Inosinic acid (BioDeep_00000405211)
Main id: BioDeep_00000002969
PANOMIX_OTCML-2023 natural product BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
化学式: C10H13N4O8P (348.0470988)
中文名称: 聚肌苷酸, 肌苷酸, 5’-肌苷酸, 肌苷5-单磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O
InChI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Inosinic acid is an endogenous metabolite.
同义名列表
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:17202
- KEGG: C00130
- PubChem: 135398640
- DrugBank: DB04566
- ChEMBL: CHEMBL1207374
- MeSH: Inosine Monophosphate
- CAS: 30918-54-8
- CAS: 25249-22-3
- CAS: 131-99-7
- MoNA: HMDB0000175_ms_ms_278
- MoNA: HMDB0000175_ms_ms_279
- MoNA: HMDB0000175_ms_ms_277
- PubChem: 3430
- KNApSAcK: C00007224
- PDB-CCD: IMP
- 3DMET: B01168
- NIKKAJI: J9.493E
- medchemexpress: HY-108213
- LOTUS: LTS0086761
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-809
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-296
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-4
- KNApSAcK: 17202
- LOTUS: LTS0140024
分类词条
相关代谢途径
Reactome(0)
BioCyc(7)
- salvage pathways of purine nucleosides
- purine nucleotide metabolism (phosphotransfer and nucleotide modification)
- salvage pathways of adenine, hypoxanthine, and their nucleosides
- purine nucleotides de novo biosynthesis I
- superpathway of histidine, purine, and pyrimidine biosynthesis
- purine nucleotides de novo biosynthesis II
- salvage pathways of purine nucleosides I
PlantCyc(11)
- superpathway of purines degradation in plants
- adenine and adenosine salvage III
- superpathway of adenosine nucleotides de novo biosynthesis I
- inosine 5'-phosphate degradation
- superpathway of purine nucleotides de novo biosynthesis I
- inosine-5'-phosphate biosynthesis II
- guanosine ribonucleotides de novo biosynthesis
- adenosine nucleotides degradation I
- adenosine ribonucleotides de novo biosynthesis
- ureide biosynthesis
- purine nucleotides degradation I (plants)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
43 个相关的物种来源信息
- 3702 - Arabidopsis thaliana: 10.1111/TPJ.14594
- 4890 - Ascomycota: LTS0140024
- 2 - Bacteria: LTS0086761
- 2 - Bacteria: LTS0140024
- 7711 - Chordata: LTS0140024
- 1890464 - Chroococcaceae: LTS0140024
- 1653 - Corynebacteriaceae: LTS0086761
- 1653 - Corynebacteriaceae: LTS0140024
- 1716 - Corynebacterium: LTS0086761
- 1716 - Corynebacterium: LTS0140024
- 1697 - Corynebacterium ammoniagenes: 10.1271/BBB.56.763
- 1697 - Corynebacterium ammoniagenes: LTS0086761
- 1697 - Corynebacterium ammoniagenes: LTS0140024
- 3028117 - Cyanophyceae: LTS0140024
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
- 543 - Enterobacteriaceae: LTS0140024
- 561 - Escherichia: LTS0140024
- 562 - Escherichia coli: LTS0140024
- 33682 - Euglenozoa: LTS0140024
- 2759 - Eukaryota: LTS0140024
- 4751 - Fungi: LTS0140024
- 1236 - Gammaproteobacteria: LTS0140024
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5653 - Kinetoplastea: LTS0140024
- 40674 - Mammalia: LTS0140024
- 33208 - Metazoa: LTS0140024
- 10066 - Muridae: LTS0140024
- 10088 - Mus: LTS0140024
- 10090 - Mus musculus: LTS0140024
- 10090 - Mus musculus: NA
- 4895 - Schizosaccharomyces: LTS0140024
- 4896 - Schizosaccharomyces pombe: 10.1039/C4MB00346B
- 4896 - Schizosaccharomyces pombe: LTS0140024
- 4894 - Schizosaccharomycetaceae: LTS0140024
- 147554 - Schizosaccharomycetes: LTS0140024
- 1890426 - Synechococcaceae: LTS0140024
- 1129 - Synechococcus: LTS0140024
- 32046 - Synechococcus elongatus: 10.1111/1462-2920.12899
- 32046 - Synechococcus elongatus: LTS0140024
- 5690 - Trypanosoma: LTS0140024
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
- 5691 - Trypanosoma brucei: LTS0140024
- 5654 - Trypanosomatidae: LTS0140024
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu, Bo Feng, Jin Huang. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.
Biochemical pharmacology.
2023 Oct; 218(?):115868. doi:
10.1016/j.bcp.2023.115868
. [PMID: 37871880] - Anamika Gupta, Rumana Ahmad, Sahabjada Siddiqui, Kusum Yadav, Aditi Srivastava, Anchal Trivedi, Bilal Ahmad, Mohsin Ali Khan, Amit Kumar Shrivastava, Girish Kumar Singh. Flavonol morin targets host ACE2, IMP-α, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis.
Journal of biomolecular structure & dynamics.
2022 08; 40(12):5515-5546. doi:
10.1080/07391102.2021.1871863
. [PMID: 33526003] - Joseph P Dewulf, Sandrine Marie, Marie-Cécile Nassogne. Disorders of purine biosynthesis metabolism.
Molecular genetics and metabolism.
2022 07; 136(3):190-198. doi:
10.1016/j.ymgme.2021.12.016
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Mymensingh medical journal : MMJ.
2022 Jul; 31(3):666-672. doi:
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- Sasikan Katemala, Amonrat Molee, Kanjana Thumanu, Jirawat Yongsawatdigul. A comparative study of meat quality and vibrational spectroscopic properties of different chicken breeds.
Poultry science.
2022 Jun; 101(6):101829. doi:
10.1016/j.psj.2022.101829
. [PMID: 35385823] - Lucas P Bonagurio, Alice E Murakami, Camila A Moreira, Jurandir F Comar, Paulo C Pozza. Dietary supplementation with inosine-5'-monophosphate improves the functional, energetic, and antioxidant status of liver and muscle growth in pigs.
Scientific reports.
2022 01; 12(1):350. doi:
10.1038/s41598-021-04023-y
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The Journal of hospital infection.
2021 Sep; 115(?):83-92. doi:
10.1016/j.jhin.2021.05.006
. [PMID: 34033889] - Jae Jung Lee, Jung Han Yoon, Sang Jin Kim, Han Soo Yoo, Seok Jong Chung, Yang Hyun Lee, Suk Yun Kang, Hae-Won Shin, Sook Keun Song, Jin Yong Hong, MunKyung Sunwoo, Ji Eun Lee, Jong Sam Baik, Young H Sohn, Phil Hyu Lee. Inosine 5'-Monophosphate to Raise Serum Uric Acid Level in Multiple System Atrophy (IMPROVE-MSA study).
Clinical pharmacology and therapeutics.
2021 05; 109(5):1274-1281. doi:
10.1002/cpt.2082
. [PMID: 33064299] - Takeaki Wajima, Yuji Hirai, Takayuki Otake, Yui Momose, Hidemasa Nakaminami, Norihisa Noguchi. First isolation of an IMP-1 metallo-β-lactamase-producing Kluyvera ascorbata in Japan.
Journal of global antimicrobial resistance.
2020 12; 23(?):228-231. doi:
10.1016/j.jgar.2020.09.026
. [PMID: 33065331] - Shu Iwata, Tatsuya Tada, Tomomi Hishinuma, Mari Tohya, Satoshi Oshiro, Kyoko Kuwahara-Arai, Miho Ogawa, Masahiro Shimojima, Teruo Kirikae. Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-β-Lactamase in Japan.
Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.00382-20
. [PMID: 32816727] - Wenjun Chang, Heng Li, Hanqing Chen, Fan Qiao, Huicai Zeng. Identification of mimp-associated effector genes in Fusarium oxysporum f. sp. cubense race 1 and race 4 and virulence confirmation of a candidate effector gene.
Microbiological research.
2020 Feb; 232(?):126375. doi:
10.1016/j.micres.2019.126375
. [PMID: 31783262] - Manrong Yu, Hui Chen, Pan Liu, Mei Yang, Leqin Zou, Dingfu Xiao. Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine.
BioMed research international.
2020; 2020(?):9494528. doi:
10.1155/2020/9494528
. [PMID: 33145362] - Baixing Wu, Dong Zhang, Hongbo Nie, Senlin Shen, Yan Li, Sisi Li. Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing.
RNA biology.
2019 10; 16(10):1504-1512. doi:
10.1080/15476286.2019.1642712
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Fish physiology and biochemistry.
2019 Apr; 45(2):613-629. doi:
10.1007/s10695-018-0581-2
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Fish & shellfish immunology.
2019 Mar; 86(?):913-921. doi:
10.1016/j.fsi.2018.12.016
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 Sep; 24(9):769-772. doi:
10.1016/j.jiac.2018.03.009
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Parkinsonism & related disorders.
2018 02; 47(?):15-21. doi:
10.1016/j.parkreldis.2017.11.333
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Journal of gastroenterology and hepatology.
2017 Nov; 32(11):1839-1845. doi:
10.1111/jgh.13785
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BMC infectious diseases.
2017 03; 17(1):229. doi:
10.1186/s12879-017-2312-1
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Toxicological sciences : an official journal of the Society of Toxicology.
2016 10; 153(2):396-408. doi:
10.1093/toxsci/kfw135
. [PMID: 27466212] - Y Hamano, Y Kurimoto. Effects of acetylated wood powder on growth performance, hepatic and muscular free amino acid profiles, and inosine 5'-monophosphate concentration of breast meat in broiler chickens.
British poultry science.
2016 Oct; 57(5):643-654. doi:
10.1080/00071668.2016.1190809
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British poultry science.
2016 Aug; 57(4):501-14. doi:
10.1080/00071668.2016.1184227
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Food & function.
2016 Jun; 7(6):2635-44. doi:
10.1039/c5fo01344e
. [PMID: 27186602] - M T Ortega, B Jeffery, J E Riviere, N A Monteiro-Riviere. Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells.
Journal of applied toxicology : JAT.
2016 Feb; 36(2):189-98. doi:
10.1002/jat.3158
. [PMID: 25976427] - Jing Wang, Xiao-jian Dai, Yi-fan Zhang, Da-fang Zhong, Yu-lin Wu, Xiao-yan Chen. [Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Oct; 50(10):1318-23. doi:
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. [PMID: 26837180] - J Koči, B Jeffery, J E Riviere, N A Monteiro-Riviere. In vitro safety assessment of food ingredients in canine renal proximal tubule cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Mar; 29(2):289-98. doi:
10.1016/j.tiv.2014.11.002
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Nuclear medicine and biology.
2015 Feb; 42(2):171-6. doi:
10.1016/j.nucmedbio.2014.08.015
. [PMID: 25441254] - Hong Li, Donald E Mager, Brenda M Sandmaier, Barry E Storer, Michael J Boeckh, Meagan J Bemer, Brian R Phillips, Linda J Risler, Jeannine S McCune. Pharmacokinetic and pharmacodynamic analysis of inosine monophosphate dehydrogenase activity in hematopoietic cell transplantation recipients treated with mycophenolate mofetil.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2014 Aug; 20(8):1121-9. doi:
10.1016/j.bbmt.2014.03.032
. [PMID: 24727337] - A C Weaver, S W Kim. Supplemental nucleotides high in inosine 5'-monophosphate to improve the growth and health of nursery pigs.
Journal of animal science.
2014 Feb; 92(2):645-51. doi:
10.2527/jas.2013-6564
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Meat science.
2014 Jan; 96(1):136-46. doi:
10.1016/j.meatsci.2013.06.023
. [PMID: 23896147] - Juan Miguel Cabello-Díaz, Francisco Antonio Quiles, Rocío Lambert, Manuel Pineda, Pedro Piedras. Identification of a novel phosphatase with high affinity for nucleotides monophosphate from common bean (Phaseolus vulgaris).
Plant physiology and biochemistry : PPB.
2012 Apr; 53(?):54-60. doi:
10.1016/j.plaphy.2012.01.012
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Proteome science.
2011 Nov; 9(?):72. doi:
10.1186/1477-5956-9-72
. [PMID: 22085406] - Sibylle von Vietinghoff, Ekaterina K Koltsova, Javier Mestas, Cody J Diehl, Joseph L Witztum, Klaus Ley. Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation.
Journal of the American College of Cardiology.
2011 May; 57(21):2194-204. doi:
10.1016/j.jacc.2010.12.030
. [PMID: 21596236] - Sofie Haglund, Svante Vikingsson, Jan Söderman, Ulf Hindorf, Christer Grännö, Margareta Danelius, Sally Coulthard, Curt Peterson, Sven Almer. The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.
Therapeutic drug monitoring.
2011 Apr; 33(2):200-8. doi:
10.1097/ftd.0b013e31820b42bb
. [PMID: 21311411] - Matthias C Raggi, Stephanie B Siebert, Werner Steimer, Tibor Schuster, Manfred J Stangl, Dietmar K Abendroth. Customized mycophenolate dosing based on measuring inosine-monophosphate dehydrogenase activity significantly improves patients' outcomes after renal transplantation.
Transplantation.
2010 Dec; 90(12):1536-41. doi:
10.1097/tp.0b013e3182000027
. [PMID: 21076373] - Reza Rahimian, Gohar Fakhfouri, Ali Daneshmand, Hamed Mohammadi, Arash Bahremand, Mohammad Reza Rasouli, Kazem Mousavizadeh, Ahmad Reza Dehpour. Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats.
European journal of pharmacology.
2010 Dec; 649(1-3):376-81. doi:
10.1016/j.ejphar.2010.09.044
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Journal of food science.
2010 Jun; 75(5):C459-64. doi:
10.1111/j.1750-3841.2010.01648.x
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Molecular biology reports.
2010 Apr; 37(4):1749-54. doi:
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Journal of clinical pharmacy and therapeutics.
2010 Feb; 35(1):79-85. doi:
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Applied microbiology and biotechnology.
2009 Nov; 85(2):347-58. doi:
10.1007/s00253-009-2254-7
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Vaccine.
2009 Oct; 27(45):6276-9. doi:
10.1016/j.vaccine.2009.04.074
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Veterinary microbiology.
2009 Oct; 139(1-2):113-20. doi:
10.1016/j.vetmic.2009.05.007
. [PMID: 19556079] - Ferdi Sombogaard, Annemiek M A Peeters, Carla C Baan, Ron A A Mathot, Monique E Quaedackers, Arnold G Vulto, Willem Weimar, Teun van Gelder. Inosine monophosphate dehydrogenase messenger RNA expression is correlated to clinical outcomes in mycophenolate mofetil-treated kidney transplant patients, whereas inosine monophosphate dehydrogenase activity is not.
Therapeutic drug monitoring.
2009 Oct; 31(5):549-56. doi:
10.1097/ftd.0b013e3181b7a9d0
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Poultry science.
2009 Oct; 88(10):2212-8. doi:
10.3382/ps.2008-00036
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The British journal of nutrition.
2009 Sep; 102(6):929-37. doi:
10.1017/s0007114509297212
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The American journal of clinical nutrition.
2009 Sep; 90(3):770S-779S. doi:
10.3945/ajcn.2009.27462n
. [PMID: 19587085] - Sara Bremer, Nils T Vethe, Helge Rootwelt, Pål F Jørgensen, Jean Stenstrøm, Hallvard Holdaas, Karsten Midtvedt, Stein Bergan. Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - a pilot study.
Journal of translational medicine.
2009 Jul; 7(?):64. doi:
10.1186/1479-5876-7-64
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BMC genomics.
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