Stavudine (BioDeep_00000406025)

Main id: BioDeep_00000003177

 


代谢物信息卡片


Stavudine

化学式: C10H12N2O4 (224.07970319999998)
中文名称: 2,3-二脱氢-3-脱氧胸苷
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO
InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2238; ORIGINAL_PRECURSOR_SCAN_NO 2235
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2232; ORIGINAL_PRECURSOR_SCAN_NO 2230
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2236; ORIGINAL_PRECURSOR_SCAN_NO 2234
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2225; ORIGINAL_PRECURSOR_SCAN_NO 2224
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2291; ORIGINAL_PRECURSOR_SCAN_NO 2290
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2235; ORIGINAL_PRECURSOR_SCAN_NO 2233
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9439; ORIGINAL_PRECURSOR_SCAN_NO 9434
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9398; ORIGINAL_PRECURSOR_SCAN_NO 9395
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9567; ORIGINAL_PRECURSOR_SCAN_NO 9562
CONFIDENCE standard compound; INTERNAL_ID 1066; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9454; ORIGINAL_PRECURSOR_SCAN_NO 9450
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

同义名列表

2 个代谢物同义名

Stavudine; d4T



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sorour Khayyatnejad Shoushtari, Khalid Zoghebi, Muhammad Imran Sajid, Rakesh Kumar Tiwari, Keykavous Parang. Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positively Charged and Hydrophobic Residues as Molecular Transporters. Molecular pharmaceutics. 2021 10; 18(10):3909-3919. doi: 10.1021/acs.molpharmaceut.1c00594. [PMID: 34491768]
  • Balagra Kasim Sumabe, Synnøve Brandt Ræder, Lisa Marie Røst, Animesh Sharma, Eric S Donkor, Lydia Mosi, Samuel Duodu, Per Bruheim, Marit Otterlei. Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis. Biomolecules. 2021 06; 11(6):. doi: 10.3390/biom11060843. [PMID: 34198819]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Himanshu G Toor, Devjani I Banerjee, Soumya Lipsa Rath, Siddhi A Darji. Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19. European journal of pharmacology. 2021 Jan; 890(?):173720. doi: 10.1016/j.ejphar.2020.173720. [PMID: 33160938]
  • Christian Eggers, Richard Hoetelmans, Stephanie Läer. Zidovudine and lamivudine reach higher concentrations in ventricular than in lumbar human cerebrospinal fluid. AIDS (London, England). 2020 11; 34(13):1883-1889. doi: 10.1097/qad.0000000000002626. [PMID: 32694416]
  • Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Thomas K Anderson, Minchen Chien, Shiv Kumar, James J Russo, Robert N Kirchdoerfer, Jingyue Ju. A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19. Antiviral research. 2020 08; 180(?):104857. doi: 10.1016/j.antiviral.2020.104857. [PMID: 32562705]
  • S A Chime, A A Attama, G C Onunkwo. Application of SRMS 154 as Sustained Release Matrix for the Delivery of Stavudine: In vitro and in vivo Evaluation and Effect of Poloxamer 188 on the Properties of the Tablets. Infectious disorders drug targets. 2020; 20(1):76-87. doi: 10.2174/1871526519666190313162635. [PMID: 30868966]
  • Salome A Chime, Godswill C Onunkwo, Anthony A Attama. Evaluation of the Properties of Encapsulated Stavudine Microparticulate Lipid-based Drug Delivery System in Immunocompromised Wistar Rats. Current HIV research. 2020; 18(4):237-247. doi: 10.2174/1570162x18666200510010738. [PMID: 32386495]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC nephrology. 2019 05; 20(1):155. doi: 10.1186/s12882-019-1335-9. [PMID: 31064340]
  • Xiao-Lu Luo, Li-da Mo, Guo-Sheng Su, Jin-Ping Huang, Jing-Yu Wu, Han-Zhen Su, Wan-Hong Huang, Shun-da Luo, Zu-Yan Ni. Incidence and types of HIV-1 drug resistance mutation among patients failing first-line antiretroviral therapy. Journal of pharmacological sciences. 2019 Apr; 139(4):275-279. doi: 10.1016/j.jphs.2018.11.016. [PMID: 30928089]
  • Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith. Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology. 2019 Apr; 27(2):387-396. doi: 10.1007/s10787-018-00551-8. [PMID: 30600474]
  • Willem Daniel Francois Venter, Andrew Kambugu, Matthew F Chersich, Stephen Becker, Andrew Hill, Natasha Arulappan, Michelle Moorhouse, Mohammed Majam, Godspower Akpomiemie, Simiso Sokhela, Selvamuthu Poongulali, Charles Feldman, Chris Duncombe, David H Brown Ripin, Alinda Vos, Nagalingeswaran Kumarasamy. Efficacy and Safety of Tenofovir Disoproxil Fumarate Versus Low-Dose Stavudine Over 96 Weeks: A Multicountry Randomized, Noninferiority Trial. Journal of acquired immune deficiency syndromes (1999). 2019 02; 80(2):224-233. doi: 10.1097/qai.0000000000001908. [PMID: 30640204]
  • Alinda G Vos, Matthew F Chersich, Kerstin Klipstein-Grobusch, Peter Zuithoff, Michelle A Moorhouse, Samanta T Lalla-Edward, Andrew Kambugu, N Kumarasamy, Diederick E Grobbee, Roos E Barth, Willem D Venter. Lipid levels, insulin resistance and cardiovascular risk over 96 weeks of antiretroviral therapy: a randomised controlled trial comparing low-dose stavudine and tenofovir. Retrovirology. 2018 12; 15(1):77. doi: 10.1186/s12977-018-0460-z. [PMID: 30547820]
  • D Mukeba-Tshialala, J B Nachega, M Mutombo-Tshingwali, V Arendt, G Gilson, M Moutschen. [Obesity, high blood pressure, hypercholesterolaemia, and untreated diabetes in HIV-infected and HIV-uninfected Adults in Mbuji-Mayi (Democratic republic of congo)]. Bulletin de la Societe de pathologie exotique (1990). 2017 Dec; 110(5):301-309. doi: 10.1007/s13149-017-0561-2. [PMID: 28623554]
  • Aylin B Unsal, Aviva S Mattingly, Sara E Jones, Julia B Purdy, James C Reynolds, Jeffrey B Kopp, Rohan Hazra, Colleen M Hadigan. Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life. The Journal of clinical endocrinology and metabolism. 2017 08; 102(8):2896-2904. doi: 10.1210/jc.2017-00197. [PMID: 28531309]
  • Saikat Ghosh, Laboni Mondal, Samrat Chakraborty, Biswajit Mukherjee. Early Stage HIV Management and Reduction of Stavudine-Induced Hepatotoxicity in Rats by Experimentally Developed Biodegradable Nanoparticles. AAPS PharmSciTech. 2017 Apr; 18(3):697-709. doi: 10.1208/s12249-016-0539-6. [PMID: 27222026]
  • A I Jegede, U Offor, I O Onanuga, E C S Naidu, O O Azu. Effect of co-administration of Hypoxis hemerocallidea extract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats. Andrologia. 2017 Mar; 49(2):. doi: 10.1111/and.12640. [PMID: 27401301]
  • Jenny Svärd, Sabina Mugusi, Doreen Mloka, Ujjwal Neogi, Genny Meini, Ferdinand Mugusi, Francesca Incardona, Maurizio Zazzi, Anders Sönnerborg. Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy. PloS one. 2017; 12(6):e0178942. doi: 10.1371/journal.pone.0178942. [PMID: 28582463]
  • Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. BioMed research international. 2017; 2017(?):7481597. doi: 10.1155/2017/7481597. [PMID: 28293638]
  • Lovish Marwaha, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Rupinder Kaur Sodhi, Anurag Kuhad. Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain. Inflammopharmacology. 2016 Dec; 24(6):319-334. doi: 10.1007/s10787-016-0285-0. [PMID: 27757590]
  • Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Wisit Prasithsirikul, Emi E Nakayama, Tatsuo Shioda, Chariya Sangsajja. A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection. PloS one. 2016; 11(1):e0147724. doi: 10.1371/journal.pone.0147724. [PMID: 26807589]
  • Oluwafeyisetan O Adebiyi, Olubunmi A Adebiyi, Peter M O Owira. Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications. Nutrients. 2015 Dec; 7(12):10352-68. doi: 10.3390/nu7125540. [PMID: 26690471]
  • Z Dai, W Cai, F Hu, Y Lan, L Li, C Chung, B Caughey, K Zhang, X Tang. Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART). Current molecular medicine. 2015; 15(10):975-9. doi: 10.2174/1566524016666151123114401. [PMID: 26592244]
  • Daudi R Mavura, E John Masenga, Eli Minja, Henning Grossmann, John A Crump, John A Bartlett. Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania. International journal of dermatology. 2015 Jan; 54(1):68-73. doi: 10.1111/ijd.12563. [PMID: 25256912]
  • Saurabh Srivastava, Rajendra Kumar, S K Arora, V R Sinha. Modified Release Biodegradable Polymeric Microspheres of Stavudine: Cell Viability, Cellular Uptake, Hemolysis Studies and In Vivo Pharmacokinetics. Current HIV research. 2015; 13(6):503-16. doi: 10.2174/1570162x13666150624112345. [PMID: 26103967]
  • Suhashni Naiker, Cathy Connolly, Lubbe Wiesner, Tracey Kellerman, Tarylee Reddy, Anthony Harries, Helen McIlleron, Christian Lienhardt, Alexander Pym. Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy. BMC pharmacology & toxicology. 2014 Nov; 15(?):61. doi: 10.1186/2050-6511-15-61. [PMID: 25406657]
  • Janet Gare, Claire E Ryan, Matthew David, Diana Timbi, Petronia Kaima, Zure Kombati, Ulato Imara, Angela Kelly-Hanku, Peter M Siba, Suzanne M Crowe, Anna C Hearps. Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea. The Journal of antimicrobial chemotherapy. 2014 Aug; 69(8):2183-6. doi: 10.1093/jac/dku089. [PMID: 24722838]
  • Aparna Mukherjee, Mohit Singla, T Velpandian, Anju Sirohiwal, M Vajpayee, Ravinder Singh, S K Kabra, Rakesh Lodha. Pharmacokinetics of nevirapine, stavudine and lamivudine in Indian HIV-infected children receiving generic fixed dose combinations. Indian pediatrics. 2014 Mar; 51(3):191-7. doi: 10.1007/s13312-014-0382-3. [PMID: 24736906]
  • Kassoum Kayentao, Etienne A Guirou, Ogobara K Doumbo, Meera Venkatesan, Christopher V Plowe, Teresa L Parsons, Craig W Hendrix, Myaing M Nyunt. Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection. The American journal of tropical medicine and hygiene. 2014 Mar; 90(3):530-534. doi: 10.4269/ajtmh.13-0655. [PMID: 24420779]
  • Julie Bertrand, Céline Verstuyft, Monidarin Chou, Laurence Borand, Phalla Chea, Kuy Huong Nay, François-Xavier Blanc, France Mentré, Anne-Marie Taburet. Dependence of efavirenz- and rifampicin-isoniazid-based antituberculosis treatment drug-drug interaction on CYP2B6 and NAT2 genetic polymorphisms: ANRS 12154 study in Cambodia. The Journal of infectious diseases. 2014 Feb; 209(3):399-408. doi: 10.1093/infdis/jit466. [PMID: 23990572]
  • Saif Ullah Munshi, Harekrushna Panda, Prasida Holla, Bharat Bhushan Rewari, Shahid Jameel. MicroRNA-150 is a potential biomarker of HIV/AIDS disease progression and therapy. PloS one. 2014; 9(5):e95920. doi: 10.1371/journal.pone.0095920. [PMID: 24828336]
  • Victor Musiime, Adrian Cook, Joshua Kayiwa, Dorothy Zangata, Carol Nansubuga, Beatrice Arach, Julia Kenny, Priscilla Wavamunno, Justine Komunyena, Desiree Kabamba, Alice R Asiimwe, Grace Mirembe, George Abongomera, Veronica Mulenga, Adeodata Kekitiinwa, Cissy Kityo, Sarah A Walker, Nigel Klein, Diana M Gibb. Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CHAPAS-3 trial. Antiviral therapy. 2014; 19(3):269-76. doi: 10.3851/imp2695. [PMID: 24717427]
  • C N Menezes, N J Crowther, R Duarte, D Van Amsterdam, D Evans, C Dickens, T Dix-Peek, M Rassool, A Prinsloo, F Raal, I Sanne. A randomized clinical trial comparing metabolic parameters after 48 weeks of standard- and low-dose stavudine therapy and tenofovir disoproxil fumarate therapy in HIV-infected South African patients. HIV medicine. 2014 Jan; 15(1):3-12. doi: 10.1111/hiv.12074. [PMID: 23980620]
  • Pere Domingo, María del Mar Gutierrez, José Miguel Gallego-Escuredo, Ferran Torres, Gracia María Mateo, Joan Villarroya, Ignacio de los Santos, Joan Carles Domingo, Francesc Villarroya, Luis Del Rio, Vicente Estrada, Marta Giralt. Effects of switching from stavudine to raltegravir on subcutaneous adipose tissue in HIV-infected patients with HIV/HAART-associated lipodystrophy syndrome (HALS). A clinical and molecular study. PloS one. 2014; 9(2):e89088. doi: 10.1371/journal.pone.0089088. [PMID: 24586518]
  • Faye Wang, Oliver P Flint. BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue. Antimicrobial agents and chemotherapy. 2013 Dec; 57(12):6205-12. doi: 10.1128/aac.01206-13. [PMID: 24080659]
  • Pornpen Srisawasdi, Tanida Suwalak, Chonlaphat Sukasem, Anchalee Chittamma, Anothai Pocathikorn, Somlak Vanavanan, Apichaya Puangpetch, Siwalee Santon, Wasun Chantratita, Sasisopin Kiertiburanakul, Martin H Kroll. Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients. American journal of clinical pathology. 2013 Oct; 140(4):506-15. doi: 10.1309/ajcpe5i3keltbxej. [PMID: 24045547]
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