Montelukast (BioDeep_00000409846)
Main id: BioDeep_00000002541
代谢物信息卡片
Montelukast
化学式: C35H36ClNO3S (585.2104296000001)
中文名称: 孟鲁司特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
InChI: InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DC - Leukotriene receptor antagonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
D065693 - Cytochrome P-450 Enzyme Inducers > D065694 - Cytochrome P-450 CYP1A2 Inducers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2745
同义名列表
1 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:94710
- ChEBI: CHEBI:50730
- KEGG: C07482
- KEGGdrug: D08229
- PubChem: 5281040
- PubChem: 4248
- DrugBank: DB00471
- ChEMBL: CHEMBL787
- CAS: 1124196-02-6
- CAS: 142522-28-9
- CAS: 158966-92-8
- MoNA: AU274506
- MoNA: AU274505
- MoNA: AU274504
- MoNA: AU274503
- MoNA: AU274502
- MoNA: AU274501
- PubChem: 9685
- PDB-CCD: MTK
- NIKKAJI: J870.100H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhi-Hui Fu, Lin Zhou, An-Zheng Nie. [Effect and mechanism of Maxing Shigan Decoction on reducing inflammatory response in rats with cough variant asthma via TLR4/MyD88/NF-κB and p38 MAPK signaling pathways].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Feb; 49(4):1000-1006. doi:
10.19540/j.cnki.cjcmm.20230921.406. [PMID: 38621907] - Surbhi Gupta, Prabhat Singh, Bhupesh Sharma. Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial Dysfunction and Associated Vascular Dementia.
Current hypertension reviews.
2024 Jan; ?(?):. doi:
10.2174/0115734021276985231204092425. [PMID: 38192137] - Hanan H Hagar, Shaima M Alhazmi, Maha Arafah, Nervana Mustafa Bayoumy. Inhibition of sepsis-induced pancreatic injury by leukotriene receptor antagonism via modulation of oxidative injury, and downregulation of inflammatory markers in experimental rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Nov; ?(?):. doi:
10.1007/s00210-023-02812-y. [PMID: 37962585] - Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou. Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Life sciences.
2023 Jul; 325(?):121772. doi:
10.1016/j.lfs.2023.121772. [PMID: 37178864] - Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol.
Alcohol (Fayetteville, N.Y.).
2023 Jun; ?(?):. doi:
10.1016/j.alcohol.2023.05.008. [PMID: 37295565] - Qian Xu, Tingting Lu, Zhongyang Song, Peng Zhu, Yana Wu, Lumei Zhang, Kehu Yang, Zhiming Zhang. Efficacy and safety of montelukast adjuvant therapy in adults with cough variant asthma: A systematic review and meta-analysis.
The clinical respiratory journal.
2023 May; ?(?):. doi:
10.1111/crj.13629. [PMID: 37218346] - Ahmed M Fleifel, Ayman A Soubh, Dalaal M Abdallah, Kawkab A Ahmed, Hanan S El-Abhar. Preferential effect of Montelukast on Dapagliflozin: Modulation of IRS-1/AKT/GLUT4 and ER stress response elements improves insulin sensitivity in soleus muscle of a type-2 diabetic rat model.
Life sciences.
2022 Oct; 307(?):120865. doi:
10.1016/j.lfs.2022.120865. [PMID: 35934057] - S Scott Sutton, Joseph Magagnoli, Tammy H Cummings, James W Hardin. Leukotriene receptor antagonism with montelukast as a possible therapeutic for venous thromboembolism prophylaxis: An observational study.
Prostaglandins & other lipid mediators.
2022 08; 161(?):106649. doi:
10.1016/j.prostaglandins.2022.106649. [PMID: 35595009] - Yun Wu, Chen Cui, Fang-Fang Bi, Cheng-Yu Wu, Jin-Rui Li, Yu-Meng Hou, Ze-Hong Jing, Qing-Ming Pan, Miao Cao, Li-Fang Lv, Xue-Lian Li, Hong-Li Shan, Xin Zhai, Yu-Hong Zhou. Montelukast, cysteinyl leukotriene receptor 1 antagonist, inhibits cardiac fibrosis by activating APJ.
European journal of pharmacology.
2022 May; 923(?):174892. doi:
10.1016/j.ejphar.2022.174892. [PMID: 35358494] - Giuseppe Fabio Parisi, Sara Manti, Maria Papale, Alessandro Giallongo, Cristiana Indolfi, Michele Miraglia Del Giudice, Carmelo Salpietro, Amelia Licari, Gian Luigi Marseglia, Salvatore Leonardi. Addition of a nutraceutical to montelukast or inhaled steroid in the treatment of wheezing during COVID-19 pandemic: a multicenter, open-label, randomized controlled trial.
Acta bio-medica : Atenei Parmensis.
2022 05; 93(2):e2022156. doi:
10.23750/abm.v93i2.11958. [PMID: 35546018] - Buğra Kerget, Ferhan Kerget, Murat Aydın, Ömer Karaşahin. Effect of montelukast therapy on clinical course, pulmonary function, and mortality in patients with COVID-19.
Journal of medical virology.
2022 05; 94(5):1950-1958. doi:
10.1002/jmv.27552. [PMID: 34958142] - Kirsten M Williams, Steven Z Pavletic, Stephanie J Lee, Paul J Martin, Don E Farthing, Frances T Hakim, Jeremy Rose, Beryl L Manning-Geist, Juan C Gea-Banacloche, Leora E Comis, Edward W Cowen, David G Justus, Kristin Baird, Guang-Shing Cheng, Daniele Avila, Seth M Steinberg, Sandra A Mitchell, Ronald E Gress. Prospective Phase II Trial of Montelukast to Treat Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation and Investigation into Bronchiolitis Obliterans Syndrome Pathogenesis.
Transplantation and cellular therapy.
2022 05; 28(5):264.e1-264.e9. doi:
10.1016/j.jtct.2022.01.021. [PMID: 35114411] - Yongkang Chen, Xiaohuan Wang, Huichun Shi, Peng Zou. Montelukast Inhibits HCoV-OC43 Infection as a Viral Inactivator.
Viruses.
2022 04; 14(5):. doi:
10.3390/v14050861. [PMID: 35632604] - Ahsan R Khan, Christian Misdary, Nikhil Yegya-Raman, Sinae Kim, Navaneeth Narayanan, Sheraz Siddiqui, Padmini Salgame, Jared Radbel, Frank De Groote, Carl Michel, Janice Mehnert, Caleb Hernandez, Thomas Braciale, Jyoti Malhotra, Michael A Gentile, Salma K Jabbour. Montelukast in hospitalized patients diagnosed with COVID-19.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2022 04; 59(4):780-786. doi:
10.1080/02770903.2021.1881967. [PMID: 33577360] - Heba M Hafez, Hanaa Hassanein. Montelukast ameliorates doxorubicin-induced cardiotoxicity via modulation of p-glycoprotein and inhibition of ROS-mediated TNF-α/NF-κB pathways.
Drug and chemical toxicology.
2022 Mar; 45(2):548-559. doi:
10.1080/01480545.2020.1730885. [PMID: 32106718] - Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Şeyma Işık, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak. The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022 02; 30(2):963-974. doi:
10.1016/j.ymthe.2021.10.014. [PMID: 34678509] - Bruce Chandler May, Kathleen Holly Gallivan. Levocetirizine and montelukast in the COVID-19 treatment paradigm.
International immunopharmacology.
2022 Feb; 103(?):108412. doi:
10.1016/j.intimp.2021.108412. [PMID: 34942461] - Francisco Mera-Cordero, Sara Bonet-Monne, Jesús Almeda-Ortega, Ana García-Sangenís, Oriol Cunillera-Puèrtolas, Sara Contreras-Martos, Gemma Alvarez-Muñoz, Ramon Monfà, Marina Balanzo-Joué, Rosa Morros, Betlem Salvador-Gonzalez. Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol.
Trials.
2022 Jan; 23(1):19. doi:
10.1186/s13063-021-05951-w. [PMID: 34991703] - Zang Ping, Xue Jun, Wang Yan, Zhang Jun. The comparison between the effect of Glycyrrhizae uralensis (Gan-Cao) and Montelukast on the expression of T-bet and GATA-3 genes in children with allergic asthma.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Jan; 67(4):306-312. doi:
10.14715/cmb/2021.67.4.34. [PMID: 35809275] - Jiachun Li, Ziliang Huang, Keying Li, Xiaoyun Jian, Binghui Liang. Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma.
Computational and mathematical methods in medicine.
2022; 2022(?):9803552. doi:
10.1155/2022/9803552. [PMID: 36132547] - Isil Gazioglu, S Evrim Kepekci Tekkeli, Angela Tartaglia, Ceylin Aslan, Marcello Locatelli, Abuzar Kabir. Simultaneous determination of febuxostat and montelukast in human plasma using fabric phase sorptive extraction and high performance liquid chromatography-fluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jan; 1188(?):123070. doi:
10.1016/j.jchromb.2021.123070. [PMID: 34920289] - Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi. Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
PloS one.
2022; 17(11):e0277307. doi:
10.1371/journal.pone.0277307. [PMID: 36395281] - Ashok K Datusalia, Gurpreet Singh, Nikita Yadav, Sachin Gaun, Moumita Manik, Rakesh K Singh. Targeted Delivery of Montelukast for the Treatment of Alzheimer's Disease.
CNS & neurological disorders drug targets.
2022; 21(10):913-925. doi:
10.2174/1871527320666210902163756. [PMID: 34477536] - Xiuling Zhou, Ye Zhang, Le Liu, Xiaochun Feng, Hongshi Zhang. Therapeutic effect of acupuncture combined montelukast sodium on cough variant asthma in children: A protocol for systematic review and meta-analysis.
Medicine.
2021 Dec; 100(51):e28048. doi:
10.1097/md.0000000000028048. [PMID: 34941045] - Andrzej Bozek, Janne Winterstein. Montelukast's ability to fight COVID-19 infection.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2021 10; 58(10):1348-1349. doi:
10.1080/02770903.2020.1786112. [PMID: 32586154] - Niusha Sharifinejad, Samin Sharafian, Sana Salekmoghadam, Marzieh Tavakol, Mostafa Qorbani. Montelukast and Coronavirus Disease 2019: A Scoping Review.
Iranian journal of allergy, asthma, and immunology.
2021 Aug; 20(4):384-393. doi:
NULL. [PMID: 34418892] - Hayder M Al-Kuraishy, Ali I Al-Gareeb, Yaaser Q Almulaiky, Natália Cruz-Martins, Gaber El-Saber Batiha. Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity.
European journal of pharmacology.
2021 Aug; 904(?):174196. doi:
10.1016/j.ejphar.2021.174196. [PMID: 34004207] - Ahmed M El-Baz, Ahmed Shata, Hanan M Hassan, Mohamed M A El-Sokkary, Ahmed E Khodir. The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress.
International immunopharmacology.
2021 Jul; 96(?):107757. doi:
10.1016/j.intimp.2021.107757. [PMID: 33991997] - Po-Yu Huang, Yao-Hsu Yang, Ying-Hua Huang, Ho-Chang Kuo, Liang-Jen Wang, Shao-Ju Chien, Ling-Sai Chang. Montelukast does not increase the risk of attention-deficit/hyperactivity disorder in pediatric asthma patients: A nationwide population-based matched cohort study.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2021 Jun; 120(6):1369-1376. doi:
10.1016/j.jfma.2020.10.018. [PMID: 33158697] - Walaa Yehia Abdelzaher, Remon Roshdy Rofaeil, Sara Mohammed Naguib Abdel-Hafez, Medhat Atta, Mohamed Ahmed Bahaa El-Deen, Dalia Mohamed Ali. Ameliorating effect of leukotriene receptor antagonist in multi-organ toxicity induced in rat offspring, a possible role for epidermal growth factor.
Immunopharmacology and immunotoxicology.
2021 Apr; 43(2):183-191. doi:
10.1080/08923973.2021.1878213. [PMID: 33504223] - René Lima-Morales, Pablo Méndez-Hernández, Yvonne N Flores, Patricia Osorno-Romero, Christian Ronal Sancho-Hernández, Elizabeth Cuecuecha-Rugerio, Adrián Nava-Zamora, Diego Rolando Hernández-Galdamez, Daniela Karola Romo-Dueñas, Jorge Salmerón. Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Apr; 105(?):598-605. doi:
10.1016/j.ijid.2021.02.014. [PMID: 33578014] - Johanna Michael, Julia Zirknitzer, Michael Stefan Unger, Rodolphe Poupardin, Tanja Rieß, Nadine Paiement, Horst Zerbe, Birgit Hutter-Paier, Herbert Reitsamer, Ludwig Aigner. The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice.
International journal of molecular sciences.
2021 Mar; 22(5):. doi:
10.3390/ijms22052782. [PMID: 33803482] - Donald H Arnold, Sara L Van Driest, Theodore F Reiss, Jennifer C King, Wendell S Akers. Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations.
Journal of clinical pharmacology.
2021 03; 61(3):360-367. doi:
10.1002/jcph.1738. [PMID: 32960980] - Chunlong Ma, Jun Wang. Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(8):. doi:
10.1073/pnas.2024420118. [PMID: 33568498] - Zhe Li, Yuxi Lin, Yi-You Huang, Runduo Liu, Chang-Guo Zhan, Xin Wang, Hai-Bin Luo. Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(8):. doi:
10.1073/pnas.2024937118. [PMID: 33568500] - Emily Yii Ling Wong, Gabriel Onn Kit Loh, Yvonne Tze Fung Tan, Kok Khiang Peh. Development of LC-MS/MS method and application to bioequivalence study of a light sensitive drug montelukast.
Drug development and industrial pharmacy.
2021 Feb; 47(2):197-206. doi:
10.1080/03639045.2020.1862177. [PMID: 33300818] - Weihong Li, Yanrong Wang, Yingzi Pei, Yue Xia. Pharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions.
Drug design, development and therapy.
2021; 15(?):1091-1099. doi:
10.2147/dddt.s298355. [PMID: 33727797] - Mangaldeep Dey, Rakesh Kumar Singh. Possible Therapeutic Potential of Cysteinyl Leukotriene Receptor Antagonist Montelukast in Treatment of SARS-CoV-2-Induced COVID-19.
Pharmacology.
2021; 106(9-10):469-476. doi:
10.1159/000518359. [PMID: 34350893] - Ken Korzekwa. Case Study 5: Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast.
Methods in molecular biology (Clifton, N.J.).
2021; 2342(?):685-693. doi:
10.1007/978-1-0716-1554-6_24. [PMID: 34272712] - Piñeyro-Garza Everardo, Gómez-Silva Magdalena, Gamino-Peña Maria Elena, Cohen-Muñoz Vanessa, Sánchez-Casado Gabriela. Bioavailability assessment of fexofenadine and montelukast in a fixed-dose combination tablet versus the components administered simultaneously.
Allergologia et immunopathologia.
2021; 49(4):15-25. doi:
10.15586/aei.v49i4.89. [PMID: 34224214] - Dennis C Copertino, Rodrigo R R Duarte, Timothy R Powell, Miguel de Mulder Rougvie, Douglas F Nixon. Montelukast drug activity and potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Journal of medical virology.
2021 01; 93(1):187-189. doi:
10.1002/jmv.26299. [PMID: 32658304] - Nitesh Sanghai, Geoffrey K Tranmer. Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms.
Drug discovery today.
2020 12; 25(12):2076-2079. doi:
10.1016/j.drudis.2020.09.013. [PMID: 32949526] - Chao-Qing Gao, Jia-Jun Zhou, Ya-Yin Tan, Chang-Jun Tong. Effectiveness of montelukast for uremic pruritus in hemodialysis patients: A protocol for systematic review and meta-analysis.
Medicine.
2020 Nov; 99(46):e23229. doi:
10.1097/md.0000000000023229. [PMID: 33181709] - Dipankar Bhattacharyya. Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.
Medical hypotheses.
2020 Nov; 144(?):110046. doi:
10.1016/j.mehy.2020.110046. [PMID: 33254480] - Nosayba Al-Azzam, Lina Elsalem. Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives.
Life sciences.
2020 Nov; 260(?):118452. doi:
10.1016/j.lfs.2020.118452. [PMID: 32956660] - Chia Siang Kow, Syed Shahzad Hasan. Montelukast in children with allergic rhinitis amid COVID-19 pandemic.
Acta paediatrica (Oslo, Norway : 1992).
2020 10; 109(10):2151. doi:
10.1111/apa.15491. [PMID: 32686128] - Francesca Citron, Luigi Perelli, Angela K Deem, Giannicola Genovese, Andrea Viale. Leukotrienes, a potential target for Covid-19.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 10; 161(?):102174. doi:
10.1016/j.plefa.2020.102174. [PMID: 32977289] - Donald C Moore, Justin R Arnall, Daniel L Thompson, Allison L Martin, Jordan Robinson, Ami Ndiaye, Barry Paul, Shebli Atrash, Manisha Bhutani, Peter M Voorhees, Saad Z Usmani. Evaluation of Montelukast for the Prevention of Infusion-related Reactions With Daratumumab.
Clinical lymphoma, myeloma & leukemia.
2020 10; 20(10):e777-e781. doi:
10.1016/j.clml.2020.05.024. [PMID: 32660902] - Muhammad Qutayba Almerie, David Daniel Kerrigan. The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast.
Medical hypotheses.
2020 Oct; 143(?):109883. doi:
10.1016/j.mehy.2020.109883. [PMID: 32492562] - Sushma Bhattachan, Yogesh Neupane, Bibhu Pradhan, Naramaya Thapa. Comparison of Outcomes Between Mometasone Furoate Intranasal Spray and Oral Montelukast in Patients with Allergic Rhinitis.
Journal of Nepal Health Research Council.
2020 Sep; 18(2):268-270. doi:
10.33314/jnhrc.v18i2.2509. [PMID: 32969391] - Cihan Fidan, Ayşe Aydoğdu. As a potential treatment of COVID-19: Montelukast.
Medical hypotheses.
2020 Sep; 142(?):109828. doi:
10.1016/j.mehy.2020.109828. [PMID: 32416408] - Ismael García-Moguel, Rocío Díaz Campos, Sergio Alonso Charterina, Consuelo Fernández Rodríguez, Jesús Fernández Crespo. COVID-19, severe asthma, and biologics.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2020 09; 125(3):357-359.e1. doi:
10.1016/j.anai.2020.06.012. [PMID: 32553608] - Christopher D Codispoti, Sindhura Bandi, Payal Patel, Mahboobeh Mahdavinia. Clinical course of asthma in 4 cases of coronavirus disease 2019 infection.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2020 08; 125(2):208-210. doi:
10.1016/j.anai.2020.05.009. [PMID: 32437838] - Mervat Z Mohamed, Nagwa M Zenhom. Mechanisms underlying the protective effect of leukotriene receptor antagonist montelukast against doxorubicin induced testicular injury in rats.
Prostaglandins & other lipid mediators.
2020 08; 149(?):106447. doi:
10.1016/j.prostaglandins.2020.106447. [PMID: 32173485] - Michele Biagioli, Adriana Carino, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Martina Bordoni, Chiara Fiorucci, Valentina Sepe, Paolo Conflitti, Vittorio Limongelli, Eleonora Distrutti, Monia Baldoni, Angela Zampella, Stefano Fiorucci. Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
Biochemical pharmacology.
2020 07; 177(?):113987. doi:
10.1016/j.bcp.2020.113987. [PMID: 32330496] - Seol Ju Moon, Kyung-Sang Yu, Jina Jung, Yong-Il Kim, Min-Gul Kim. Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects
.
International journal of clinical pharmacology and therapeutics.
2020 Jun; 58(6):354-362. doi:
10.5414/cp203709. [PMID: 32271144] - Nate T Gaeckle, Laurel Stephenson, Ronald A Reilkoff. Alpha-1 Antitrypsin Deficiency and Pregnancy.
COPD.
2020 06; 17(3):326-332. doi:
10.1080/15412555.2020.1754778. [PMID: 32308050] - Ahmad Hormati, Sajjad Ahmadpour, Mahdieh Afkhami Ardekani, Fatemeh Khodadust, Soheila Refahi. Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice.
Journal of biochemical and molecular toxicology.
2020 Jun; 34(6):e22479. doi:
10.1002/jbt.22479. [PMID: 32125029] - Joshua J Field, Adetola Kassim, Amanda Brandow, Stephen H Embury, Neil Matsui, Karina Wilkerson, Valencia Bryant, Liyun Zhang, Pippa Simpson, Michael R DeBaun. Phase 2 trial of montelukast for prevention of pain in sickle cell disease.
Blood advances.
2020 03; 4(6):1159-1165. doi:
10.1182/bloodadvances.2019001165. [PMID: 32208487] - Arif Aydin, Mehmet Melih Sunay, Tolga Karakan, Serkan Özcan, Ahmet Metin Hasçiçek, İbrahim Yardimci, Hatice Surer, Meliha Korkmaz, Sema Hücümenoğlu, Emre Huri. The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine ın renal ıschemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model.
Acta cirurgica brasileira.
2020; 35(9):e202000905. doi:
10.1590/s0102-865020200090000005. [PMID: 33084735] - Mohammad S Hareedy, Esraa A Ahmed, Marwa F Ali. Montelukast modifies simvastatin-induced myopathy and hepatotoxicity.
Drug development research.
2019 11; 80(7):1000-1009. doi:
10.1002/ddr.21581. [PMID: 31389048] - Nayana Venugopal, Pooja Acharya, Mehrdad Zarei, Ramaprasad Ravichandra Talahalli. Cysteinyl leukotriene receptor antagonism: a promising pharmacological strategy for lowering the severity of arthritis.
Inflammopharmacology.
2019 Oct; 27(5):923-931. doi:
10.1007/s10787-019-00618-0. [PMID: 31309487] - Hongtu Wu, Xian Ding, Deyu Zhao, Yong Liang, Wei Ji. Effect of montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia.
The Journal of international medical research.
2019 Jun; 47(6):2555-2561. doi:
10.1177/0300060518820412. [PMID: 31072180] - Wu Sun, Hai-Yan Liu. Montelukast and Budesonide for Childhood Cough Variant Asthma.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Apr; 29(4):345-348. doi:
10.29271/jcpsp.2019.04.345. [PMID: 30925958] - Poonam Giri, Prashant Delvadia, Meera K Ladani, Namrata Prajapati, Lakshmikant Gupta, Nirmal Patel, Vipul Joshi, Shyamkumar Giri, Mukul R Jain, Nuggehally R Srinivas, Pankaj R Patel. Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Mar; 130(?):107-113. doi:
10.1016/j.ejps.2019.01.005. [PMID: 30633968] - Yi-Chen Chen, Jane R Kenny, Matthew Wright, Cornelis E C A Hop, Zhengyin Yan. Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.
Journal of pharmaceutical sciences.
2019 03; 108(3):1296-1302. doi:
10.1016/j.xphs.2018.10.011. [PMID: 30326208] - Qing Guo, Zhao-Bo Shen, Xiao-Min Sun, Dan Chen, Ping Kang. [Association of cytoplasmic phospholipase A2 gene polymorphism with bronchial asthma and response to montelukast in children].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2019 Feb; 21(2):155-160. doi:
. [PMID: 30782278] - Katherine N Cahill, Katherine Murphy, Joseph Singer, Elliot Israel, Joshua A Boyce, Tanya M Laidlaw. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease.
The Journal of allergy and clinical immunology.
2019 02; 143(2):799-803.e2. doi:
10.1016/j.jaci.2018.10.007. [PMID: 30339852] - Qian Li, Kai Wang, Hai-Yan Shi, Yue-E Wu, Yue Zhou, Min Kan, Yi Zheng, Guo-Xiang Hao, Xin-Mei Yang, Yi-Lei Yang, Le-Qun Su, Xiao-Ling Wang, Evelyne Jacqz-Aigrain, Jun Zhou, Wei Zhao. Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children.
Drug design, development and therapy.
2019; 13(?):4405-4411. doi:
10.2147/dddt.s226913. [PMID: 31920289] - Jeremy Dennison, Adeep Puri, Steven Warrington, Takamasa Endo, Temitope Adeloye, Atholl Johnston. Amenamevir: Studies of Potential CYP2C8- and CYP2B6-Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers.
Clinical pharmacology in drug development.
2018 11; 7(8):860-870. doi:
10.1002/cpdd.578. [PMID: 29870591] - Ana Carolina Araújo, Xiao Tang, Jesper Z Haeggström. Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.
Prostaglandins & other lipid mediators.
2018 11; 139(?):24-28. doi:
10.1016/j.prostaglandins.2018.09.007. [PMID: 30248405] - A A Hashim, M M Helmy, S M Mouneir. Cysteinyl leukotrienes predominantly mediate cisplatin-induced acute renal damage in male rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Oct; 69(5):. doi:
10.26402/jpp.2018.5.12. [PMID: 30683829] - Nikolaos Lazarinis, Johan Bood, Cristina Gomez, Johan Kolmert, Ann-Sofie Lantz, Pär Gyllfors, Andy Davis, Craig E Wheelock, Sven-Erik Dahlén, Barbro Dahlén. Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor.
The Journal of allergy and clinical immunology.
2018 10; 142(4):1080-1089. doi:
10.1016/j.jaci.2018.02.024. [PMID: 29518425] - Malvina Hoxha, Anne-Mary Lewis-Mikhael, Aurora Bueno-Cavanillas. Potential role of leukotriene receptor antagonists in reducing cardiovascular and cerbrovascular risk: A systematic review of human clinical trials and in vivo animal studies.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):956-965. doi:
10.1016/j.biopha.2018.07.033. [PMID: 30119268] - Noha M Hosny, Noha N Atia, Samia M El-Gizawy, Dalia M Badary, Mohammad S Hareedy. Innovative HPTLC method with fluorescence detection for assessment of febuxostat-montelukast combination and study of their protective effects against gouty arthritis.
The Analyst.
2018 Sep; 143(18):4366-4378. doi:
10.1039/c8an00772a. [PMID: 30113041] - Walaa Yehia Abdelzaher, Haitham Ahmed Bahaa, Nisreen D M Toni, Ahmad Sameer Sanad. Mechanisms underlying the protective effect of montelukast in prevention of endometrial hyperplasia in female rats.
International immunopharmacology.
2018 Sep; 62(?):326-333. doi:
10.1016/j.intimp.2018.07.008. [PMID: 30056375] - Tomoe Nishimura, Osamu Kaminuma, Mayumi Saeki, Noriko Kitamura, Minoru Gotoh, Akio Mori, Takachika Hiroi. Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.
Allergology international : official journal of the Japanese Society of Allergology.
2018 Sep; 67S(?):S25-S31. doi:
10.1016/j.alit.2018.05.002. [PMID: 29910099] - Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim. Comparison of the pharmacokinetics and tolerability of montelukast/levocetirizine administered as a fixed-dose combination and as separate tablets.
International journal of clinical pharmacology and therapeutics.
2018 Sep; 56(9):443-450. doi:
10.5414/cp203265. [PMID: 30021691] - Matti K Itkonen, Aleksi Tornio, Anne M Filppula, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.
Clinical pharmacology and therapeutics.
2018 09; 104(3):495-504. doi:
10.1002/cpt.947. [PMID: 29171020] - Elodie Gautier-Veyret, Magnus Bäck, Claire Arnaud, Elise Belaïdi, Renaud Tamisier, Patrick Lévy, Nathalie Arnol, Marion Perrin, Jean-Louis Pépin, Françoise Stanke-Labesque. Cysteinyl-leukotriene pathway as a new therapeutic target for the treatment of atherosclerosis related to obstructive sleep apnea syndrome.
Pharmacological research.
2018 08; 134(?):311-319. doi:
10.1016/j.phrs.2018.06.014. [PMID: 29920371] - Wangda Zhou, Trevor N Johnson, Khanh H Bui, S Y Amy Cheung, Jianguo Li, Hongmei Xu, Nidal Al-Huniti, Diansong Zhou. Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
Clinical pharmacology and therapeutics.
2018 07; 104(1):188-200. doi:
10.1002/cpt.905. [PMID: 29027194] - Päivi Hirvensalo, Aleksi Tornio, Mikko Neuvonen, Tuija Tapaninen, Maria Paile-Hyvärinen, Vesa Kärjä, Ville T Männistö, Jussi Pihlajamäki, Janne T Backman, Mikko Niemi. Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.
Clinical pharmacology and therapeutics.
2018 07; 104(1):158-168. doi:
10.1002/cpt.891. [PMID: 28940478] - Antonio Di Gennaro, Ana Carolina Araújo, Albert Busch, Hong Jin, Dick Wågsäter, Emina Vorkapic, Kenneth Caidahl, Per Eriksson, Bengt Samuelsson, Lars Maegdefessel, Jesper Z Haeggström. Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.
Proceedings of the National Academy of Sciences of the United States of America.
2018 02; 115(8):1907-1912. doi:
10.1073/pnas.1717906115. [PMID: 29432192] - Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li. Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Journal of medicinal chemistry.
2018 01; 61(1):224-250. doi:
10.1021/acs.jmedchem.7b01300. [PMID: 29243920] - Neelam Singh, Giriraj T Kulkarni, Yatendra Kumar. Montelukast Sodium Formulation Containing Green Tea Extract to Reduce the Oxidative Stress in Guinea Pig Model of Chronic Allergic Asthma.
Recent patents on drug delivery & formulation.
2018; 12(4):267-276. doi:
10.2174/1872211313666181211123903. [PMID: 30539707] - Xuehui Wang, Ziting Tian, Fengli Gao, Xia Zhang, Jianqiu Liu, Zhuying Li. Traditional Chinese medicine as an adjunctive therapy to oral montelukast for treating patients with chronic asthma.
Medicine.
2017 Dec; 96(51):e9291. doi:
10.1097/md.0000000000009291. [PMID: 29390493] - Kanokkarn Sunkonkit, Suchada Sritippayawan, Montida Veeravikrom, Jitladda Deerojanawong, Nuanchan Prapphal. Urinary cysteinyl leukotriene E4 level and therapeutic response to montelukast in children with mild obstructive sleep apnea.
Asian Pacific journal of allergy and immunology.
2017 Dec; 35(4):233-238. doi:
10.12932/ap0879. [PMID: 28364411] - Amany M Gad, Ola M Abd El-Raouf, Bahia M El-Sayeh, Hala M Fawzy, Dalaal M Abdallah. Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats.
Journal of biochemical and molecular toxicology.
2017 Dec; 31(12):. doi:
10.1002/jbt.21979. [PMID: 28902463] - Amtul Fayyaz, Junaid Ali Khan, Muhammad Mudassar Ashraf, Naheed Akhter, Bilal Aslam, Muhammad Fiaz Khalid, Sidra Altaf, Rana Dawood Naseer, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir. Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers.
Pakistan journal of pharmaceutical sciences.
2017 Nov; 30(6(Supplementary)):2435-2439. doi:
NULL. [PMID: 29188782] - L R Li, J H Qi, Z Y Cui, H C Wang, P P Zhang, X Q Han, H Y Wang. [The effect of monrustet on the exhalation of nitric oxide and inflammatory cytokines in patients with asthma combined with OSAHS].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery.
2017 Oct; 31(20):1589-1592. doi:
10.13201/j.issn.1001-1781.2017.20.011. [PMID: 29797956] - Bodduluri Haribabu. Back to the future of targeting leukotriene B4 mediated inflammation.
Seminars in immunology.
2017 10; 33(?):1-2. doi:
10.1016/j.smim.2017.09.010. [PMID: 28988622] - Yoichiro Hamamoto, Satoshi Ano, Benoit Allard, Michael O'Sullivan, Toby K McGovern, James G Martin. Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse.
British journal of pharmacology.
2017 Oct; 174(19):3346-3358. doi:
10.1111/bph.13953. [PMID: 28718891] - Tae-Sun Ha, Ja Ae Nam, Su-Bin Seong, Moin A Saleem, Se Jin Park, Jae Il Shin. Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2017 Sep; 66(9):793-802. doi:
10.1007/s00011-017-1058-y. [PMID: 28608180] - Fatma H Rizk, Marwa A A Ibrahim, Marwa M Abd-Elsalam, Nema A Soliman, Sherief M Abd-Elsalam. Gastroprotective effects of montelukast and Nigella sativa oil against corticosteroid-induced gastric damage: they are much more than antiasthmatic drugs.
Canadian journal of physiology and pharmacology.
2017 Jun; 95(6):714-720. doi:
10.1139/cjpp-2016-0374. [PMID: 28187265] - Zheng-Liang Tu, Zhen-Yu Zhou, Hai-Chao Xu, Jin-Lin Cao, Peng Ye, Lu-Ming Wang, Wang Lv, Jian Hu. LTB4 and montelukast in transplantation-related bronchiolitis obliterans in rats.
Journal of cardiothoracic surgery.
2017 May; 12(1):43. doi:
10.1186/s13019-017-0605-5. [PMID: 28545478] - Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.
Scientific reports.
2017 05; 7(1):1646. doi:
10.1038/s41598-017-01602-w. [PMID: 28490767] - Xiuhua Di, Xuelu Tang, Xiuting Di. Montelukast inhibits oxidized low-density lipoproteins (ox-LDL) induced vascular endothelial attachment: An implication for the treatment of atherosclerosis.
Biochemical and biophysical research communications.
2017 04; 486(1):58-62. doi:
10.1016/j.bbrc.2017.02.125. [PMID: 28246014] - Xiaoyan Wang, Baoqin Liu, Bin Lu, Yanmei Zhang, Liran Wang, Haijin Li, Xue Han, Dan Ding. [Micro-invasive embedding combined with montelukast sodium for children cough variant asthma:a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Mar; 37(3):259-264. doi:
10.13703/j.0255-2930.2017.03.011. [PMID: 29231431] - Mahmoud M Said, Maarten C Bosland. The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Feb; 390(2):197-205. doi:
10.1007/s00210-016-1325-4. [PMID: 27909742]