3-mercaptopyruvic acid (BioDeep_00000405437)
Main id: BioDeep_00000004526
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
3-mercaptopyruvic acid
化学式: C3H4O3S (119.9881)
中文名称: 巯基丙酮酸钠二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)C(=O)O)S
InChI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)
描述信息
A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a sulfanyl group at position 3.
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:16208
- KEGG: C00957
- PubChem: 98
- CAS: 2464-23-5
- MoNA: HMDB0001368_ms_ms_1535
- MoNA: HMDB0001368_ms_ms_1534
- MoNA: HMDB0001368_ms_ms_1536
- MetaboLights: MTBLC16208
- PubChem: 4208
- KNApSAcK: C00007464
- 3DMET: B00208
- NIKKAJI: J72.997C
- RefMet: 3-Mercaptopyruvic acid
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-524
- KNApSAcK: 16208
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maher N Ibrahim, Abeer A Khalifa, Dalia A Hemead, Amira Ebrahim Alsemeh, Marwa A Habib. 1,25-Dihydroxycholecalciferol down-regulates 3-mercaptopyruvate sulfur transferase and caspase-3 in rat model of non-alcoholic fatty liver disease.
Journal of molecular histology.
2023 Apr; 54(2):119-134. doi:
10.1007/s10735-023-10118-9. [PMID: 36930413] - Patrycja Bronowicka-Adamska, Anna Bentke, Małgorzata Lasota, Maria Wróbel. Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031090. [PMID: 32041330] - Michael Gröger, Martin Wepler, Ulrich Wachter, Tamara Merz, Oscar McCook, Sandra Kress, Britta Lukaschewski, Sebastian Hafner, Markus Huber-Lang, Enrico Calzia, Michael Georgieff, Noriyuki Nagahara, Csaba Szabó, Peter Radermacher, Clair Hartmann. The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.
Shock (Augusta, Ga.).
2019 04; 51(4):472-478. doi:
10.1097/shk.0000000000001165. [PMID: 29668565] - Norihiro Shibuya. [Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2018; 152(5):216-222. doi:
10.1254/fpj.152.216. [PMID: 30393252] - Saskia Höfler, Christin Lorenz, Tjorven Busch, Mascha Brinkkötter, Takayuki Tohge, Alisdair R Fernie, Hans-Peter Braun, Tatjana M Hildebrandt. Dealing with the sulfur part of cysteine: four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria.
Physiologia plantarum.
2016 Jul; 157(3):352-66. doi:
10.1111/ppl.12454. [PMID: 27105581] - Yan Zhang, Jun Yang, Tao Wang, Shao-Gang Wang, Ji-Hong Liu, Chun-Ping Yin, Zhang-Qun Ye. Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.
The journal of sexual medicine.
2016 Mar; 13(3):350-60. doi:
10.1016/j.jsxm.2016.01.002. [PMID: 26853047] - Michael W Stutelberg, Joseph K Dzisam, Alexandre R Monteil, Ilona Petrikovics, Gerry R Boss, Steven E Patterson, Gary A Rockwood, Brian A Logue. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jan; 1008(?):181-188. doi:
10.1016/j.jchromb.2015.11.027. [PMID: 26655110] - Ciro Coletta, Katalin Módis, Bartosz Szczesny, Attila Brunyánszki, Gábor Oláh, Ester C S Rios, Kazunori Yanagi, Akbar Ahmad, Andreas Papapetropoulos, Csaba Szabo. Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Molecular medicine (Cambridge, Mass.).
2015 Feb; 21(?):1-14. doi:
10.2119/molmed.2015.00035. [PMID: 25715337] - Michael W Stutelberg, Chakravarthy V Vinnakota, Brendan L Mitchell, Alexandre R Monteil, Steven E Patterson, Brian A Logue. Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Feb; 949-950(?):94-8. doi:
10.1016/j.jchromb.2014.01.006. [PMID: 24480329] - Inga Kwiecień, Małgorzata Iciek, Lidia Włodek. Acceleration of anaerobic cysteine transformations to sulfane sulfur consequent to γ-glutamyl transpeptidase inhibition.
TheScientificWorldJournal.
2012; 2012(?):253724. doi:
10.1100/2012/253724. [PMID: 22629124] - Yong-Sheng Ren, Sheng-Ying Wu, Xing-Jun Wang, Fang Yu, Jing Zhao, Chao-Shu Tang, Jing-Ping Ouyang, Bin Geng. Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats.
Chinese medical journal.
2011 Nov; 124(21):3468-75. doi:
. [PMID: 22340160] - Bridgette F Moody, John W Calvert. Emergent role of gasotransmitters in ischemia-reperfusion injury.
Medical gas research.
2011 Apr; 1(1):3. doi:
10.1186/2045-9912-1-3. [PMID: 22146243] - Arjun Sengupta, Angika Basant, Soumita Ghosh, Shobhona Sharma, Haripalsingh M Sonawat. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria.
Journal of parasitology research.
2011; 2011(?):901854. doi:
10.1155/2011/901854. [PMID: 21772982] - Jing Zhao, Li-ping Fang, Ge-yang Xu, Chao-shu Tang, Bin Geng. [Assay of endogenous hydrogen sulfide from erythrocytes].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2007 Oct; 39(5):449-52. doi:
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The Plant journal : for cell and molecular biology.
2002 Dec; 32(6):879-89. doi:
10.1046/j.1365-313x.2002.01477.x. [PMID: 12492831] - N Nagahara, T Ito, H Kitamura, T Nishino. Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis.
Histochemistry and cell biology.
1998 Sep; 110(3):243-50. doi:
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Journal of biochemical toxicology.
1992; 7(2):65-72. doi:
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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
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10.1016/0742-8413(91)90247-q. [PMID: 1685401] - J Mårtensson, L Nilsson, B Sörbo. The decarboxylation of 3-mercaptopyruvate to 2-mercaptoacetate.
FEBS letters.
1984 Oct; 176(2):334-6. doi:
10.1016/0014-5793(84)81191-6. [PMID: 6489522] - S Kiguchi. Metabolism of 3-mercaptopyruvate in rat tissues.
Acta medica Okayama.
1983 Apr; 37(2):85-91. doi:
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Biochemical medicine.
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