nifedipine (BioDeep_00000398974)
Main id: BioDeep_00000001629
natural product
代谢物信息卡片
Nifedipine (Adalat)
化学式: C17H18N2O6 (346.1164808)
中文名称: 硝苯地平
谱图信息:
最多检出来源 Danio rerio(blood) 30%
分子结构信息
SMILES: C1=CC(=C(C=C1)[N+]([O-])=O)C2C(=C(NC(=C2C(=O)OC)C)C)C(OC)=O
InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:7565
- KEGG: C07266
- KEGGdrug: D00437
- PubChem: 4485
- DrugBank: DB01115
- ChEMBL: CHEMBL193
- MeSH: Nifedipine
- CAS: 101539-70-2
- CAS: 193689-82-6
- CAS: 21829-25-4
- MoNA: MoNA037626
- MoNA: MoNA033403
- MoNA: MoNA033402
- MoNA: MoNA033400
- MoNA: FiehnHILIC002180
- MoNA: FiehnHILIC000613
- MoNA: CCMSLIB00000078299
- MetaboLights: MTBLC7565
- PubChem: 9475
- PDB-CCD: C5U
- NIKKAJI: J3.467C
- RefMet: Nifedipine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 Homo sapiens: 10.1038/NBT.2488
- 9606 Homo sapiens: 10.1038/NBT.2488
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mariam S El-Semary, F Belal, Ali A El-Emam, Eman M Rabie Shehab El-Din, Amal A El-Masry. Ginseng root extract-mediated synthesis of monodisperse silver nanoparticles as a fluorescent probe for the spectrofluorometric determination of nilvadipine; Evaluation of remarkable anti-bacterial, anti-fungal and in-vitro cytotoxic activities.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Apr; 311(?):124017. doi:
10.1016/j.saa.2024.124017. [PMID: 38354677] - Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Mater H Mahnashi, Saif Ullah Khan Khalil, Muhammad Masoom Akhtar. N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism.
European journal of pharmacology.
2024 Feb; 964(?):176195. doi:
10.1016/j.ejphar.2023.176195. [PMID: 38142849] - Fernanda D'Avila da Silva, Maria Eduarda de Andrade Galiciolli, Ana Carolina Irioda, Cláudia Sirlene Oliveira, Bruna Candia Piccoli, Alessandro de Souza Prestes, Bruna Cogo Borin, Andre Passaglia Schuch, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, João Batista Teixeira da Rocha. Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications.
Blood cells, molecules & diseases.
2024 Jan; 106(?):102827. doi:
10.1016/j.bcmd.2024.102827. [PMID: 38301450] - Altaf Al-Romaiyan, Willias Masocha, Sunday Oyedemi, Sulaiman K Marafie, Guo-Cai Huang, Peter M Jones, Shanta J Persaud. Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase.
Journal of ethnopharmacology.
2023 Feb; 302(Pt B):115937. doi:
10.1016/j.jep.2022.115937. [PMID: 36410575] - Hong-Jaan Wang, Elise Chia-Hui Tan, Tzu-Yi Chiang, Wei-Ching Chen, Chien-Chang Shen, Yune-Fang Ueng. Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment.
Journal of food and drug analysis.
2022 03; 30(1):111-127. doi:
10.38212/2224-6614.3401. [PMID: 35647719] - Yongqiang Zhou, Helv Yan, Ting Li, Mei Xie, Xiuya Li, Chunli Zhao. New use of old medicine: Nifedipine acts on the TRP family and inflammatory proteins in the treatment of chilblain.
Burns : journal of the International Society for Burn Injuries.
2022 03; 48(2):372-380. doi:
10.1016/j.burns.2021.05.005. [PMID: 34103198] - S R Vaibavi, Manoj Sivasubramaniapandian, Rahul Vaippully, Privita Edwina, Basudev Roy, Saumendra Kumar Bajpai. Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells.
Cell biochemistry and biophysics.
2022 Mar; 80(1):171-190. doi:
10.1007/s12013-021-01035-3. [PMID: 34643835] - Yanbing Yuan, Ning Chen, Luyao Wang, Xuedian Zhang, Hui Chen, Pei Ma. Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2022 02; 38(2):359-368. doi:
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Journal of nutritional science and vitaminology.
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2021 12; 135(24):2749-2761. doi:
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Free radical biology & medicine.
2021 12; 177(?):189-200. doi:
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Renal failure.
2021 Dec; 43(1):651-657. doi:
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Advances in therapy.
2021 09; 38(9):4771-4785. doi:
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British journal of clinical pharmacology.
2021 07; 87(7):2790-2806. doi:
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Behavioural pharmacology.
2021 06; 32(4):286-294. doi:
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Journal of ethnopharmacology.
2021 May; 271(?):113914. doi:
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2021 May; 201(?):111635. doi:
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Iranian journal of medical sciences.
2021 03; 46(2):136-143. doi:
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Chronobiology international.
2021 03; 38(3):443-450. doi:
10.1080/07420528.2020.1866004. [PMID: 33356611] - Xuanshuo Liu, Shuli Man, Chen Luo, Yu Liu, Yan Liu, Changxiao Liu, Wenyuan Gao. Shunaoxin pills improve the antihypertensive effect of nifedipine and alleviate its renal lipotoxicity in spontaneous hypertension rats.
Environmental toxicology.
2021 Mar; 36(3):386-395. doi:
10.1002/tox.23044. [PMID: 33098358] - Eduardo Tozatto, Jhohann Richard de Lima Benzi, Adriana Rocha, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Nifedipine Does Not Alter the Pharmacokinetics of Venlafaxine Enantiomers in Healthy Subjects Phenotyped for CYP2D6, CYP2C19, and CYP3A.
Journal of clinical pharmacology.
2021 03; 61(3):319-327. doi:
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2021 Feb; 26(5):. doi:
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2021 Jan; 43(1):49-55. doi:
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Pharmaceutical nanotechnology.
2021; 9(4):262-270. doi:
10.2174/2211738509666210707162155. [PMID: 34238180] - Ranjeet P Dash, Vijayabhaskar Veeravalli, Jennifer A Thomas, Clint Rosenfeld, Nirali Mehta, Nuggehally R Srinivas. Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection?.
Future medicinal chemistry.
2021 01; 13(2):157-171. doi:
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2021 01; 288(1):127-141. doi:
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Journal of clinical hypertension (Greenwich, Conn.).
2020 12; 22(12):2296-2305. doi:
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European journal of pharmacology.
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2020 Nov; 20(1):330. doi:
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Life sciences.
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Toxicology letters.
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Pakistan journal of pharmaceutical sciences.
2020 Sep; 33(5):2059-2065. doi:
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Annals of the American Thoracic Society.
2020 08; 17(8):918-921. doi:
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Andrologia.
2020 Jul; 52(6):e13606. doi:
10.1111/and.13606. [PMID: 32352181] - Teruki Hamada, Yukiko Watanabe, Koichi Iida, Noriyasu Sano, Nobuyuki Amano. Microminipig: A suitable animal model to estimate oral absorption of sustained-release formulation in humans.
International journal of pharmaceutics.
2020 Jun; 584(?):119457. doi:
10.1016/j.ijpharm.2020.119457. [PMID: 32464228] - Yen-Chung Lin, Jhih-Cheng Wang, Mai-Szu Wu, Yuh-Feng Lin, Chang-Rong Chen, Chang-Yu Chen, Kuan-Chou Chen, Chiung-Chi Peng. Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study.
International journal of molecular sciences.
2020 Jun; 21(12):. doi:
10.3390/ijms21124359. [PMID: 32575412] - Y Wu, D-J Wang, Y Zhang, Y-X Zhang, R Zhang. Regulation of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia.
European review for medical and pharmacological sciences.
2020 05; 24(9):5062-5070. doi:
10.26355/eurrev_202005_21199. [PMID: 32432770] - Chiung-Chi Peng, Chang-Rong Chen, Chang-Yu Chen, Yen-Chung Lin, Kuan-Chou Chen, Robert Y Peng. Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress.
International journal of molecular sciences.
2020 Apr; 21(9):. doi:
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Cureus.
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American journal of physiology. Renal physiology.
2020 02; 318(2):F496-F505. doi:
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Drug research.
2020 Feb; 70(2-03):91-96. doi:
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Scientific reports.
2020 01; 10(1):565. doi:
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Molecules (Basel, Switzerland).
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Molecular pharmacology.
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Zhonghua xin xue guan bing za zhi.
2019 May; 47(5):374-380. doi:
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MedChemComm.
2019 May; 10(5):742-756. doi:
10.1039/c8md00611c. [PMID: 31191865] - Ken Takahashi, Shogo Hayashi, Mari Miyajima, Marei Omori, Jing Wang, Keiko Kaihara, Masatoshi Morimatsu, Chen Wang, Jian Chen, Gentaro Iribe, Keiji Naruse, Masahiro Sokabe. L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2.
Cell calcium.
2019 05; 79(?):68-74. doi:
10.1016/j.ceca.2019.02.008. [PMID: 30836292] - Bianca Nayra Malfará, Jhohann Richard de Lima Benzi, Gabriela Campos de Oliveira Filgueira, Cleslei Fernando Zanelli, Geraldo Duarte, Ricardo de Carvalho Cavalli, Natália Valadares de Moraes. ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women.
Reproductive toxicology (Elmsford, N.Y.).
2019 04; 85(?):1-5. doi:
10.1016/j.reprotox.2019.01.007. [PMID: 30659932] - Ersen Eraslan, Ayhan Tanyeli, Elif Polat, Elif Polat. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury.
Journal of cellular physiology.
2019 04; 234(4):4572-4581. doi:
10.1002/jcp.27236. [PMID: 30191993] - Yen-Chung Lin, Mai-Szu Wu, Yuh-Feng Lin, Chang-Rong Chen, Chang-Yu Chen, Chang-Jui Chen, Che-Chou Shen, Kuan-Chou Chen, Chiung-Chi Peng. Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway.
International journal of molecular sciences.
2019 Mar; 20(7):. doi:
10.3390/ijms20071570. [PMID: 30934807] - Silvia Franzè, Umberto M Musazzi, Paola Minghetti, Francesco Cilurzo. Drug-in-micelles-in-liposomes (DiMiL) systems as a novel approach to prevent drug leakage from deformable liposomes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Mar; 130(?):27-35. doi:
10.1016/j.ejps.2019.01.013. [PMID: 30654112] - Snigdha Reddy, Belinda Jim. Hypertension and Pregnancy: Management and Future Risks.
Advances in chronic kidney disease.
2019 03; 26(2):137-145. doi:
10.1053/j.ackd.2019.03.017. [PMID: 31023448] - Jian-Qi Zhang, Guo-Hong Yang, Xin Zhou, Jun-Xiang Liu, Rui Shi, Yan Dong, Shao-Bo Chen, Yu-Ming Li. Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension.
Medicine.
2019 Mar; 98(12):e14907. doi:
10.1097/md.0000000000014907. [PMID: 30896643] - Corrado Campochiaro, Sirin Atay, Kristina E N Clark, Voon Ong, Christopher P Denton. Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency.
BMJ case reports.
2019 Jan; 12(1):. doi:
10.1136/bcr-2017-223180. [PMID: 30610030] - Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang Ueng. Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation.
Journal of food and drug analysis.
2019 01; 27(1):284-294. doi:
10.1016/j.jfda.2018.10.005. [PMID: 30648582] - Susan Hua, Benjamin Vaughan. In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications.
International journal of nanomedicine.
2019; 14(?):2191-2206. doi:
10.2147/ijn.s198116. [PMID: 30988616] - Hans F Fritz, Andrea C Ortiz, Sitaram P Velaga, Javier O Morales. Preparation of a novel lipid-core micelle using a low-energy emulsification method.
Drug delivery and translational research.
2018 12; 8(6):1807-1814. doi:
10.1007/s13346-018-0521-9. [PMID: 29663150] - Juanhong Zhang, Yuyan Chen, Yuemei Sun, Rong Wang, Junmin Zhang, Zhengping Jia. Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine.
Drug delivery.
2018 Nov; 25(1):1175-1181. doi:
10.1080/10717544.2018.1469687. [PMID: 29790376] - Safaa H Hammoud, Sahar Alkhansa, Neamah Mahjoub, Amal G Omar, Mahmoud M El-Mas, Assaad A Eid. Molecular basis of the counteraction by calcium channel blockers of cyclosporine nephrotoxicity.
American journal of physiology. Renal physiology.
2018 09; 315(3):F572-F582. doi:
10.1152/ajprenal.00275.2017. [PMID: 29767558] - Michal Behuliak, Michal Bencze, Kamila Polgárová, Jaroslav Kuneš, Ivana Vaněčková, Josef Zicha. Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats.
Hypertension (Dallas, Tex. : 1979).
2018 09; 72(3):676-685. doi:
10.1161/hypertensionaha.118.09909. [PMID: 30354755] - Shinji Iwasaki, Hideki Hirabayashi, Nobuyuki Amano. Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 Aug; 48(8):770-780. doi:
10.1080/00498254.2017.1370744. [PMID: 28851254] - André Dallmann, Ibrahim Ince, Katrin Coboeken, Thomas Eissing, Georg Hempel. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.
Clinical pharmacokinetics.
2018 06; 57(6):749-768. doi:
10.1007/s40262-017-0594-5. [PMID: 28924743] - S-H Ok, I-W Shin, S H Lee, J Park, M S Woo, J-M Hong, J Kim, J-T Sohn. Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Human & experimental toxicology.
2018 Jun; 37(6):636-646. doi:
10.1177/0960327117721963. [PMID: 28741374] - Hui Chen, Xuelan Li, Yue Wu, Lihong Fan, Gang Tian. Pregnancy-induced complications in IgA nephropathy: A case report.
Medicine.
2018 Apr; 97(15):e0470. doi:
10.1097/md.0000000000010470. [PMID: 29642221] - Jing Li, Xiaoli Fan, Qin Wang. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: A case report.
Medicine.
2018 Mar; 97(11):e0073. doi:
10.1097/md.0000000000010073. [PMID: 29538199] - Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.
Journal of pharmacological and toxicological methods.
2018 Mar; 90(?):58-66. doi:
10.1016/j.vascn.2017.12.003. [PMID: 29274391] - Xi Luo, Lu Xue, Hao Xu, Qing-Yang Zhao, Qian Wang, Yu-Shan She, Dun-An Zang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Shu Chen, Shanshan Chen, Xiangning Fu, Sheng Hu, Xiaowei Nie, Chenyou Shen, Chunbin Zou, Gangjian Qin, Jiapei Dai, Guangju Ji, Yunchao Su, Shen Hu, Jingyu Chen, Qing-Hua Liu. Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle.
Scientific reports.
2018 02; 8(1):3114. doi:
10.1038/s41598-018-20409-x. [PMID: 29449621] - Yong Wang, Dandan Shi, Ling Chen. Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies.
Journal of clinical hypertension (Greenwich, Conn.).
2018 02; 20(2):394-399. doi:
10.1111/jch.13161. [PMID: 29316154] - Lisette Haddad, Stéphanie Corriveau, Eric Rousseau, Simon Blouin, Jean-Charles Pasquier, Yves Ponsot, Marie-Ève Roy-Lacroix. Impact of tamsulosin and nifedipine on contractility of pregnant rat ureters in vitro.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2018 Jan; 31(2):191-196. doi:
10.1080/14767058.2017.1280017. [PMID: 28068846] - Andrea K Pinto-Martinez, Jessica Rodriguez-Durán, Xenon Serrano-Martin, Vanessa Hernandez-Rodriguez, Gustavo Benaim. Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca2+ Channel.
Antimicrobial agents and chemotherapy.
2018 01; 62(1):. doi:
10.1128/aac.01614-17. [PMID: 29061745] - Safaa H Hammoud, Amal G Omar, Assaad A Eid, Mahmoud M El-Mas. CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats.
Toxicology and applied pharmacology.
2017 11; 334(?):110-119. doi:
10.1016/j.taap.2017.09.007. [PMID: 28899749] - Tong-Xin Yang, Bang-Hua Liao, Yun-Tian Chen, Hong Li, Qing He, Qin-Yu Liu, Kun-Jie Wang. A network meta-analysis on the beneficial effect of medical expulsive therapy after extracorporeal shock wave lithotripsy.
Scientific reports.
2017 10; 7(1):14429. doi:
10.1038/s41598-017-14862-3. [PMID: 29089544] - Catalin Chimerel, Cristian Riccio, Keir Murison, Fiona M Gribble, Frank Reimann. Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.
Endocrinology.
2017 10; 158(10):3426-3434. doi:
10.1210/en.2017-00434. [PMID: 28938466] - Samarth P Shah, Timothy H Self, Robert W Bradsher, Ryan E Owens. Clarithromycin-nifedipine-induced acute kidney injury.
The Nurse practitioner.
2017 Sep; 42(9):49-51. doi:
10.1097/01.npr.0000521991.15440.a7. [PMID: 28832423] - Futoshi Toyoda, Pietro Mesirca, Stefan Dubel, Wei-Guang Ding, Joerg Striessnig, Matteo E Mangoni, Hiroshi Matsuura. CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current.
Scientific reports.
2017 08; 7(1):7869. doi:
10.1038/s41598-017-08191-8. [PMID: 28801600] - Gabriela Campos de Oliveira Filgueira, Osmany Alberto Silva Filgueira, Daniela Miarelli Carvalho, Maria Paula Marques, Elaine Christine Dantas Moisés, Geraldo Duarte, Vera Lucia Lanchote, Ricardo Carvalho Cavalli. Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women.
British journal of clinical pharmacology.
2017 07; 83(7):1571-1579. doi:
10.1111/bcp.13226. [PMID: 28042936] - Jin Zhao, Tao Sun, Jing-Jing Wu, Yun-Feng Cao, Zhong-Ze Fang, Hong-Zhi Sun, Zhi-Tu Zhu, Kun Yang, Yong-Zhe Liu, Frank J Gonzalez, Jun Yin. Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.
Fitoterapia.
2017 Jun; 119(?):26-31. doi:
10.1016/j.fitote.2017.03.010. [PMID: 28344076] - Kristoffer Bernhem, Kalaiselvan Krishnan, Alexander Bondar, Hjalmar Brismar, Anita Aperia, Lena Scott. AT1-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers.
BMC cardiovascular disorders.
2017 05; 17(1):126. doi:
10.1186/s12872-017-0562-x. [PMID: 28514967] - Jun Chen, Michael J Sanderson. Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle.
The Journal of physiology.
2017 05; 595(10):3203-3218. doi:
10.1113/jp272694. [PMID: 27396568] - Sheon Mary, Heather Yvonne Small, Justyna Siwy, William Mullen, Ashok Giri, Christian Delles. Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.
Hypertension (Dallas, Tex. : 1979).
2017 05; 69(5):910-918. doi:
10.1161/hypertensionaha.116.08826. [PMID: 28348009] - Priscilla Kolibea Mante, Donatus Wewura Adongo, Eric Woode. Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
BMC research notes.
2017 Apr; 10(1):167. doi:
10.1186/s13104-017-2488-x. [PMID: 28446201] - Halina Falfushynska, Lesya Gnatyshyna, Oksana Horyn, Inna Sokolova, Oksana Stoliar. Endocrine and cellular stress effects of zinc oxide nanoparticles and nifedipine in marsh frogs Pelophylax ridibundus.
Aquatic toxicology (Amsterdam, Netherlands).
2017 Apr; 185(?):171-182. doi:
10.1016/j.aquatox.2017.02.009. [PMID: 28226256] - Yuwang Liu, Michael-Friedrich Boettcher, Anja Schmidt, Sigrun Unger, Atef Halabi, Erich Brendel, Hartmut Blode. Pharmacokinetics and safety of nifedipine GITS/candesartan fixed-dose combination in subjects with hepatic impairment
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International journal of clinical pharmacology and therapeutics.
2017 Mar; 55(3):246-255. doi:
10.5414/cp202700. [PMID: 28025965] - N Ozturk, D Ozturk, Z Pala-Kara, A Okyar. Pharmacokinetics of talinolol is modified by barnidipine: implication of P-glycoprotein modulation.
Die Pharmazie.
2017 Jan; 72(1):29-34. doi:
10.1691/ph.2017.6786. [PMID: 29441894] - Md Ashraf Ali, Noriko Kataoka, Abdul-Hackam Ranneh, Yasunori Iwao, Shuji Noguchi, Toshihiko Oka, Shigeru Itai. Enhancing the Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs Using Monoolein Cubosomes.
Chemical & pharmaceutical bulletin.
2017; 65(1):42-48. doi:
10.1248/cpb.c16-00513. [PMID: 28049915] - G Sargazi Zadeh, N Panahi. Endothelium-independent vasorelaxant activity of Trachyspermum ammi essential oil on rat aorta.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2017; 39(2):133-138. doi:
10.1080/10641963.2016.1235178. [PMID: 28287882] - Eikan Mishima, Kazuichi Maruyama, Toru Nakazawa, Takaaki Abe, Sadayoshi Ito. Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole.
Internal medicine (Tokyo, Japan).
2017; 56(13):1687-1690. doi:
10.2169/internalmedicine.56.8313. [PMID: 28674358] - Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns. Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2016 12; 12(4):380-385. doi:
10.1007/s13181-016-0572-6. [PMID: 27501853]