Taurocholic Acid (BioDeep_00000406031)

Main id: BioDeep_00000002590

 

natural product Bile acids PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)-taurine

化学式: C26H45NO7S (515.2917)
中文名称: 牛磺胆酸, 牛磺胆酸盐, 牛黄胆酸
谱图信息: 最多检出来源 Homo sapiens(natural_products) 62.96%

分子结构信息

SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1

描述信息

A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; WBWWGRHZICKQGZ-HZAMXZRMSA-N_STSL_0093_Taurocholic acid_8000fmol_180416_S2_LC02_MS02_101; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
CONFIDENCE standard compound; INTERNAL_ID 59
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.

同义名列表

5 个代谢物同义名

Taurocholic Acid; N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)-taurine; ST 24:1;O5;T; N-Choloyltaurine; Taurocholate



数据库引用编号

49 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ABCB1, AKT1, ALB
Endoplasmic reticulum membrane 2 CYP7A1, HMGCR
Nucleus 3 AKT1, ALB, MPO
cytosol 4 AKT1, ALB, LIPE, PRKCQ
centrosome 1 ALB
nucleoplasm 2 AKT1, MPO
Cell membrane 8 ABCB1, ABCB11, AKT1, LIPE, SLC10A1, SLCO1A2, SLCO1B1, TNF
lamellipodium 1 AKT1
Multi-pass membrane protein 8 ABCB1, ABCB11, ABCC2, ABCC3, HMGCR, SLC10A1, SLCO1A2, SLCO1B1
cell cortex 1 AKT1
cell surface 4 ABCB1, ABCB11, ABCC2, TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 1 ALB
Golgi membrane 2 ABCB11, INS
neuronal cell body 1 TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 LIPE
Lysosome 1 MPO
endosome 1 ABCB11
plasma membrane 12 ABCB1, ABCB11, ABCC2, ABCC3, AKT1, GCG, PRKCQ, SLC10A1, SLC10A2, SLCO1A2, SLCO1B1, TNF
Membrane 10 ABCB1, ABCB11, ABCC2, ABCC3, AKT1, HMGCR, LIPE, SLC10A1, SLCO1A2, SLCO1B1
apical plasma membrane 5 ABCB1, ABCB11, ABCC2, SLC10A2, SLCO1A2
axon 1 CCK
basolateral plasma membrane 4 ABCC3, SLC10A1, SLCO1A2, SLCO1B1
caveola 1 LIPE
extracellular exosome 4 ABCB1, ABCB11, ALB, MPO
endoplasmic reticulum 2 ALB, HMGCR
extracellular space 7 ALB, CCK, GCG, IL6, INS, MPO, TNF
intercellular canaliculus 2 ABCB11, ABCC2
protein-containing complex 2 AKT1, ALB
intracellular membrane-bounded organelle 2 CYP7A1, MPO
Microsome membrane 1 CYP7A1
Secreted 5 ALB, CCK, GCG, IL6, INS
extracellular region 7 ALB, CCK, GCG, IL6, INS, MPO, TNF
Single-pass membrane protein 1 CYP7A1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 TNF
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 2 ABCB11, TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 3 ABCB1, ABCB11, ABCC2
Membrane raft 1 TNF
spindle 1 AKT1
peroxisomal membrane 1 HMGCR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
ciliary basal body 2 AKT1, ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 2 ABCC3, SLCO1B1
Recycling endosome membrane 1 ABCB11
endosome lumen 1 INS
microvillus 1 SLC10A2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Peroxisome membrane 1 HMGCR
basal plasma membrane 3 ABCC3, SLCO1A2, SLCO1B1
azurophil granule 1 MPO
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, GCG, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
phagocytic vesicle lumen 1 MPO
Basal cell membrane 3 ABCC3, SLCO1A2, SLCO1B1
external side of apical plasma membrane 1 ABCB1
intracellular canaliculus 1 ABCB11
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Ana Clara Sabbione, María Cristina Añón, Adriana Scilingo. Characterization and Bile Acid Binding Capacity of Dietary Fiber Obtained from Three Different Amaranth Products. Plant foods for human nutrition (Dordrecht, Netherlands). 2024 Mar; 79(1):38-47. doi: 10.1007/s11130-023-01116-z. [PMID: 37938455]
  • Zehui Qin, Minhua Li, Juanjuan Cheng, Ziwei Huang, Gaoxiang Ai, Chang Qu, Youliang Xie, Yucui Li, Huijun Liao, Jianhui Xie, Ziren Su. Self-Assembled nanoparticles Combining Berberine and Sodium Taurocholate for Enhanced Anti-Hyperuricemia Effect. International journal of nanomedicine. 2023; 18(?):4101-4120. doi: 10.2147/ijn.s409513. [PMID: 37525694]
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  • Dariusz Zakrzewicz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, Joachim Geyer. Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes. Viruses. 2022 06; 14(6):. doi: 10.3390/v14061259. [PMID: 35746730]
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  • Zhen Xun, Jinpiao Lin, Qingqing Yu, Can Liu, Jinlan Huang, Hongyan Shang, Jianhui Guo, Yuchen Ye, Wennan Wu, Yongbin Zeng, Songhang Wu, Siyi Xu, Tianbin Chen, Jing Chen, Qishui Ou. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cellular & molecular immunology. 2021 02; 18(2):461-471. doi: 10.1038/s41423-020-00601-8. [PMID: 33432062]
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