Stavudine (BioDeep_00000406025)

Main id: BioDeep_00000003177

 


代谢物信息卡片


Stavudine

化学式: C10H12N2O4 (224.0797)
中文名称: 2,3-二脱氢-3-脱氧胸苷
谱图信息: 最多检出来源 Homo sapiens(blood) 16.89%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO
InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2238; ORIGINAL_PRECURSOR_SCAN_NO 2235
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2232; ORIGINAL_PRECURSOR_SCAN_NO 2230
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2236; ORIGINAL_PRECURSOR_SCAN_NO 2234
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2225; ORIGINAL_PRECURSOR_SCAN_NO 2224
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2291; ORIGINAL_PRECURSOR_SCAN_NO 2290
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2235; ORIGINAL_PRECURSOR_SCAN_NO 2233
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9439; ORIGINAL_PRECURSOR_SCAN_NO 9434
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9398; ORIGINAL_PRECURSOR_SCAN_NO 9395
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9567; ORIGINAL_PRECURSOR_SCAN_NO 9562
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9454; ORIGINAL_PRECURSOR_SCAN_NO 9450
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

同义名列表

3 个代谢物同义名

Stavudine; d4T; Stavudine



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADIG, AXIN2, CASP3, FABP4, FASN, PPARG, SRY
Endoplasmic reticulum membrane 1 CD4
Nucleus 7 ADIG, AXIN2, CASP3, CS, FABP4, PPARG, SRY
cytosol 9 AXIN2, CASP3, FABP4, FASN, GPT, LEP, LIPE, MTHFR, PPARG
centrosome 1 AXIN2
nucleoplasm 3 CASP3, PPARG, SRY
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 CD4, CD8A, LIPE, TNF
cell surface 2 ADIPOQ, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 FASN
Golgi membrane 1 INS
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 1 LIPE
plasma membrane 6 AXIN2, CD4, CD8A, FASN, IFNLR1, TNF
Membrane 5 ADIG, CS, FASN, IFNLR1, LIPE
caveola 1 LIPE
extracellular exosome 4 CS, FABP4, FASN, GPT
endoplasmic reticulum 1 ADIPOQ
extracellular space 5 ADIPOQ, IL6, INS, LEP, TNF
perinuclear region of cytoplasm 1 PPARG
mitochondrion 1 CS
intracellular membrane-bounded organelle 1 PPARG
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, CD8A, IFNLR1
Secreted 5 ADIG, ADIPOQ, IL6, INS, LEP
extracellular region 7 ADIG, ADIPOQ, CD8A, IL6, INS, LEP, TNF
Single-pass membrane protein 1 ADIG
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 CS
mitochondrial matrix 1 CS
external side of plasma membrane 3 CD4, CD8A, TNF
beta-catenin destruction complex 1 AXIN2
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
collagen trimer 1 ADIPOQ
collagen-containing extracellular matrix 1 ADIPOQ
nuclear speck 1 SRY
receptor complex 2 CD8A, PPARG
chromatin 2 PPARG, SRY
phagocytic cup 1 TNF
endosome lumen 1 INS
Lipid droplet 3 ADIG, FABP4, LIPE
Membrane, caveola 1 LIPE
Melanosome 1 FASN
Nucleus speckle 1 SRY
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 CD4, IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
glycogen granule 1 FASN
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Sorour Khayyatnejad Shoushtari, Khalid Zoghebi, Muhammad Imran Sajid, Rakesh Kumar Tiwari, Keykavous Parang. Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positively Charged and Hydrophobic Residues as Molecular Transporters. Molecular pharmaceutics. 2021 10; 18(10):3909-3919. doi: 10.1021/acs.molpharmaceut.1c00594. [PMID: 34491768]
  • Balagra Kasim Sumabe, Synnøve Brandt Ræder, Lisa Marie Røst, Animesh Sharma, Eric S Donkor, Lydia Mosi, Samuel Duodu, Per Bruheim, Marit Otterlei. Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis. Biomolecules. 2021 06; 11(6):. doi: 10.3390/biom11060843. [PMID: 34198819]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Himanshu G Toor, Devjani I Banerjee, Soumya Lipsa Rath, Siddhi A Darji. Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19. European journal of pharmacology. 2021 Jan; 890(?):173720. doi: 10.1016/j.ejphar.2020.173720. [PMID: 33160938]
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  • S A Chime, A A Attama, G C Onunkwo. Application of SRMS 154 as Sustained Release Matrix for the Delivery of Stavudine: In vitro and in vivo Evaluation and Effect of Poloxamer 188 on the Properties of the Tablets. Infectious disorders drug targets. 2020; 20(1):76-87. doi: 10.2174/1871526519666190313162635. [PMID: 30868966]
  • Salome A Chime, Godswill C Onunkwo, Anthony A Attama. Evaluation of the Properties of Encapsulated Stavudine Microparticulate Lipid-based Drug Delivery System in Immunocompromised Wistar Rats. Current HIV research. 2020; 18(4):237-247. doi: 10.2174/1570162x18666200510010738. [PMID: 32386495]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC nephrology. 2019 05; 20(1):155. doi: 10.1186/s12882-019-1335-9. [PMID: 31064340]
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  • Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith. Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology. 2019 Apr; 27(2):387-396. doi: 10.1007/s10787-018-00551-8. [PMID: 30600474]
  • Willem Daniel Francois Venter, Andrew Kambugu, Matthew F Chersich, Stephen Becker, Andrew Hill, Natasha Arulappan, Michelle Moorhouse, Mohammed Majam, Godspower Akpomiemie, Simiso Sokhela, Selvamuthu Poongulali, Charles Feldman, Chris Duncombe, David H Brown Ripin, Alinda Vos, Nagalingeswaran Kumarasamy. Efficacy and Safety of Tenofovir Disoproxil Fumarate Versus Low-Dose Stavudine Over 96 Weeks: A Multicountry Randomized, Noninferiority Trial. Journal of acquired immune deficiency syndromes (1999). 2019 02; 80(2):224-233. doi: 10.1097/qai.0000000000001908. [PMID: 30640204]
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  • Saikat Ghosh, Laboni Mondal, Samrat Chakraborty, Biswajit Mukherjee. Early Stage HIV Management and Reduction of Stavudine-Induced Hepatotoxicity in Rats by Experimentally Developed Biodegradable Nanoparticles. AAPS PharmSciTech. 2017 Apr; 18(3):697-709. doi: 10.1208/s12249-016-0539-6. [PMID: 27222026]
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  • Jenny Svärd, Sabina Mugusi, Doreen Mloka, Ujjwal Neogi, Genny Meini, Ferdinand Mugusi, Francesca Incardona, Maurizio Zazzi, Anders Sönnerborg. Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy. PloS one. 2017; 12(6):e0178942. doi: 10.1371/journal.pone.0178942. [PMID: 28582463]
  • Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. BioMed research international. 2017; 2017(?):7481597. doi: 10.1155/2017/7481597. [PMID: 28293638]
  • Lovish Marwaha, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Rupinder Kaur Sodhi, Anurag Kuhad. Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain. Inflammopharmacology. 2016 Dec; 24(6):319-334. doi: 10.1007/s10787-016-0285-0. [PMID: 27757590]
  • Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Wisit Prasithsirikul, Emi E Nakayama, Tatsuo Shioda, Chariya Sangsajja. A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection. PloS one. 2016; 11(1):e0147724. doi: 10.1371/journal.pone.0147724. [PMID: 26807589]
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  • Pornpen Srisawasdi, Tanida Suwalak, Chonlaphat Sukasem, Anchalee Chittamma, Anothai Pocathikorn, Somlak Vanavanan, Apichaya Puangpetch, Siwalee Santon, Wasun Chantratita, Sasisopin Kiertiburanakul, Martin H Kroll. Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients. American journal of clinical pathology. 2013 Oct; 140(4):506-15. doi: 10.1309/ajcpe5i3keltbxej. [PMID: 24045547]
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