan; 265(?):113299. doi: 10.1016/j.jep.2020.113299. [PMID: 32841694]
  • Mariusz J Świąder, Katarzyna Świąder, Izabela Zakrocka, Maciej Krzyżanowski, Andrzej Wróbel, Jarogniew J Łuszczki, Stanisław J Czuczwar. Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. Pharmacological reports : PR. 2020 Apr; 72(2):322-330. doi: 10.1007/s43440-019-00037-6. [PMID: 32048251]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Simranjot Kaur, Leonid N Maslov, Nirmal Singh, Amteshwar Singh Jaggi. Dual role of T-type calcium channels in anxiety-related behavior. Journal of basic and clinical physiology and pharmacology. 2019 Oct; 31(3):. doi: 10.1515/jbcpp-2019-0067. [PMID: 31644427]
  • Simranjot Kaur, Nirmal Singh, Amteshwar Singh Jaggi. Opening of T-type Ca2+ channels and activation of HCN channels contribute in stress adaptation in cold water immersion stress-subjected mice. Life sciences. 2019 Sep; 232(?):116605. doi: 10.1016/j.lfs.2019.116605. [PMID: 31254588]
  • Ying-Jung Wu, Yi-Shan Li, Wei-Lung Tseng, Chi-Yu Lu. Microextraction combined with microderivatization for drug monitoring and protein modification analysis from limited blood volume using mass spectrometry. Analytical and bioanalytical chemistry. 2018 Nov; 410(28):7405-7414. doi: 10.1007/s00216-018-1349-3. [PMID: 30191273]
  • Paula San-José, Ruth Cano-Corres, Vicente Aguadero, Paula Miralles-Albors, Eugenio Berlanga-Escalera. Interference between ethosuximide and barbiturates in an immunochromatographic method. Clinical chemistry and laboratory medicine. 2018 01; 56(2):e50-e52. doi: 10.1515/cclm-2017-0441. [PMID: 28763298]
  • Yongxia Ji, Jia Lin, Xiaolan Peng, Xiuyun Liu, Fei Li, Yinglan Zhang, Ning Guo, Qiang Li. Behavioural responses of zebrafish larvae to acute ethosuximide exposure. Behavioural pharmacology. 2017 09; 28(6):428-440. doi: 10.1097/fbp.0000000000000312. [PMID: 28537944]
  • Keaton S Smetana, Aaron M Cook, Melissa L Thompson Bastin, Douglas R Oyler. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. Journal of critical care. 2016 12; 36(?):116-124. doi: 10.1016/j.jcrc.2016.06.023. [PMID: 27546759]
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  • Majid Asadi-Shekaari, Azam Eslami, Tajpari Kalantaripour, Siyavash Joukar. Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2014; 23(6):538-42. doi: 10.1159/000365759. [PMID: 25196480]
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  • Mai Shibata, Sachiyo Hashi, Haruka Nakanishi, Satohiro Masuda, Toshiya Katsura, Ikuko Yano. Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring. Biomedical chromatography : BMC. 2012 Dec; 26(12):1519-28. doi: 10.1002/bmc.2726. [PMID: 22383262]
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  • Nicole Pagès, Pierre Maurois, Bernadette Delplanque, Pierre Bac, Joseph Vamecq. Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions. Prostaglandins, leukotrienes, and essential fatty acids. 2012 Aug; 87(2-3):63-70. doi: 10.1016/j.plefa.2012.06.002. [PMID: 22749692]
  • Danièle Bentué-Ferrer, Olivier Tribut, Marie-Clémence Verdier. [Therapeutic drug monitoring of ethosuximide]. Therapie. 2012 Jul; 67(4):391-6. doi: 10.2515/therapie/2012035. [PMID: 23110840]
  • L Tabatabaie, L W J Klomp, M E Rubio-Gozalbo, L J M Spaapen, A A M Haagen, L Dorland, T J de Koning. Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency. Journal of inherited metabolic disease. 2011 Feb; 34(1):181-4. doi: 10.1007/s10545-010-9249-5. [PMID: 21113737]
  • M Sayyah, A Khodaparast, A Yazdi, S Sardari. Screening of the anticonvulsant activity of some plants from Fabaceae family in experimental seizure models in mice. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(4):301-5. doi: ". [PMID: 22615673]
  • Jae Ho Lee, Hak Jun Ahn, Sang Jin Lee, Myung Chan Gye, Churl K Min. Effects of L- and T-type Ca²(+) channel blockers on spermatogenesis and steroidogenesis in the prepubertal mouse testis. Journal of assisted reproduction and genetics. 2011 Jan; 28(1):23-30. doi: 10.1007/s10815-010-9480-x. [PMID: 20859763]
  • Hiroko Ikeda, Tateki Fujiwara, Hideo Shigematsu, Katsumi Imai, Hidemoto Kubota, Yuko Kubota, Yukitoshi Takahashi, Yushi Inoue. [Symptoms and clinical course of epilepsy with myoclonic absences]. No to hattatsu = Brain and development. 2011 Jan; 43(1):14-8. doi: NULL. [PMID: 21400926]
  • Muhannad R M Salih, Mohd Baidi Bahari, Arwa Y Abd. Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients. Nutrition journal. 2010 Dec; 9(?):71. doi: 10.1186/1475-2891-9-71. [PMID: 21194458]
  • Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications. Current neuropharmacology. 2010 Sep; 8(3):254-67. doi: 10.2174/157015910792246254. [PMID: 21358975]
  • Chunbo Zhang, Patrick Kwan, Zhong Zuo, Larry Baum. In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. Life sciences. 2010 Jun; 86(23-24):899-905. doi: 10.1016/j.lfs.2010.04.008. [PMID: 20417647]
  • Mitesh Bhatt, Sanjay Shah, Shivprakash. Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jun; 878(19):1605-10. doi: 10.1016/j.jchromb.2010.03.019. [PMID: 20417157]
  • Koichi Hasegawa, Satsuki Miwa, Kaname Tsutsumiuchi, Johji Miwa. Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. PloS one. 2010 Feb; 5(2):e9267. doi: 10.1371/journal.pone.0009267. [PMID: 20174640]
  • F P Ching, E K I Omogbai, I O Otokiti. Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2009 Jul; 6(4):544-8. doi: 10.4314/ajtcam.v6i4.57197. [PMID: 20606775]
  • G N Bogdanov, D V Mishchenko, R A Kotel'nikova, E S Frog, I I Faĭngol'd, L V Tat'ianenko, O V Dorokhotova, Ia R Nartsissov. [Anticonvulsants as bioantioxidants under stress conditions]. Biomeditsinskaia khimiia. 2009 Jul; 55(4):519-24. doi: ". [PMID: 20000129]
  • Kokoro Matsuura, Yoshinari Morimoto, Mitsutaka Sugimura, Kunitaka Taki, Maki Maeda, Hitoshi Niwa. [Case report of dentatorubral pallidoluysian atrophy in a patient on a ketogenic diet]. Masui. The Japanese journal of anesthesiology. 2009 Jun; 58(6):762-4. doi: . [PMID: 19522273]
  • Pamela M Crawford. Managing epilepsy in women of childbearing age. Drug safety. 2009; 32(4):293-307. doi: 10.2165/00002018-200932040-00004. [PMID: 19388721]
  • Jarogniew J Luszczki. Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. Naunyn-Schmiedeberg's archives of pharmacology. 2008 Nov; 378(5):483-92. doi: 10.1007/s00210-008-0305-8. [PMID: 18566800]
  • Zhi-Qiang Yang, James C Barrow, William D Shipe, Kelly-Ann S Schlegel, Youheng Shu, F Vivien Yang, Craig W Lindsley, Kenneth E Rittle, Mark G Bock, George D Hartman, Victor N Uebele, Cindy E Nuss, Steve V Fox, Richard L Kraus, Scott M Doran, Thomas M Connolly, Cuyue Tang, Jeanine E Ballard, Yuhsin Kuo, Emily D Adarayan, Thomayant Prueksaritanont, Matthew M Zrada, Michael J Marino, Valerie Kuzmick Graufelds, Anthony G DiLella, Ian J Reynolds, Hugo M Vargas, Patricia B Bunting, Richard F Woltmann, Michael M Magee, Kenneth S Koblan, John J Renger. Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. Journal of medicinal chemistry. 2008 Oct; 51(20):6471-7. doi: 10.1021/jm800830n. [PMID: 18817368]
  • Kevin Yi-Lwern Yap, Wai Keung Chui, Alexandre Chan. Drug interactions between chemotherapeutic regimens and antiepileptics. Clinical therapeutics. 2008 Aug; 30(8):1385-407. doi: 10.1016/j.clinthera.2008.08.011. [PMID: 18803983]
  • S Ueshima, T Aiba, T Makita, S Nishihara, Y Kitamura, Y Kurosaki, H Kawasaki, T Sendo, Y Ohtsuka, Y Gomita. Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children. Journal of clinical pharmacy and therapeutics. 2008 Feb; 33(1):31-8. doi: 10.1111/j.1365-2710.2008.00885.x. [PMID: 18211614]
  • T A C Vermeij, P M Edelbroek. Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 857(1):40-6. doi: 10.1016/j.jchromb.2007.06.023. [PMID: 17627908]
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  • B Koristkova, M Grundmann, H Brozmanova. Differences between prescribed daily doses and defined daily doses of antiepileptics--therapeutic drug monitoring as a marker of the quality of the treatment. International journal of clinical pharmacology and therapeutics. 2006 Sep; 44(9):438-42. doi: 10.5414/cpp44438. [PMID: 16995332]
  • A L Martínez, F Domínguez, S Orozco, M Chávez, H Salgado, M González, M E González-Trujano. Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. Journal of ethnopharmacology. 2006 Jun; 106(2):250-5. doi: 10.1016/j.jep.2006.01.003. [PMID: 16442760]
  • Miki Inutsuka, Katsuhiro Kobayashi, Makio Oka, Junri Hattori, Yoko Ohtsuka. Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain & development. 2006 Jun; 28(5):281-6. doi: 10.1016/j.braindev.2005.09.004. [PMID: 16376508]
  • Renzo Guerrini. Valproate as a mainstay of therapy for pediatric epilepsy. Paediatric drugs. 2006; 8(2):113-29. doi: 10.2165/00148581-200608020-00004. [PMID: 16608372]
  • Mariusz J Swiader, Jacek Porebiak, Katarzyna Swiader, Marian Wielosz, Stanisław J Czuczwar. Influence of cimetidine on the anticonvulsant activity of conventional antiepileptic drugs against pentetrazole-induced seizures in mice. Pharmacological reports : PR. 2006 Jan; 58(1):131-4. doi: NULL. [PMID: 16531641]
  • Torbjörn Tomson. Gender aspects of pharmacokinetics of new and old AEDs: pregnancy and breast-feeding. Therapeutic drug monitoring. 2005 Dec; 27(6):718-21. doi: 10.1097/01.ftd.0000179843.63515.8f. [PMID: 16404803]
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  • Katarzyna Makarska-Białek, Rafał M Kamiński, Stanisław J Czuczwar. Influence of the antagonist of the glycine site of NMDA receptors, MRZ 2/576, on the anticonvulsant activity of conventional antiepileptic drugs in mice. Pharmacological reports : PR. 2005 Jul; 57(4):458-66. doi: NULL. [PMID: 16129912]
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  • E Ngo Bum, A Rakotonirina, S V Rakotonirina, P Herrling. Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge. Journal of ethnopharmacology. 2003 Jul; 87(1):27-34. doi: 10.1016/s0378-8741(03)00103-x. [PMID: 12787951]
  • Kinga K Borowicz, Jarogniew J Luszczki, Andrzej M Duda, Stanislaw J Czuczwar. Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. Epilepsia. 2003 May; 44(5):640-6. doi: 10.1046/j.1528-1157.2003.45202.x. [PMID: 12752462]
  • Mariusz Swiader, Jarogniew Łuszczki, Marian Wielosz, Stanisław J Czuczwar. Influence of vigabatrin, a novel antiepileptic drug, on the anticonvulsant activity of conventional antiepileptics in pentetrazole-induced seizures in mice. Polish journal of pharmacology. 2003 May; 55(3):363-70. doi: . [PMID: 14506315]
  • Noriyasu Fukuoka, Toyohisa Tsukamoto, Junji Uno, Michio Kimura, Shushi Morita. Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2003 Jan; 123(1):35-42. doi: 10.1248/yakushi.123.35. [PMID: 12607943]
  • John F Wilson, Ian D Watson, John Williams, Pat A Toseland, Alison H Thomson, Grace Sweeney, Brian L Smith, Lance N Sandle, John D Ramsey, Nigel E Capps. Primary standardization of assays for anticonvulsant drugs: comparison of accuracy and precision. Clinical chemistry. 2002 Nov; 48(11):1963-9. doi: 10.1093/clinchem/48.11.1963. [PMID: 12406982]
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