flecainide (BioDeep_00000408821)
Main id: BioDeep_00000001975
代谢物信息卡片
flecainide
化学式: C17H20F6N2O3 (414.1378042)
中文名称: 氟卡尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C2)CNC(C2)CNC(=O)c(c1)c(OCC(F)(F)F)ccc(OCC(F)(F)F)1
InChI: InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BC - Antiarrhythmics, class ic
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
1 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:75984
- KEGG: C07001
- KEGGdrug: D07962
- PubChem: 3356
- DrugBank: DB01195
- ChEMBL: CHEMBL652
- MeSH: Flecainide
- CAS: 54143-55-4
- MoNA: WA000821
- MoNA: WA000820
- MoNA: WA000819
- MoNA: WA000818
- MoNA: WA000817
- PubChem: 9214
- NIKKAJI: J12.413C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gaspar Tuero León, Jesús González, Néstor González, Isabel Gomila Muñiz, Laura Sahuquillo Frías, Bernardino Barceló Martín. Usefulness of lipid emulsion for the management of cardiac toxicity in acute flecainide overdose.
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.
2023 Aug; 35(4):318-319. doi:
. [PMID: 37439431] - Samantha C Salvage, Christopher L-H Huang, James A Fraser, Angela F Dulhunty. How does flecainide impact RyR2 channel function?.
The Journal of general physiology.
2022 09; 154(9):. doi:
10.1085/jgp.202213089. [PMID: 35713932] - Daniel J McCabe, Rachel D Walsh, Peter K Georgakakos, Joshua B Radke, Bryan Z Wilson. Flecainide poisoning and prolongation of elimination due to alkalinization.
The American journal of emergency medicine.
2022 06; 56(?):394.e1-394.e4. doi:
10.1016/j.ajem.2022.03.006. [PMID: 35287973] - Harry J G M Crijns, Arif Elvan, Nadea Al-Windy, Ype S Tuininga, Erik Badings, Ismail Aksoy, Isabelle C Van Gelder, Prashanti Madhavapeddi, A John Camm, Peter R Kowey, Jeremy N Ruskin, Luiz Belardinelli. Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm.
Circulation. Arrhythmia and electrophysiology.
2022 03; 15(3):e010204. doi:
10.1161/circep.121.010204. [PMID: 35196871] - Jerry S Liu, Eugene H Fan. Toxic Effects of Flecainide in a Patient With Kidney Failure and Tachyarrhythmia.
JAMA internal medicine.
2021 11; 181(11):1516-1518. doi:
10.1001/jamainternmed.2021.5030. [PMID: 34515729] - Samantha C Salvage, Esther M Gallant, James A Fraser, Christopher L-H Huang, Angela F Dulhunty. Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action.
Cells.
2021 08; 10(8):. doi:
10.3390/cells10082101. [PMID: 34440870] - Ana B Rabêlo Evangelista, Felipe R Monteiro, Bruce D Nearing, Luiz Belardinelli, Richard L Verrier. Flecainide-induced QRS complex widening correlates with negative inotropy.
Heart rhythm.
2021 08; 18(8):1416-1422. doi:
10.1016/j.hrthm.2021.04.007. [PMID: 33848647] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Dmytro O Kryshtal, Daniel J Blackwell, Christian L Egly, Abigail N Smith, Suzanne M Batiste, Jeffrey N Johnston, Derek R Laver, Bjorn C Knollmann. RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Circulation research.
2021 02; 128(3):321-331. doi:
10.1161/circresaha.120.316819. [PMID: 33297863] - Nisha Donthi, Tejasri Chandrabhatla, Leonard Genovese, Christopher deFilippi. Fast and furious: flecainide toxicity presenting as monomorphic ventricular tachycardia.
BMJ case reports.
2020 Dec; 13(12):. doi:
10.1136/bcr-2020-236932. [PMID: 33318242] - Allan Plant, Daniel Gold, Jarryd Walker. More than merely potassium: an uncommon cause for sine waves in renal failure.
The New Zealand medical journal.
2020 11; 133(1525):119-122. doi:
NULL. [PMID: 33223555] - Joshua M Newson, Cynthia D Santos, Bradford L Walters, Brett R Todd. The Case of Flecainide Toxicity: What to Look for and How to Treat.
The Journal of emergency medicine.
2020 Aug; 59(2):e43-e47. doi:
10.1016/j.jemermed.2020.04.052. [PMID: 32536493] - Bao Hui Poh, Jan Hau Lee, Abdul Alim Abdul Haium, Tze Liang Jonathan Choo. Complete Heart Block Secondary to Flecainide Toxicity: Is It Time for CYP2D6 Genotype Testing?.
Pediatrics.
2020 07; 146(1):. doi:
10.1542/peds.2019-2608. [PMID: 32561613] - Richard L Verrier, Luiz Belardinelli. Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation.
Journal of cardiovascular pharmacology.
2020 04; 75(4):276-283. doi:
10.1097/fjc.0000000000000804. [PMID: 32032206] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - J-T Sohn. Treatment of flecainide intoxication with a lipid emulsion.
The Netherlands journal of medicine.
2019 10; 77(8):303. doi:
". [PMID: 31814584] - John M Suffredini, Joshua Rutland, Peter Akpunonu, Regan Baum, John Catanzaro, Claude S Elayi. Flecainide Toxicity Resulting in Pacemaker Latency and Intermittent Failure to Capture.
The American journal of case reports.
2019 Aug; 20(?):1279-1283. doi:
10.12659/ajcr.916370. [PMID: 31467262] - M Heldens, G A M van der Nat, P G Melman. Renal failure, shock, and loss of pacemaker capture: A case of flecainide intoxication.
The Netherlands journal of medicine.
2019 06; 77(5):189-192. doi:
NULL. [PMID: 31264585] - Mohammed Rahman, Lewis Couchman, Valentyna Povstyan, Verity Bainbridge, Karin Kipper, Toqa El-Nahhas, Atholl Johnston, David Holt. Rapid Quantitation of Flecainide in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography and Time-of-Flight Mass Spectrometry.
Therapeutic drug monitoring.
2019 06; 41(3):391-395. doi:
10.1097/ftd.0000000000000586. [PMID: 30520831] - Lucio Boglione, Amedeo De Nicolò, Giovanni Di Perri, Antonio D'Avolio. Flecainide plasma level modifications during ledipasvir/sofosbuvir coadministration in two patients affected by chronic hepatitis C.
Antiviral therapy.
2019; 24(7):553-555. doi:
10.3851/imp3328. [PMID: 31502554] - Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
The Journal of toxicological sciences.
2019; 44(7):441-457. doi:
10.2131/jts.44.441. [PMID: 31270301] - Kosuke Doki, Sándor Apáti, Takeshi Sakata, Masato Homma. Involvement of Renal Efflux Transporter MATE1 in Renal Excretion of Flecainide.
Biological & pharmaceutical bulletin.
2019; 42(7):1226-1229. doi:
10.1248/bpb.b19-00031. [PMID: 31257298] - Alexandre A Marum, Bruna A Silva, Alexandre L Bortolotto, Anderson C Silva, Victor Z de Antonio, Luiz Belardinelli, Richard L Verrier. Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration.
International journal of cardiology.
2019 Jan; 274(?):170-174. doi:
10.1016/j.ijcard.2018.09.029. [PMID: 30217428] - Fernando G Stocco, Ederson Evaristo, Anderson C Silva, Victor Zandona de Antonio, Juergen Pfeiffer, Narasimhan Rangachari, Luiz Belardinelli, Richard L Verrier. Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs.
Journal of cardiovascular pharmacology.
2018 09; 72(3):129-135. doi:
10.1097/fjc.0000000000000605. [PMID: 29923887] - Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.
Journal of pharmacological and toxicological methods.
2018 Mar; 90(?):58-66. doi:
10.1016/j.vascn.2017.12.003. [PMID: 29274391] - Kosuke Doki. [Use of Pharmacogenetic Information for Therapeutic Drug Monitoring of an Antiarrhythmic Drug].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2018; 138(9):1145-1150. doi:
10.1248/yakushi.18-00114. [PMID: 30175758] - Tolga Aksu, Tümer Erdem Güler, Kazım Serhan Özcan, Serdar Bozyel, Kıvanç Yalın. Renal sympathetic denervation assisted treatment of electrical storm due to polymorphic ventricular tachycardia in a patient with cathecolaminergic polymorphic ventricular tachycardia.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.
2017 Jul; 45(5):441-449. doi:
10.5543/tkda.2017.72773. [PMID: 28694398] - Prince J Kannankeril, Jeremy P Moore, Marina Cerrone, Silvia G Priori, Naomi J Kertesz, Pamela S Ro, Anjan S Batra, Elizabeth S Kaufman, David L Fairbrother, Elizabeth V Saarel, Susan P Etheridge, Ronald J Kanter, Michael P Carboni, Matthew V Dzurik, Darlene Fountain, Heidi Chen, E Wesley Ely, Dan M Roden, Bjorn C Knollmann. Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.
JAMA cardiology.
2017 07; 2(7):759-766. doi:
10.1001/jamacardio.2017.1320. [PMID: 28492868] - Martin Steinmetz, Georg Nickenig, Tilman Sauerbruch, Florian Eyer, Christian Rabe. Effect of hemoperfusion on flecainide serum concentration - a case report.
Clinical toxicology (Philadelphia, Pa.).
2017 Feb; 55(2):153-154. doi:
10.1080/15563650.2016.1241400. [PMID: 27728980] - Fahima Syeda, Andrew P Holmes, Ting Y Yu, Samantha Tull, Stefan Michael Kuhlmann, Davor Pavlovic, Daniel Betney, Genna Riley, Jan P Kucera, Florian Jousset, Joris R de Groot, Stephan Rohr, Nigel A Brown, Larissa Fabritz, Paulus Kirchhof. PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers.
Journal of the American College of Cardiology.
2016 10; 68(17):1881-1894. doi:
10.1016/j.jacc.2016.07.766. [PMID: 27765191] - Julius J Schmidt, Leyla Ramazan, Clemens Bockemeyer, Hans-Heinrich Günter, Jens Martens-Lobenhoffer, Tina Ganzenmüller, Stefanie M Bode-Böger, Jan T Kielstein. Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy.
BMC nephrology.
2016 Mar; 17(?):28. doi:
10.1186/s12882-016-0240-8. [PMID: 26980436] - Matthew H Slawson, Kamisha L Johnson-Davis. Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):11-9. doi:
10.1007/978-1-4939-3252-8_2. [PMID: 26660169] - Joshua C Reynolds, Bryan S Judge. Successful treatment of flecainide-induced cardiac arrest with extracorporeal membrane oxygenation in the ED.
The American journal of emergency medicine.
2015 Oct; 33(10):1542.e1-2. doi:
10.1016/j.ajem.2015.07.054. [PMID: 26299692] - Yuji Mano, Yoshiki Asakawa, Kenji Kita, Takuho Ishii, Koichiro Hotta, Kazutomi Kusano. Validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of flecainide in human plasma and its clinical application.
Biomedical chromatography : BMC.
2015 Sep; 29(9):1399-405. doi:
10.1002/bmc.3437. [PMID: 25641720] - Kosuke Doki, Yukio Sekiguchi, Keisuke Kuga, Kazutaka Aonuma, Masato Homma. Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
Drug metabolism and pharmacokinetics.
2015 Aug; 30(4):257-62. doi:
10.1016/j.dmpk.2015.04.001. [PMID: 26195225] - Omar Mukhtar, John Rh Archer, Paul I Dargan, David M Wood. Lesson of the month 1: Acute flecainide overdose and the potential utility of lipid emulsion therapy.
Clinical medicine (London, England).
2015 Jun; 15(3):301-3. doi:
10.7861/clinmedicine.15-3-301. [PMID: 26031986] - Wei Wang, Jia-jia Zhao, Ting Wang, Ling Wang, Xue-hua Jiang. [Transplacental transport mechanisms of drugs for transplacental treatment of fetal tachyarrhythmia of MDCKII/MDCKII-BCRP cell line].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Mar; 50(3):305-11. doi:
. [PMID: 26118109] - D Mehra, M S Imtiaz, D F van Helden, B C Knollmann, D R Laver. Multiple modes of ryanodine receptor 2 inhibition by flecainide.
Molecular pharmacology.
2014 Dec; 86(6):696-706. doi:
10.1124/mol.114.094623. [PMID: 25274603] - Trisha V Vigneswaran, Nicky Callaghan, Rachel E Andrews, Owen Miller, Eric Rosenthal, Gurleen K Sharland, John M Simpson. Correlation of maternal flecainide concentrations and therapeutic effect in fetal supraventricular tachycardia.
Heart rhythm.
2014 Nov; 11(11):2047-53. doi:
10.1016/j.hrthm.2014.07.031. [PMID: 25068572] - Kosuke Doki, Yukio Sekiguchi, Keisuke Kuga, Kazutaka Aonuma, Yukinao Kohda, Masato Homma. Stereoselective analysis of flecainide enantiomers using reversed-phase liquid chromatography for assessing CYP2D6 activity.
Biomedical chromatography : BMC.
2014 Sep; 28(9):1193-8. doi:
10.1002/bmc.3143. [PMID: 24523024] - Lars B van Middendorp, Marc Strik, Patrick Houthuizen, Marion Kuiper, Jos G Maessen, Angelo Auricchio, Frits W Prinzen. Electrophysiological and haemodynamic effects of vernakalant and flecainide in dyssynchronous canine hearts.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
2014 Aug; 16(8):1249-56. doi:
10.1093/europace/eut429. [PMID: 24481779] - Kevin N Oguayo, Ola O Oyetayo, Steven M Costa, Timothy A Mixon. An unusual case of flecainide-induced QT prolongation leading to cardiac arrest.
Pharmacotherapy.
2014 May; 34(5):e30-3. doi:
10.1002/phar.1403. [PMID: 24510469] - Asuka Horie, Kazuya Ishida, Kaito Shibata, Masato Taguchi, Ayaka Ozawa, Keiichi Hirono, Fukiko Ichida, Yukiya Hashimoto. Pharmacokinetic variability of flecainide in younger Japanese patients and mechanisms for renal excretion and intestinal absorption.
Biopharmaceutics & drug disposition.
2014 Apr; 35(3):145-53. doi:
10.1002/bdd.1877. [PMID: 24166085] - Sara Llamas Velasco, Fernando Sierra-Hidalgo, Rosa María Ceballos Rodríguez, Antonio José Méndez Guerreo, Juan Ruiz Morales. Flecainide-induced myoclonus.
Clinical neuropharmacology.
2014 Mar; 37(2):65-6. doi:
10.1097/wnf.0000000000000025. [PMID: 24614665] - Johan Sällström, Ahmad Al-Saffar, Rikard Pehrson. Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.
Journal of pharmacological and toxicological methods.
2014 Jan; 69(1):24-9. doi:
10.1016/j.vascn.2013.10.001. [PMID: 24140388] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - Kosuke Doki, Masato Homma, Keisuke Kuga, Kazutaka Aonuma, Yukinao Kohda. SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients.
Pharmacogenetics and genomics.
2013 Jul; 23(7):349-54. doi:
10.1097/fpc.0b013e328361fb8d. [PMID: 23635804] - G Cave, M Harvey, P Quinn, D Heys. Hypertonic sodium bicarbonate versus intravenous lipid emulsion in a rabbit model of intravenous flecainide toxicity: no difference, no sink.
Clinical toxicology (Philadelphia, Pa.).
2013 Jun; 51(5):394-7. doi:
10.3109/15563650.2013.794282. [PMID: 23700986] - Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - Joseph J Lynch, Christopher P Regan, Gregory N Beatch, Gilbert W Gleim, Christopher J Morabito. Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues.
Journal of cardiovascular pharmacology.
2013 Mar; 61(3):226-32. doi:
10.1097/fjc.0b013e31827afd29. [PMID: 23188129] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Yi Luo, Payal Rana, Yvonne Will. Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):346-62. doi:
10.1093/toxsci/kfs208. [PMID: 22700542] - Daniel Kiblboeck, Michael Braeuer-Mocker, Peter Siostrzonek, Johann Reisinger. A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
BMJ case reports.
2012 Aug; 2012(?):. doi:
10.1136/bcr-2012-006868. [PMID: 22927286] - Orhan Uzun, Kadir Babaoglu, Anju Sinha, Spyridon Massias, Bryan Beattie. Rapid control of foetal supraventricular tachycardia with digoxin and flecainide combination treatment.
Cardiology in the young.
2012 Aug; 22(4):372-80. doi:
10.1017/s1047951111001272. [PMID: 22008551] - C Y DU, A El Harchi, Y H Zhang, C H Orchard, J C Hancox. Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
Journal of cardiovascular electrophysiology.
2011 Oct; 22(10):1163-70. doi:
10.1111/j.1540-8167.2011.02060.x. [PMID: 21489024] - Pierre Etienne Moussot, Fouad Marhar, Vincent Minville, Baptiste Vallé, Emilie Dehours, Vincent Bounes, Jean-Louis Ducassé. Use of intravenous lipid 20\% emulsion for the treatment of a voluntary intoxication of flecainide with refractory shock.
Clinical toxicology (Philadelphia, Pa.).
2011 Jul; 49(6):514. doi:
10.3109/15563650.2011.590940. [PMID: 21824065] - Christian Pott, Dirk G Dechering, Florian Reinke, Adam Muszynski, Stephan Zellerhoff, Alex Bittner, Julia Köbe, Kristina Wasmer, Eric Schulze-Bahr, Gerold Mönnig, Stefan Kotthoff, Lars Eckardt. Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
2011 Jun; 13(6):897-901. doi:
10.1093/europace/euq517. [PMID: 21292648] - Beth Allison, Yi Yang, Marc Pourrier, John K Gibson. Comparison of the in vivo hemodynamic effects of the antiarrhythmic agents vernakalant and flecainide in a rat hindlimb perfusion model.
Journal of cardiovascular pharmacology.
2011 Apr; 57(4):463-8. doi:
10.1097/fjc.0b013e318210276b. [PMID: 21283020] - Hyun Seok Hwang, Can Hasdemir, Derek Laver, Divya Mehra, Kutsal Turhan, Michela Faggioni, Huiyong Yin, Björn C Knollmann. Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Circulation. Arrhythmia and electrophysiology.
2011 Apr; 4(2):128-35. doi:
10.1161/circep.110.959916. [PMID: 21270101] - M Doniz Campos, G Illodo Miramontes, B Bobillo, T Otero Amoedo, P Filgueira, F Rey López, J C Diz Gómez. [Flecainide poisoning].
Revista espanola de anestesiologia y reanimacion.
2010 Nov; 57(9):596-8. doi:
10.1016/s0034-9356(10)70288-7. [PMID: 21155342] - Fredrick A Hilliard, Derek S Steele, Derek Laver, Zhaokang Yang, Sylvain J Le Marchand, Nagesh Chopra, David W Piston, Sabine Huke, Björn C Knollmann. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.
Journal of molecular and cellular cardiology.
2010 Feb; 48(2):293-301. doi:
10.1016/j.yjmcc.2009.10.005. [PMID: 19835880] - Lisa C A D'Alessandro, Michael J Rieder, Jane Gloor, David Freeman, Ilan Buffo-Sequiera. Life-threatening flecainide intoxication in a young child secondary to medication error.
The Annals of pharmacotherapy.
2009 Sep; 43(9):1522-7. doi:
10.1345/aph.1l549. [PMID: 19671803] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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The Annals of pharmacotherapy.
2009 Jul; 43(7):1366-9. doi:
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British journal of clinical pharmacology.
2009 Jul; 68(1):89-96. doi:
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Journal of pharmacological sciences.
2009 Jun; 110(2):150-9. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Journal of analytical toxicology.
2008 Jul; 32(6):451-3. doi:
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Cardiology.
2008; 111(2):83-6. doi:
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International journal of chronic obstructive pulmonary disease.
2008; 3(1):45-53. doi:
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Cardiology.
2008; 111(2):82. doi:
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European journal of clinical pharmacology.
2007 Oct; 63(10):951-7. doi:
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Journal of clinical pharmacy and therapeutics.
2007 Aug; 32(4):409-11. doi:
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Nephrologie & therapeutique.
2006 Dec; 2(7):442-5. doi:
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European journal of clinical pharmacology.
2006 Nov; 62(11):919-26. doi:
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American journal of physiology. Heart and circulatory physiology.
2006 Jul; 291(1):H29-37. doi:
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British journal of pharmacology.
2006 Mar; 147(5):468-75. doi:
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Circulation research.
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Pediatric cardiology.
2005 Nov; 26(6):815-20. doi:
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Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.
2005 Apr; 10(2):206-10. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):282-92. doi:
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The Journal of pharmacy and pharmacology.
2005 Jan; 57(1):47-51. doi:
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European journal of clinical pharmacology.
2004 Dec; 60(10):693-701. doi:
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Journal of pharmaceutical and biomedical analysis.
2004 Sep; 35(5):1307-12. doi:
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European heart journal.
2004 Aug; 25(15):1318-24. doi:
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Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
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Receptors & channels.
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The Journal of general physiology.
2003 Sep; 122(3):365-74. doi:
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The Annals of thoracic surgery.
2003 Jul; 76(1):148-51; discussion 151. doi:
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Journal of pharmaceutical and biomedical analysis.
2003 Jun; 32(2):375-80. doi:
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Revista espanola de cardiologia.
2003 Jun; 56(6):631-2. doi:
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Journal of cardiovascular pharmacology.
2003 May; 41(5):771-9. doi:
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Circulation journal : official journal of the Japanese Circulation Society.
2003 Mar; 67(3):195-8. doi:
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The Journal of general physiology.
2003 Mar; 121(3):199-214. doi:
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Journal of analytical toxicology.
2003 Jan; 27(1):47-52. doi:
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Journal of pharmaceutical and biomedical analysis.
2002 Aug; 30(1):171-4. doi:
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Clinical pharmacology and therapeutics.
2002 Aug; 72(2):112-22. doi:
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