celecoxib (BioDeep_00000398859)
Main id: BioDeep_00000002549
natural product
代谢物信息卡片
Antibiotic CJ 14258
化学式: C17H14F3N3O2S (381.0759)
中文名称: 塞来昔布, 塞来昔布-D7
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=C(C=C1)S(N)(=O)=O)N2C(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)C
InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AH - Coxibs
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C80509 - COX-2 Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Production by Hericium ramosum. Antibiotic CJ 14258 is found in mushrooms.
同义名列表
3 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:41423
- KEGG: C07589
- KEGGdrug: D00567
- PubChem: 2662
- DrugBank: DB00482
- ChEMBL: CHEMBL118
- MeSH: Celecoxib
- foodb: FDB011022
- CAS: 184007-95-2
- CAS: 194044-54-7
- CAS: 544686-20-6
- CAS: 169590-42-5
- CAS: 544686-21-7
- CAS: 169590-42-5,184007-95-2, 194044-54-7
- MoNA: CCMSLIB00000078076
- PubChem: 9791
- PDB-CCD: CEL
- NIKKAJI: J833.239H
- RefMet: Celecoxib
- KNApSAcK: 41423
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Umme Ammara Maqbool Ahmad Ansari, Qamar Uddin, Nazim Husain, Tasleem Ahmad, Syeda Hajra Fatima, Ahmed Minhajuddin. Evaluation of the efficacy and safety of a herbal formulation for rheumatoid arthritis - A non-inferiority randomized controlled trial.
Journal of ethnopharmacology.
2024 May; 325(?):117833. doi:
10.1016/j.jep.2024.117833. [PMID: 38316221] - Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li. Combination Nano-Delivery Systems Remodel the Immunosuppressive Tumor Microenvironment for Metastatic Triple-Negative Breast Cancer Therapy.
Molecular pharmaceutics.
2024 May; 21(5):2148-2162. doi:
10.1021/acs.molpharmaceut.3c00242. [PMID: 38536949] - Mengying Wu, Wei Zhang, Xueru Zhou, Zijun Wang, Sha Li, Chenqi Guo, Yuping Yang, Rongping Zhang, Zhirong Zhang, Xun Sun, Tao Gong. An in situ forming gel co-loaded with pirarubicin and celecoxib inhibits postoperative recurrence and metastasis of breast cancer.
International journal of pharmaceutics.
2024 Mar; 653(?):123897. doi:
10.1016/j.ijpharm.2024.123897. [PMID: 38360289] - Shengqi Yang, Yongwei Jia, Jianpo Zhang, Weifeng Zhai, Yue Xie, Ji Guo. A randomized controlled trial: The efficacy and safety of Bushen Huoxue formula in the management of lower back pain from lumbar disc herniation.
Medicine.
2024 Feb; 103(7):e37293. doi:
10.1097/md.0000000000037293. [PMID: 38363892] - Youzhi Wang, Guoqing Yang, Huizhen Shen, Ying Liang, Haijuan Dong, Ximing Guo, Qingjing Hao, Jinxin Wang. Hybrids of selective COX-2 inhibitors and active derivatives of edaravone as COX-2 selective NSAIDs with free radical scavenging activity: Design, synthesis and biological activities.
European journal of medicinal chemistry.
2024 Feb; 266(?):116155. doi:
10.1016/j.ejmech.2024.116155. [PMID: 38266553] - Xiao-Xi Zheng, Cheng-Feng Zhang, Li-Qing Li, Jun-Rui Ye, Si-Yu Ren, Zhao Zhang, Xin He, Shi-Feng Chu, Nai-Hong Chen. Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB.
Brain research bulletin.
2024 Jan; ?(?):110871. doi:
10.1016/j.brainresbull.2024.110871. [PMID: 38211740] - Mengjie Zeng, Zhiquan Wu, Jinying Liang, Aimin Gong. Efficacy and safety of Sodium hyaluronate combined with Celecoxib for Knee osteoarthritis: A systematic review and meta-analysis.
Asian journal of surgery.
2023 Nov; ?(?):. doi:
10.1016/j.asjsur.2023.11.077. [PMID: 38008631] - Yulong Deng, Man Zhang, Wei Li, Shuguo Cui, Junge Dong, Chenglin Mu, Zhiyuan Zheng, Jiaxiang Yang. Investigation of the Therapeutic Effect and Mechanism of Holographic Meridian Scraping Therapy on Knee Osteoarthritis.
Alternative therapies in health and medicine.
2023 Oct; 29(7):440-443. doi:
". [PMID: 37573584] - Huan Liu, Rui Deng, Cheng-Wei Zhu, Hong-Kuan Han, Gang-Fan Zong, Lang Ren, Peng Cheng, Zhong-Hong Wei, Yang Zhao, Su-Yun Yu, Yin Lu. Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis.
Acta pharmacologica Sinica.
2023 Sep; ?(?):. doi:
10.1038/s41401-023-01158-8. [PMID: 37749237] - Urszula Bąk, Anna Krupa. Challenges and Opportunities for Celecoxib Repurposing.
Pharmaceutical research.
2023 Aug; ?(?):. doi:
10.1007/s11095-023-03571-4. [PMID: 37552383] - Jun Zhou, Fang Zeng, Shirui Cheng, Xiaohui Dong, Nannan Jiang, Xinyue Zhang, Chenjian Tang, Wenhua He, Yang Chen, Ning Sun, Yuanfang Zhou, Xinling Li, Shengjie Hu, Ruirui Sun, Max Wintermark, Weihua Yang, Fanrong Liang, Zhengjie Li. Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients.
CNS neuroscience & therapeutics.
2023 07; 29(7):1965-1980. doi:
10.1111/cns.14153. [PMID: 36890655] - Lichun Dong, Mingxuan Zhao, Huiyuan Huang, Runfang Guan, Ruixia Li, Yuxin Fan, Jin Feng, Juan Zhang, Wenhong Zou, Jiong Chen, Shuxian Long, Jianchang He. Bioequivalence of Celecoxib Capsules in Chinese Healthy Volunteers.
Clinical pharmacology in drug development.
2023 May; ?(?):. doi:
10.1002/cpdd.1270. [PMID: 37246720] - Hossein Ali Ebrahimi, Samira Esmaeli, Saleh Khezri, Ahmad Salimi. Curcumin-Loaded Chitosan Nanoparticle Preparation and Its Protective Effect on Celecoxib-induced Toxicity in Rat isolated Cardiomyocytes and Mitochondria.
Drug research.
2023 Mar; 73(3):125-136. doi:
10.1055/a-1960-3092. [PMID: 36423624] - Hui Xu, Chi Zhao, Guangxin Guo, Yulin Li, Xinyu A, Guowei Qiu, Yuxia Wang, Bingxin Kang, Xirui Xu, Jun Xie, Lianbo Xiao. The Effectiveness of Tuina in Relieving Pain, Negative Emotions, and Disability in Knee Osteoarthritis: A Randomized Controlled Trial.
Pain medicine (Malden, Mass.).
2023 03; 24(3):244-257. doi:
10.1093/pm/pnac127. [PMID: 35997590] - Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.
Toxicology letters.
2023 Feb; ?(?):. doi:
10.1016/j.toxlet.2023.02.009. [PMID: 36863539] - Yi Zhou, Xiaoyan Liu, Chuan Ding, Bingyan Xiang, Ling Yan. Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study.
Pain research & management.
2023; 2023(?):7088004. doi:
10.1155/2023/7088004. [PMID: 36686371] - Kimberley Elbrink, Sofie Van Hees, Dirk Roelant, Tine Loomans, René Holm, Filip Kiekens. The influence on the oral bioavailability of solubilized and suspended drug in a lipid nanoparticle formulation: In vitro and in vivo evaluation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 Oct; 179(?):1-10. doi:
10.1016/j.ejpb.2022.08.010. [PMID: 36031014] - Archana Yadav, Chetna Singh. Cyclooxygenase-2 activates the free radical-mediated apoptosis of polymorphonuclear leukocytes in the maneb- and paraquat-intoxicated rats.
Pesticide biochemistry and physiology.
2022 Oct; 187(?):105202. doi:
10.1016/j.pestbp.2022.105202. [PMID: 36127053] - Lilei Zhang, Ming Li, Wei Wang, Weiran Yu, Hua Liu, Kexin Wang, Mengyuan Chang, Chunyan Deng, Yanan Ji, Yuntian Shen, Lei Qi, Hualin Sun. Celecoxib alleviates denervation-induced muscle atrophy by suppressing inflammation and oxidative stress and improving microcirculation.
Biochemical pharmacology.
2022 09; 203(?):115186. doi:
10.1016/j.bcp.2022.115186. [PMID: 35882305] - Seham S El-Hawary, Mohamed A Rabeh, Mohamed A El Raey, Essam M Abd El-Kadder, Mansor Sobeh, Usama Ramadan Abdelmohsen, Amgad Albohy, Alexander M Andrianov, Ivan P Bosko, Mohammad M Al-Sanea, Dalia G El-Kolobby. Metabolomic profiling of three Araucaria species, and their possible potential role against COVID-19.
Journal of biomolecular structure & dynamics.
2022 09; 40(14):6426-6438. doi:
10.1080/07391102.2021.1885494. [PMID: 33596787] - Ozgu Aydogdu, Fernando Perez, Patrik Aronsson, Pinar Uyar Gocun, Thomas Carlsson, Peter Sandner, Bhavik Patel, Michael Winder. Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder function in an in vivo rat model of chronic prostatitis.
European journal of pharmacology.
2022 Jul; 927(?):175052. doi:
10.1016/j.ejphar.2022.175052. [PMID: 35643304] - Margaret Haney, Gillinder Bedi, Ziva D Cooper, Evan S Herrmann, Stephanie Collins Reed, Richard W Foltin, Philip J Kingsley, Lawrence J Marnett, Sachin Patel. Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers.
Addiction biology.
2022 Jul; 27(4):e13183. doi:
10.1111/adb.13183. [PMID: 35754107] - Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu. Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway.
Journal of cellular and molecular medicine.
2022 07; 26(14):3995-4006. doi:
10.1111/jcmm.17435. [PMID: 35713152] - Piotr Wójcik, Michał Biernacki, Natalia Domian, Neven Žarković, Elżbieta Skrzydlewska. Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids.
Biomolecules.
2022 06; 12(6):. doi:
10.3390/biom12060842. [PMID: 35740969] - Ahmed M Abd-Eldayem, Marwa A Dahpy, Dalia M Badary, Sulaiman Mohammed Alnasser, Mohammad Salem Hareedy. Celecoxib has Preventive and Therapeutic Benefits against Nephrotoxicity Caused by Gentamicin in Mice.
Drug research.
2022 Jun; 72(5):259-267. doi:
10.1055/a-1785-4005. [PMID: 35359021] - Fatma Abd El-Fattah Ragab, Yassin Mohammed Nissan, M Alaraby Salem, Mamdouh Moawad Ali, Ahmed Abbass Mohamed Abdelrahman Selim. Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity.
Natural product research.
2022 May; 36(10):2486-2494. doi:
10.1080/14786419.2021.1907383. [PMID: 33813964] - Eman Ibrahim Ibrahim, Iman Fathy Abou-El-Naga, Mona Mohamed El-Temsahy, Eman Sheta Ali Elsawy, Shaimaa Makled, Nermine Mogahed Fawzy Hussein Mogahed. A single oral dose of celecoxib-loaded solid lipid nanoparticles for treatment of different developmental stages of experimental schistosomiasis mansoni.
Acta tropica.
2022 May; 229(?):106342. doi:
10.1016/j.actatropica.2022.106342. [PMID: 35157841] - Nutchareeporn Nillert, Chantana Boonyarat, Jariya Umka Welbat, Komsun Bunreungthong, Ploenthip Puthongking, Wanassanun Pannangrong. Clausena Harmandiana root extract attenuated cognitive impairments via reducing amyloid accumulation and neuroinflammation in Aβ1-42-induced rats.
BMC complementary medicine and therapies.
2022 Apr; 22(1):108. doi:
10.1186/s12906-022-03591-4. [PMID: 35439990] - Guo Xiao, Yang Yunhao, Liao Dongmei, Pang Fang, Yang Zhixue, Zhu Zhengwei, Luo Ao, Tang Chenglin. Effect of manipulation on cartilage in rats with knee osteoarthritis based on the Rho-associated protein kinase/LIM kinase 1/Cofilin signaling pathways.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 04; 42(2):194-199. doi:
10.19852/j.cnki.jtcm.20220311.005. [PMID: 35473339] - Akinori Kaneguchi, Takuya Umehara, Kaoru Yamaoka, Junya Ozawa. Bilateral muscle atrophy after anterior cruciate ligament reconstruction in rats: Protective effects of anti-inflammatory drug celecoxib.
The Knee.
2022 Mar; 35(?):201-212. doi:
10.1016/j.knee.2022.03.011. [PMID: 35381572] - Junfeng Yang, Shanfu Wang, Lei Liu, Yang Shao, Jianwei Wang. The analgesic effect and safety of preoperative versus postoperative administration of celecoxib in patients who underwent arthroscopic rotator cuff repair: a randomized, controlled study.
Inflammopharmacology.
2022 Feb; 30(1):185-191. doi:
10.1007/s10787-021-00893-w. [PMID: 35094258] - Saman Atashbar, Zhaleh Jamali, Saleh Khezri, Ahmad Salimi. Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: An analysis for its cardiotoxic adverse effect.
Journal of biochemical and molecular toxicology.
2022 Jan; 36(1):e22934. doi:
10.1002/jbt.22934. [PMID: 34668290] - Wenxiao Jiang, Yijun Zhang, Ye Huang, Yunfeng Cheng. Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis.
Journal of healthcare engineering.
2022; 2022(?):1979892. doi:
10.1155/2022/1979892. [PMID: 35399859] - M Yasmin Begum, Riyaz Ali M Osmani, Ali Alqahtani, Mohammed Ghazwani, Umme Hani, Hissana Ather, Akhtar Atiya, Mohamed Rahamathulla, Ayesha Siddiqua. Development of stealth liposomal formulation of celecoxib: In vitro and in vivo evaluation.
PloS one.
2022; 17(4):e0264518. doi:
10.1371/journal.pone.0264518. [PMID: 35472207] - Tarek M Mostafa, Mohamed A Alm El-Din, Amira R Rashdan. Celecoxib as an adjuvant to chemotherapy for patients with metastatic colorectal cancer: A randomized controlled clinical study.
Saudi medical journal.
2022 Jan; 43(1):37-44. doi:
10.15537/smj.2022.43.1.20210574. [PMID: 35022282] - A Salimi, S Atashbar, M Shabani. Gallic acid inhibits celecoxib-induced mitochondrial permeability transition and reduces its toxicity in isolated cardiomyocytes and mitochondria.
Human & experimental toxicology.
2021 Dec; 40(12_suppl):S530-S539. doi:
10.1177/09603271211053299. [PMID: 34715756] - Yan Zhang, Han Shi, Ge Yang, Yongfeng Yang, Wenqiang Li, Meng Song, Minglong Shao, Xi Su, Luxian Lv. Associations between expression of indoleamine 2, 3-dioxygenase enzyme and inflammatory cytokines in patients with first-episode drug-naive Schizophrenia.
Translational psychiatry.
2021 11; 11(1):595. doi:
10.1038/s41398-021-01688-x. [PMID: 34802039] - Jesús A Mosquera-Sulbaran, Adriana Pedreañez, Yenddy Carrero, Diana Callejas. C-reactive protein as an effector molecule in Covid-19 pathogenesis.
Reviews in medical virology.
2021 11; 31(6):e2221. doi:
10.1002/rmv.2221. [PMID: 34773448] - Jessica A Martinez, Meghan B Skiba, H-H Sherry Chow, Wade M Chew, Kathylynn Saboda, Peter Lance, Nathan A Ellis, Elizabeth T Jacobs. A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium.
Nutrients.
2021 Oct; 13(11):. doi:
10.3390/nu13113877. [PMID: 34836131] - Xiaobin Huang, Leilei Zhong, Eefje van Helvoort, Floris Lafeber, Simon Mastbergen, Jan Hendriks, Janine N Post, Marcel Karperien. The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.
Cartilage.
2021 10; 12(4):496-504. doi:
10.1177/1947603519841676. [PMID: 30947534] - M U Maneesh, Syed Sagheer Ahmed, T Yunus Pasha, B Ramesh, Manish Majumder. A Simple Bioanalytical Method for Simultaneous Estimation of Amlodipine and Celecoxib in Rat Plasma by High Performance Liquid Chromatography.
Journal of chromatographic science.
2021 Jun; 59(7):627-633. doi:
10.1093/chromsci/bmab046. [PMID: 33912904] - Sumit Mukesh, Prachi Joshi, Arvind K Bansal, Mahesh Chand Kashyap, Sanjay K Mandal, Vasant Sathe, Abhay T Sangamwar. Amorphous Salts Solid Dispersions of Celecoxib: Enhanced Biopharmaceutical Performance and Physical Stability.
Molecular pharmaceutics.
2021 06; 18(6):2334-2348. doi:
10.1021/acs.molpharmaceut.1c00144. [PMID: 34003656] - Qilei Chen, Lin Zhu, Ka Man Yip, Yancheng Tang, Yi Liu, Tao Jiang, Jianye Zhang, Zhongzhen Zhao, Tao Yi, Hubiao Chen. A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz.
Journal of ethnopharmacology.
2021 May; 271(?):113849. doi:
10.1016/j.jep.2021.113849. [PMID: 33485983] - Jin Zhang, Ruiyi Ge, Ziquan Yang. Effect of celecoxib combined with glucosamine hydrochloride in promoting the functional recovery and decreasing the inflammatory factor levels in patients with knee osteoarthritis.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3(Special)):1277-1282. doi:
NULL. [PMID: 34602400] - Yang Zhang, Chao Ning, Huijie Zhou, Yingjie Yan, Fulai Liu, Yayun Huang. Interleukin-1β, interleukin-6, and interleukin-17A as indicators reflecting clinical response to celecoxib in ankylosing spondylitis patients.
Irish journal of medical science.
2021 May; 190(2):631-638. doi:
10.1007/s11845-020-02366-5. [PMID: 32955700] - Mennatallah A Gowayed, Amany Abdel-Bary, Rasha A El-Tahan. The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
BMC pharmacology & toxicology.
2021 05; 22(1):24. doi:
10.1186/s40360-021-00488-9. [PMID: 33933169] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Mohammad Abdel-Halim, Sara Sigler, Nora A S Racheed, Amr Hefnawy, Reem K Fathalla, Mennatallah A Hammam, Ahmed Maher, Yulia Maxuitenko, Adam B Keeton, Rolf W Hartmann, Matthias Engel, Gary A Piazza, Ashraf H Abadi. From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Journal of medicinal chemistry.
2021 04; 64(8):4462-4477. doi:
10.1021/acs.jmedchem.0c01120. [PMID: 33793216] - Saman Atashbar, Towhid Sabzalipour, Ahmad Salimi. Stabilization of Mitochondrial Function by Ellagic Acid Prevents Celecoxib-induced Toxicity in Rat Cardiomyocytes and Isolated Mitochondria.
Drug research.
2021 Apr; 71(4):219-227. doi:
10.1055/a-1308-1585. [PMID: 33276407] - Chao Wan, Jian-Yu Pang, Wei Jiang, Xiao-Wei Zhang, Xiang-Guo Hu. Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib.
The Journal of organic chemistry.
2021 03; 86(6):4557-4566. doi:
10.1021/acs.joc.0c02980. [PMID: 33586981] - Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.
European journal of medicinal chemistry.
2021 Mar; 213(?):113165. doi:
10.1016/j.ejmech.2021.113165. [PMID: 33454546] - Mohammed Imaduddin, Mahesh Sultania, B Vigneshwaran, Dillip Kumar Muduly, Madhabananda Kar. Metronomic therapy using Methotrexate and Celecoxib: A Boon for Oral Cancer patients during COVID-19 Pandemic.
Oral oncology.
2021 03; 114(?):105069. doi:
10.1016/j.oraloncology.2020.105069. [PMID: 33144057] - Rida Siddique, Faqir Muhammad, Bilal Aslam, M Naeem Faisal. Characterization and in vivo evaluation of nanoformulations in FCA induced rheumatoid arthritis in rats.
Pakistan journal of pharmaceutical sciences.
2021 Mar; 34(2(Supplementary)):787-793. doi:
". [PMID: 34275816] - Hetao Huang, Minghui Luo, Haodong Liang, Jianke Pan, Weiyi Yang, Lingfeng Zeng, Guihong Liang, Senrong Hou, Jinlong Zhao, Jun Liu. Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis.
Pain medicine (Malden, Mass.).
2021 02; 22(2):352-362. doi:
10.1093/pm/pnaa230. [PMID: 32797224] - Xue-Tao Xu, Jie Chen, Xiang Ren, Yu-Ran Ma, Xiao Wang, Yan-Yan Ma, Den-Gao Zhao, Ren-Ping Zhou, Kun Zhang, Susan Goodin, Dong-Li Li, Xi Zheng. Effects of atorvastatin in combination with celecoxib and tipifarnib on proliferation and apoptosis in pancreatic cancer sphere-forming cells.
European journal of pharmacology.
2021 Feb; 893(?):173840. doi:
10.1016/j.ejphar.2020.173840. [PMID: 33359649] - Hai-Jiao Chen, Hao-Ran Yang, Ying Zhi, Qing-Qiang Yao, Bo Liu. Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Bioorganic & medicinal chemistry letters.
2021 02; 34(?):127754. doi:
10.1016/j.bmcl.2020.127754. [PMID: 33347967] - Milene Volpato, Nicola Ingram, Sarah L Perry, Jade Spencer, Amanda D Race, Catriona Marshall, John M Hutchinson, Anna Nicolaou, Paul M Loadman, P Louise Coletta, Mark A Hull. Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid.
Cancer chemotherapy and pharmacology.
2021 02; 87(2):173-184. doi:
10.1007/s00280-020-04157-2. [PMID: 33040178] - Martins Ekor, Phyllis Elsie Owusu Agyei, Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Meshack Antwi-Adjei, Ewura Seidu Yahaya, Gordon Amoakohene, Patrick Kafui Akakpo. Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia.
PloS one.
2021; 16(8):e0247735. doi:
10.1371/journal.pone.0247735. [PMID: 34403420] - Regine Brox, Holger Hackstein. Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes.
PloS one.
2021; 16(8):e0254606. doi:
10.1371/journal.pone.0254606. [PMID: 34428217] - Carlos A Cañas, Felipe Cañas, Mario Bautista-Vargas, Fabio Bonilla-Abadía. Role of Tissue Factor in the Pathogenesis of COVID-19 and the Possible Ways to Inhibit It.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2021 Jan; 27(?):10760296211003983. doi:
10.1177/10760296211003983. [PMID: 33784877] - Glenn Lemmens, Joachim Brouwers, Jan Snoeys, Patrick Augustijns, Tim Vanuytsel. Insight into the Colonic Disposition of Sulindac in Humans.
Journal of pharmaceutical sciences.
2021 01; 110(1):259-267. doi:
10.1016/j.xphs.2020.09.034. [PMID: 33002468] - Jie Hu, Xin-Juan Su, Hui-Ling Si, Rui-Xiang Song, Fang Zhang, Xiang-Jun Qiu, Xing-Peng Chen. Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics.
Drug design, development and therapy.
2021; 15(?):2529-2541. doi:
10.2147/dddt.s314562. [PMID: 34163139] - Liping Mao, Jinxue Yang, Jiaxin Yue, Yang Chen, Hongrui Zhou, Dongdong Fan, Qiuhua Zhang, Simone Buraschi, Renato V Iozzo, Xiuli Bi. Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis.
Matrix biology : journal of the International Society for Matrix Biology.
2021 01; 95(?):1-14. doi:
10.1016/j.matbio.2020.10.001. [PMID: 33065248] - Semih Baghaki, Can Ege Yalcin, Hayriye Sema Baghaki, Servet Yekta Aydin, Basak Daghan, Ersin Yavuz. COX2 inhibition in the treatment of COVID-19: Review of literature to propose repositioning of celecoxib for randomized controlled studies.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Dec; 101(?):29-32. doi:
10.1016/j.ijid.2020.09.1466. [PMID: 33007455] - Tsong-Hai Lee, Pei-Shan Liu, Ming-Ming Tsai, Jiun-Liang Chen, Su-Jane Wang, Hsi-Lung Hsieh. The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling.
Cell communication and signaling : CCS.
2020 11; 18(1):185. doi:
10.1186/s12964-020-00680-0. [PMID: 33228717] - Rakesh Kumar Mishra, Anas Ahmad, Ajay Kumar, Akshay Vyawahare, Syed Shadab Raza, Rehan Khan. Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis.
Materials science & engineering. C, Materials for biological applications.
2020 Nov; 116(?):111103. doi:
10.1016/j.msec.2020.111103. [PMID: 32806257] - Khaled Attala, Maya S Eissa, Mohamed A Hasan, Magda M El-Henawee, Soad S Abd El-Hay. An enhanced first derivative synchronous spectrofluorimetric method for determination of the newly co-formulated drugs, amlodipine and celecoxib in pharmaceutical preparation and human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Oct; 240(?):118533. doi:
10.1016/j.saa.2020.118533. [PMID: 32526403] - Keisuke Okamoto, Yoshitaka Saito, Katsuya Narumi, Ayako Furugen, Ken Iseki, Masaki Kobayashi. Comparison of the nephroprotective effects of non-steroidal anti-inflammatory drugs on cisplatin-induced nephrotoxicity in vitro and in vivo.
European journal of pharmacology.
2020 Oct; 884(?):173339. doi:
10.1016/j.ejphar.2020.173339. [PMID: 32726655] - David Edberg, Debra Hoppensteadt, Amanda Walborn, Jawed Fareed, James Sinacore, Angelos Halaris. Plasma MCP-1 levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment.
Journal of psychiatric research.
2020 10; 129(?):189-197. doi:
10.1016/j.jpsychires.2020.06.010. [PMID: 32763585] - Koosha Kamali, Javad Nikbakht, Erfan Ayubi, Mostafa Nabizadeh, Saeedeh Sarhadi. Comparison of the Efficacy of Oxybutynin, Phenazopyridine, Celecoxib, and Placebo in the Treatment of Urinary Tract Symptoms after BCG Therapy in Patients with Bladder Tumors.
Urology journal.
2020 Sep; 18(4):439-444. doi:
10.22037/uj.v16i7.5947. [PMID: 32981029] - Pedro H F Araújo, Ryan S Ramos, Jorddy N da Cruz, Sebastião G Silva, Elenilze F B Ferreira, Lúcio R de Lima, Williams J C Macêdo, José M Espejo-Román, Joaquín M Campos, Cleydson B R Santos. Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184183. [PMID: 32932669] - Soley Bayraktar, Sema Baghaki, Jimin Wu, Diane D Liu, Angelica M Gutierrez-Barrera, Therese B Bevers, Vicente Valero, Nour Sneige, Banu K Arun. Biomarker Modulation Study of Celecoxib for Chemoprevention in Women at Increased Risk for Breast Cancer: A Phase II Pilot Study.
Cancer prevention research (Philadelphia, Pa.).
2020 09; 13(9):795-802. doi:
10.1158/1940-6207.capr-20-0095. [PMID: 32513785] - Seyedeh Maedeh Majidi, Mohammad Reza Hadjmohammadi. Dimethyldioctadecylanimonium bentonite immobilized magnetic chitosan nanoparticles as an efficient adsorbent for vortex-assisted magnetic dispersive micro-solid-phase extraction of celecoxib from human breast milk, plasma and urine samples.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4877. doi:
10.1002/bmc.4877. [PMID: 32386244] - Alexandra-Roxana Ilie, Brendan T Griffin, Martin Brandl, Annette Bauer-Brandl, Ann-Christin Jacobsen, Maria Vertzoni, Martin Kuentz, Ruzica Kolakovic, René Holm. Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Sep; 152(?):105452. doi:
10.1016/j.ejps.2020.105452. [PMID: 32622980] - B Mora-Ramiro, M Jiménez-Estrada, A Zentella-Dehesa, J L Ventura-Gallegos, L E Gomez-Quiroz, W Rosiles-Alanis, F J Alarcón-Aguilar, J C Almanza-Pérez. Cacalol Acetate, a Sesquiterpene from Psacalium decompositum, Exerts an Anti-inflammatory Effect through LPS/NF-KB Signaling in Raw 264.7 Macrophages.
Journal of natural products.
2020 08; 83(8):2447-2455. doi:
10.1021/acs.jnatprod.0c00300. [PMID: 32672964] - Sakshi Mishra, Aman Divakar, Sonal Srivastava, Jayant Dewangan, Divyansh Sharma, Somya Asthana, Swati Chaturvedi, Muhammad Wahajuddin, Sadan Kumar, Srikanta Kumar Rath. N-acetyl-cysteine in combination with celecoxib inhibits Deoxynivalenol induced skin tumor initiation via induction of autophagic pathways in swiss mice.
Free radical biology & medicine.
2020 08; 156(?):70-82. doi:
10.1016/j.freeradbiomed.2020.06.001. [PMID: 32561319] - Ruben Reyes-Sosa, Agustin Lugo-Radillo, Lizzet Cruz-Santiago, Celia Rubi Garcia-Cruz, Oliver Mendoza-Cano. Clinical comparison of platelet-rich plasma injection and daily celecoxib administration in the treatment of early knee osteoarthritis: A randomized clinical trial.
Journal of applied biomedicine.
2020 Aug; 18(2-3):41-45. doi:
10.32725/jab.2020.012. [PMID: 34907724] - Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo, Cheng-Wei Tang. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
World journal of gastroenterology.
2020 Jul; 26(28):4094-4107. doi:
10.3748/wjg.v26.i28.4094. [PMID: 32821072] - Jintao Liu, Yu Zhu, Zhiqiang Wang, Pengfei Yu, Chunchun Xue, Hong Jiang, Xiaofeng Li, Dezhi Tang. Clinical research for whether the Traditional Chinese medicine could promote the resorption of lumbar disc herniation: a randomized controlled trial.
Medicine.
2020 Jul; 99(27):e21069. doi:
10.1097/md.0000000000021069. [PMID: 32629737] - Stephen Murata, Michael Murphy, Debra Hoppensteadt, Jawed Fareed, Amanda Welborn, Angelos Halaris. Effects of adjunctive inflammatory modulation on IL-1β in treatment resistant bipolar depression.
Brain, behavior, and immunity.
2020 07; 87(?):369-376. doi:
10.1016/j.bbi.2020.01.004. [PMID: 31923551] - Ubaid Ullah, Haroon Badshah, Zulkifal Malik, Zia Uddin, Mahboob Alam, Sadia Sarwar, Akhtar Aman, Arif-Ullah Khan, Fawad Ali Shah. Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.
Immunopharmacology and immunotoxicology.
2020 Jun; 42(3):255-263. doi:
10.1080/08923973.2020.1746802. [PMID: 32249710] - Aleix Gimeno, Júlia Mestres-Truyol, María José Ojeda-Montes, Guillem Macip, Bryan Saldivar-Espinoza, Adrià Cereto-Massagué, Gerard Pujadas, Santiago Garcia-Vallvé. Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition.
International journal of molecular sciences.
2020 May; 21(11):. doi:
10.3390/ijms21113793. [PMID: 32471205] - Kiran A Vaidya, Matthew P Donnelly, Terence W Gee, Marine-Ayan Ibrahim Aibo, Stephen Byers, Jonathan T Butcher. Induction of aortic valve calcification by celecoxib and its COX-2 independent derivatives is glucocorticoid-dependent.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.
2020 May; 46(?):107194. doi:
10.1016/j.carpath.2019.107194. [PMID: 31982687] - Shirui Cheng, Ming Xin, Jun Zhou, Ying Cheng, Guixing Xu, Yuanfang Zhou, Zhengjie Li, Fanrong Liang. The cardiovascular risk of celecoxib for knee osteoarthritis: A protocol for systematic review and meta-analysis.
Medicine.
2020 May; 99(18):e19976. doi:
10.1097/md.0000000000019976. [PMID: 32358371] - Aaron J Schain, Agustin Melo-Carrillo, Sait Ashina, Andrew M Strassman, Rami Burstein. Celecoxib reduces cortical spreading depression-induced macrophage activation and dilatation of dural but not pial arteries in rodents: implications for mechanism of action in terminating migraine attacks.
Pain.
2020 05; 161(5):1019-1026. doi:
10.1097/j.pain.0000000000001789. [PMID: 31895267] - Jiahui Sun, Jing Li, Qi Liu, Min Jiang, Mengjia Yang, Siwen Zhan, Tong Qiu, Kaiyong He, Xueqiong Zhang. Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Apr; 146(?):105277. doi:
10.1016/j.ejps.2020.105277. [PMID: 32105783] - Yihui Ma, Lirong Yang, Xiuxiu Liu, Jun Yang, Xianglong Sun. Development of celecoxib-derived antifungals for crop protection.
Bioorganic chemistry.
2020 04; 97(?):103670. doi:
10.1016/j.bioorg.2020.103670. [PMID: 32088417] - Pratiksha Saxena, Pramod K Sharma, Priyank Purohit. A journey of celecoxib from pain to cancer.
Prostaglandins & other lipid mediators.
2020 04; 147(?):106379. doi:
10.1016/j.prostaglandins.2019.106379. [PMID: 31726219] - Mohamed A Shabaan, Aliaa M Kamal, Samar I Faggal, Ayman E Elsahar, Khaled O Mohamed. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
Archiv der Pharmazie.
2020 Apr; 353(4):e1900308. doi:
10.1002/ardp.201900308. [PMID: 32031284] - Hetao Huang, Jianke Pan, Weiyi Yang, Hongyun Chen, Guihong Liang, Lingfeng Zeng, Jun Liu, Biqi Pan. Celecoxib vs diclofenac sodium in patients with knee osteoarthritis: A protocol for systematic review and meta analysis.
Medicine.
2020 Apr; 99(15):e19680. doi:
10.1097/md.0000000000019680. [PMID: 32282721] - Glenn Lemmens, Joachim Brouwers, Jan Snoeys, Patrick Augustijns, Tim Vanuytsel. Insight into the colonic disposition of celecoxib in humans.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Mar; 145(?):105242. doi:
10.1016/j.ejps.2020.105242. [PMID: 32014580] - Ixsy A Ramirez, Nathan S Rubalcava, George B Mychaliska, Raja Rabah, Manuel Arteta. Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options.
Pediatric pulmonology.
2020 03; 55(3):788-790. doi:
10.1002/ppul.24666. [PMID: 31986238] - Rasha Abdelmawla Ghazala, Azza El Medney, Anisa Meleis, Passant Mohie El Dien, Hend Samir. Role of anti-inflammatory interventions in high-fat-diet-induced obesity.
Biomedical chromatography : BMC.
2020 Mar; 34(3):e4743. doi:
10.1002/bmc.4743. [PMID: 31715013] - Zhiyin Huang, Xiao Ma, Xintong Jia, Rui Wang, Ling Liu, Mingguang Zhang, Xiaoyan Wan, Chengwei Tang, Libin Huang. Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial.
The American journal of gastroenterology.
2020 03; 115(3):473-480. doi:
10.14309/ajg.0000000000000529. [PMID: 32142484] - Alexandra-Roxana Ilie, Brendan T Griffin, Ruzica Kolakovic, Maria Vertzoni, Martin Kuentz, René Holm. Supersaturated lipid-based drug delivery systems - exploring impact of lipid composition type and drug properties on supersaturability and physical stability.
Drug development and industrial pharmacy.
2020 Mar; 46(3):356-364. doi:
10.1080/03639045.2020.1721526. [PMID: 31975613] - Emma Hernandez-Sanabria, Evelien Heiremans, Marta Calatayud Arroyo, Ruben Props, Laurent Leclercq, Jan Snoeys, Tom Van de Wiele. Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation.
NPJ biofilms and microbiomes.
2020 02; 6(1):9. doi:
10.1038/s41522-020-0119-0. [PMID: 32075981] - Monica Feliz R Castillo, Arielle Cohen, David Edberg, Debra Hoppensteadt, Jawed Fareed, Brendan Martin, Angelos Halaris. Vascular endothelial growth factor in bipolar depression: A potential biomarker for diagnosis and treatment outcome prediction.
Psychiatry research.
2020 02; 284(?):112781. doi:
10.1016/j.psychres.2020.112781. [PMID: 31986357] - Shan Jiang, Guoqing Zhang, Lei Wang, Ye Zeng, Wenjie Liu, Zeneng Cheng. Development of a Two-Compartment System In vitro Dissolution Test and Correlation with In vivo Pharmacokinetic Studies for Celecoxib.
AAPS PharmSciTech.
2020 Jan; 21(2):59. doi:
10.1208/s12249-019-1612-8. [PMID: 31912248] - Rehab S Abdelrahman, Marwa E Abdelmageed. Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats.
Chemico-biological interactions.
2020 Jan; 315(?):108863. doi:
10.1016/j.cbi.2019.108863. [PMID: 31628940]
