aminoglutethimide (BioDeep_00000398945)

Main id: BioDeep_00000006551

 

natural product


代谢物信息卡片


Aminoglutethimide (Cytadren)

化学式: C13H16N2O2 (232.1211716)
中文名称: 氨鲁米特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=CC=C(C=C1)N)C2(CCC(NC2=O)=O)CC
InChI: InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)

描述信息

L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BG - Aromatase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C2355 - Anti-Adrenal
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

aminoglutethimide; Aminoglutethimide (Cytadren)



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fenglin Luo, Yoshiaki Manse, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911233. [PMID: 36232534]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Long Zhao, Mei-Hong Chai, Hong-Fei Yao, Yan-Ping Huang, Zhao-Sheng Liu. Molecularly Imprinted Polymers Doped with Carbon Nanotube with Aid of Metal-Organic Gel for Drug Delivery Systems. Pharmaceutical research. 2020 Sep; 37(10):193. doi: 10.1007/s11095-020-02902-z. [PMID: 32914377]
  • M Bencze, A Vavřínová, J Zicha, M Behuliak. Pharmacological suppression of endogenous glucocorticoid synthesis attenuated blood pressure and heart rate response to acute restraint in Wistar rats. Physiological research. 2020 07; 69(3):415-426. doi: 10.33549/physiolres.934432. [PMID: 32469228]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yafei Xu, Scot M Hutchison, José J Hernández-Ledezma, Randy L Bogan. Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion. Molecular human reproduction. 2018 01; 24(1):2-13. doi: 10.1093/molehr/gax061. [PMID: 29177442]
  • Mayu Mutsuga, Yoshiji Asaoka, Naoko Imura, Tomoya Miyoshi, Yuko Togashi. Aminoglutethimide-induced lysosomal changes in adrenal gland in mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2017 Sep; 69(7):424-429. doi: 10.1016/j.etp.2017.04.004. [PMID: 28410883]
  • Ken'ichi Yamaguchi. Evaluation for roles of neurosteroids in modulating forebrain mechanisms controlling vasopressin secretion and related phenomena in conscious rats. Neuroscience research. 2015 Jun; 95(?):38-50. doi: 10.1016/j.neures.2015.01.002. [PMID: 25598212]
  • Jia-Ping Lai, Fang Chen, Hui Sun, Li Fan, Gui-Ling Liu. Molecularly imprinted microspheres for the anticancer drug aminoglutethimide: synthesis, characterization, and solid-phase extraction applications in human urine samples. Journal of separation science. 2014 May; 37(9-10):1170-6. doi: 10.1002/jssc.201400008. [PMID: 24596062]
  • Yoko Nishimura, Yuji Morikawa, Chiaki Kondo, Yutaka Tonomura, Ryou Fukushima, Mikinori Torii, Takeki Uehara. Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies. Journal of applied toxicology : JAT. 2013 Oct; 33(10):1120-30. doi: 10.1002/jat.2867. [PMID: 23558518]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Gunapala Shetty, Karen L Porter, Wei Zhou, Shan H Shao, Connie C Y Weng, Marvin L Meistrich. Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature. Endocrinology. 2011 Sep; 152(9):3504-14. doi: 10.1210/en.2011-0251. [PMID: 21733828]
  • Luiz Gustavo A Chuffa, Fábio R F Seiva, Wagner José Fávaro, Giovana R Teixeira, João P A Amorim, Leonardo O Mendes, Beatriz A Fioruci, Patrícia Fernanda F Pinheiro, Ana Angélica H Fernandes, Janete A A Franci, Flávia K Delella, Marcelo Martinez, Francisco E Martinez. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation. Reproductive biology and endocrinology : RB&E. 2011 Aug; 9(?):108. doi: 10.1186/1477-7827-9-108. [PMID: 21810236]
  • Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh, Paramvir S Ahuja. Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound. BMC chemical biology. 2011 May; 11(?):1. doi: 10.1186/1472-6769-11-1. [PMID: 21624145]
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  • Włodzimierz Matysiak, Barbara Jodłowska-Jedrych. Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies. Protoplasma. 2010 Oct; 246(1-4):109-18. doi: 10.1007/s00709-010-0194-9. [PMID: 20721677]
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  • Víctor Manuel Andía Melero, Rogelio García Centeno, Jesús Bayort Fernández, Carlos Vigovich, Petra Sánchez García-Cervigón, Antonino Jara Albarrán. [Feminizing adrenal tumours in Spain: report of a case and review of the five previously published patients]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 2009 Nov; 56(9):470-4. doi: 10.1016/s1575-0922(09)72970-5. [PMID: 20096213]
  • Cecilia Heng Vong, Maguelone Forest, Marc Nicolino. Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome. The Journal of pediatrics. 2009 Mar; 154(3):467-8; author reply 468. doi: 10.1016/j.jpeds.2008.12.003. [PMID: 19874777]
  • Yiu-Keung Lau, Manpreet K Chadha, Alan Litwin, Donald L Trump. A dramatic, objective antiandrogen withdrawal response: case report and review of the literature. Journal of hematology & oncology. 2008 Nov; 1(?):21. doi: 10.1186/1756-8722-1-21. [PMID: 18986533]
  • S Paoletta, G B Steventon, D Wildeboer, T M Ehrman, P J Hylands, D J Barlow. Screening of herbal constituents for aromatase inhibitory activity. Bioorganic & medicinal chemistry. 2008 Sep; 16(18):8466-70. doi: 10.1016/j.bmc.2008.08.034. [PMID: 18778944]
  • Per E Lønning, Jürgen Geisler. Aromatase inhibitors: assessment of biochemical efficacy measured by total body aromatase inhibition and tissue estrogen suppression. The Journal of steroid biochemistry and molecular biology. 2008 Feb; 108(3-5):196-202. doi: 10.1016/j.jsbmb.2007.09.017. [PMID: 17996443]
  • Stefano Gonnelli, Roberto Petrioli. Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer. Clinical interventions in aging. 2008; 3(4):647-57. doi: 10.2147/cia.s3466. [PMID: 19281057]
  • Tetsuo Nishikawa, Jun Saito, Masao Omura. [Medical treatment for Cushing's syndrome]. Nihon rinsho. Japanese journal of clinical medicine. 2008 Jan; 66(1):186-91. doi: . [PMID: 18186263]
  • David C Kem, Jordan P Metcalf, Ana Cornea, Monica Dunnam, Alice Engelbrecht, Xichun Yu. Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2007 Mar; 13(2):153-8. doi: 10.4158/ep.13.2.153. [PMID: 17490929]
  • Hershel Raff, Lauren Jacobson. Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat. The Journal of endocrinology. 2007 Feb; 192(2):453-8. doi: 10.1677/joe-06-0103. [PMID: 17283245]
  • Min-Jung Kang, Yong Hee Hwang, Won Lee, Dong-Hyun Kim. Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2007; 21(2):252-64. doi: 10.1002/rcm.2834. [PMID: 17171780]
  • Hiroaki Fukuda, Manabu Arai, Tomoki Soh, Nobuhiko Yamauchi, Masa-Aki Hattori. Progesterone regulation of the expression and function of multidrug resistance type I in porcine granulosa cells. Reproductive toxicology (Elmsford, N.Y.). 2006 Jul; 22(1):62-8. doi: 10.1016/j.reprotox.2005.11.003. [PMID: 16337358]
  • Marcy J Balunas, Bin Su, Serena Landini, Robert W Brueggemeier, A Douglas Kinghorn. Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. Journal of natural products. 2006 Apr; 69(4):700-3. doi: 10.1021/np050513p. [PMID: 16643058]
  • W Saeger, M Fassnacht. [Effects of drugs on the adrenal cortex and its tumors]. Der Pathologe. 2006 Feb; 27(1):61-4. doi: 10.1007/s00292-005-0804-z. [PMID: 16320017]
  • Samuel Cos, Alicia González, Andrés Güezmes, Maria Dolores Mediavilla, Carlos Martínez-Campa, Carolina Alonso-González, Emilio J Sánchez-Barceló. Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity. International journal of cancer. 2006 Jan; 118(2):274-8. doi: 10.1002/ijc.21401. [PMID: 16080194]
  • Carlos Castillo, Enrique F Castillo, Jorge López, Ruth M López. [Testosterone inhibits the contractile responses to phenylephrine associated with the release of intracellular calcium in rat aorta]. Gaceta medica de Mexico. 2006 Jan; 142(1):1-8. doi: . [PMID: 16548285]
  • Hanzhong Li, Weigang Yan, Quanzong Mao, Zhaolin Lu, Zhengpei Zeng. Role of adrenalectomy in ectopic ACTH syndrome. Endocrine journal. 2005 Dec; 52(6):721-6. doi: 10.1507/endocrj.52.721. [PMID: 16410664]
  • Mary Iruthayanathan, Yi-Hong Zhou, Gwen V Childs. Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors. Endocrinology. 2005 Dec; 146(12):5176-87. doi: 10.1210/en.2005-0811. [PMID: 16150906]
  • E Liszewska, R Rekawiecki, J Kotwica. Effect of progesterone on the expression of bax and bcl-2 and on caspase activity in bovine luteal cells. Prostaglandins & other lipid mediators. 2005 Dec; 78(1-4):67-81. doi: 10.1016/j.prostaglandins.2005.03.003. [PMID: 16303606]
  • K K Borowicz, S J Czuczwar. Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. Journal of neural transmission (Vienna, Austria : 1996). 2005 Jul; 112(7):891-903. doi: 10.1007/s00702-004-0238-4. [PMID: 15526139]
  • F Journe, C Chaboteaux, J-C Dumon, G Leclercq, G Laurent, J-J Body. Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells. British journal of cancer. 2004 Nov; 91(9):1703-10. doi: 10.1038/sj.bjc.6602181. [PMID: 15477866]
  • W H J Kruit, G Stoter, J G M Klijn. Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy. Anti-cancer drugs. 2004 Oct; 15(9):843-7. doi: 10.1097/00001813-200410000-00004. [PMID: 15457124]
  • Joseph Cernich, Jill D Jacobson, Wayne V Moore, Jadranka Popovic. Use of aromatase inhibitors in children with short stature. Pediatric endocrinology reviews : PER. 2004 Sep; 2(1):2-7. doi: ". [PMID: 16429098]
  • Nicoletta Zilembo, Emilio Bajetta, Ettore Bichisao, Antonia Martinetti, Ignazia La Torre, Paolo Bidoli, Raffaella Longarini, Tindara Portale, Ettore Seregni, Emilio Bombardieri. The estrogen suppression after sequential treatment with formestane in advanced breast cancer patients. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2004 May; 58(4):255-9. doi: 10.1016/j.biopha.2003.12.009. [PMID: 15183852]
  • Anthony Howell, Mitch Dowsett. Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. Breast cancer research : BCR. 2004; 6(6):269-74. doi: 10.1186/bcr945. [PMID: 15535858]
  • Tomoko Chiyo, Takeshi Yamazaki, Kenji Aoshika, Shiro Kominami, Yoshihiro Ohta. Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells. Endocrinology. 2003 Aug; 144(8):3376-81. doi: 10.1210/en.2002-221126. [PMID: 12865316]
  • Yan Chen, Branka Dabovic, Cristina Colarossi, Fabio R Santori, Mirjana Lilic, Stanislav Vukmanovic, Daniel B Rifkin. Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice. Journal of cellular physiology. 2003 Aug; 196(2):319-25. doi: 10.1002/jcp.10296. [PMID: 12811825]
  • L M Thurston, E Chin, K C Jonas, I J Bujalska, P M Stewart, D R E Abayasekara, A E Michael. Expression of 11beta-hydroxysteroid dehydrogenase (11betaHSD) proteins in luteinizing human granulosa-lutein cells. The Journal of endocrinology. 2003 Jul; 178(1):127-35. doi: 10.1677/joe.0.1780127. [PMID: 12844344]
  • Leonardo Ferrari, Emilio Bajetta, Antonia Martinetti, Luigi Celio, Raffaella Longarini, Ignazia La Torre, Roberto Buzzoni, Luca Gattinoni, Ettore Seregni, Emilio Bombardieri. Could exemestane affect insulin-like growth factors, interleukin 6 and bone metabolism in postmenopausal advanced breast cancer patients after failure on aminoglutethimide, anastrozole or letrozole?. International journal of oncology. 2003 May; 22(5):1081-9. doi: . [PMID: 12684675]
  • Rongzi Yan, Quang Nguyen, James Gonzaga, Mai Johnson, Ronald F Ritzmann, Eve M Taylor. Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones. Psychopharmacology. 2003 Apr; 166(4):400-7. doi: 10.1007/s00213-002-1350-5. [PMID: 12605287]
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