thiamphenicol (BioDeep_00000399093)
natural product
代谢物信息卡片
Thiamphenicol (Thiophenicol)
化学式: C12H15Cl2NO5S (355.0048)
中文名称: 甲砜霉素
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C1=C(C=CC(=C1)[C@H]([C@H](NC(C(Cl)Cl)=O)CO)O)S(C)(=O)=O
InChI: InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01B - Amphenicols > J01BA - Amphenicols
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
C784 - Protein Synthesis Inhibitor
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:32215
- KEGGdrug: D01407
- PubChem: 27200
- DrugBank: DB08621
- ChEMBL: CHEMBL1236282
- MeSH: Thiamphenicol
- CAS: 15318-45-3
- CAS: 847-25-6
- MoNA: CCMSLIB00000078520
- MetaboLights: MTBLC32215
- RefMet: Thiamphenicol
- CAS: 15318-453
- KEGG: C12853
- PubChem: 583242
- KNApSAcK: 32215
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiang-Yu Tang, Wen-Min Yin, Guang Yang, Jun-Fang Cui, Jian-Hua Cheng, Fei Yang, Xiao-Yu Li, Chun-Yan Wu, Sen-Gen Zhu. Biochar reduces antibiotic transport by altering soil hydrology and enhancing antibiotic sorption.
Journal of hazardous materials.
2024 Jul; 472(?):134468. doi:
10.1016/j.jhazmat.2024.134468. [PMID: 38703680] - Xing Zhang, Yiming Huo, Yifei Kong, Wenlin Zhou, Feiju Qin, Xiaolong Hu. Effects of short-term florfenicol exposure on the gene expression pattern, midgut microbiota, and metabolome in the lepidopteran model silkworm (Bombyx mori).
The Science of the total environment.
2024 Feb; 912(?):169099. doi:
10.1016/j.scitotenv.2023.169099. [PMID: 38056650] - Lin Zhang, Jing Qiu, Yameng Li, Linjuan He, Mingcai Mao, Tiancai Wang, Yecan Pan, Zishu Li, Xiyan Mu, Yongzhong Qian. Maternal transfer of florfenicol impacts development and disrupts metabolic pathways in F1 offspring zebrafish by destroying mitochondria.
Ecotoxicology and environmental safety.
2023 Mar; 252(?):114597. doi:
10.1016/j.ecoenv.2023.114597. [PMID: 36739738] - Yuxuan Zhang, Peiyong Guo, Yanmei Wu, Meixian Wang, Jun Deng, Haitao Su, Yinshi Sun. Effects of natural nanoparticles on the acute toxicity, chronic effect, and oxidative stress response of phenicol antibiotics in Daphnia magna.
Environmental science and pollution research international.
2023 Feb; 30(8):21535-21547. doi:
10.1007/s11356-022-23695-1. [PMID: 36272006] - Xinhui Li, Fei Zhao, Chen Fu, Yanyu Yang, Qianru Xu, Yinfei Hao, Xueqing Shi, Dong Chen, Xuejun Bi, Zhilin Gong, Shujian Wu, Haifeng Zhang. Early- and whole-life exposures to florfenicol disrupts lipid metabolism and induces obesogenic effects in zebrafish (Danio rerio).
Chemosphere.
2022 Dec; 308(Pt 3):136429. doi:
10.1016/j.chemosphere.2022.136429. [PMID: 36115475] - Wei Liu, Ying Liu, Siyuan Fang, Weiyu Yao, Xiao Wang, Yongzhan Bao, Wanyu Shi. Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways.
Poultry science.
2022 Sep; 101(9):101989. doi:
10.1016/j.psj.2022.101989. [PMID: 35841637] - Xiaoming Wang, Yue Wang, Ci Fang, Qianmei Gong, Jinhu Huang, Yujuan Zhang, Liping Wang. Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers.
Poultry science.
2022 Jul; 101(7):101947. doi:
10.1016/j.psj.2022.101947. [PMID: 35688033] - Chunyu Lu, Lu Zhang, Yuqing Cui, Guozhong Jin, Yongzhan Bao, Wanyu Shi. Proteome and transcriptome explore the mechanism of Salvia miltiorrhiza polysaccharides to relieve florfenicol-induced kidney injury in broilers.
Environmental science and pollution research international.
2022 Jun; 29(30):45872-45884. doi:
10.1007/s11356-022-19114-0. [PMID: 35150422] - Wei Liu, Xiao Wang, Ying Liu, Siyuan Fang, Zhanjun Wu, Chao Han, Wanyu Shi, Yongzhan Bao. Effects of early florfenicol exposure on glutathione signaling pathway and PPAR signaling pathway in chick liver.
Ecotoxicology and environmental safety.
2022 Jun; 237(?):113529. doi:
10.1016/j.ecoenv.2022.113529. [PMID: 35487170] - Avishek Bardhan, Thangapalam Jawahar Abraham, Jasmine Singha, Suchismita Saha, Sudeshna Sarker, Prasanna Kumar Patil. The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.).
Environmental science and pollution research international.
2022 Jun; 29(26):39914-39927. doi:
10.1007/s11356-021-18418-x. [PMID: 35112251] - Fábio S Zanuzzo, Rebeccah M Sandrelli, Ellen de Fátima C Peroni, Jennifer R Hall, Matthew L Rise, Anthony K Gamperl. Atlantic Salmon (Salmo salar) bacterial and viral innate immune responses are not impaired by florfenicol or tetracycline administration.
Fish & shellfish immunology.
2022 Apr; 123(?):298-313. doi:
10.1016/j.fsi.2022.02.034. [PMID: 35189324] - Xiao Wang, Wei Liu, Guozhong Jin, Zhanjun Wu, Di Zhang, Yongzhan Bao, Wanyu Shi. Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis.
Ecotoxicology and environmental safety.
2022 Mar; 233(?):113339. doi:
10.1016/j.ecoenv.2022.113339. [PMID: 35219255] - Sicong Li, Bin Wang, Min Zhang, Dingsheng Yuan, Jinliang Li, Xuting Li, Ge Liang. Effects of berberine on the pharmacokinetics of florfenicol and levels of cytochrome P450 3A37, multidrug resistance 1, and chicken xenobiotic-sensing orphan nuclear receptor mRNA expression in broilers.
Veterinary medicine and science.
2022 03; 8(2):619-625. doi:
10.1002/vms3.660. [PMID: 34766459] - Kai Yang, Sanguo Ren, Meng Mei, Yuanpei Jin, Wei Xiang, Zunji Shi, Zhihui Ai, Li Yi, Bo Xie. Removal of antibiotic thiamphenicol by bacterium Aeromonas hydrophila HS01.
World journal of microbiology & biotechnology.
2022 Jan; 38(3):37. doi:
10.1007/s11274-021-03223-y. [PMID: 35018528] - Majid Gholami-Ahangaran, Maryam Karimi-Dehkordi, Abdolrasul Namjoo, Hasan Shojaei, Asiye Ahmadi-Dastgerdi. The co-administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens.
Veterinary medicine and science.
2022 01; 8(1):211-218. doi:
10.1002/vms3.626. [PMID: 34498431] - A Bello, B Poźniak, A Smutkiewicz, M Świtała. The influence of the site of drug administration on florfenicol pharmacokinetics in turkeys.
Poultry science.
2022 Jan; 101(1):101536. doi:
10.1016/j.psj.2021.101536. [PMID: 34784513] - Yumeng Geng, Chunyu Lu, Guozhong Jin, Shuying Li, Yuqing Cui, Chao Han, Wanyu Shi, Yongzhan Bao. Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol.
Environmental science and pollution research international.
2022 Jan; 29(3):3372-3385. doi:
10.1007/s11356-021-15687-4. [PMID: 34389946] - Fahimeh Nematollahi, Tahoora Shomali, Bahman Abdi-Hachesoo, Azizollah Khodakaram-Tafti. Effect of prophylactic vitamin C administration on the efficiency of florfenicol or sulfadiazine-trimethoprim antimicrobial therapy in chickens with staphylococcal arthritis.
Tropical animal health and production.
2021 Dec; 54(1):25. doi:
10.1007/s11250-021-03033-2. [PMID: 34957533] - T Rairat, Y Chi, S-K Chang, C-Y Hsieh, N Chuchird, C-C Chou. Differential effects of aquatic anaesthetics on the pharmacokinetics of antibiotics: Examples using florfenicol in Nile tilapia (Oreochromis niloticus).
Journal of fish diseases.
2021 Oct; 44(10):1579-1586. doi:
10.1111/jfd.13480. [PMID: 34152617] - Mingrong Qian, Jianmei Wang, Xiaofeng Ji, Hua Yang, Biao Tang, Hu Zhang, Guiling Yang, Zhiwei Bao, Yuanxiang Jin. Sub-chronic exposure to antibiotics doxycycline, oxytetracycline or florfenicol impacts gut barrier and induces gut microbiota dysbiosis in adult zebrafish (Daino rerio).
Ecotoxicology and environmental safety.
2021 Sep; 221(?):112464. doi:
10.1016/j.ecoenv.2021.112464. [PMID: 34198189] - Chao Han, Yuqing Cui, Yiwei Guo, Di Zhang, Xiao Wang, Yumeng Geng, Wanyu Shi, Yongzhan Bao. Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers.
Poultry science.
2021 Sep; 100(9):101228. doi:
10.1016/j.psj.2021.101228. [PMID: 34293615] - Xuting Li, Sicong Li, Bin Wang, Min Zhang, Dingsheng Yuan, Jinliang Li, Ge Liang. Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats.
The Journal of veterinary medical science.
2021 Aug; 83(8):1338-1344. doi:
10.1292/jvms.20-0641. [PMID: 34176823] - Sonia Nina Coccitto, Simona Fioriti, Marzia Cinthi, Gianluca Morroni, Elisabetta Di Giannatale, Marina Mingoia, Andrea Brenciani, Eleonora Giovanetti. Detection of phenicol-oxazolidinone resistance gene optrA in Aerococcus viridans from bovine faeces, Italy.
The Journal of antimicrobial chemotherapy.
2021 08; 76(9):2479-2481. doi:
10.1093/jac/dkab162. [PMID: 34008028] - Bin Li, Yi Hu, Yujie Guo, Renjie Xu, Xiaoping Fang, Xuecheng Xiao, Cuiping Jiang, Shan Lu. Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation.
Journal of pharmaceutical sciences.
2021 06; 110(6):2544-2554. doi:
10.1016/j.xphs.2021.02.005. [PMID: 33577826] - Dimitra Kogiannou, Chrysanthi Nikoloudaki, Pantelis Katharios, Adriana Triga, George Rigos. Evaluation of absorption and depletion of florfenicol in European seabass Dicentrarchus labrax.
Veterinary medicine and science.
2021 05; 7(3):987-997. doi:
10.1002/vms3.415. [PMID: 33369159] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Chao Han, Xiao Wang, Di Zhang, Yuanyuan Wei, Yuqing Cui, Wanyu Shi, Yongzhan Bao. Synergistic use of florfenicol and Salvia miltiorrhiza polysaccharide can enhance immune responses in broilers.
Ecotoxicology and environmental safety.
2021 Mar; 210(?):111825. doi:
10.1016/j.ecoenv.2020.111825. [PMID: 33412284] - He Guo, Zhen Li, Liangrui Xiang, Nan Jiang, Ying Zhang, Huijuan Wang, Jie Li. Efficient removal of antibiotic thiamphenicol by pulsed discharge plasma coupled with complex catalysis using graphene-WO3-Fe3O4 nanocomposites.
Journal of hazardous materials.
2021 02; 403(?):123673. doi:
10.1016/j.jhazmat.2020.123673. [PMID: 32829229] - Xiao Wang, Chao Han, Yuqing Cui, Yumeng Geng, Yuanyuan Wei, Wanyu Shi, Yongzhan Bao. Florfenicol induces renal toxicity in chicks by promoting oxidative stress and apoptosis.
Environmental science and pollution research international.
2021 Jan; 28(1):936-946. doi:
10.1007/s11356-020-10550-4. [PMID: 32827115] - Xiao Wang, Chao Han, Yuqing Cui, Shuying Li, Guozhong Jin, Wanyu Shi, Yongzhan Bao. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers.
Ecotoxicology and environmental safety.
2021 Jan; 207(?):111282. doi:
10.1016/j.ecoenv.2020.111282. [PMID: 32949928] - Tirawat Rairat, Yu-Shin Kuo, Chao-Chia Chang, Chia-Yu Hsieh, Chi-Chung Chou. Bath immersion pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus).
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):520-526. doi:
10.1111/jvp.12887. [PMID: 32573800] - Mohamed Aboubakr, Ahmed Soliman. Pharmacokinetics of thiamphenicol in Japanese quails (Coturnix japonica) after single intravenous and oral administrations.
Journal of veterinary pharmacology and therapeutics.
2020 Sep; 43(5):512-515. doi:
10.1111/jvp.12902. [PMID: 32779236] - Wei Zhang, Chun-Ping Liu, Shi-Qi Chen, Meng-Jiao Liu, Li Zhang, Shi-Yu Lin, Gang Shu, Zhi-Xiang Yuan, Ju-Chun Lin, Guang-Neng Peng, Zhi-Jun Zhong, Li-Zi Yin, Lin Zhao, Hua-Lin Fu. Poloxamer modified florfenicol instant microparticles for improved oral bioavailability.
Colloids and surfaces. B, Biointerfaces.
2020 Sep; 193(?):111078. doi:
10.1016/j.colsurfb.2020.111078. [PMID: 32422561] - Marta Pastor-Belda, Natalia Campillo, Natalia Arroyo-Manzanares, Manuel Hernández-Córdoba, Pilar Viñas. Determination of amphenicol antibiotics and their glucuronide metabolites in urine samples using liquid chromatography with quadrupole time-of-flight mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122122. doi:
10.1016/j.jchromb.2020.122122. [PMID: 32334391] - Tingyuan Zhu, Suzhen Liu, Yuanyuan Ying, Lei Xu, Yabo Liu, Junjie Jin, Jun Ying, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Qiyu Bao, Peizhen Li. Genomic and functional characterization of fecal sample strains of Proteus cibarius carrying two floR antibiotic resistance genes and a multiresistance plasmid-encoded cfr gene.
Comparative immunology, microbiology and infectious diseases.
2020 Apr; 69(?):101427. doi:
10.1016/j.cimid.2020.101427. [PMID: 32058867] - Chao Han, Yuanyuan Wei, Yuqing Cui, Yumemg Geng, Yongzhan Bao, Wanyu Shi. Florfenicol induces oxidative stress and hepatocyte apoptosis in broilers via Nrf2 pathway.
Ecotoxicology and environmental safety.
2020 Mar; 191(?):110239. doi:
10.1016/j.ecoenv.2020.110239. [PMID: 31991393] - Samy A Elgeddawy, Hazem M Shaheen, Yasser S El-Sayed, Magdy Abd Elaziz, Ashraf Darwish, Dalia Samak, Gaber E Batiha, Rehab A Mady, May Bin-Jumah, Ahmed A Allam, Mahmoud Alagawany, Ayman E Taha, Amany El-Mleeh, Sabry A A El-Sayed, Mohamed E Abd El-Hack, Shaaban S Elnesr. Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken.
Journal of animal physiology and animal nutrition.
2020 Mar; 104(2):549-557. doi:
10.1111/jpn.13317. [PMID: 32017274] - Yabo Liu, Fei Wu, Qing Chen, Yuanyuan Ying, Yi Jiang, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Qiyu Bao, Liyan Ni. Comparative genomics analysis of Raoultella planticola S25 isolated from duck in China, with florfenicol resistance.
Comparative immunology, microbiology and infectious diseases.
2020 Feb; 68(?):101398. doi:
10.1016/j.cimid.2019.101398. [PMID: 31775114] - Yuying Huang, Yihai Wang, Jingwen Xu, Jianying Feng, Xiangjiu He. Propacin, a coumarinolignoid isolated from durian, inhibits the lipopolysaccharide-induced inflammatory response in macrophages through the MAPK and NF-κB pathways.
Food & function.
2020 Jan; 11(1):596-605. doi:
10.1039/c9fo02202c. [PMID: 31859327] - DanNa Zhou, YaChao Li, LingLi Huang, MingRong Qian, Dong Li, GuiZhi Sun, Bo Yang. A reliable and cost-efficient TLC-HPLC method for determining total florfenicol residues in porcine edible tissues.
Food chemistry.
2020 Jan; 303(?):125399. doi:
10.1016/j.foodchem.2019.125399. [PMID: 31470274] - M S El-Gohary, Adel M El Gamal, A A Atia, M F El-Dakroury. Treatment Trial of Nile Tilapia (Oreochromis niloticus) Experimentally Infected with Vibrio alginolyticus Isolated from Sea bass (Dicentrarchus labrax).
Pakistan journal of biological sciences : PJBS.
2020 Jan; 23(12):1591-1600. doi:
10.3923/pjbs.2020.1591.1600. [PMID: 33274891] - Fan Yang, Chao-Shuo Zhang, Han Wang, Fang Yang. Depletion study and withdrawal period calculation of florfenicol in the crucian carp (Carassius auratus) following multiple intramuscular injections.
Journal of veterinary pharmacology and therapeutics.
2020 Jan; 43(1):79-86. doi:
10.1111/jvp.12822. [PMID: 31691990] - Audrey Martinez, Seenivasan Subbiah, Paul Stonum, Tiffanie Brooks, Shanoy Anderson, Odia Osemwegie, Ernest E Smith. Characterization of serotonin following exposure to antibiotics in white-tailed deer.
General and comparative endocrinology.
2020 01; 285(?):113265. doi:
10.1016/j.ygcen.2019.113265. [PMID: 31473183] - Kamelia Osman, Tara Rava Zolnikov, Jihan Badr, Heba Naim, Mai Hanafy, Aalaa Saad, Ayman Elbehiry. Vancomycin and florfenicol resistant Enterococcus faecalis and Enterococcus faecium isolated from human urine in an Egyptian urban-rural community.
Acta tropica.
2020 Jan; 201(?):105209. doi:
10.1016/j.actatropica.2019.105209. [PMID: 31600524] - Rosemary Booth, Sharon Nyari. Clinical comparison of five anti-chlamydial antibiotics in koalas (Phascolarctos cinereus).
PloS one.
2020; 15(7):e0236758. doi:
10.1371/journal.pone.0236758. [PMID: 32730301] - Sicong Li, Xuting Li, Rui Yang, Bin Wang, Jinliang Li, Liang Cao, Songyang Xiao, Wei Huang. Effects of anemoside B4 on pharmacokinetics of florfenicol and mRNA expression of CXR, MDR1, CYP3A37 and UGT1E in broilers.
The Journal of veterinary medical science.
2019 Dec; 81(12):1804-1809. doi:
10.1292/jvms.19-0293. [PMID: 31611492] - M Lis, M Szczypka, A Suszko-Pawłowska, M Świtała, P Pawłowski, B Obmińska-Mrukowicz. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens.
Polish journal of veterinary sciences.
2019 Dec; 22(4):481-487. doi:
10.24425/pjvs.2019.129980. [PMID: 31867932] - Guoqing Fan, Li Zhang, Yun Shen, Gang Shu, Zhixiang Yuan, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin, Hualin Fu. Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs.
Scientific reports.
2019 11; 9(1):16739. doi:
10.1038/s41598-019-53304-0. [PMID: 31723173] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Pei Li, Jianzhi Ye, Shaodong Zeng, Chunliang Yang. Florfenicol alleviated lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella through inhibiting toll / NF-κB signaling pathways.
Fish & shellfish immunology.
2019 Nov; 94(?):479-484. doi:
10.1016/j.fsi.2019.08.073. [PMID: 31472264] - Murugesan Sathiya Deepika, Ramar Thangam, Tharumasivam Siva Vijayakumar, Rajendran Sasirekha, R T V Vimala, Srinivasan Sivasubramanian, Sridhar Arun, Manikandan Dinesh Babu, Ramasamy Thirumurugan. Antibacterial synergy between rutin and florfenicol enhances therapeutic spectrum against drug resistant Aeromonas hydrophila.
Microbial pathogenesis.
2019 Oct; 135(?):103612. doi:
10.1016/j.micpath.2019.103612. [PMID: 31252064] - Yuqing Huang, Xiaoxuan Chen, Huan Wang, Hui Zhao, Yaner Luo, Zhixin Wu. Pharmacokinetics of florfenicol in blunt-snout bream (Megalobrama amblycephala) at two water temperatures with single-dose oral administration.
Journal of veterinary pharmacology and therapeutics.
2019 Sep; 42(5):564-571. doi:
10.1111/jvp.12773. [PMID: 31197852] - Nima Shiry, Siyavash Soltanian, Tahoora Shomali, Hamed Paknejad, Seyed Hossein Hoseinifar. Immunomodulatory effects of orally administrated florfenicol in rainbow trout (Oncorhynchus mykiss) following experimental challenge with streptococcosis/lactococcosis.
International immunopharmacology.
2019 Aug; 73(?):236-245. doi:
10.1016/j.intimp.2019.05.007. [PMID: 31108388] - Tirawat Rairat, Chia-Yu Hsieh, Wipavee Thongpiam, Chi-Chung Chou. Pharmacokinetic-pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels.
Journal of fish diseases.
2019 Aug; 42(8):1181-1190. doi:
10.1111/jfd.13040. [PMID: 31157416] - Mingrong Qian, Danna Zhou, Qianyong Wang, Jindong Gao, Dong Li, Yachao Li, Bo Yang. A reliable, simple and cost-efficient TLC-HPLC method for simultaneously determining florfenicol and florfenicol amine in porcine urine: application to residue surveillance.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2019 Aug; 36(8):1218-1227. doi:
10.1080/19440049.2019.1627004. [PMID: 31192771] - Chang Sun, Deming Dong, Sinan He, Liwen Zhang, Xun Zhang, Chaoqian Wang, Xiuyi Hua, Zhiyong Guo. Multimedia fate modeling of antibiotic sulfamethoxazole, lincomycin, and florfenicol in a seasonally ice-covered river receiving WWTP effluents.
Environmental science and pollution research international.
2019 Jun; 26(17):17351-17361. doi:
10.1007/s11356-019-05121-1. [PMID: 31016586] - Francisco Arriagada, Germán Günther, Irene Zabala, Jorge Rubio-Retama, Javier Morales. Development and Characterization of Florfenicol-Loaded BSA Nanoparticles as Controlled Release Carrier.
AAPS PharmSciTech.
2019 May; 20(5):202. doi:
10.1208/s12249-019-1419-7. [PMID: 31140015] - Zhixin Lei, Qianying Liu, Haseeb Khaliq, Jiyue Cao, Qigai He. Resistant cutoff values and optimal scheme establishments for florfenicol against Escherichia coli with PK-PD modeling analysis in pigs.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):324-335. doi:
10.1111/jvp.12754. [PMID: 30801741] - Weixuan Lan, Xia Xiao, Yongjia Jiang, Lijie Jiang, Xu Zhao, Zhaoyang Yu, Biwen Zhu, Congcong Li, Lin Bian, Zhiqiang Wang. Comparative pharmacokinetics of florfenicol in healthy and Pasteurella multocida-infected Gaoyou ducks.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):355-360. doi:
10.1111/jvp.12761. [PMID: 30912167] - Fan Yang, Zhoumeng Lin, Jim E Riviere, Ronald E Baynes. Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Apr; 126(?):285-294. doi:
10.1016/j.fct.2019.02.029. [PMID: 30825586] - Seok Hyeon Na, Dong Chan Moon, Myeong-Ja Choi, Sun-Joo Oh, Dae-Young Jung, Hee Young Kang, Bang-Hun Hyun, Suk-Kyung Lim. Detection of oxazolidinone and phenicol resistant enterococcal isolates from duck feces and carcasses.
International journal of food microbiology.
2019 Mar; 293(?):53-59. doi:
10.1016/j.ijfoodmicro.2019.01.002. [PMID: 30640000] - Xue Ping Lei, Geng Yi, Kai Yu Wang, Ping OuYang, De Fang Chen, Xiao Li Huang, Chao Huang, Wei Min Lai, Zi Jun Zhong, Chang Liang Huo, Ze Xiao Yang. Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa).
Transboundary and emerging diseases.
2019 Mar; 66(2):1049-1053. doi:
10.1111/tbed.13101. [PMID: 30554477] - Nima Shiry, Tahoora Shomali, Siyavash Soltanian, Mostafa Akhlaghi. Comparative single-dose pharmacokinetics of orally administered florfenicol in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) at health and experimental infection with Streptococcus iniae or Lactococcus garvieae.
Journal of veterinary pharmacology and therapeutics.
2019 Mar; 42(2):214-221. doi:
10.1111/jvp.12736. [PMID: 30474150] - Kamelia M Osman, Jihan Badr, Ahmed Orabi, Ayman Elbehiry, Aalaa Saad, Mai D S Ibrahim, Mai H Hanafy. Poultry as a vector for emerging multidrug resistant Enterococcus spp.: First report of vancomycin (van) and the chloramphenicol-florfenicol (cat-fex-cfr) resistance genes from pigeon and duck faeces.
Microbial pathogenesis.
2019 Mar; 128(?):195-205. doi:
10.1016/j.micpath.2019.01.006. [PMID: 30615998] - Yanyan Feng, Qianqian Zhai, Jiajia Wang, Jitao Li, Jian Li. Comparison of florfenicol pharmacokinetics in Exopalaemon carinicauda at different temperatures and administration routes.
Journal of veterinary pharmacology and therapeutics.
2019 Mar; 42(2):230-238. doi:
10.1111/jvp.12734. [PMID: 30488568] - Qianqian Zhai, Jian Li, Yanyan Feng, Qianqian Ge. Evaluation of combination effects of Astragalus polysaccharides and florfenicol against acute hepatopancreatic necrosis disease-causing strain of Vibrio parahaemolyticus in Litopenaeus vannamei.
Fish & shellfish immunology.
2019 Mar; 86(?):374-383. doi:
10.1016/j.fsi.2018.11.065. [PMID: 30502463] - A N Ngigi, Y S Ok, S Thiele-Bruhn. Biochar-mediated sorption of antibiotics in pig manure.
Journal of hazardous materials.
2019 Feb; 364(?):663-670. doi:
10.1016/j.jhazmat.2018.10.045. [PMID: 30396139] - Betty San Martín, Marcela Fresno, Javiera Cornejo, Marcos Godoy, Rolando Ibarra, Roberto Vidal, Marcelo Araneda, Arturo Anadón, Lisette Lapierre. Optimization of florfenicol dose against Piscirickettsia salmonis in Salmo salar through PK/PD studies.
PloS one.
2019; 14(5):e0215174. doi:
10.1371/journal.pone.0215174. [PMID: 31083666] - Marta Tikhomirov, Błażej Poźniak, Andrzej Smutkiewicz, Marcin Świtała. Pharmacokinetics of florfenicol and thiamphenicol in ducks.
Journal of veterinary pharmacology and therapeutics.
2019 Jan; 42(1):116-120. doi:
10.1111/jvp.12714. [PMID: 30242846] - Zhiqiang Chang, Zhao Chen, Haiyu Gao, Qianqian Zhai, Jian Li. Pharmacokinetic profiles of florfenicol in spotted halibut, Verasper variegatus, at two water temperatures.
Journal of veterinary pharmacology and therapeutics.
2019 Jan; 42(1):121-125. doi:
10.1111/jvp.12668. [PMID: 30506567] - Andre L Ferreira, Matheus P S Amorim, Emilene R Souza, Marianne Schorer, Gustavo H F Castro, Marcelo M Pedreira. Probiotic, antibiotic and combinations in Nile tilapia juveniles culture.
Anais da Academia Brasileira de Ciencias.
2019; 91(4):e20180169. doi:
10.1590/0001-3765201920180169. [PMID: 31721914] - Yuanhao Yang, Juanning Yang, Derong Shang, Fengling Li, Lvzhou Wang, Fenggang Li, Yi Li, Yuhang Sun, Shuangheng He, Jinxing Wu. Tissue distribution and elimination features of florfenicol in hybrid sturgeon cultured in cool water.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):894-901. doi:
10.1111/jvp.12689. [PMID: 30043988] - Fabíola M Barreto, Mariana R da Silva, Patrícia A C Braga, Adriana P A Bragotto, Hamilton Hisano, Felix G R Reyes. Evaluation of the leaching of florfenicol from coated medicated fish feed into water.
Environmental pollution (Barking, Essex : 1987).
2018 Nov; 242(Pt B):1245-1252. doi:
10.1016/j.envpol.2018.08.017. [PMID: 30118912] - Xian-Liang Zhao, He Chen, Ke-Ke Zhong, Li Li, Xiang-Hui Kong. Myo-inositol as an adjuvant to florfenicol against Aeromonas hydrophila infection in common carp Cyprinus carpio.
FEMS microbiology letters.
2018 10; 365(20):. doi:
10.1093/femsle/fny212. [PMID: 30184134] - Zhichang Liu, Ting Rong, Dongping Zeng, Xiangguang Shen, Xianyong Ma, Zhenling Zeng. Bayesian population pharmacokinetic modeling of florfenicol in pigs after intravenous and intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2018 Oct; 41(5):719-725. doi:
10.1111/jvp.12677. [PMID: 29974964] - S L Forster, T Real, K P Doucette, S B King. A randomized placebo-controlled trial of the efficacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis externa.
BMC veterinary research.
2018 Aug; 14(1):262. doi:
10.1186/s12917-018-1589-7. [PMID: 30170597] - Amr Fadel, Mahmoud Mabrok, Salah Aly. Epizootics of Pseudomonas anguilliseptica among cultured seabream (Sparus aurata) populations: Control and treatment strategies.
Microbial pathogenesis.
2018 Aug; 121(?):1-8. doi:
10.1016/j.micpath.2018.04.021. [PMID: 29673977] - Kazuyuki Tanno, Kensaku Maejima, Akio Miyazaki, Hiroaki Koinuma, Nozomu Iwabuchi, Yugo Kitazawa, Takamichi Nijo, Masayoshi Hashimoto, Yasuyuki Yamaji, Shigetou Namba. Comprehensive screening of antimicrobials to control phytoplasma diseases using an in vitro plant-phytoplasma co-culture system.
Microbiology (Reading, England).
2018 08; 164(8):1048-1058. doi:
10.1099/mic.0.000681. [PMID: 29952745] - Yuan Yao, Yijun Shao, Ming Zhan, Xiaoli Zou, Weidong Qu, Ying Zhou. Rapid and sensitive determination of nine bisphenol analogues, three amphenicol antibiotics, and six phthalate metabolites in human urine samples using UHPLC-MS/MS.
Analytical and bioanalytical chemistry.
2018 Jun; 410(16):3871-3883. doi:
10.1007/s00216-018-1062-2. [PMID: 29671029] - Lúcia Guilhermino, Luís R Vieira, Diogo Ribeiro, Ana Sofia Tavares, Vera Cardoso, Anabela Alves, José Manuel Almeida. Uptake and effects of the antimicrobial florfenicol, microplastics and their mixtures on freshwater exotic invasive bivalve Corbicula fluminea.
The Science of the total environment.
2018 May; 622-623(?):1131-1142. doi:
10.1016/j.scitotenv.2017.12.020. [PMID: 29890582] - A Watteyn, S Croubels, S De Baere, P De Backer, M Devreese. Pharmacokinetics of florfenicol in turkey plasma, lung tissue, and pulmonary epithelial lining fluid after single oral bolus or continuous administration in the drinking water.
Poultry science.
2018 Apr; 97(4):1134-1140. doi:
10.3382/ps/pex416. [PMID: 29381781] - Siti N Nurbaeti, Jean-Christophe Olivier, Christophe Adier, Sandrine Marchand, William Couet, Julien Brillault. Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model.
Journal of pharmaceutical sciences.
2018 04; 107(4):1178-1184. doi:
10.1016/j.xphs.2017.11.021. [PMID: 29221992] - Z Ling, L Yonghong, L Junfeng, Z Li, L Xianqiang. Tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):307-313. doi:
10.1111/jvp.12465. [PMID: 29139136] - Christie C Balcomb, John A Angelos, Munashe Chigerwe, Barbara A Byrne, V Michael Lane, Scott E Wetzlich, Orhan Sahin, Larry Holler, Shuping Zhang, Lisa A Tell. Comparative pharmacokinetics of two florfenicol formulations following intramuscular and subcutaneous administration to sheep.
American journal of veterinary research.
2018 Jan; 79(1):107-114. doi:
10.2460/ajvr.79.1.107. [PMID: 29287162] - Renilde Cordeiro de Souza, Mateus Matiuzzi da Costa, Bernardo Baldisserotto, Berta Maria Heinzmann, Denise Schmidt, Braulio Otomar Caron, Carlos Eduardo Copatti. Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp.
Microbial pathogenesis.
2017 Dec; 113(?):29-33. doi:
10.1016/j.micpath.2017.10.013. [PMID: 29038058] - M R Qian, Q Y Wang, H Yang, G Z Sun, X B Ke, L L Huang, J D Gao, J J Yang, B Yang. Diffusion-limited PBPK model for predicting pulmonary pharmacokinetics of florfenicol in pig.
Journal of veterinary pharmacology and therapeutics.
2017 Dec; 40(6):e30-e38. doi:
10.1111/jvp.12419. [PMID: 28568482] - JinJing Yang, GuiZhi Sun, MingRong Qian, LingLi Huang, XianBing Ke, Bo Yang. Development of a high-performance liquid chromatography method for the determination of florfenicol in animal feedstuffs.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1068-1069(?):9-14. doi:
10.1016/j.jchromb.2017.09.045. [PMID: 29028619] - Muhammad Imran, Fazal-E-Habib, Abdul Tawab, Waqar Rauf, Moazur Rahman, Qaiser Mehmood Khan, Muhammad Rafique Asi, Mazhar Iqbal. LC-MS/MS based method development for the analysis of florfenicol and its application to estimate relative distribution in various tissues of broiler chicken.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1063(?):163-173. doi:
10.1016/j.jchromb.2017.08.029. [PMID: 28866358] - Claudia Pașca, Liviu Mărghitaș, Daniel Dezmirean, Otilia Bobiș, Victorița Bonta, Flore Chirilă, Ioana Matei, Nicodim Fiț. Medicinal Plants Based Products Tested on Pathogens Isolated from Mastitis Milk.
Molecules (Basel, Switzerland).
2017 Sep; 22(9):. doi:
10.3390/molecules22091473. [PMID: 28869568] - C Budd, C Flanagan, A Gillett, J Hanger, J J Loader, M Govendir. Assessment of florfenicol as a possible treatment for chlamydiosis in koalas (Phascolarctos cinereus).
Australian veterinary journal.
2017 Sep; 95(9):343-349. doi:
10.1111/avj.12617. [PMID: 28845567] - Xianyun Ren, Zhuqing Wang, Baoquan Gao, Ping Liu, Jian Li. Effects of florfenicol on the antioxidant status, detoxification system and biomolecule damage in the swimming crab (Portunus trituberculatus).
Ecotoxicology and environmental safety.
2017 Sep; 143(?):6-11. doi:
10.1016/j.ecoenv.2017.05.003. [PMID: 28486145] - Lucy Dorey, Peter Lees. Impact of growth matrix on pharmacodynamics of antimicrobial drugs for pig pneumonia pathogens.
BMC veterinary research.
2017 Jun; 13(1):192. doi:
10.1186/s12917-017-1086-4. [PMID: 28645327] - Z Ling, L Yonghong, S Changqing, L Junfeng, Z Li, J Chunyu, L Xianqiang. Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles.
Journal of veterinary pharmacology and therapeutics.
2017 Jun; 40(3):293-303. doi:
10.1111/jvp.12356. [PMID: 27687707] - Rubén Pérez-Fernández, Victoria Cazanga, Jessie Ana Jeldres, Pedro P Silva, José Riquelme, Fernando Quiroz, Cristina Palma, Maria D Carretta, Rafael A Burgos. Plasma and tissue disposition of florfenicol in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 May; 47(5):408-415. doi:
10.1080/00498254.2016.1195522. [PMID: 27378216] - Meixian Wang, Yuxuan Zhang, Peiyong Guo. Effect of florfenicol and thiamphenicol exposure on the photosynthesis and antioxidant system of Microcystis flos-aquae.
Aquatic toxicology (Amsterdam, Netherlands).
2017 May; 186(?):67-76. doi:
10.1016/j.aquatox.2017.02.022. [PMID: 28257901] - B Poźniak, P Pawłowski, U Pasławska, T Grabowski, A Suszko, M Lis, M Świtała. The influence of rapid growth in broilers on florfenicol pharmacokinetics - allometric modelling of the pharmacokinetic and haemodynamic parameters.
British poultry science.
2017 Apr; 58(2):184-191. doi:
10.1080/00071668.2016.1261994. [PMID: 28125301] - Migma Dorji Tamang, Dong Chan Moon, Su-Ran Kim, Hee Young Kang, Kichan Lee, Hyang-Mi Nam, Geum-Chan Jang, Hee-Soo Lee, Suk-Chan Jung, Suk-Kyung Lim. Detection of novel oxazolidinone and phenicol resistance gene optrA in enterococcal isolates from food animals and animal carcasses.
Veterinary microbiology.
2017 Mar; 201(?):252-256. doi:
10.1016/j.vetmic.2017.01.035. [PMID: 28284617] - V-R de Ocenda, S Almeida-Prieto, A Luzardo-Álvarez, J L Barja, F J Otero-Espinar, J Blanco-Méndez. Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed.
Journal of fish diseases.
2017 Mar; 40(3):411-424. doi:
10.1111/jfd.12525. [PMID: 27502011] - Lucy Dorey, Ludovic Pelligand, Zhangrui Cheng, Peter Lees. Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida.
PloS one.
2017; 12(5):e0177568. doi:
10.1371/journal.pone.0177568. [PMID: 28552968]
