cocaine (BioDeep_00000406209)

Main id: BioDeep_00000002162

 

natural product


代谢物信息卡片


cocaine

化学式: C17H21NO4 (303.1470506)
中文名称: 古卡因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC
InChI: InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AD - Anesthetics, local
S - Sensory organs > S02 - Otologicals > S02D - Other otologicals > S02DA - Analgesics and anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BC - Esters of benzoic acid
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

cocaine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ying Wang, Ke Li, Weijian Shen, Xingxu Huang, Lina Wu. Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors. Analytical biochemistry. 2024 Aug; 691(?):115526. doi: 10.1016/j.ab.2024.115526. [PMID: 38621604]
  • Moeka Nomura, Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochemical and biophysical research communications. 2024 Feb; 695(?):149438. doi: 10.1016/j.bbrc.2023.149438. [PMID: 38160532]
  • Pamela Cabarcos-Fernández, Ivan Álvarez-Freire, Nelida Cristina Rubio, Ana Maria Bermejo-Barrera, Antonio Moreda-Piñeiro, Ines Sánchez-Sellero, Maria Jesus Tabernero-Duque. Evaluation of an Oral Fluid Collection Device and a Solid-Phase Extraction Method for the Determination of Coca Leaf Alkaloids by Gas Chromatography-Mass Spectrometry. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030592. [PMID: 38338336]
  • Marina Bellot, Fernando Soria, Raul López-Arnau, Cristian Gómez-Canela, Carlos Barata. Daphnia magna an emerging environmental model of neuro and cardiotoxicity of illicit drugs. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 344(?):123355. doi: 10.1016/j.envpol.2024.123355. [PMID: 38228265]
  • Rong Chen. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). 2024; 99(?):35-59. doi: 10.1016/bs.apha.2023.09.004. [PMID: 38467486]
  • I Álvarez-Freire, P Cabarcos-Fernández, N C Rubio, A Moreda-Piñeiro, M J Tabernero-Duque, I Sánchez-Sellero, P Bermejo-Barrera, A M Bermejo-Barrera. Detection of coca alkaloids in oral fluid from coca leaf (tea) consumers: using solid phase extraction to improve validation parameters and widen the detection window. Analytical methods : advancing methods and applications. 2023 Nov; ?(?):. doi: 10.1039/d3ay01298k. [PMID: 37937436]
  • Nikolaos Rousis, Richard Bade, Iván Romero-Sánchez, Jochen F Mueller, Nikolaos S Thomaidis, Kevin V Thomas, Emma Gracia-Lor. Festivals following the easing of COVID-19 restrictions: Prevalence of new psychoactive substances and illicit drugs. Environment international. 2023 Jun; 178(?):108075. doi: 10.1016/j.envint.2023.108075. [PMID: 37399770]
  • Macarena González-Portilla, Marta Moya, Sandra Montagud-Romero, Fernando Rodríguez de Fonseca, Laura Orio, Marta Rodríguez-Arias. Oleoylethanolamide attenuates the stress-mediated potentiation of rewarding properties of cocaine associated with an increased TLR4 proinflammatory response. Progress in neuro-psychopharmacology & biological psychiatry. 2023 06; 124(?):110722. doi: 10.1016/j.pnpbp.2023.110722. [PMID: 36724838]
  • Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek. Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach. The Science of the total environment. 2023 May; ?(?):164386. doi: 10.1016/j.scitotenv.2023.164386. [PMID: 37263433]
  • Jesús Herrera-Imbroda, María Flores-López, Nerea Requena-Ocaña, Pedro Araos, Jessica Ropero, Nuria García-Marchena, Antonio Bordallo, Juan Suarez, Francisco Javier Pavón-Morón, Antonia Serrano, Fermín Mayoral, Fernando Rodríguez de Fonseca. Antipsychotic Medication Influences the Discriminative Value of Acylethanolamides as Biomarkers of Substance Use Disorder. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119371. [PMID: 37298321]
  • Macarena González-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodríguez de Fonseca, María Pascual, Marta Rodríguez-Arias. Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum. Behavioral and brain functions : BBF. 2023 May; 19(1):8. doi: 10.1186/s12993-023-00210-1. [PMID: 37226219]
  • Yong-Jiang Wang, Tian Tain, Jia-Yi Yu, Jie Li, Bingyan Xu, Jianghua Chen, John C D'Auria, Jian-Ping Huang, Sheng-Xiong Huang. Genomic and structural basis for evolution of tropane alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr; 120(17):e2302448120. doi: 10.1073/pnas.2302448120. [PMID: 37068250]
  • Taja Verovšek, Ariana Šuštarič, Maria Laimou-Geraniou, Ivona Krizman-Matasic, Helena Prosen, Tina Eleršek, Vlasta Kramarič Zidar, Vesna Mislej, Boštjan Mišmaš, Marjeta Stražar, Marjetka Levstek, Bernardka Cimrmančič, Simon Lukšič, Nataša Uranjek, Tjaša Kozlovič-Bobič, Tina Kosjek, David Kocman, David Heath, Ester Heath. Removal of residues of psychoactive substances during wastewater treatment, their occurrence in receiving river waters and environmental risk assessment. The Science of the total environment. 2023 Mar; 866(?):161257. doi: 10.1016/j.scitotenv.2022.161257. [PMID: 36608822]
  • Shiyu Wang, Anna I Neel, Kristen L Adams, Haiguo Sun, Sara R Jones, Allyn C Howlett, Rong Chen. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 2023 03; 225(?):109387. doi: 10.1016/j.neuropharm.2022.109387. [PMID: 36567004]
  • Andrés Angel Calderon-Garcia, Maria Perez-Fernandez, Daniel Curto-Aguilera, Ivan Rodriguez-Martin, Mercedes Sánchez-Barba, Veronica Gonzalez-Nunez. Exposure to Morphine and Cocaine Modify the Transcriptomic Landscape in Zebrafish Embryos. Neuroscience. 2022 12; 507(?):14-27. doi: 10.1016/j.neuroscience.2022.10.017. [PMID: 36404518]
  • Yong-Jiang Wang, Jian-Ping Huang, Tian Tian, Yijun Yan, Yin Chen, Jing Yang, Jianghua Chen, Yu-Cheng Gu, Sheng-Xiong Huang. Discovery and Engineering of the Cocaine Biosynthetic Pathway. Journal of the American Chemical Society. 2022 12; 144(48):22000-22007. doi: 10.1021/jacs.2c09091. [PMID: 36376019]
  • Benjamin G Chavez, Prashanth Srinivasan, Kayla Glockzin, Neill Kim, Olga Montero Estrada, Jan Jirschitzka, Gage Rowden, Jonathan Shao, Lyndel Meinhardt, Christina D Smolke, John C D'Auria. Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform. Proceedings of the National Academy of Sciences of the United States of America. 2022 12; 119(49):e2215372119. doi: 10.1073/pnas.2215372119. [PMID: 36442128]
  • C C Cingi, D Eroglu. Efficacy of nasal stimulants on interpersonal communication - a narrative review. European review for medical and pharmacological sciences. 2022 12; 26(2 Suppl):99-102. doi: 10.26355/eurrev_202212_30492. [PMID: 36524917]
  • Hongchun Li, Rong Chen, Yuanyi Zhou, Haichuan Wang, Luqiang Sun, Zhen Yang, Lin Bai, Jie Zhang. Endocannabinoids regulate cocaine-associated memory through brain AEA-CB1R signalling activation. Molecular metabolism. 2022 11; 65(?):101597. doi: 10.1016/j.molmet.2022.101597. [PMID: 36096452]
  • Beatrice De Felice, Federico De Pascalis, Raoul Manenti, Radmila Pavlovic, Federica di Cesare, Rita Nasti, Giangiacomo Beretta, Marco Parolini. Differential biochemical and behavioral responses induced by cocaine and benzoylecgonine exposure to the red swamp crayfish Procambarus clarkii. The Science of the total environment. 2022 Oct; 844(?):157025. doi: 10.1016/j.scitotenv.2022.157025. [PMID: 35777565]
  • Roberta Zilles Hahn, Marcos Frank Bastiani, Lilian de Lima Feltraco Lizot, Anelise Schneider, Isabela Caroline da Silva Moreira, Yasmin Fazenda Meireles, Mariana Freitas Viana, Carlos Augusto do Nascimento, Rafael Linden. Long-term monitoring of drug consumption patterns during the COVID-19 pandemic in a small-sized community in Brazil through wastewater-based epidemiology. Chemosphere. 2022 Sep; 302(?):134907. doi: 10.1016/j.chemosphere.2022.134907. [PMID: 35561781]
  • Victoria Paulus, Joël Billieux, Amine Benyamina, Laurent Karila. Cannabidiol in the context of substance use disorder treatment: A systematic review. Addictive behaviors. 2022 09; 132(?):107360. doi: 10.1016/j.addbeh.2022.107360. [PMID: 35580370]
  • Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Jie Li, Bingyan Xu, Yin Chen, Li Wang, Jing Yang, Yijun Yan, Sheng-Xiong Huang. Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis. Nature communications. 2022 08; 13(1):4994. doi: 10.1038/s41467-022-32776-1. [PMID: 36008484]
  • Andrea Estévez-Danta, Lubertus Bijlsma, Ricardo Capela, Rafael Cela, Alberto Celma, Félix Hernández, Unax Lertxundi, João Matias, Rosa Montes, Gorka Orive, Ailette Prieto, Miguel M Santos, Rosario Rodil, José Benito Quintana. Use of illicit drugs, alcohol and tobacco in Spain and Portugal during the COVID-19 crisis in 2020 as measured by wastewater-based epidemiology. The Science of the total environment. 2022 Aug; 836(?):155697. doi: 10.1016/j.scitotenv.2022.155697. [PMID: 35523346]
  • Fang Zheng, Zhenyu Jin, Jing Deng, Xiabin Chen, Xirong Zheng, Guojun Wang, Kyungbo Kim, Linyue Shang, Ziyuan Zhou, Chang-Guo Zhan. Development of a Highly Efficient Long-Acting Cocaine Hydrolase Entity to Accelerate Cocaine Metabolism. Bioconjugate chemistry. 2022 07; 33(7):1340-1349. doi: 10.1021/acs.bioconjchem.2c00210. [PMID: 35767675]
  • César Antonio Araújo Melo, Hanna Rabech Garcia Guimarães, Raphael Crhistian Fernandes Medeiros, Georgia Costa de Araújo Souza, Patrícia Bittencourt Dutra Dos Santos, Ana Clara Soares Paiva Tôrres. Oral changes in cocaine abusers: an integrative review. Brazilian journal of otorhinolaryngology. 2022 Jul; 88(4):633-641. doi: 10.1016/j.bjorl.2021.04.011. [PMID: 34034978]
  • Jing Deng, Ting Zhang, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zheng. Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase. Addiction biology. 2022 Jul; 27(4):e13179. doi: 10.1111/adb.13179. [PMID: 35754103]
  • Vahid Azimi, Ronald Jackups, Christopher W Farnsworth, Melissa M Budelier. Use of laboratory data for illicit drug use surveillance and identification of socioeconomic risk factors. Drug and alcohol dependence. 2022 Jul; 236(?):109499. doi: 10.1016/j.drugalcdep.2022.109499. [PMID: 35605528]
  • Amy S Kohtz, Belle Lin, Hannah Davies, Mark Presker, Gary Aston-Jones. Hormonal milieu drives economic demand for cocaine in female rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022 07; 47(8):1484-1492. doi: 10.1038/s41386-022-01304-6. [PMID: 35338254]
  • Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Fabio Fumagalli, Judith R Homberg. Responsivity of serotonin transporter knockout rats to short and long access to cocaine: Modulation of the glutamate signalling in the nucleus accumbens shell. British journal of pharmacology. 2022 07; 179(14):3727-3739. doi: 10.1111/bph.15823. [PMID: 35174489]
  • Sean D Regnier, Justin C Strickland, William W Stoops. A preliminary investigation of schedule parameters on cocaine abstinence in contingency management. Journal of the experimental analysis of behavior. 2022 Jul; 118(1):83-95. doi: 10.1002/jeab.770. [PMID: 35538731]
  • Guillaume Drevin, Marie Briet, Severine Ferec, Chadi Abbara. Toxicity of designer benzodiazepines: A case of etizolam and cocaine intoxication. Forensic science international. 2022 Jul; 336(?):111324. doi: 10.1016/j.forsciint.2022.111324. [PMID: 35525006]
  • Sangwar Wadtey Oung, Nora Kremer, Safa Ben Amara, Ali Zaidi, Thorsten Koslowski. Protonation and orientation: a computational approach to cocaine diffusion through a model membrane. Physical chemistry chemical physics : PCCP. 2022 Jun; 24(23):14219-14227. doi: 10.1039/d2cp01140a. [PMID: 35647789]
  • Jasmin N Beaver, Brady L Weber, Matthew T Ford, Anna E Anello, Sarah K Kassis, T Lee Gilman. Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools. Cells. 2022 06; 11(12):. doi: 10.3390/cells11121874. [PMID: 35741002]
  • Giovanni Martinotti, Mauro Pettorruso, Chiara Montemitro, Primavera Alessandra Spagnolo, Cecilia Acuti Martellucci, Francesco Di Carlo, Fabrizio Fanella, Massimo di Giannantonio. Repetitive transcranial magnetic stimulation in treatment-seeking subjects with cocaine use disorder: A randomized, double-blind, sham-controlled trial. Progress in neuro-psychopharmacology & biological psychiatry. 2022 06; 116(?):110513. doi: 10.1016/j.pnpbp.2022.110513. [PMID: 35074451]
  • Nicolas Arlicot, Johnny Vercouillie, Cécile Malherbe, Rudy Bidault, Valérie Gissot, Serge Maia, Laurent Barantin, Jean-Philippe Cottier, Jean-Bernard Deloye, Denis Guilloteau, Maria-Joao Ribeiro. Imaging of dopamine transporter with [18F]LBT-999: initial evaluation in healthy volunteers. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2022 Jun; 66(2):148-155. doi: 10.23736/s1824-4785.19.03175-3. [PMID: 31496203]
  • Moritz Losacker, Marica Hundertmark, Siegfried Zörntlein, Jörg Röhrich, Cornelius Hess. Chiral pharmacokinetics of tetramisole stereoisomers-Enantioselective quantification of levamisole and dexamisole in serum samples from users of adulterated cocaine. Drug testing and analysis. 2022 Jun; 14(6):1053-1064. doi: 10.1002/dta.3227. [PMID: 35060339]
  • Tim Boogaerts, Maarten Quireyns, Maarten De Prins, Bram Pussig, Hans De Loof, Catharina Matheï, Bert Aertgeerts, Virginie Van Coppenolle, Erik Fransen, Adrian Covaci, Alexander L N van Nuijs. Temporal monitoring of stimulants during the COVID-19 pandemic in Belgium through the analysis of influent wastewater. The International journal on drug policy. 2022 06; 104(?):103679. doi: 10.1016/j.drugpo.2022.103679. [PMID: 35427945]
  • Penn Whitley, Leah LaRue, Soledad A Fernandez, Steven D Passik, Eric Dawson, Rebecca D Jackson. Analysis of Urine Drug Test Results From Substance Use Disorder Treatment Practices and Overdose Mortality Rates, 2013-2020. JAMA network open. 2022 06; 5(6):e2215425. doi: 10.1001/jamanetworkopen.2022.15425. [PMID: 35657623]
  • Mian Harris Iftikhar, Aneeqa Yousaf Dar, Alexandra Haw. Cocaine-induced rhabdomyolysis and compartment syndrome. BMJ case reports. 2022 May; 15(5):. doi: 10.1136/bcr-2022-249413. [PMID: 35589265]
  • Anna C Everett, Ben E Graul, Joakim W Ronström, J Kayden Robinson, Daniel B Watts, Rodrigo A España, Cody A Siciliano, Jordan T Yorgason. Effectiveness and Relationship between Biased and Unbiased Measures of Dopamine Release and Clearance. ACS chemical neuroscience. 2022 05; 13(10):1534-1548. doi: 10.1021/acschemneuro.2c00033. [PMID: 35482592]
  • Deborah S Hasin, David S Fink, Mark Olfson, Andrew J Saxon, Carol Malte, Katherine M Keyes, Jaimie L Gradus, Magdalena Cerdá, Charles C Maynard, Salomeh Keyhani, Silvia S Martins, Ofir Livne, Zachary L Mannes, Scott E Sherman, Melanie M Wall. Substance use disorders and COVID-19: An analysis of nation-wide Veterans Health Administration electronic health records. Drug and alcohol dependence. 2022 05; 234(?):109383. doi: 10.1016/j.drugalcdep.2022.109383. [PMID: 35279457]
  • Maged M Harraz, Adarsha P Malla, Evan R Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M Snowman, Pedro Cortés, Senthilkumar S Karuppagounder, Ted M Dawson, Valina L Dawson, Solomon H Snyder. A high-affinity cocaine binding site associated with the brain acid soluble protein 1. Proceedings of the National Academy of Sciences of the United States of America. 2022 04; 119(16):e2200545119. doi: 10.1073/pnas.2200545119. [PMID: 35412917]
  • Rachel A Rabin, Muhammad A Parvaz, Nelly Alia-Klein, Rita Z Goldstein. Emotion recognition in individuals with cocaine use disorder: the role of abstinence length and the social brain network. Psychopharmacology. 2022 Apr; 239(4):1019-1033. doi: 10.1007/s00213-021-05868-x. [PMID: 34089343]
  • Constanza Daigre, Lara Grau-López, Raúl F Palma-Alvarez, Marta Perea-Ortueta, Marta Sorribes-Puertas, Pedro Serrano-Pérez, Marta Quesada, Lidia Segura, Marta Coronado, Josep Antoni Ramos-Quiroga, Joan Colom. A Multicenter Study on the Impact of Gender, Age, and Dual Diagnosis on Substance Consumption and Mental Health Status in Outpatients Treated for Substance Use Disorders During COVID-19 Lockdown. Journal of dual diagnosis. 2022 Apr; 18(2):71-80. doi: 10.1080/15504263.2022.2051110. [PMID: 35324373]
  • Eleftherios Mellos, Thomas Paparrigopoulos. Substance use during the COVID-19 pandemic: What is really happening?. Psychiatrike = Psychiatriki. 2022 Mar; 33(1):17-20. doi: 10.22365/jpsych.2022.072. [PMID: 35255473]
  • Miguel Á Luján, Laia Alegre-Zurano, Ana Martín-Sánchez, Lídia Cantacorps, Olga Valverde. CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2022 03; 113(?):110462. doi: 10.1016/j.pnpbp.2021.110462. [PMID: 34688811]
  • Rasoul Moradi, Nazila Pour Khalili, Ni Luh Wulan Septiani, Chia-Hung Liu, Esmail Doustkhah, Yusuke Yamauchi, Slava V Rotkin. Nanoarchitectonics for Abused-Drug Biosensors. Small (Weinheim an der Bergstrasse, Germany). 2022 03; 18(10):e2104847. doi: 10.1002/smll.202104847. [PMID: 34882957]
  • James N Brundage, Colin P Mason, Hillary A Wadsworth, Chris S Finuf, Josh J Nelson, P Joakim W Ronström, Sara R Jones, Cody A Siciliano, Scott C Steffensen, Jordan T Yorgason. Regional and sex differences in spontaneous striatal dopamine transmission. Journal of neurochemistry. 2022 03; 160(6):598-612. doi: 10.1111/jnc.15473. [PMID: 34265080]
  • Gustavo A Angarita, Patrick D Worhunsky, Mika Naganawa, Takuya Toyonaga, Nabeel B Nabulsi, Chiang-Shan R Li, Irina Esterlis, Patrick D Skosnik, Rajiv Radhakrishnan, Brian Pittman, Ralitza Gueorguieva, Marc N Potenza, Sjoerd J Finnema, Yiyun Huang, Richard E Carson, Robert T Malison. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11 C-UCB-J positron emission tomography study in humans. Addiction biology. 2022 03; 27(2):e13123. doi: 10.1111/adb.13123. [PMID: 34852401]
  • Javier A Tamargo, Kenneth E Sherman, Rafick-Pierre Sékaly, Rebeka Bordi, Daniela Schlatzer, Shenghan Lai, Jag H Khalsa, Raul N Mandler, Richard L Ehman, Marianna K Baum. Cocaethylene, simultaneous alcohol and cocaine use, and liver fibrosis in people living with and without HIV. Drug and alcohol dependence. 2022 03; 232(?):109273. doi: 10.1016/j.drugalcdep.2022.109273. [PMID: 35033954]
  • S Boyle, M Hussain, C Kirby, S Brennan, L Clarke, R Mullan, D Halpenny, N Conlon, M A Little, B J Conlon, S Abdulrahman. Oro-Naso-Sino-Orbital-Cutaneous Fistula From Prolonged Cocaine Use. Irish medical journal. 2022 02; 115(2):544. doi: . [PMID: 35420004]
  • Núria Nadal-Gratacós, Esther Lleixà, Mónica Gibert-Serramià, Roger Estrada-Tejedor, Xavier Berzosa, Xavier Batllori, David Pubill, Jordi Camarasa, Elena Escubedo, Raúl López-Arnau. Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP ("flakka") Derivatives. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042226. [PMID: 35216339]
  • Emilie Feisthauer, Alice Ameline, Laurie Gheddar, Nadia Arbouche, Jean-Sébastien Raul, Pascal Kintz. Analysis of Cocaine and Its Metabolites in Urine after Consumption of Coca Tea by Five Subjects and Subsequent Hair Testing. Journal of analytical toxicology. 2022 Feb; 46(1):108-113. doi: 10.1093/jat/bkaa190. [PMID: 33277893]
  • Riley B Longtain, David P Graham, Mark J Harding, Richard De La Garza Ii, David A Nielsen. Methylation of the serotonin transporter gene moderates the depressive subjective effect of cocaine. Behavioural brain research. 2022 02; 418(?):113675. doi: 10.1016/j.bbr.2021.113675. [PMID: 34798166]
  • André Niebel, Fritz Pragst, Franziska Krumbiegel, Sven Hartwig. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international. 2022 Feb; 331(?):111148. doi: 10.1016/j.forsciint.2021.111148. [PMID: 34923263]
  • Chao Li, Ye Shen, Qian Xiao, Stephen L Rathbun, Hui Huang, Yongtao Guan. Mean corrected generalized estimating equations for longitudinal binary outcomes with report bias. Statistical methods in medical research. 2022 02; 31(2):315-333. doi: 10.1177/09622802211065160. [PMID: 34931910]
  • Hong-Chun Li, Jia-Mei Zhang, Rui Xu, Yong-Hai Wang, Wei Xu, Rong Chen, Xue-Mei Wan, Hao-Luo Zhang, Liang Wang, Xiao-Jie Wang, Lin-Hong Jiang, Bin Liu, Ying Zhao, Yuan-Yuan Chen, Yan-Ping Dai, Min Li, Hua-Qin Zhang, Zhen Yang, Lin Bai, Jie Zhang, Hong-Bo Wang, Jing-Wei Tian, Ying-Lan Zhao, Xiao-Bo Cen. mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens. Acta pharmacologica Sinica. 2022 Feb; 43(2):295-306. doi: 10.1038/s41401-021-00760-y. [PMID: 34522005]
  • Thuy Nguyen, Thomas F Gamage, David B Finlay, Ann M Decker, Tiffany L Langston, Daniel Barrus, Michelle Glass, Jun-Xu Li, Terry P Kenakin, Yanan Zhang. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior. Journal of medicinal chemistry. 2022 01; 65(1):257-270. doi: 10.1021/acs.jmedchem.1c01432. [PMID: 34929081]
  • Kana Unuma, Homare Kaga, Takeshi Funakoshi, Moeka Nomura, Toshihiko Aki, Koichi Uemura. Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PloS one. 2022; 17(11):e0277032. doi: 10.1371/journal.pone.0277032. [PMID: 36441681]
  • Su Ying Yeoh, Emmert Roberts, Fraser Scott, Timothy R Nicholson, Anthony S David, Jonathan P Rogers. Catatonic Episodes Related to Substance Use: A Cross-Sectional Study Using Electronic Healthcare Records. Journal of dual diagnosis. 2022 Jan; 18(1):52-58. doi: 10.1080/15504263.2021.2016342. [PMID: 35001837]
  • Jing Deng, Kyungbo Kim, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zheng. Cocaine hydrolase blocks cocaine-induced dopamine transporter trafficking to the plasma membrane. Addiction biology. 2022 01; 27(1):e13089. doi: 10.1111/adb.13089. [PMID: 34363291]
  • Sophia Laposchan, Ruben F Kranenburg, Arian C van Asten. Impurities, adulterants and cutting agents in cocaine as potential candidates for retrospective mining of GC-MS data. Science & justice : journal of the Forensic Science Society. 2022 01; 62(1):60-75. doi: 10.1016/j.scijus.2021.11.004. [PMID: 35033329]
  • Christopher J McLouth, Carrie B Oser, Danelle Stevens-Watkins. Concordance between Self-Reported Drug Use and Urinalysis in a Sample of Black American Women. Substance use & misuse. 2022; 57(4):495-503. doi: 10.1080/10826084.2021.2019778. [PMID: 35067171]
  • Ju Nyeong Park, Jill Owczarzak, Glenna Urquhart, Miles Morris, Noelle P Weicker, Saba Rouhani, Susan G Sherman. HIV Risk Among Urban and Suburban People Who Inject Drugs: Elevated Risk Among Fentanyl and Cocaine Injectors in Maryland. AIDS and behavior. 2022 Jan; 26(1):277-283. doi: 10.1007/s10461-021-03381-y. [PMID: 34287755]
  • Astor Reigstad, Ole Reigstad. The history of local anaesthesia – from coca leaves to effective analgesia. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 2021 12; 141(18):. doi: 10.4045/tidsskr.21.0381. [PMID: 34911266]
  • Kristen P Morie, Elise E DeVito, Marc N Potenza, Patrick D Worhunsky. Longitudinal changes in network engagement during cognitive control in cocaine use disorder. Drug and alcohol dependence. 2021 12; 229(Pt A):109151. doi: 10.1016/j.drugalcdep.2021.109151. [PMID: 34753083]
  • Gunnar Sørensen, Mattias Rickhag, Damiana Leo, Matthew D Lycas, Pernille Herrstedt Ridderstrøm, Pia Weikop, Jamila H Lilja, Pedro Rifes, Freja Herborg, David Woldbye, Gitta Wörtwein, Raul R Gainetdinov, Anders Fink-Jensen, Ulrik Gether. Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation. The Journal of biological chemistry. 2021 12; 297(6):101361. doi: 10.1016/j.jbc.2021.101361. [PMID: 34756883]
  • Burkhard Madea, Elvira Ruppel, Julian Prangenberg, Michael Krämer, Elke Doberentz. Expression of heat shock proteins 27, 60, and 70 in amphetamine and cocaine associated deaths. Forensic science international. 2021 Dec; 329(?):111088. doi: 10.1016/j.forsciint.2021.111088. [PMID: 34773820]
  • Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen. Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling. Neuroscience bulletin. 2021 Dec; 37(12):1683-1702. doi: 10.1007/s12264-021-00771-z. [PMID: 34491535]
  • Juan L Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M Wright, Dondre L Marable, Lionel A Rodriguez, Sherry Lam, Meghan L Carlton, Randall J Ellis, Chloe J Jordan, Guo-Hua Bi, Oscar Solis, Marco Pignatelli, Michael J Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides. Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior. Translational psychiatry. 2021 11; 11(1):570. doi: 10.1038/s41398-021-01693-0. [PMID: 34750356]
  • Benjamin S Frey, Deidre E Damon, Danyelle M Allen, Jill Baker, Samuel Asamoah, Abraham K Badu-Tawiah. Protective mechanism of dried blood spheroids: stabilization of labile analytes in whole blood, plasma, and serum. The Analyst. 2021 Nov; 146(22):6780-6787. doi: 10.1039/d1an01132d. [PMID: 34636822]
  • Qwynn Landfield, Mitsuo Saito, Audrey Hashim, Stefanie Canals-Baker, Henry Sershen, Efrat Levy, Mariko Saito. Cocaine Induces Sex-Associated Changes in Lipid Profiles of Brain Extracellular Vesicles. Neurochemical research. 2021 Nov; 46(11):2909-2922. doi: 10.1007/s11064-021-03395-x. [PMID: 34245421]
  • James Bailey, Nicola J Kalk, Rebecca Andrews, Sarah Yates, Limon Nahar, Michael Kelleher, Susan Paterson. Alcohol and cocaine use prior to suspected suicide: Insights from toxicology. Drug and alcohol review. 2021 11; 40(7):1195-1201. doi: 10.1111/dar.13260. [PMID: 33715255]
  • Derek Blevins, Chamindi Seneviratne, Xin-Qun Wang, Bankole A Johnson, Nassima Ait-Daoud. A randomized, double-blind, placebo-controlled trial of ondansetron for the treatment of cocaine use disorder with post hoc pharmacogenetic analysis. Drug and alcohol dependence. 2021 11; 228(?):109074. doi: 10.1016/j.drugalcdep.2021.109074. [PMID: 34600264]
  • Robert Suchting, Charles E Green, Constanza de Dios, Jessica Vincent, F Gerard Moeller, Scott D Lane, Joy M Schmitz. Citalopram for treatment of cocaine use disorder: A Bayesian drop-the-loser randomized clinical trial. Drug and alcohol dependence. 2021 11; 228(?):109054. doi: 10.1016/j.drugalcdep.2021.109054. [PMID: 34600245]
  • Pablo Giménez-Gómez, Raúl Ballestín, Leticia Gil de Biedma-Elduayen, Rebeca Vidal, Carmen Ferrer-Pérez, Marina D Reguilón, Esther O'Shea, José Miñarro, María Isabel Colado, Marta Rodríguez-Arias. Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward. Neuropharmacology. 2021 10; 197(?):108753. doi: 10.1016/j.neuropharm.2021.108753. [PMID: 34389399]
  • Thomas Bouvarel, Christophe Chendo, Nathalie Delaunay, Valérie Pichon. Simplified miniaturized analytical set-up based on molecularly imprinted polymer directly coupled to UV detection for the determination of benzoylecgonine in urine. Talanta. 2021 Oct; 233(?):122611. doi: 10.1016/j.talanta.2021.122611. [PMID: 34215095]
  • Kuo Hao Lee, Andrew D Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Mary Kudaibergenova, Williams E Miranda, Therese Ku, Jianjing Cao, Soren Wacker, Henry J Duff, Amy Hauck Newman, Sergei Y Noskov, Lei Shi. Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach. Journal of chemical information and modeling. 2021 09; 61(9):4266-4279. doi: 10.1021/acs.jcim.1c00856. [PMID: 34420294]
  • Anders Helander, Tomas Villen. [Drug use and drug trends in Sweden 2010-2020 - results from urine drug testing in the workplace]. Lakartidningen. 2021 09; 118(?):. doi: NULL. [PMID: 34515329]
  • Yue Li, Linda D Simmler, Ruud Van Zessen, Jérôme Flakowski, Jin-Xia Wan, Fei Deng, Yu-Long Li, Katherine M Nautiyal, Vincent Pascoli, Christian Lüscher. Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science (New York, N.Y.). 2021 Sep; 373(6560):1252-1256. doi: 10.1126/science.abi9086. [PMID: 34516792]
  • Giuliano Boscutti, Vittorio Di Maso, Alessandra Marega, Ugo Gerini, Alberto Zacchi, Francesco Bianco. [Droghe d'abuso e rene]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2021 Sep; 38(Suppl 77):. doi: NULL. [PMID: 34669304]
  • Amadeo Pesce, Raymond Sundyhanata, Dennis Ritz, Richard Thomas, Gregory Ackerman, Katie Bollman. Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients. Annals of clinical and laboratory science. 2021 Sep; 51(5):694-697. doi: . [PMID: 34686512]
  • Jin H Yoon, Robert Suchting, Constanza de Dios, Jessica N Vincent, Sarah A McKay, Scott D Lane, Joy M Schmitz. Decreased cocaine demand following contingency management treatment. Drug and alcohol dependence. 2021 09; 226(?):108883. doi: 10.1016/j.drugalcdep.2021.108883. [PMID: 34198136]
  • Todd M Hillhouse, Keith M Olson, James E Hallahan, Lauren G Rysztak, Bryan F Sears, Claire Meurice, Mehrnoosh Ostovar, Peyton O Koppenhaver, Joshua L West, Emily M Jutkiewicz, Stephen M Husbands, John R Traynor. The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice. The Journal of pharmacology and experimental therapeutics. 2021 09; 378(3):287-299. doi: 10.1124/jpet.121.000524. [PMID: 34183434]
  • Ana Olívia Martins Laurentino, Janaína Solómon, Bruna Ducatti Tonietto, Larissa Vivan Cestonaro, Nícolas Guimarães Dos Santos, Yasmin Vendruscolo Piton, Lucas Izolan, Douglas Marques, Marina Tuerlinckx Costa-Valle, Solange Cristina Garcia, Viviane Sebben, Eliane Dallegrave, Pedro Guilherme Schaefer, Elvino José Barros, Marcelo Dutra Arbo, Mirna Bainy Leal. Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations in Wistar rats. Toxicology and applied pharmacology. 2021 09; 426(?):115649. doi: 10.1016/j.taap.2021.115649. [PMID: 34273407]
  • Marie A Doyle, Vedrana Bali, Andrew L Eagle, Ali R Stark, Barbara Fallon, Rachael L Neve, A J Robison, Michelle S Mazei-Robison. Serum- and glucocorticoid-inducible kinase 1 activity in ventral tegmental area dopamine neurons regulates cocaine conditioned place preference but not cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 08; 46(9):1574-1583. doi: 10.1038/s41386-021-01032-3. [PMID: 34007042]
  • Ewa Domagalska, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Marzena Kata, Beata Szpiech, Michał Kaliszan. Fatal N-Ethylhexedrone Intoxication. Journal of analytical toxicology. 2021 Jul; 45(6):e1-e6. doi: 10.1093/jat/bkaa159. [PMID: 33048166]
  • Gamze Avcioglu, Gulsen Yilmaz, Safak Yalcin Sahiner, L Didem Kozaci, Ceylan Bal, Fatma Meric Yilmaz. Evaluation of the diagnostic performance of an oral fluid screening test device for substance abuse at traffic controls. Clinical biochemistry. 2021 Jul; 93(?):112-118. doi: 10.1016/j.clinbiochem.2021.04.009. [PMID: 33882283]
  • Eduardo A Garza-Villarreal, Ruth Alcala-Lozano, Sofia Fernandez-Lozano, Erik Morelos-Santana, Alan Dávalos, Viviana Villicaña, Sarael Alcauter, F Xavier Castellanos, Jorge J Gonzalez-Olvera. Clinical and Functional Connectivity Outcomes of 5-Hz Repetitive Transcranial Magnetic Stimulation as an Add-on Treatment in Cocaine Use Disorder: A Double-Blind Randomized Controlled Trial. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021 07; 6(7):745-757. doi: 10.1016/j.bpsc.2021.01.003. [PMID: 33508499]
  • Mohamed Abou El Hassan, David Colantonio, Sergei Likhodii, Bassam A Nassar. The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard. Clinical biochemistry. 2021 Jul; 93(?):99-103. doi: 10.1016/j.clinbiochem.2021.04.003. [PMID: 33844982]
  • Claudia Calpe-López, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares, Jose Miñarro, Maria A Aguilar. Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice. Journal of psychopharmacology (Oxford, England). 2021 Jul; 35(7):864-874. doi: 10.1177/0269881120965952. [PMID: 33427014]
  • Daniel Ciccarone. The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis. Current opinion in psychiatry. 2021 07; 34(4):344-350. doi: 10.1097/yco.0000000000000717. [PMID: 33965972]
  • Bree A Humburg, Chloe J Jordan, Hai-Ying Zhang, Hui Shen, Xiao Han, Guo-Hua Bi, Briana Hempel, Ewa Galaj, Michael H Baumann, Zheng-Xiong Xi. Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice. Addiction biology. 2021 07; 26(4):e13005. doi: 10.1111/adb.13005. [PMID: 33538103]
  • Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorthy. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. 2021 06; 408(?):113267. doi: 10.1016/j.bbr.2021.113267. [PMID: 33794225]
  • Minnan Al-Khafaji, Sabina Podbicanin, Deep Ghaghda, Saajan Basi, Shuja Punekar. Simultaneous multifocal intracranial haemorrhage (ICH) and subarachnoid haemorrhage (SAH) in the setting of long-term cocaine usage. BMJ case reports. 2021 Jun; 14(6):. doi: 10.1136/bcr-2020-241311. [PMID: 34140326]
  • Brandon M Baker, Mary Anna Carbone, Wen Huang, Robert R H Anholt, Trudy F C Mackay. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 2021 06; 118(23):. doi: 10.1073/pnas.2104131118. [PMID: 34074789]
  • Jiye Wang, Xingyu Deng, Yanan Wu, Yuyu Huang, Shurong Hou, Yun Zhang, Ting Qiu, Junsen Tong, Xiabin Chen. Sub-lethal toxicity and elimination of the cocaine metabolite, benzoylecgonine: a narrative review. Annals of palliative medicine. 2021 Jun; 10(6):6936-6947. doi: 10.21037/apm-21-243. [PMID: 34118862]
  • Patrick S Thomas, Ellen M Nielsen, Catherine J Spellicy, Mark J Harding, An Ye, Michelle Patriquin, Sara C Hamon, Thomas R Kosten, David A Nielsen. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatric genetics. 2021 06; 31(3):88-94. doi: 10.1097/ypg.0000000000000279. [PMID: 33953123]