Oxyacanthine (BioDeep_00000409191)

Main id: BioDeep_00000003999

 


代谢物信息卡片


2H-1,24:12,15-Dietheno-6,10-metheno-16H-pyrido[2,3:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinolin-9-ol,3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aR,16aS)-

化学式: C37H40N2O6 (608.2886)
中文名称: 尖刺檗鹼
谱图信息: 最多检出来源 Viridiplantae(not specific) 14.75%

分子结构信息

SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=CC(=C(C=C7CCN6C)OC)O3)O)OC)OC
InChI: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)17-23-8-11-30(40)31(18-23)44-26-9-6-22(7-10-26)16-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3

描述信息

A macrocycle that is oxyacanthan that is substituted by methoxy groups at positions 6, 6, and 7, methyl groups at positions 2 and 2, and a hydroxy group at the 12 position.
Annotation level-1

同义名列表

3 个代谢物同义名

2H-1,24:12,15-Dietheno-6,10-metheno-16H-pyrido[2,3:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinolin-9-ol,3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aR,16aS)-; Oxyacanthine; Oxyacanthine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tanuja Joshi, Sunaullah Bhat, Hemlata Pundir, Subhash Chandra. Identification of Berbamine, Oxyacanthine and Rutin from Berberis asiatica as anti-SARS-CoV-2 compounds: An in silico study. Journal of molecular graphics & modelling. 2021 12; 109(?):108028. doi: 10.1016/j.jmgm.2021.108028. [PMID: 34649146]
  • Jun-Jiang Lv, Min Xu, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Yi-Fei Wang, Yan Li, Ying-Jun Zhang. Cytotoxic bisbenzylisoquinoline alkaloids from Stephania epigaea. Journal of natural products. 2013 May; 76(5):926-32. doi: 10.1021/np400084t. [PMID: 23621840]
  • Paul Klausmeyer, Thomas G McCloud, Dominic A Scudiero, Michael J Currens, John H Cardellina Ii, Robert H Shoemaker. Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα. Bioorganic & medicinal chemistry. 2012 Aug; 20(15):4646-52. doi: 10.1016/j.bmc.2012.06.017. [PMID: 22766217]
  • Lucia Rackova, Marek Oblozinsky, Daniela Kostalova, Viktor Kettmann, Lydia Bezakova. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. Journal of inflammation (London, England). 2007 Jul; 4(?):15. doi: 10.1186/1476-9255-4-15. [PMID: 17634120]
  • Ursula Rohrer, Eva M Kulik Kunz, Krystyna Lenkeit, Willi Schaffner, Jürg Meyer. Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia. 2007; 117(11):1126-31. doi: ". [PMID: 18072463]
  • Esra Küpeli, Müberra Koşar, Erdem Yeşilada, K Hüsnü, C Başer. A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life sciences. 2002 Dec; 72(6):645-57. doi: 10.1016/s0024-3205(02)02200-2. [PMID: 12467905]
  • Marta Cernáková, Daniela Kost'álová, Viktor Kettmann, Miriam Plodová, Jaroslav Tóth, Ján Drímal. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC complementary and alternative medicine. 2002 Feb; 2(?):2. doi: 10.1186/1472-6882-2-2. [PMID: 11943071]
  • N Ivanovska, S Philipov. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. International journal of immunopharmacology. 1996 Oct; 18(10):553-61. doi: 10.1016/s0192-0561(96)00047-1. [PMID: 9080249]
  • R Sotníková, D Kost'álová, S Vaverková. Effect of bisbenzylisoquinoline alkaloids from Mahonia aquifolium on the isolated rat aorta. General pharmacology. 1994 Nov; 25(7):1405-10. doi: 10.1016/0306-3623(94)90165-1. [PMID: 7896052]