porphobilinogen (BioDeep_00000405227)

Main id: BioDeep_00000001667

 

PANOMIX_OTCML-2023


代谢物信息卡片


porphobilinogen

化学式: C10H14N2O4 (226.0953524)
中文名称: 胆色素原
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)c1c[nH]c(CN)c1CC(=O)O
InChI: InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)

描述信息

A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively.

同义名列表

1 个代谢物同义名

porphobilinogen



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yushen Wang, Junjie Wang, Liqing Chen, Xiaowei Meng, Xiaoxi Zhen, Yinpei Liang, Yuanhuai Han, Hongying Li, Bin Zhang. Identification and function analysis of yellow-leaf mutant (YX-yl) of broomcorn millet. BMC plant biology. 2022 Sep; 22(1):463. doi: 10.1186/s12870-022-03843-y. [PMID: 36167497]
  • Yuxuan Wang, Jinrong Yang, Qingxiu Chen, Junyi Su, Wen-Jing Shi, Lei Zhang, Chunli Xia, Jinwu Yan. Rotor-Tuning Boron Dipyrromethenes for Dual-Functional Imaging of Aβ Oligomers and Viscosity. ACS applied bio materials. 2022 06; 5(6):3049-3056. doi: 10.1021/acsabm.2c00335. [PMID: 35671477]
  • Maria Grostøl Ørnhøj Østergaard, Erland Jørn Erlandsen, Henrik Holm Thomsen, Else Randers. Peritoneal dialysis resulting in discontinuance of recurring attacks of acute intermittent porphyria: A case report. Seminars in dialysis. 2022 01; 35(1):93-95. doi: 10.1111/sdi.13025. [PMID: 34558740]
  • Hongxia Xu, Shankun Yao, Yuncong Chen, Changli Zhang, Shuren Zhang, Hao Yuan, Zhongyan Chen, Yang Bai, Tao Yang, Zijian Guo, Weijiang He. Tracking Labile Copper Fluctuation In Vivo/Ex Vivo: Design and Application of a Ratiometric Near-Infrared Fluorophore Derived from 4-Aminostyrene-Conjugated Boron Dipyrromethene. Inorganic chemistry. 2021 Dec; 60(24):18567-18574. doi: 10.1021/acs.inorgchem.1c01779. [PMID: 34826221]
  • Thomas W Fredrick, Manuel B Braga Neto, Daniel O Johnsrud, Michael Camilleri, Victor G Chedid. Turning Purple with Pain. The New England journal of medicine. 2021 08; 385(6):549-554. doi: 10.1056/nejmcps2105278. [PMID: 34347956]
  • Galina Guseva, Elena Antina, Mikhail Berezin, Svetlana Lisovskaya, Roman Pavelyev, Airat Kayumov, Olga Lodochnikova, Daut Islamov, Konstantin Usachev, Sergei Boichuk, Liliya Nikitina. Spectroscopic and In Vitro Investigations of Boron(III) Complex with Meso-4-Methoxycarbonylpropylsubstituted Dipyrromethene for Fluorescence Bioimaging Applications. Molecules (Basel, Switzerland). 2020 Oct; 25(19):. doi: 10.3390/molecules25194541. [PMID: 33023057]
  • Giuseppe Comentale, Rachele Manzo, Emanuele Pilato. Sars-Cov-2 interference in HEME production: is it the time for an early predictive biomarker?. Journal of molecular medicine (Berlin, Germany). 2020 08; 98(8):1053-1054. doi: 10.1007/s00109-020-01945-4. [PMID: 32601795]
  • Yon Namkoong, Jinrok Oh, Jong-In Hong. Electrochemiluminescent detection of glucose in human serum by BODIPY-based chemodosimeters for hydrogen peroxide using accelerated self-immolation of boronates. Chemical communications (Cambridge, England). 2020 Jul; 56(55):7577-7580. doi: 10.1039/d0cc03315d. [PMID: 32510098]
  • Sagar Agarwal, Amy R Simon, Varun Goel, Bahru A Habtemariam, Valerie A Clausen, Jae B Kim, Gabriel J Robbie. Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria. Clinical pharmacology and therapeutics. 2020 07; 108(1):63-72. doi: 10.1002/cpt.1802. [PMID: 31994716]
  • Manisha Balwani, Eliane Sardh, Paolo Ventura, Paula Aguilera Peiró, David C Rees, Ulrich Stölzel, D Montgomery Bissell, Herbert L Bonkovsky, Jerzy Windyga, Karl E Anderson, Charles Parker, Samuel M Silver, Siobán B Keel, Jiaan-Der Wang, Penelope E Stein, Pauline Harper, Daphne Vassiliou, Bruce Wang, John Phillips, Aneta Ivanova, Janneke G Langendonk, Raili Kauppinen, Elisabeth Minder, Yutaka Horie, Craig Penz, Jihong Chen, Shangbin Liu, John J Ko, Marianne T Sweetser, Pushkal Garg, Akshay Vaishnaw, Jae B Kim, Amy R Simon, Laurent Gouya. Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria. The New England journal of medicine. 2020 06; 382(24):2289-2301. doi: 10.1056/nejmoa1913147. [PMID: 32521132]
  • Anis Cerovac, Alma Brigic, Dzenana Softic, Amna Barakovic, Semir Adzajlic. Uncontrolled Acute Intermittent Porphyria as a Cause of Spontaneous Abortion. Medical archives (Sarajevo, Bosnia and Herzegovina). 2020 Apr; 74(2):153-155. doi: 10.5455/medarh.2020.74.153-155. [PMID: 32577061]
  • José Bustos, Ledmar Vargas, Ricardo Quintero. Acute intermittent porphyria: A case report. Biomedica : revista del Instituto Nacional de Salud. 2020 03; 40(1):14-19. doi: 10.7705/biomedica.4767. [PMID: 32220159]
  • R Golla, A Mukherjee, R K Gone, H Singh, A K Pannu, V Suri, A Bhalla. Acute intermittent porphyria and anti-tuberculosis therapy. QJM : monthly journal of the Association of Physicians. 2020 Mar; 113(3):207-208. doi: 10.1093/qjmed/hcz289. [PMID: 31693148]
  • Karl E Anderson. Acute hepatic porphyrias: Current diagnosis & management. Molecular genetics and metabolism. 2019 11; 128(3):219-227. doi: 10.1016/j.ymgme.2019.07.002. [PMID: 31311713]
  • Diego Vera-Yunca, Irantzu Serrano-Mendioroz, Ana Sampedro, Daniel Jericó, Iñaki F Trocóniz, Antonio Fontanellas, Zinnia P Parra-Guillén. Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. Molecular genetics and metabolism. 2019 11; 128(3):367-375. doi: 10.1016/j.ymgme.2018.12.009. [PMID: 30639045]
  • Elin Storjord, Jim A Dahl, Anne Landsem, Judith K Ludviksen, Marlene B Karlsen, Bård O Karlsen, Ole-L Brekke. Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway. Molecular genetics and metabolism. 2019 11; 128(3):254-270. doi: 10.1016/j.ymgme.2018.12.006. [PMID: 30583995]
  • Kevin J Guzman, Laxmi A Suthar. Axonal Polyneuropathy in a Man Treated for Pulmonary Cocci: A Case of Acute Intermittent Porphyria. The American journal of case reports. 2019 Sep; 20(?):1378-1381. doi: 10.12659/ajcr.917134. [PMID: 31530795]
  • Ulrich Stölzel, Manfred O Doss, Detlef Schuppan. Clinical Guide and Update on Porphyrias. Gastroenterology. 2019 08; 157(2):365-381.e4. doi: 10.1053/j.gastro.2019.04.050. [PMID: 31085196]
  • Yi He, Gong-Jian Fan, Cai-E Wu, Xiao-Hong Kou, Ting-Ting Li. Influence of illumination on the greening and relative enzyme activity of garlic puree. Journal of food biochemistry. 2019 07; 43(7):e12871. doi: 10.1111/jfbc.12871. [PMID: 31353726]
  • Mehmet M Tatari, Josiah D McCain, Jed C Cowdell. 28-Year-Old Woman With Severe Generalized Abdominal Pain. Mayo Clinic proceedings. 2019 07; 94(7):1334-1338. doi: 10.1016/j.mayocp.2018.10.031. [PMID: 31272576]
  • Makiko Yasuda, Lin Gan, Brenden Chen, Chunli Yu, Jinglan Zhang, Miguel A Gama-Sosa, Daniela D Pollak, Stefanie Berger, John D Phillips, Winfried Edelmann, Robert J Desnick. Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria. Human molecular genetics. 2019 06; 28(11):1755-1767. doi: 10.1093/hmg/ddz003. [PMID: 30615115]
  • María Barreda-Sánchez, Juan Buendía-Martínez, Guillermo Glover-López, Carmen Carazo-Díaz, María Juliana Ballesta-Martínez, Vanesa López-González, María José Sánchez-Soler, Lidya Rodriguez-Peña, Ana Teresa Serrano-Antón, Remedios Gil-Ferrer, Maria Del Carmen Martínez-Romero, Pablo Carbonell-Meseguer, Encarna Guillén-Navarro. High penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor. Orphanet journal of rare diseases. 2019 02; 14(1):59. doi: 10.1186/s13023-019-1031-7. [PMID: 30808393]
  • Eliane Sardh, Pauline Harper, Manisha Balwani, Penelope Stein, David Rees, D Montgomery Bissell, Robert Desnick, Charles Parker, John Phillips, Herbert L Bonkovsky, Daphne Vassiliou, Craig Penz, Amy Chan-Daniels, Qiuling He, William Querbes, Kevin Fitzgerald, Jae B Kim, Pushkal Garg, Akshay Vaishnaw, Amy R Simon, Karl E Anderson. Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria. The New England journal of medicine. 2019 02; 380(6):549-558. doi: 10.1056/nejmoa1807838. [PMID: 30726693]
  • Yi Ren, Lin-Xin Xu, Yun-Feng Liu, Chen-Yu Xiang, Fei Gao, Yan Wang, Tao Bai, Jian-Hong Yin, Yang-Lu Zhao, Jing Yang. A novel 55-basepair deletion of hydroxymethylbilane synthase gene found in a Chinese patient with acute intermittent porphyria and her family: A case report. Medicine. 2018 Sep; 97(37):e12295. doi: 10.1097/md.0000000000012295. [PMID: 30212967]
  • Silvina Fernanda Ruspini, Johanna Romina Zuccoli, Jimena Verónica Lavandera, Marìa Del Carmen Martínez, Leda María Oliveri, Esther Noemí Gerez, Alcira María Del Carmen Batlle, Ana María Buzaleh. Effects of volatile anaesthetics on heme metabolism in a murine genetic model of Acute Intermittent Porphyria. A comparative study with other porphyrinogenic drugs. Biochimica et biophysica acta. General subjects. 2018 06; 1862(6):1296-1305. doi: 10.1016/j.bbagen.2018.02.013. [PMID: 29476795]
  • Alexander Lang, Christian Heckl, Michael Vogeser, Thomas Stauch, Christian Homann, Georg Hennig, Ronald Sroka, Herbert Stepp. Rapid spectrophotometric quantification of urinary porphyrins and porphobilinogen as screening tool for attacks of acute porphyria. Journal of biomedical optics. 2018 05; 23(5):1-12. doi: 10.1117/1.jbo.23.5.055006. [PMID: 29855177]
  • Jon-Duri Senn, Lars C Huber, Jasmin Barman-Aksözen, Elisabeth Minder. [CME: Acute Intermittent Porphyria: When to Think of It? What Must be Checked? How to Treat?]. Praxis. 2018 Jan; 107(3):117-124. doi: 10.1024/1661-8157/a002887. [PMID: 29382268]
  • Jacqueline Woolf, Joanne T Marsden, Timothy Degg, Sharon Whatley, Paul Reed, Nadia Brazil, M Felicity Stewart, Michael Badminton. Best practice guidelines on first-line laboratory testing for porphyria. Annals of clinical biochemistry. 2017 Mar; 54(2):188-198. doi: 10.1177/0004563216667965. [PMID: 27555665]
  • Andreas Paulus, Marco Maenen, Natascha Drude, Emmani B M Nascimento, Wouter D van Marken Lichtenbelt, Felix M Mottaghy, Matthias Bauwens. Synthesis, radiosynthesis and in vitro evaluation of 18F-Bodipy-C16/triglyceride as a dual modal imaging agent for brown adipose tissue. PloS one. 2017; 12(8):e0182297. doi: 10.1371/journal.pone.0182297. [PMID: 28817670]
  • Manisha Balwani, Preeti Singh, Anju Seth, Ekta Malik Debnath, Hetanshi Naik, Dana Doheny, Brenden Chen, Makiko Yasuda, Robert J Desnick. Acute Intermittent Porphyria in children: A case report and review of the literature. Molecular genetics and metabolism. 2016 12; 119(4):295-299. doi: 10.1016/j.ymgme.2016.10.005. [PMID: 27769855]
  • Sumant Arora, Steven Young, Sudha Kodali, Ashwani K Singal. Hepatic porphyria: A narrative review. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2016 Nov; 35(6):405-418. doi: 10.1007/s12664-016-0698-0. [PMID: 27796941]
  • Nicholette M Oosthuizen, Janine Olivier, Janine Martins, Clara Schutte, Tahir S Pillay. Red-Brown Urine in a Patient with Chronic HIV Infection and Quadriparesis. Clinical chemistry. 2016 09; 62(9):1181-4. doi: 10.1373/clinchem.2015.250746. [PMID: 27573452]
  • Rosanna Grimes, Yvonne Gilleece, Timothy Appleby, Sarah Stockwell, Nicolas Pinto-Sander, Tatyana Sahabandu, Penelope Stein, Daniel Bradshaw. A case of hereditary coproporphyria precipitated by efavirenz. AIDS (London, England). 2016 08; 30(13):2142-3. doi: 10.1097/qad.0000000000001173. [PMID: 27465283]
  • Rushad Patell, Rupal Dosi, Harsh Joshi, Purav Shah, Rishi Tripathi. Challenges in the successful management of a case of acute intermittent porphyria in India. Tropical doctor. 2016 Jul; 46(3):150-3. doi: 10.1177/0049475515610939. [PMID: 26472549]
  • Michael Johns, Sakineh Esmaeili Mohsen Abadi, Nehal Malik, Joshua Lee, William L Neumann, Smita Rausaria, Maryam Imani-Nejad, Timothy McPherson, Joseph Schober, Guim Kwon. Oral administration of SR-110, a peroxynitrite decomposing catalyst, enhances glucose homeostasis, insulin signaling, and islet architecture in B6D2F1 mice fed a high fat diet. Archives of biochemistry and biophysics. 2016 04; 596(?):126-37. doi: 10.1016/j.abb.2016.03.002. [PMID: 26970045]
  • Tobias Braun, Christian Kleusch, Elena Naumovska, Rudolf Merkel, Agnes Csiszár. A bioanalytical assay to distinguish cellular uptake routes for liposomes. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2016 Mar; 89(3):301-8. doi: 10.1002/cyto.a.22792. [PMID: 26551759]
  • Yu S Marfin, E L Aleksakhina, D A Merkushev, E V Rumyantsev, I K Tomilova. Interaction of BODIPY Dyes with the Blood Plasma Proteins. Journal of fluorescence. 2016 Jan; 26(1):255-61. doi: 10.1007/s10895-015-1707-x. [PMID: 26520852]
  • Urszula Jarocka, Róża Sawicka, Anna Stachyra, Anna Góra-Sochacka, Agnieszka Sirko, Włodzimierz Zagórski-Ostoja, Violetta Sączyńska, Anna Porębska, Wim Dehaen, Jerzy Radecki, Hanna Radecka. A biosensor based on electroactive dipyrromethene-Cu(II) layer deposited onto gold electrodes for the detection of antibodies against avian influenza virus type H5N1 in hen sera. Analytical and bioanalytical chemistry. 2015 Oct; 407(25):7807-14. doi: 10.1007/s00216-015-8949-y. [PMID: 26297459]
  • Nicolas Pallet, Iadh Mami, Caroline Schmitt, Zoubida Karim, Arnaud François, Marion Rabant, Dominique Nochy, Laurent Gouya, Jean-Charles Deybach, Yichum Xu-Dubois, Eric Thervet, Hervé Puy, Alexandre Karras. High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria. Kidney international. 2015 Aug; 88(2):386-95. doi: 10.1038/ki.2015.97. [PMID: 25830761]
  • Josep Marcos, Maria Ibañez, Rosa Ventura, Jordi Segura, Jordi To-Figueras, Oscar J Pozo. Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria. Journal of mass spectrometry : JMS. 2015 Jul; 50(7):929-37. doi: 10.1002/jms.3603. [PMID: 26349648]
  • Feiyi Wang, Ying Zhu, Li Zhou, Liang Pan, Zhifen Cui, Qiang Fei, Sihang Luo, Dun Pan, Qing Huang, Rui Wang, Chunchang Zhao, He Tian, Chunhai Fan. Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase. Angewandte Chemie (International ed. in English). 2015 Jun; 54(25):7349-53. doi: 10.1002/anie.201502899. [PMID: 25940513]
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  • Christopher M Benton, Lewis Couchman, Joanne T Marsden, David C Rees, Caje Moniz, Chang Kee Lim. Direct and simultaneous determination of 5-aminolaevulinic acid and porphobilinogen in urine by hydrophilic interaction liquid chromatography-electrospray ionisation/tandem mass spectrometry. Biomedical chromatography : BMC. 2012 Aug; 26(8):1033-40. doi: 10.1002/bmc.2770. [PMID: 22740490]
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