trimeprazine (BioDeep_00000408939)
Main id: BioDeep_00000001884
代谢物信息卡片
trimeprazine
化学式: C18H22N2S (298.1504)
中文名称: 异丁嗪
谱图信息:
最多检出来源 Homo sapiens(urine) 55%
分子结构信息
SMILES: CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
InChI: InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
描述信息
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AD - Phenothiazine derivatives
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
D003879 - Dermatologic Agents > D000982 - Antipruritics
同义名列表
2 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A S Rybasova, I P Remezova, D A Lyubchenko, E V Svetlichnaya, N S Avramenko. [The development of the methods for the extraction, identification, and quantitative determination of alimemazine in the biological fluids from the laboratory animals under the acute poisoning conditions].
Sudebno-meditsinskaia ekspertiza.
2019 ; 62(1):31-35. doi:
10.17116/sudmed20196201131. [PMID: 30724891] - Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández. Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions.
Water research.
2018 Sep; 141(?):57-64. doi:
10.1016/j.watres.2018.05.008. [PMID: 29775773] - Isabel Gomila, Victoria López-Corominas, Manuela Pellegrini, Loreto Quesada, Elena Miravet, Simona Pichini, Bernardino Barceló. Alimemazine poisoning as evidence of Munchausen syndrome by proxy: A pediatric case report.
Forensic science international.
2016 Sep; 266(?):e18-e22. doi:
10.1016/j.forsciint.2016.08.010. [PMID: 27567044] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - F G Sánchez, A Navas Díaz, E Sánchez Torreño, A Aguilar, I Medina Lama, M Algarra. Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards.
Biomedical chromatography : BMC.
2012 Oct; 26(10):1241-6. doi:
10.1002/bmc.2685. [PMID: 22311573] - Chika Hasegawa, Takeshi Kumazawa, Masaru Terada, Xiao-Pen Lee, Keizo Sato, Seisaku Uchigasaki, Kunihiko Kurosaki. A new method for quantitative determination of dimemorfan in human plasma using monolithic silica solid-phase extraction tips.
Legal medicine (Tokyo, Japan).
2012 Sep; 14(5):267-71. doi:
10.1016/j.legalmed.2012.03.004. [PMID: 22546247] - Ragnhild Birkeland Waade, Hege Christensen, Ida Rudberg, Helge Refsum, Monica Hermann. Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole.
Therapeutic drug monitoring.
2009 Apr; 31(2):233-8. doi:
10.1097/ftd.0b013e3181956726. [PMID: 19142178] - Kavita Agrawal, Hui-Fen Wu. Drop-to-drop solvent microextraction coupled with gas chromatography/mass spectrometry for rapid determination of trimeprazine in urine and blood of rats: application to pharmacokinetic studies.
Rapid communications in mass spectrometry : RCM.
2007; 21(20):3352-6. doi:
10.1002/rcm.3221. [PMID: 17880040] - Pascal Kintz, Marion Villain, Vincent Cirimele. Determination of trimeprazine-facilitated sedation in children by hair analysis.
Journal of analytical toxicology.
2006 Jul; 30(6):400-2. doi:
10.1093/jat/30.6.400. [PMID: 16872573] - Rainer Schindler, Tanja Fielenbach, Gerhard Rave. A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats.
The British journal of nutrition.
2005 Nov; 94(5):675-83. doi:
10.1079/bjn20051495. [PMID: 16277768] - Alvaro Lassaletta, Ricardo Martino, Pilar Gónzalez-Santiago, Carmen Torrijos, Margarita Cebrero, Enrique García-Frías. Reversal of an antihistamine-induced coma with flumazenil.
Pediatric emergency care.
2004 May; 20(5):319-20. doi:
10.1097/01.pec.0000125662.28066.91. [PMID: 15123905] - M F Sauvage, A Rousseau, P Marquet, F Dumeirain, C Raby, G Lachâtre. In vitro and in vivo study of the antithyroid side effects of trimeprazine.
Toxicology and applied pharmacology.
1999 Jul; 158(2):125-31. doi:
10.1006/taap.1999.8699. [PMID: 10406927] - H Hattori, S Yamamoto, M Iwata, E Takashima, T Yamada, O Suzuki. Sensitive determination of phenothiazines in body fluids by gas chromatography with surface ionization detection.
Journal of chromatography.
1992 Sep; 579(2):247-52. doi:
10.1016/0378-4347(92)80388-7. [PMID: 1358904] - T J Kim, J S Park, H S Shin. Identification of new urinary metabolites of trimeprazine in rats by gas chromatography-mass spectrometry.
Journal of chromatography.
1992 Mar; 575(2):295-300. doi:
10.1016/0378-4347(92)80160-r. [PMID: 1629308] - R Varshney, R K Kale. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes.
International journal of radiation biology.
1990 Nov; 58(5):733-43. doi:
10.1080/09553009014552121. [PMID: 1977818] - R K Kale, S L Sitasawad. Modification of radiation induced lipid peroxidation by calmodulin antagonists.
Indian journal of experimental biology.
1990 Aug; 28(8):757-61. doi:
". [PMID: 2253969] - P Kintz, B Godelar, A Tracqui, P Mangin, A A Lugnier, A J Chaumont. Fly larvae: a new toxicological method of investigation in forensic medicine.
Journal of forensic sciences.
1990 Jan; 35(1):204-7. doi:
NULL. [PMID: 2313261] - O Y Hu, E Gfeller, J H Perrin, S H Curry. Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection.
The Journal of pharmacy and pharmacology.
1986 Mar; 38(3):172-6. doi:
10.1111/j.2042-7158.1986.tb04539.x. [PMID: 2871150] - S Pfeifer, I Bornschein, P Franke, C Fischer. [Biotransformation of alimemazine].
Die Pharmazie.
1986 Feb; 41(2):111-3. doi:
. [PMID: 3725848] - G McKay, G A Rauw, M D Stonkus, R A Dulos, R G Gedir, E M Hawes, K K Midha. Radioimmunoassay for trimeprazine in human plasma.
Journal of pharmacological methods.
1984 Oct; 12(3):203-11. doi:
10.1016/0160-5402(84)90061-5. [PMID: 6536824] - G McKay, J Geddes, M J Cowper, T S Gurnsey. Recent advances in the analysis of phenothiazine drugs and their metabolites using high performance liquid chromatography.
Progress in neuro-psychopharmacology & biological psychiatry.
1983; 7(4-6):703-7. doi:
10.1016/0278-5846(83)90049-0. [PMID: 6141612] - G McKay, J K Cooper, K K Midha, K Hall, E M Hawes. Simple and sensitive high-performance liquid chromatographic procedure with electrochemical detection for the determination of plasma concentrations of trimeprazine following single oral doses.
Journal of chromatography.
1982 Dec; 233(?):417-22. doi:
10.1016/s0378-4347(00)81778-8. [PMID: 7161357] - R G Bramwell, M L Manford. Premedication of children with trimeprazine tartrate.
British journal of anaesthesia.
1981 Aug; 53(8):821-6. doi:
10.1093/bja/53.8.821. [PMID: 7023520] - A Hulshoff, J H Perrin. Quantitative correlations between albumin binding constants and chromatographic Rm values of phenothiazine derivatives.
Journal of medicinal chemistry.
1977 Mar; 20(3):430-9. doi:
10.1021/jm00213a022. [PMID: 576620] - P C Huang, S Gabay. Examination of phenothiazine-albumin interaction by ultraviolet difference spectrophotometry.
Biochemical pharmacology.
1974 Mar; 23(5):957-72. doi:
10.1016/0006-2952(74)90026-4. [PMID: 4156471] - J Krieglstein, W Meiler, J Staab. Hydrophobic and ionic interactions of phenothiazine derivatives with bovine serum albumin.
Biochemical pharmacology.
1972 Apr; 21(7):985-97. doi:
10.1016/0006-2952(72)90403-0. [PMID: 5064735] - L A Hadwiger. Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs.
Biochemical and biophysical research communications.
1972 Jan; 46(1):71-9. doi:
10.1016/0006-291x(72)90631-6. [PMID: 4399452] - J E Wallace, J D Biggs. Determination of phenothiazine compounds in biologic specimens by UV spectrophotometry.
Journal of pharmaceutical sciences.
1971 Sep; 60(9):1346-50. doi:
10.1002/jps.2600600912. [PMID: 4398099] - Y Stephan, L Welin, F Mainard. [Binding to human serum proteins of drugs belonging to phenothiazine series, iminodibenzyle, thioxanthene and thiophenylpyridylamine].
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles.
1971 Mar; 272(10):1451-4. doi:
NULL. [PMID: 4994988] - J Staab, J Krieglstein. [Participation of the basic side-chain of phenothiazine derivatives in their albumin binding].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1970; 266(4):456-7. doi:
NULL. [PMID: 4253875] - T H LIN, J R GUARINI, S P ERIKSEN, J V SWINTOSKY. EFFECT OF THE SITE OF RELEASE ON THE ABSORPTION OF TRIMEPRAZINE-S35 AND PENICILLIN G IN DOGS.
Journal of pharmaceutical sciences.
1964 Nov; 53(?):1357-9. doi:
10.1002/jps.2600531116. [PMID: 14253594] - G E WELCH, D C BROWNE, M HURTADO. EVALUATION OF THE ANALGESIC EFFECT OF METHOTRIMEPRAZINE IN UPPER GASTROINTESTINAL ENDOSCOPY AND MALIGNANT DISEASE.
Bulletin of gastrointestinal endoscopy.
1964 Feb; 10(?):25-6. doi:
NULL. [PMID: 14132118] - L VALLADE, R CORSETTI. [URINARY STEROIDS AND PSYCHOTROPIC CHEMOTHERAPY].
Annales medico-psychologiques.
1963 Dec; 121(?):709-20. doi:
NULL. [PMID: 14101917]
