biopterin (BioDeep_00000402984)
Main id: BioDeep_00000017782
natural product PANOMIX_OTCML-2023
代谢物信息卡片
6-Biopterin
化学式: C9H11N5O3 (237.0861856)
中文名称: L-生物喋呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C1=CN=C2C(=N1)C(=O)NC(=N2)N)O)O
InChI: InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)
描述信息
A pterin derivative that consists of pterin bearing amino, oxo and 1,2-dihydroxypropyl substituents at positions 2, 4 and 6 respectively. The parent of the class of biopterins; the L-erythro isomer occurs widely in nature.
6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
同义名列表
4 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:63931
- ChEBI: CHEBI:15373
- KEGG: C06313
- PubChem: 135403659
- PubChem: 135398729
- MeSH: Biopterin
- CAS: 22150-76-1
- CAS: 9036-22-0
- CAS: 36183-24-1
- MoNA: HMDB0000468_ms_ms_682
- MoNA: HMDB0000468_ms_ms_681
- MoNA: HMDB0000468_ms_ms_680
- MoNA: PM002320
- MetaboLights: MTBLC15373
- PubChem: 8549
- NIKKAJI: J209.325A
- RefMet: Biopterin
- medchemexpress: HY-102015
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Katherine A Kelly, Cristine L Heaps, Guoyao Wu, Vinod Labhasetwar, Cynthia J Meininger. Nanoparticle-mediated delivery of tetrahydrobiopterin restores endothelial function in diabetic rats.
Nitric oxide : biology and chemistry.
2024 Jul; 148(?):13-22. doi:
10.1016/j.niox.2024.04.009. [PMID: 38642795] - Zengyi Liu, Ruixin Kang, Ning Yang, Xiuhua Pan, Jie Yang, Hongjie Yu, Wanli Deng, Zengguang Jia, Jun Zhang, Qi Shen. Tetrahydrobiopterin inhibitor-based antioxidant metabolic strategy for enhanced cancer ferroptosis-immunotherapy.
Journal of colloid and interface science.
2024 Mar; 658(?):100-113. doi:
10.1016/j.jcis.2023.12.042. [PMID: 38100967] - Zijing Wang, Nan Zhang, Miao Zhang, Yao Jiang, Aik Seng Ng, Esther Bridges, Wei Zhang, Xin Zeng, Qi Luo, Jiabien Liang, Balázs Győrffy, Philip Hublitz, Zhu Liang, Roman Fischer, David Kerr, Adrian L Harris, Shijie Cai. GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner.
Cancer research.
2023 Oct; 83(20):3400-3413. doi:
10.1158/0008-5472.can-22-3471. [PMID: 37463466] - Long-Ji Ze, Ping Xu, Jian-Jian Wu, Lin Jin, Ahmad Ali Anjum, Guo-Qing Li. Disruption of tetrahydrobiopterin (BH4) biosynthesis pathway affects cuticle pigmentation in Henosepilachna vigintioctopunctata.
Journal of insect physiology.
2023 01; 144(?):104457. doi:
10.1016/j.jinsphys.2022.104457. [PMID: 36427533] - Zongtao Liu, Nianguo Dong, Haipeng Hui, Yixuan Wang, Fayun Liu, Li Xu, Ming Liu, Zhenqi Rao, Zhen Yuan, Yuqiang Shang, Jun Feng, Zhejun Cai, Fei Li. Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
European heart journal.
2022 05; 43(17):1652-1664. doi:
10.1093/eurheartj/ehac037. [PMID: 35139535] - Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi. Establishing pteridine metabolism in a progressive isogenic breast cancer cell model - part II.
Metabolomics : Official journal of the Metabolomic Society.
2022 04; 18(5):27. doi:
10.1007/s11306-022-01885-9. [PMID: 35482254] - Sahin Erdol, Huseyin Bilgin. Evaluation of patients with phenylalanine metabolism disorder: a single center experience.
Journal of pediatric endocrinology & metabolism : JPEM.
2022 Apr; 35(4):463-467. doi:
10.1515/jpem-2021-0737. [PMID: 35084144] - Katsuya Miyajima, Yusuke Sudo, Sho Sanechika, Yoshitaka Hara, Mieko Horiguchi, Feng Xu, Minori Suzuki, Satoshi Hara, Koichi Tanda, Ken-Ichi Inoue, Masahiko Takada, Nozomu Yoshioka, Hirohide Takebayashi, Masayo Mori-Kojima, Masahiro Sugimoto, Chiho Sumi-Ichinose, Kazunao Kondo, Keizo Takao, Tsuyoshi Miyakawa, Hiroshi Ichinose. Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin.
Journal of neurochemistry.
2022 04; 161(2):129-145. doi:
10.1111/jnc.15600. [PMID: 35233765] - Angela V Bisconti, Ryan S Garten, Ryan M Broxterman, Catherine L Jarrett, Soung Hun Park, Katherine L Shields, Heather L Clifton, Stephen M Ratchford, Van Reese, Jia Zhao, D Walter Wray, Russell S Richardson. No effect of acute tetrahydrobiopterin (BH4) supplementation on vascular dysfunction in the old.
Journal of applied physiology (Bethesda, Md. : 1985).
2022 03; 132(3):773-784. doi:
10.1152/japplphysiol.00711.2021. [PMID: 35112931] - Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan. Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients.
Scientific reports.
2022 02; 12(1):3076. doi:
10.1038/s41598-022-06758-8. [PMID: 35197509] - Mina Tamura, Shizuka Seki, Yasuyuki Kakurai, Shuichi Chikada, Kento Wada. Sapropterin for phenylketonuria: A Japanese post-marketing surveillance study.
Pediatrics international : official journal of the Japan Pediatric Society.
2022 Jan; 64(1):e14939. doi:
10.1111/ped.14939. [PMID: 34331785] - Kathrin M Engel, Sven Baumann, Janet Blaurock, Ulrike Rolle-Kampczyk, Jürgen Schiller, Martin von Bergen, Sonja Grunewald. Differences in the sperm metabolomes of smoking and nonsmoking men†.
Biology of reproduction.
2021 12; 105(6):1484-1493. doi:
10.1093/biolre/ioab179. [PMID: 34554205] - Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo. Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals.
Journal of biochemistry.
2021 Dec; 170(4):559-567. doi:
10.1093/jb/mvab076. [PMID: 34181024] - Muriel Bouly, Marie-Pierre Bourguignon, Susanne Roesch, Pascal Rigouin, Willy Gosgnach, Elodie Bossard, Emilie Royere, Nicolas Diguet, Patricia Sansilvestri-Morel, Ariane Bonnin, Laura Xuereb, Pascal Berson, Michel Komajda, Peter Bernhardt, Benoit Tyl. Aging increases circulating BH2 without modifying BH4 levels and impairs peripheral vascular function in healthy adults.
Translational research : the journal of laboratory and clinical medicine.
2021 12; 238(?):36-48. doi:
10.1016/j.trsl.2021.07.004. [PMID: 34332154] - Gabor Czibik, Zaineb Mezdari, Dogus Murat Altintas, Juliette Bréhat, Maria Pini, Thomas d'Humières, Thaïs Delmont, Costin Radu, Marielle Breau, Hao Liang, Cecile Martel, Azania Abatan, Rizwan Sarwar, Ophélie Marion, Suzain Naushad, Yanyan Zhang, Maissa Halfaoui, Nadine Suffee, Didier Morin, Serge Adnot, Stéphane Hatem, Arash Yavari, Daigo Sawaki, Geneviève Derumeaux. Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.
Circulation.
2021 08; 144(7):559-574. doi:
10.1161/circulationaha.121.054204. [PMID: 34162223] - Katja Schmitz, Sandra Trautmann, Lisa Hahnefeld, Caroline Fischer, Yannick Schreiber, Annett Wilken-Schmitz, Robert Gurke, Robert Brunkhorst, Ernst R Werner, Katrin Watschinger, Sabine Wicker, Dominique Thomas, Gerd Geisslinger, Irmgard Tegeder. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 07; 18(3):1862-1879. doi:
10.1007/s13311-021-01043-4. [PMID: 33844153] - Victória Caroline Bottino Pontes, Juliana Pereira Tavares de Melo Tavares, Tatiana Rosado Rosenstock, Domingos Sávio Rodrigues, Marcelo Icimoto Yudi, Jaqueline Pereira Moura Soares, Suzana Costa Ribeiro, Rafael Sutti, Luce Maria Brandão Torres, Fabiana Henriques Machado de Melo, Maria Thereza Gamberini. Increased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. fruit pulp in rats in vivo is not related to the direct activation of endothelial cells.
Journal of ethnopharmacology.
2021 May; 271(?):113885. doi:
10.1016/j.jep.2021.113885. [PMID: 33539952] - Shelly A Buffington, Sean W Dooling, Martina Sgritta, Cecilia Noecker, Oscar D Murillo, Daniela F Felice, Peter J Turnbaugh, Mauro Costa-Mattioli. Dissecting the contribution of host genetics and the microbiome in complex behaviors.
Cell.
2021 04; 184(7):1740-1756.e16. doi:
10.1016/j.cell.2021.02.009. [PMID: 33705688] - Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N Simon, Simona Mafrici, Ritu Arya, Esther Roselló-Lletí, Surawee Chuaiphichai, Damian Tyler, Craig A Lygate, Keith M Channon, Barbara Casadei. BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.
Circulation research.
2021 03; 128(5):585-601. doi:
10.1161/circresaha.120.316656. [PMID: 33494625] - Federica Klaus, Karoline Guetter, Rebecca Schlegel, Erich Seifritz, Anahita Rassi, Beat Thöny, Flurin Cathomas, Stefan Kaiser. Peripheral biopterin and neopterin in schizophrenia and depression.
Psychiatry research.
2021 03; 297(?):113745. doi:
10.1016/j.psychres.2021.113745. [PMID: 33524773] - Mariluz Soula, Ross A Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Frederick Yen, Henrik Molina, Javier Garcia-Bermudez, Derek A Pratt, Kıvanç Birsoy. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.
Nature chemical biology.
2020 12; 16(12):1351-1360. doi:
10.1038/s41589-020-0613-y. [PMID: 32778843] - Helene Nehring, Svenja Meierjohann, Jose Pedro Friedmann Angeli. Emerging aspects in the regulation of ferroptosis.
Biochemical Society transactions.
2020 10; 48(5):2253-2259. doi:
10.1042/bst20200523. [PMID: 33125483] - Sinem Gürcü, Gözde Girgin, Göknur Yorulmaz, Bilge Kılıçarslan, Belgin Efe, Terken Baydar. Neopterin and biopterin levels and tryptophan degradation in patients with diabetes.
Scientific reports.
2020 10; 10(1):17025. doi:
10.1038/s41598-020-74183-w. [PMID: 33046801] - Ronja Hesthammer, Stian Dahle, Jon Peder Storesund, Torunn Eide, Rune Djurhuus, Asbjørn M Svardal, Einar Thorsen. Nitric oxide in exhaled gas and tetrahydrobiopterin in plasma after exposure to hyperoxia.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2020 Sec; 47(2):197-202. doi:
. [PMID: 32574435] - Masahide Fujita, Débora da Luz Scheffer, Bruna Lenfers Turnes, Shane J F Cronin, Alban Latrémolière, Michael Costigan, Clifford J Woolf, Alexandra Latini, Nick A Andrews. Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.
Arthritis & rheumatology (Hoboken, N.J.).
2020 01; 72(1):57-66. doi:
10.1002/art.41060. [PMID: 31350812] - James T Meyer, Brian A Sparling, William J McCarty, Maosheng Zhang, Marcus Soto, Stephen Schneider, Hao Chen, Jonathan Roberts, Helming Tan, Thomas Kornecook, Paul S Andrews, Charles G Knutson. Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat.
The Journal of pharmacology and experimental therapeutics.
2019 11; 371(2):476-486. doi:
10.1124/jpet.119.257105. [PMID: 31110114] - Juan Carlos Torres-Narváez, Israel Pérez-Torres, Vicente Castrejón-Téllez, Elvira Varela-López, Víctor Hugo Oidor-Chan, Verónica Guarner-Lans, Álvaro Vargas-González, Raúl Martínez-Memije, Pedro Flores-Chávez, Etzna Zizith Cervantes-Yañez, Claudia Angélica Soto-Peredo, Gustavo Pastelín-Hernández, Leonardo Del Valle-Mondragón. The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
International journal of environmental research and public health.
2019 09; 16(19):. doi:
10.3390/ijerph16193576. [PMID: 31557799] - Peyman Eshraghi, Samaneh Noroozi Asl, Sepideh Bagheri, Vajiheh Chalak. Response to sapropterin hydrochloride (Kuvan®) in children with phenylketonuria (PKU): a clinical trial.
Journal of pediatric endocrinology & metabolism : JPEM.
2019 Aug; 32(8):885-888. doi:
10.1515/jpem-2018-0503. [PMID: 31237861] - Christian Ott, Agnes Bosch, Nicole Winzer, Stephanie Friedrich, Reinhard Schinzel, Frank Tegtmeier, Roland E Schmieder. Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers.
British journal of clinical pharmacology.
2019 05; 85(5):900-907. doi:
10.1111/bcp.13870. [PMID: 30666700] - Neil Smith, Nicola Longo, Keith Levert, Keith Hyland, Nenad Blau. Phase I clinical evaluation of CNSA-001 (sepiapterin), a novel pharmacological treatment for phenylketonuria and tetrahydrobiopterin deficiencies, in healthy volunteers.
Molecular genetics and metabolism.
2019 04; 126(4):406-412. doi:
10.1016/j.ymgme.2019.02.001. [PMID: 30922814] - M Kuczeriszka, A Walkowska, K H Olszynski, J Rafalowska, J Sadowski, E Kompanowska-Jezierska. Arginine and tetrahydrobiopterin supplementation in rats with salt-induced blood pressure increase: minor hypotensive effect but improvement of renal haemodynamics.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2019 Apr; 70(2):. doi:
10.26402/jpp.2019.2.05. [PMID: 31356183] - Sibtain Ahmed, Hafsa Majid, Lena Jafri, Aysha Habib Khan, Zeba Zulfiqar Ali, Bushra Afroze. Retrospective Study of Patients with Hyperphenylalaninemia- Experience from a Tertiary Care Center in Pakistan.
JPMA. The Journal of the Pakistan Medical Association.
2019 04; 69(4):509-513. doi:
NULL. [PMID: 31000854] - Xiao Yang, Huang Huang, Qing Lu, Shao-Hong Chen, Feng Wang, Ou-Ping Huang, Bin Hu, Bi-Cheng Yang. High-throughput polymer tip-electrospray ionization mass spectrometry for enhanced detection of neopterin and biopterin in clinical urine samples.
Journal of mass spectrometry : JMS.
2019 Feb; 54(2):189-194. doi:
10.1002/jms.4322. [PMID: 30597687] - Katja Zschiebsch, Caroline Fischer, Annett Wilken-Schmitz, Gerd Geisslinger, Keith Channon, Katrin Watschinger, Irmgard Tegeder. Mast cell tetrahydrobiopterin contributes to itch in mice.
Journal of cellular and molecular medicine.
2019 02; 23(2):985-1000. doi:
10.1111/jcmm.13999. [PMID: 30450838] - Pei-Zhong Bao, Jun Ye, Lian-Shu Han, Wen-Juan Qiu, Hui-Wen Zhang, Yong-Guo Yu, Jian-Guo Wang, Xue-Fan Gu. Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
World journal of pediatrics : WJP.
2019 Feb; 15(1):66-71. doi:
10.1007/s12519-018-0202-2. [PMID: 30443829] - Jin Hee Jeong, Nichole Lee, Matthew A Tucker, Paula Rodriguez-Miguelez, Jacob Looney, Jeffrey Thomas, Casandra C Derella, Ahmed El-Marakby, Jacqueline B Musall, Jennifer C Sullivan, Kathleen T McKie, Caralee Forseen, Gareth W Davison, Ryan A Harris. Tetrahydrobiopterin improves endothelial function in patients with cystic fibrosis.
Journal of applied physiology (Bethesda, Md. : 1985).
2019 01; 126(1):60-66. doi:
10.1152/japplphysiol.00629.2018. [PMID: 30433862] - Marwan Al-Nimer, Rawa Ratha, Taha Mahwi. Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations.
Journal of diabetes research.
2019; 2019(?):3426878. doi:
10.1155/2019/3426878. [PMID: 31828160] - Saki Kasuga, Daijiro Kabata, Tomoko Sakaguchi, Satoshi Kudoh, Satsuki Nishigaki, Yusuke Higa, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki, Haruo Shintaku. Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study.
Allergology international : official journal of the Japanese Society of Allergology.
2019 Jan; 68(1):96-100. doi:
10.1016/j.alit.2018.08.012. [PMID: 30297096] - Jaume Campistol Plana. [Early diagnosis of phenylketonuria. Physiopathology of the neuronal damage and therapeutic options].
Medicina.
2019; 79 Suppl 3(?):2-5. doi:
NULL. [PMID: 31603834] - Dalia G Mostafa, Salwa Fares Ahmed, Ola A Hussein. Protective effect of tetrahydrobiopterin on hepatic and renal damage after acute cadmium exposure in male rats.
Ultrastructural pathology.
2018 Nov; 42(6):516-531. doi:
10.1080/01913123.2018.1559566. [PMID: 30595070] - Kristen D Brantley, Teresa D Douglas, Rani H Singh. One-year follow-up of B vitamin and Iron status in patients with phenylketonuria provided tetrahydrobiopterin (BH4).
Orphanet journal of rare diseases.
2018 10; 13(1):192. doi:
10.1186/s13023-018-0923-2. [PMID: 30373601] - Zhiqi Tang, Lijuan Liu, Yujie Guo, Guoxiong Deng, Meixiang Chen, Jinru Wei. Exendin‑4 reverses endothelial dysfunction in mice fed a high‑cholesterol diet by a GTP cyclohydrolase‑1/tetrahydrobiopterin pathway.
Molecular medicine reports.
2018 Sep; 18(3):3350-3358. doi:
10.3892/mmr.2018.9345. [PMID: 30085331] - Paula Rodriguez-Miguelez, Justin Gregg, Nichole Seigler, Leon Bass, Jeffrey Thomas, Jennifer S Pollock, Jennifer C Sullivan, Thomas A Dillard, Ryan A Harris. Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.
Chest.
2018 09; 154(3):597-606. doi:
10.1016/j.chest.2018.04.028. [PMID: 29705218] - Arafat Nasser, Anette Torvin Møller, Vibe Hellmund, Sidsel Salling Thorborg, Cathrine Jespersgaard, Ole J Bjerrum, Erik Dupont, Gösta Nachman, Jens Lykkesfeldt, Troels Staehelin Jensen, Lisbeth Birk Møller. Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
Pain.
2018 Jun; 159(6):1012-1024. doi:
10.1097/j.pain.0000000000001175. [PMID: 29470312] - Jinqiu Wei, Yujiao Zhang, Zhan Li, Ximin Wang, Linlin Chen, Juanjuan Du, Jing Liu, Ju Liu, Yinglong Hou. GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial-tachypacing via tetrahydrobiopterin pathway regulated by microRNA-206.
Pacing and clinical electrophysiology : PACE.
2018 05; 41(5):459-471. doi:
10.1111/pace.13289. [PMID: 29436714] - Teng-Fei Yuan, Han-Qi Huang, Ling Gao, Shao-Ting Wang, Yan Li. A novel and reliable method for tetrahydrobiopterin quantification: Benzoyl chloride derivatization coupled with liquid chromatography-tandem mass spectrometry analysis.
Free radical biology & medicine.
2018 04; 118(?):119-125. doi:
10.1016/j.freeradbiomed.2018.02.035. [PMID: 29501564] - James D Clelland, Laura L Read, Jennifer Smeed, Catherine L Clelland. Regulation of cortical and peripheral GCH1 expression and biopterin levels in schizophrenia-spectrum disorders.
Psychiatry research.
2018 04; 262(?):229-236. doi:
10.1016/j.psychres.2018.02.020. [PMID: 29471261] - Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yasuhiro Kajiwara, Yuji Ozeki, Miho Ota, Kotaro Hattori, Teruhiko Higuchi, Hiroshi Kunugi. 13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder.
Journal of psychiatric research.
2018 04; 99(?):142-150. doi:
10.1016/j.jpsychires.2018.01.019. [PMID: 29454221] - Cristina Espinosa-Díez, Verónica Miguel, Susana Vallejo, Francisco J Sánchez, Elena Sandoval, Eva Blanco, Pablo Cannata, Concepción Peiró, Carlos F Sánchez-Ferrer, Santiago Lamas. Role of glutathione biosynthesis in endothelial dysfunction and fibrosis.
Redox biology.
2018 04; 14(?):88-99. doi:
10.1016/j.redox.2017.08.019. [PMID: 28888203] - Hiroyuki Kinoshita, Kazunobu Otake, Takashi Yamasaki. The Unknown Mechanism of Exogenous Tetrahydrobiopterin in the Renal Protection of Sheep Ischemia and Reperfusion.
Anesthesia and analgesia.
2018 03; 126(3):1088. doi:
10.1213/ane.0000000000002784. [PMID: 29346125] - Raquel Gil-Gómez, Javier Blasco-Alonso, Pilar Sánchez-Yáñez, Vanessa Rosa-Camacho, Guillermo Milano Manso. [Neopterin levels and systemic inflammatory response syndrome in pediatric critically ill patients].
Anales de pediatria (Barcelona, Spain : 2003).
2017 Dec; 87(6):343-349. doi:
10.1016/j.anpedi.2016.11.011. [PMID: 28442215] - Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa. Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.
Molecular and cellular biochemistry.
2017 Nov; 435(1-2):97-108. doi:
10.1007/s11010-017-3060-7. [PMID: 28534121] - Simone R Potje, Zhenlong Chen, Suellen D'Arc S Oliveira, Lusiane M Bendhack, Roberto S da Silva, Marcelo G Bonini, Cristina Antoniali, Richard D Minshall. Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production.
Free radical biology & medicine.
2017 11; 112(?):587-596. doi:
10.1016/j.freeradbiomed.2017.09.004. [PMID: 28899725] - Jiao Xue, Chenxiao Yu, Wenjiong Sheng, Wei Zhu, Judong Luo, Qi Zhang, Hongying Yang, Han Cao, Wenjie Wang, Jundong Zhou, Jinchang Wu, Peng Cao, Ming Chen, Wei-Qun Ding, Jianping Cao, Shuyu Zhang. The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade.
The Journal of investigative dermatology.
2017 10; 137(10):2059-2068. doi:
10.1016/j.jid.2017.05.019. [PMID: 28596000] - Lokmane Rahmania, Diego Orbegozo, Fuhong Su, Fabio Silvio Taccone, Jean-Louis Vincent, Daniel De Backer. Administration of Tetrahydrobiopterin (BH4) Protects the Renal Microcirculation From Ischemia and Reperfusion Injury.
Anesthesia and analgesia.
2017 10; 125(4):1253-1260. doi:
10.1213/ane.0000000000002131. [PMID: 28632534] - Gry Freja Skovsted, Pernille Tveden-Nyborg, Maiken Marie Lindblad, Stine Normann Hansen, Jens Lykkesfeldt. Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs.
Nutrients.
2017 Jul; 9(7):. doi:
10.3390/nu9070691. [PMID: 28671625] - Francesca Nardecchia, Flavia Chiarotti, Claudia Carducci, Silvia Santagata, Giulia Valentini, Antonio Angeloni, Nenad Blau, Vincenzo Leuzzi. Altered tetrahydrobiopterin metabolism in patients with phenylalanine hydroxylase deficiency.
European journal of pediatrics.
2017 Jul; 176(7):917-924. doi:
10.1007/s00431-017-2932-x. [PMID: 28540433] - Jin-Song Shen, Erland Arning, Michael L West, Taniqua S Day, Shuyuan Chen, Xing-Li Meng, Sabrina Forni, Nathan McNeill, Ozlem Goker-Alpan, Xuan Wang, Paula Ashcraft, David F Moore, Seng H Cheng, Raphael Schiffmann, Teodoro Bottiglieri. Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease.
Human molecular genetics.
2017 03; 26(6):1182-1192. doi:
10.1093/hmg/ddx032. [PMID: 28158561] - Silvia Santagata, Emanuele Di Carlo, Carla Carducci, Vincenzo Leuzzi, Antonio Angeloni, Claudia Carducci. Development of a new UPLC-ESI-MS/MS method for the determination of biopterin and neopterin in dried blood spot.
Clinica chimica acta; international journal of clinical chemistry.
2017 Mar; 466(?):145-151. doi:
10.1016/j.cca.2017.01.019. [PMID: 28109742] - Jianyun Wang, Qianqian Yang, Yaxing Nie, Hao Guo, Fan Zhang, Xueyan Zhou, Xiaoxing Yin. Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy.
The Journal of pharmacy and pharmacology.
2017 Feb; 69(2):182-190. doi:
10.1111/jphp.12677. [PMID: 28033650] - Jaques Belik, Yulia Shifrin, Erland Arning, Teodoro Bottiglieri, Jingyi Pan, Michelle C Daigneault, Emma Allen-Vercoe. Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.
Scientific reports.
2017 01; 7(?):39854. doi:
10.1038/srep39854. [PMID: 28079055] - Roxana Loperena, David G Harrison. Oxidative Stress and Hypertensive Diseases.
The Medical clinics of North America.
2017 Jan; 101(1):169-193. doi:
10.1016/j.mcna.2016.08.004. [PMID: 27884227] - N Liu, D H Zhao, X L Li, L X Cui, Q H Wu, M Jiang, X D Kong. [PTPS gene analysis and prenatal diagnosis in patients with 6-pyruvoyl-tetra hydropterin synthase deficiency].
Zhonghua fu chan ke za zhi.
2016 Dec; 51(12):890-894. doi:
10.3760/cma.j.issn.0529-567x.2016.12.003. [PMID: 28057123] - Matthew S Alkaitis, Hans C Ackerman. Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria.
ACS infectious diseases.
2016 11; 2(11):827-838. doi:
10.1021/acsinfecdis.6b00124. [PMID: 27641435] - Hongchao Wang, Chen Zhang, Jinghan Feng, Yuan Liu, Qin Yang, Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, Yong Q Chen. Role of dihydrofolate reductase in tetrahydrobiopterin biosynthesis and lipid metabolism in the oleaginous fungus Mortierella alpina.
Microbiology (Reading, England).
2016 09; 162(9):1544-1553. doi:
10.1099/mic.0.000345. [PMID: 27488762] - Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Häussler, Heinfried Radeke, Sabine Grösch, Nerea Ferreirós, Gerd Geisslinger, Ernst R Werner, Irmgard Tegeder. Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.
Journal of Crohn's & colitis.
2016 Aug; 10(8):965-78. doi:
10.1093/ecco-jcc/jjw056. [PMID: 26928964] - Tae Woong Cha, Minjoo Kim, Minkyung Kim, Jey Sook Chae, Jong Ho Lee. Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects.
Hypertension research : official journal of the Japanese Society of Hypertension.
2016 Jun; 39(6):449-56. doi:
10.1038/hr.2016.7. [PMID: 26843120] - Ann M Lin, Peizhou Liao, Erin C Millson, Arshed A Quyyumi, Jeanie Park. Tetrahydrobiopterin ameliorates the exaggerated exercise pressor response in patients with chronic kidney disease: a randomized controlled trial.
American journal of physiology. Renal physiology.
2016 05; 310(10):F1016-25. doi:
10.1152/ajprenal.00527.2015. [PMID: 26962106] - Atilla Engin, Ipek Isik Gonul, Ayse Basak Engin, Ahmet Karamercan, Aylin Sepici Dincel, Ayse Dursun. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
World journal of gastroenterology.
2016 Apr; 22(13):3592-601. doi:
10.3748/wjg.v22.i13.3592. [PMID: 27053851] - Germaine Korner, Tanja Scherer, Dea Adamsen, Alexander Rebuffat, Mark Crabtree, Anahita Rassi, Rossana Scavelli, Daigo Homma, Birgit Ledermann, Daniel Konrad, Hiroshi Ichinose, Christian Wolfrum, Marion Horsch, Birgit Rathkolb, Martin Klingenspor, Johannes Beckers, Eckhard Wolf, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Nenad Blau, Jan Rozman, Beat Thöny. Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Journal of inherited metabolic disease.
2016 Mar; 39(2):309-19. doi:
10.1007/s10545-015-9909-6. [PMID: 26830550] - A Lindsay, J Healy, W Mills, J Lewis, N Gill, N Draper, S P Gieseg. Impact-induced muscle damage and urinary pterins in professional rugby: 7,8-dihydroneopterin oxidation by myoglobin.
Scandinavian journal of medicine & science in sports.
2016 Mar; 26(3):329-37. doi:
10.1111/sms.12436. [PMID: 25772829] - Ádám Fazakas, Zsuzsanna Szelényi, Gábor Szénási, Gábor Nyírő, Péter M Szabó, Attila Patócs, Narcis Tegze, Bertalan C Fekete, Attila Molvarec, Bálint Nagy, Judit Jakus, Ferenc Örsi, István Karádi, András Vereckei. Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress.
Journal of the American Society of Hypertension : JASH.
2016 Feb; 10(2):124-32. doi:
10.1016/j.jash.2015.11.013. [PMID: 26778769] - Shoji Yano, Kathryn Moseley, Xiaowei Fu, Colleen Azen. Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters.
PloS one.
2016; 11(8):e0160892. doi:
10.1371/journal.pone.0160892. [PMID: 27513937] - Akiko Ohashi, Yusuke Saeki, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa. Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats.
PloS one.
2016; 11(10):e0164305. doi:
10.1371/journal.pone.0164305. [PMID: 27711248] - M Zvarik, D Martinicky, L Hunakova, L Sikurova. Differences in pteridine urinary levels in patients with malignant and benign ovarian tumors in comparison with healthy individuals.
Journal of photochemistry and photobiology. B, Biology.
2015 Dec; 153(?):191-7. doi:
10.1016/j.jphotobiol.2015.09.019. [PMID: 26414289] - Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneris. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.
ACS chemical neuroscience.
2015 Jul; 6(7):1198-205. doi:
10.1021/cn500331z. [PMID: 25642596] - Abrar Turki, Gayathri Murthy, Keiko Ueda, Barbara Cheng, Alette Giezen, Sylvia Stockler-Ipsiroglu, Rajavel Elango. Minimally invasive (13)C-breath test to examine phenylalanine metabolism in children with phenylketonuria.
Molecular genetics and metabolism.
2015 Jun; 115(2-3):78-83. doi:
10.1016/j.ymgme.2015.04.005. [PMID: 25943030] - Bingjuan Han, Hui Zou, Bingchao Han, Weiwei Zhu, Zhiyang Cao, Yingxia Liu. Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China.
Brain & development.
2015 Jun; 37(6):592-8. doi:
10.1016/j.braindev.2014.09.008. [PMID: 25304915] - Curtis M Loer, Ana C Calvo, Katrin Watschinger, Gabriele Werner-Felmayer, Delia O'Rourke, Dave Stroud, Amy Tong, Jennifer R Gotenstein, Andrew D Chisholm, Jonathan Hodgkin, Ernst R Werner, Aurora Martinez. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4).
Genetics.
2015 May; 200(1):237-53. doi:
10.1534/genetics.114.174110. [PMID: 25808955] - Kathryn D Moseley, Martha J Ottina, Colleen G Azen, Shoji Yano. Pilot study to evaluate the effects of tetrahydrobiopterin on adult individuals with phenylketonuria with measurable maladaptive behaviors.
CNS spectrums.
2015 Apr; 20(2):157-63. doi:
10.1017/s1092852914000455. [PMID: 25323746] - Hendrik Gremmels, Lonneke M Bevers, Joost O Fledderus, Branko Braam, Anton Jan van Zonneveld, Marianne C Verhaar, Jaap A Joles. Oleic acid increases mitochondrial reactive oxygen species production and decreases endothelial nitric oxide synthase activity in cultured endothelial cells.
European journal of pharmacology.
2015 Mar; 751(?):67-72. doi:
10.1016/j.ejphar.2015.01.005. [PMID: 25595727] - Tsin W Yeo, Daniel A Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N Price, J Brice Weinberg, Keith Hyland, Donald L Granger, Nicholas M Anstey. Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.
PLoS pathogens.
2015 Mar; 11(3):e1004667. doi:
10.1371/journal.ppat.1004667. [PMID: 25764397] - Matthew P Rubach, Jackson Mukemba, Salvatore Florence, Bert K Lopansri, Keith Hyland, Alicia D Volkheimer, Tsin W Yeo, Nicholas M Anstey, J Brice Weinberg, Esther D Mwaikambo, Donald L Granger. Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity.
PLoS pathogens.
2015 Mar; 11(3):e1004655. doi:
10.1371/journal.ppat.1004655. [PMID: 25764173] - Katrin Watschinger, Markus A Keller, Eileen McNeill, Mohammad T Alam, Steven Lai, Sabrina Sailer, Veronika Rauch, Jyoti Patel, Albin Hermetter, Georg Golderer, Stephan Geley, Gabriele Werner-Felmayer, Robert S Plumb, Giuseppe Astarita, Markus Ralser, Keith M Channon, Ernst R Werner. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Feb; 112(8):2431-6. doi:
10.1073/pnas.1414887112. [PMID: 25675482] - Yulan Qi, Diane R Mould, Huiyu Zhou, Markus Merilainen, Donald G Musson. A prospective population pharmacokinetic analysis of sapropterin dihydrochloride in infants and young children with phenylketonuria.
Clinical pharmacokinetics.
2015 Feb; 54(2):195-207. doi:
10.1007/s40262-014-0196-4. [PMID: 25338975] - Jeanie Park, Peizhou Liao, Salman Sher, Robert H Lyles, Don D Deveaux, Arshed A Quyyumi. Tetrahydrobiopterin lowers muscle sympathetic nerve activity and improves augmentation index in patients with chronic kidney disease.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 Feb; 308(3):R208-18. doi:
10.1152/ajpregu.00409.2014. [PMID: 25477424] - Pandu Gangula, Kalpana Ravella, Sasanka Chukkapalli, Mercedes Rivera, Shanthi Srinivasan, Ashley Hale, Keith Channon, Janet Southerland, Lakshmyya Kesavalu. Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression.
PloS one.
2015; 10(6):e0129885. doi:
10.1371/journal.pone.0129885. [PMID: 26111153] - Andrea Leiva, Bárbara Fuenzalida, Francisco Westermeier, Fernando Toledo, Carlos Salomón, Jaime Gutiérrez, Carlos Sanhueza, Fabián Pardo, Luis Sobrevia. Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
Oxidative medicine and cellular longevity.
2015; 2015(?):5346327. doi:
10.1155/2016/5346327. [PMID: 26697136] - Haruo Shintaku, Toshihiro Ohura. Sapropterin is safe and effective in patients less than 4-years-old with BH4-responsive phenylalanine hydrolase deficiency.
The Journal of pediatrics.
2014 Dec; 165(6):1241-4. doi:
10.1016/j.jpeds.2014.08.003. [PMID: 25223838] - V T Ramaekers, B Thöny, J M Sequeira, M Ansseau, P Philippe, F Boemer, V Bours, E V Quadros. Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
Molecular genetics and metabolism.
2014 Dec; 113(4):307-14. doi:
10.1016/j.ymgme.2014.10.002. [PMID: 25456743] - Kin Lung Siu, Hua Cai. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.
American journal of physiology. Heart and circulatory physiology.
2014 Dec; 307(11):H1559-64. doi:
10.1152/ajpheart.00444.2014. [PMID: 25260610] - Sze Ma, Christopher Cheng-Hwa Ma. Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide.
Vascular pharmacology.
2014 Nov; 63(2):63-70. doi:
10.1016/j.vph.2014.08.001. [PMID: 25139660] - Anna Starr, Claire A Sand, Lamia Heikal, Peter D Kelly, Domenico Spina, Mark Crabtree, Keith M Channon, James M Leiper, Manasi Nandi. Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.
Shock (Augusta, Ga.).
2014 Nov; 42(5):432-9. doi:
10.1097/shk.0000000000000235. [PMID: 25046538] - I Bedanova, E Voslarova, G Zelinska, J Blahova, P Marsalek, J Chloupek. Neopterin and biopterin as biomarkers of immune system activity associated with crating in broiler chickens.
Poultry science.
2014 Oct; 93(10):2432-8. doi:
10.3382/ps.2014-04043. [PMID: 25125562] - John F Stover, Antonio Belli, Henry Boret, Diederik Bulters, Juan Sahuquillo, Erich Schmutzhard, Elisabeth Zavala, Urban Ungerstedt, Reinhard Schinzel, Frank Tegtmeier. Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA).
Journal of neurotrauma.
2014 Oct; 31(19):1599-606. doi:
10.1089/neu.2014.3344. [PMID: 24831445] - Junko Takeda, Rieko Nakata, Hiroshi Ueno, Akio Murakami, Mineo Iseki, Masakatsu Watanabe. Possible involvement of a tetrahydrobiopterin in photoreception for UV-B-induced anthocyanin synthesis in carrot.
Photochemistry and photobiology.
2014 Sep; 90(5):1043-9. doi:
10.1111/php.12302. [PMID: 24943195] - M J Reimann, J Häggström, A Mortensen, J Lykkesfeldt, J E Møller, T Falk, L H Olsen. Biopterin status in dogs with myxomatous mitral valve disease is associated with disease severity and cardiovascular risk factors.
Journal of veterinary internal medicine.
2014 Sep; 28(5):1520-6. doi:
10.1111/jvim.12425. [PMID: 25274442] - Andréa E M Stinghen, Jean-Marc Chillon, Ziad A Massy, Agnès Boullier. Differential effects of indoxyl sulfate and inorganic phosphate in a murine cerebral endothelial cell line (bEnd.3).
Toxins.
2014 Jun; 6(6):1742-60. doi:
10.3390/toxins6061742. [PMID: 24902077] - Ana María Gámez-Méndez, Hilda Vargas-Robles, Mónica Arellano-Mendoza, Erika Cruz-Laguna, Amelia Rios, Bruno Escalante. Early stage of obesity potentiates nitric oxide reduction during the development of renal failure.
Journal of nephrology.
2014 Jun; 27(3):281-7. doi:
10.1007/s40620-013-0029-9. [PMID: 24446346]