L-Dihydroorotic acid (BioDeep_00000399870)

Main id: BioDeep_00000001339

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


(S)-dihydroorotic acid

化学式: C5H6N2O4 (158.0328)
中文名称: L-氢化乳清酸, L-二氢乳清酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(NC(=O)NC1=O)C(=O)O
InChI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1

描述信息

The (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine.
L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme[1].

同义名列表

5 个代谢物同义名

(S)-dihydroorotic acid; L-Dihydroorotic acid; (S)-Dihydroorotate; (S)-Dihydroorotate; L-Dihydroorotic acid



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, ELANE, MYC, PKM
Peripheral membrane protein 1 COQ6
Nucleus 2 MYC, PKM
cytosol 3 DHODH, ELANE, PKM
phagocytic vesicle 1 ELANE
nucleoplasm 3 ATP2B1, DHODH, MYC
Cell membrane 2 ACE, ATP2B1
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
cell surface 1 ELANE
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 COQ6
mitochondrial inner membrane 2 COQ6, DHODH
presynaptic membrane 1 ATP2B1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 2 ACE, ATP2B1
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ACE, ATP2B1, DHODH, MYC
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ACE, ATP2B1, ELANE, PKM
extracellular space 2 ACE, ELANE
mitochondrion 3 COQ6, DHODH, PKM
protein-containing complex 1 MYC
intracellular membrane-bounded organelle 1 ATP2B1
Single-pass type I membrane protein 1 ACE
Secreted 2 ACE, TRH
extracellular region 4 ACE, ELANE, PKM, TRH
Single-pass membrane protein 1 DHODH
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ACE
Extracellular vesicle 1 PKM
nucleolus 1 MYC
vesicle 1 PKM
Mitochondrion inner membrane 2 COQ6, DHODH
Matrix side 1 COQ6
collagen-containing extracellular matrix 2 ELANE, PKM
secretory granule 2 ELANE, TRH
lateral plasma membrane 1 ATP2B1
cilium 1 PKM
chromatin 1 MYC
cell projection 2 ATP2B1, COQ6
brush border membrane 1 ACE
Nucleus, nucleolus 1 MYC
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 MYC
Nucleus, nucleoplasm 1 MYC
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
transcription repressor complex 1 ELANE
specific granule lumen 1 ELANE
RNA polymerase II transcription repressor complex 1 MYC
azurophil granule lumen 1 ELANE
immunological synapse 1 ATP2B1
Rough endoplasmic reticulum 2 MYC, PKM
Cytoplasmic vesicle, phagosome 1 ELANE
ubiquinone biosynthesis complex 1 COQ6
Myc-Max complex 1 MYC
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
extrinsic component of mitochondrial inner membrane 1 COQ6
nucleoplasmic reticulum 1 MYC


文献列表

  • Brian J Koos, Jeffrey A Gornbein. Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. American journal of obstetrics and gynecology. 2021 02; 224(2):215.e1-215.e7. doi: 10.1016/j.ajog.2020.07.050. [PMID: 32739399]
  • John A Duley, Michael G Henman, Kevin H Carpenter, Michael J Bamshad, George A Marshall, Chee Y Ooi, Bridget Wilcken, Jason R Pinner. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine. Molecular genetics and metabolism. 2016 09; 119(1-2):83-90. doi: 10.1016/j.ymgme.2016.06.008. [PMID: 27370710]
  • Joe Rainger, Hemant Bengani, Leigh Campbell, Eve Anderson, Kishan Sokhi, Wayne Lam, Angelika Riess, Morad Ansari, Sarah Smithson, Melissa Lees, Catherine Mercer, Kathryn McKenzie, Tobias Lengfeld, Blanca Gener Querol, Peter Branney, Stewart McKay, Harris Morrison, Bethan Medina, Morag Robertson, Jürgen Kohlhase, Colin Gordon, Jean Kirk, Dagmar Wieczorek, David R Fitzpatrick. Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Human molecular genetics. 2012 Sep; 21(18):3969-83. doi: 10.1093/hmg/dds218. [PMID: 22692683]
  • Helio Tedesco Silva, Paula Pinheiro Machado, Claudia Rosso Felipe, Jose Osmar Medina Pestana. Immunotherapy for De Novo renal transplantation: what's in the pipeline?. Drugs. 2006; 66(13):1665-84. doi: 10.2165/00003495-200666130-00002. [PMID: 16978033]
  • E S Cleaveland, D W Zaharevitz, J A Kelley, K Paull, D A Cooney, H Ford. Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar. Biochemical and biophysical research communications. 1996 Jun; 223(3):654-9. doi: 10.1006/bbrc.1996.0950. [PMID: 8687451]
  • R P Durschlag, J L Robinson. Orotic acid-induced metabolic changes in the rat. The Journal of nutrition. 1980 Apr; 110(4):816-21. doi: 10.1093/jn/110.4.816. [PMID: 7365548]
  • M Toro, C Gómez-Lojero, M Montal, S Estrada-O. Charge transfer mediated by nigericin in black lipid membranes. Journal of bioenergetics. 1976 Feb; 8(1):19-26. doi: 10.1007/bf01559387. [PMID: 8444]