Oxitriptan (BioDeep_00000398605)
Main id: BioDeep_00000000117
PANOMIX_OTCML-2023
代谢物信息卡片
L-5-Hydroxytryptophan
化学式: C11H12N2O3 (220.0848)
中文名称: 5-羟基色氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
InChI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
描述信息
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.053
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].
同义名列表
5 个代谢物同义名
L-5-Hydroxytryptophan; Oxitriptan 1; Oxitriptan; L-5-HTP; 5-Hydroxy-L-tryptophan
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:17780
- KEGG: C00643
- PubChem: 439280
- DrugBank: DB02959
- ChEMBL: CHEMBL350221
- MeSH: 5-Hydroxytryptophan
- CAS: 4350-09-8
- MoNA: BML81873
- MoNA: BML81872
- MoNA: BML81871
- MoNA: BML81870
- MoNA: BML01229
- MoNA: BML01223
- MoNA: BML01217
- PubChem: 3916
- KNApSAcK: C00001371
- PDB-CCD: 4PQ
- 3DMET: B01298
- NIKKAJI: J4.572A
- medchemexpress: HY-B1716
- KNApSAcK: 17780
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinying Fu, Siyang Yan, Zongren Hu, Wen Sheng, Wanyu Li, Shida Kuang, Xue Feng, Lumei Liu, Wei Zhang, Qinghu He. Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway.
Journal of ethnopharmacology.
2024 May; 326(?):117972. doi:
10.1016/j.jep.2024.117972. [PMID: 38403005] - Yu Fang, Yanqing Li, Xin Liao, Jie Deng, Qiannan Wang, Jingtao Liang, Bohua Yan. Corydalis yanhusuo Polysaccharides Ameliorate Chronic Stress-Induced Depression in Mice through Gut Microbiota-Derived Short-Chain Fatty Acid Activation of 5-Hydroxytryptamine Signaling.
Journal of medicinal food.
2023 Dec; 26(12):890-901. doi:
10.1089/jmf.2023.k.0050. [PMID: 38010856] - Liguo Liu, Dongmei Xu, Fengxin Chen, Shengnan Cai, Jin Wei, Jiaheng Deng, Jianhua Zheng, Qi Jin, Wenhui Lun. Identification of potential biomarkers for diagnosis of syphilis from the cerebrospinal fluid based on untargeted metabolomic analysis.
Molecular omics.
2023 Apr; ?(?):. doi:
10.1039/d3mo00026e. [PMID: 37185577] - Archana Sarangi, Mayukh Ghosh, Suman Sangwan, Rajesh Kumar, Sunesh Balhara, S K Phulia, R K Sharma, Subhasish Sahu, Sandeep Kumar, A K Mohanty, A K Balhara. Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes.
Scientific reports.
2022 09; 12(1):16295. doi:
10.1038/s41598-022-20298-1. [PMID: 36175438] - Ramkripa Raghavan, Neha S Anand, Guoying Wang, Xiumei Hong, Colleen Pearson, Barry Zuckerman, Hehuang Xie, Xiaobin Wang. Association between cord blood metabolites in tryptophan pathway and childhood risk of autism spectrum disorder and attention-deficit hyperactivity disorder.
Translational psychiatry.
2022 07; 12(1):270. doi:
10.1038/s41398-022-01992-0. [PMID: 35810183] - Pan Luo, Jiawen Xu, Shiqiang Cheng, Ke Xu, Wensen Jing, Feng Zhang, Peng Xu. Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites.
Scientific reports.
2022 05; 12(1):7888. doi:
10.1038/s41598-022-12021-x. [PMID: 35551264] - Saurabh Bhatia, Ahmed Al-Harrasi, Arun Kumar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Md Khalid Anwer, Deepak Kaushik, Vineet Mittal, Sridevi Chigurupati, Pritam Babu Sharma, Lotfi Aleya, Celia Vargas-de-la-Cruz, Md Tanvir Kabir. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn.
Environmental science and pollution research international.
2022 Apr; 29(18):27460-27478. doi:
10.1007/s11356-021-17810-x. [PMID: 34981370] - Yingying Wang, Xueman Chen, Qiaoyu Chen, Ning Zhou, Xin Wang, Alei Zhang, Kequan Chen, Pingkai Ouyang. Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.
Microbial cell factories.
2022 Mar; 21(1):47. doi:
10.1186/s12934-022-01745-0. [PMID: 35331215] - ZhiFei Zhang, Wei Du, WenYi Liu, Braden T Wong, HuiLing Zheng. Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats.
Journal of animal science.
2022 Mar; 100(3):. doi:
10.1093/jas/skac065. [PMID: 35235945] - A B Cunningham, J A Brinckmann, D E V Harter. From forest to pharmacy: Should we be depressed about a sustainable Griffonia simplicifolia (Fabaceae) seed supply chain?.
Journal of ethnopharmacology.
2021 Oct; 278(?):114202. doi:
10.1016/j.jep.2021.114202. [PMID: 33991640] - Jun Pan, Fengming Li, Caidie Wang, Xiaobin Li, Shiqi Zhang, Wenjie Zhang, Guodong Zhao, Chen Ma, Guoshi Liu, Kailun Yang. Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175275. [PMID: 34500708] - Ernesto Limón-Bernal, José E Roa-Coria, Ángel Zúñiga-Romero, Juan C Huerta-Cruz, Irma R C Ruíz-Velasco, Francisco J Flores-Murrieta, Eleazar Lara-Padilla, Juan G Reyes-García, Héctor I Rocha-González. Anorectic interaction and safety of 5-hydroxytryptophan/carbidopa plus phentermine or diethylpropion in rat.
Behavioural pharmacology.
2021 08; 32(5):368-381. doi:
10.1097/fbp.0000000000000625. [PMID: 33660661] - E E L Valente, M L Damasceno, J L Klotz, D L Harmon. Residual effects of abomasal 5-hydroxytryptophan administration on serotonin metabolism in cattle.
Domestic animal endocrinology.
2021 07; 76(?):106627. doi:
10.1016/j.domaniend.2021.106627. [PMID: 33882449] - Sena L Field, Marcela G Marrero, Lihe Liu, Francisco Peñagaricano, Jimena Laporta. Histological and transcriptomic analysis of adipose and muscle of dairy calves supplemented with 5-hydroxytryptophan.
Scientific reports.
2021 05; 11(1):9665. doi:
10.1038/s41598-021-88443-w. [PMID: 33958639] - Yuying Liu, Nannan Zhou, Li Zhou, Jing Wang, Yabo Zhou, Tianzhen Zhang, Yi Fang, Jinwei Deng, Yunfeng Gao, Xiaoyu Liang, Jiadi Lv, Zhenfeng Wang, Jing Xie, Yuanbo Xue, Huafeng Zhang, Jingwei Ma, Ke Tang, Yiliang Fang, Feiran Cheng, Chengjuan Zhang, Bing Dong, Yuzhou Zhao, Peng Yuan, Quanli Gao, Haizeng Zhang, F Xiao-Feng Qin, Bo Huang. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor.
Nature immunology.
2021 03; 22(3):358-369. doi:
10.1038/s41590-020-00850-9. [PMID: 33432230] - E E L Valente, J L Klotz, D L Harmon. 5-Hydroxytryptophan strongly stimulates serotonin synthesis in Holstein steers.
Domestic animal endocrinology.
2021 01; 74(?):106560. doi:
10.1016/j.domaniend.2020.106560. [PMID: 33035847] - Barbora Waclawiková, Amber Bullock, Markus Schwalbe, Carmen Aranzamendi, Sieger A Nelemans, Gertjan van Dijk, Sahar El Aidy. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.
PLoS biology.
2021 01; 19(1):e3001070. doi:
10.1371/journal.pbio.3001070. [PMID: 33481771] - Shabbir Ahmad, Mujahid Mohammed, Lakshmi Prasuna Mekala, Sasikala Chintalapati, Venkata Ramana Chintalapati. Tryptophan, a non-canonical melanin precursor: New L-tryptophan based melanin production by Rubrivivax benzoatilyticus JA2.
Scientific reports.
2020 06; 10(1):8925. doi:
10.1038/s41598-020-65803-6. [PMID: 32488041] - Maryam Zamanian-Daryoush, Valentin Gogonea, Anthony J DiDonato, Jennifer A Buffa, Ibrahim Choucair, Bruce S Levison, Randall A Hughes, Andrew D Ellington, Ying Huang, Xinmin S Li, Joseph A DiDonato, Stanley L Hazen. Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis.
The Journal of biological chemistry.
2020 04; 295(15):4836-4848. doi:
10.1074/jbc.ra119.012092. [PMID: 32098873] - Zheng Guan, Gabriel Jacobs, Hans van Pelt, Joop M A Van Gerven, Jacobus Burggraaf, Wei Zhao. PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva.
Pharmacology research & perspectives.
2020 04; 8(2):e00574. doi:
10.1002/prp2.574. [PMID: 32168433] - Susanna D Mitro, Gloria T Larrabure-Torrealva, Sixto E Sanchez, Samantha A Molsberry, Michelle A Williams, Clary Clish, Bizu Gelaye. Metabolomic markers of antepartum depression and suicidal ideation.
Journal of affective disorders.
2020 02; 262(?):422-428. doi:
10.1016/j.jad.2019.11.061. [PMID: 31744743] - Martijn van Faassen, Grytsje Bouma, Lotte D de Hosson, Marloes A M Peters, Gursah Kats-Ugurlu, Elisabeth G E de Vries, Annemiek M E Walenkamp, Ido P Kema. Quantitative Profiling of Platelet-Rich Plasma Indole Markers by Direct-Matrix Derivatization Combined with LC-MS/MS in Patients with Neuroendocrine Tumors.
Clinical chemistry.
2019 11; 65(11):1388-1396. doi:
10.1373/clinchem.2019.305359. [PMID: 31551315] - Jacob P R Jacobsen, Adrianna Oh, Rachel Bangle, Wendy L Roberts, Elizabeth L Royer, Nathan Modesto, Sonora A Windermere, Zixuan Yi, Rebecca Vernon, Manuel Cajina, Nikhil M Urs, Joshua C Snyder, Peter J Nicholls, Benjamin D Sachs, Marc G Caron. Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 11; 44(12):2082-2090. doi:
10.1038/s41386-019-0400-1. [PMID: 31035282] - Yildirim Kayacan, Hayrullah Yazar, Günay Cerit, Babak Elmi Ghojebeigloo. A new oxidative stress indicator: Effect of 5-hydroxytryptophan on thiol-disulfide homeostasis in exercise.
Nutrition (Burbank, Los Angeles County, Calif.).
2019 Jul; 63-64(?):114-119. doi:
10.1016/j.nut.2019.01.013. [PMID: 30939385] - Peijun Tian, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen. Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis.
The Journal of nutritional biochemistry.
2019 04; 66(?):43-51. doi:
10.1016/j.jnutbio.2019.01.007. [PMID: 30743155] - Ivano Vigliante, Giuseppe Mannino, Massimo E Maffei. Chemical Characterization and DNA Fingerprinting of Griffonia simplicifolia Baill.
Molecules (Basel, Switzerland).
2019 Mar; 24(6):. doi:
10.3390/molecules24061032. [PMID: 30875930] - Aruna Sharma, Rudy J Castellani, Mark A Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, Hari Shanker Sharma. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
International review of neurobiology.
2019; 146(?):1-44. doi:
10.1016/bs.irn.2019.06.005. [PMID: 31349924] - Tiantian Ye, Xiaoming Yin, Lei Yu, Shu-Jian Zheng, Wen-Jing Cai, Yan Wu, Yu-Qi Feng. Metabolic analysis of the melatonin biosynthesis pathway using chemical labeling coupled with liquid chromatography-mass spectrometry.
Journal of pineal research.
2019 Jan; 66(1):e12531. doi:
10.1111/jpi.12531. [PMID: 30299556] - Mi Ni, Qiong Wu, Gui S Wang, Qian Q Liu, Mei X Yu, Jun Tang. Analysis of metabolic changes in Trichoderma asperellum TJ01 at different fermentation time-points by LC-QQQ-MS.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2019; 54(1):20-26. doi:
10.1080/03601234.2018.1507227. [PMID: 30896331] - DSouza Serena Stephen, Asha Abraham. High-fat simple carbohydrate (HFSC) diet impairs hypothalamic and corpus striatal serotonergic metabolic pathway in metabolic syndrome (MetS) induced C57BL/6J mice.
Nutritional neuroscience.
2019 Jan; 22(1):51-62. doi:
10.1080/1028415x.2017.1354511. [PMID: 28745143] - Xiaomin Wang, Yukun Zuo, Hu Jiang, Li Yang. Relationship Between the Incidence of Road Traffic Accidents, Psychological Characteristics, and Genotype in Bus Drivers in a Chinese Population.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Aug; 24(?):5566-5572. doi:
10.12659/msm.909245. [PMID: 30096132] - Heidi Ormstad, Vesna Bryn, Robert Verkerk, Ola H Skjeldal, Bente Halvorsen, Ola Didrik Saugstad, Jorn Isaksen, Michael Maes. Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
CNS & neurological disorders drug targets.
2018; 17(8):626-639. doi:
10.2174/1871527317666180720163221. [PMID: 30033880] - Lorenzo E Hernández-Castellano, Ranya Özçelik, Laura L Hernandez, Rupert M Bruckmaier. Short communication: Supplementation of colostrum and milk with 5-hydroxy-l-tryptophan affects immune factors but not growth performance in newborn calves.
Journal of dairy science.
2018 Jan; 101(1):794-800. doi:
10.3168/jds.2017-13501. [PMID: 29102139] - Ulrich Gergs, Franziska Jung, Igor B Buchwalow, Britt Hofmann, Andreas Simm, Hendrik Treede, Joachim Neumann. Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human hearts.
American journal of physiology. Heart and circulatory physiology.
2017 Dec; 313(6):H1087-H1097. doi:
10.1152/ajpheart.00350.2017. [PMID: 28916638] - Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang. Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction.
Journal of proteome research.
2017 09; 16(9):3180-3189. doi:
10.1021/acs.jproteome.7b00168. [PMID: 28722418] - Lorenzo E Hernández-Castellano, Laura L Hernandez, Helga Sauerwein, Rupert M Bruckmaier. Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor.
Journal of dairy science.
2017 Jun; 100(6):5050-5057. doi:
10.3168/jds.2016-12441. [PMID: 28434742] - Lu Chen, Hui-Ting Lian, Xiang-Ying Sun, Bin Liu. Sensitive detection of L-5-hydroxytryptophan based on molecularly imprinted polymers with graphene amplification.
Analytical biochemistry.
2017 06; 526(?):58-65. doi:
10.1016/j.ab.2017.03.017. [PMID: 28327452] - Marta Pratelli, Sara Migliarini, Barbara Pelosi, Francesco Napolitano, Alessandro Usiello, Massimo Pasqualetti. Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry.
eNeuro.
2017 Mar; 4(2):. doi:
10.1523/eneuro.0376-16.2017. [PMID: 28413824] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto, Tsuyoshi Hattori. Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats.
Neurourology and urodynamics.
2017 03; 36(3):604-609. doi:
10.1002/nau.23028. [PMID: 27128660] - Lorenzo E Hernández-Castellano, Laura L Hernandez, Samantha Weaver, Rupert M Bruckmaier. Increased serum serotonin improves parturient calcium homeostasis in dairy cows.
Journal of dairy science.
2017 Feb; 100(2):1580-1587. doi:
10.3168/jds.2016-11638. [PMID: 27988124] - Joanna Gdula-Argasińska, Paweł Paśko, Katarzyna Sułkowska-Ziaja, Katarzyna Kała, Bożena Muszyńska. Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells.
Acta biochimica Polonica.
2017; 64(3):551-559. doi:
10.18388/abp.2017_1534. [PMID: 28880969] - Isabel M Vincent, Rónán Daly, Bertrand Courtioux, Amy M Cattanach, Sylvain Biéler, Joseph M Ndung'u, Sylvie Bisser, Michael P Barrett. Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.
PLoS neglected tropical diseases.
2016 12; 10(12):e0005140. doi:
10.1371/journal.pntd.0005140. [PMID: 27941966] - Jacob P R Jacobsen, Andrew D Krystal, K Ranga R Krishnan, Marc G Caron. Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.
Trends in pharmacological sciences.
2016 11; 37(11):933-944. doi:
10.1016/j.tips.2016.09.001. [PMID: 27692695] - Rashmi Srivastava, Chandra Mohini Chaturvedi. Expression of arginine vasotocin and estrogen receptor alpha (ERα) in the shell gland altered by the specific phase relations of neural oscillations affects the reproductive physiology of Japanese quail.
Physiology & behavior.
2016 10; 165(?):98-107. doi:
10.1016/j.physbeh.2016.07.001. [PMID: 27394660] - Amanda Eskelund, David P Budac, Connie Sanchez, Betina Elfving, Gregers Wegener. Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Neuroscience.
2016 08; 329(?):337-48. doi:
10.1016/j.neuroscience.2016.05.024. [PMID: 27210075] - Ouissame Mnie-Filali, Thorsten Lau, Friederike Matthaeus, Erika Abrial, Sarah Delcourte, Mostafa El Mansari, Alan Pershon, Patrick Schloss, Connie Sánchez, Nasser Haddjeri. Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.
CNS neuroscience & therapeutics.
2016 08; 22(8):691-9. doi:
10.1111/cns.12562. [PMID: 27171685] - Samantha R Weaver, Austin P Prichard, Elizabeth L Endres, Stefanie A Newhouse, Tonia L Peters, Peter M Crump, Matthew S Akins, Thomas D Crenshaw, Rupert M Bruckmaier, Laura L Hernandez. Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow.
The Journal of endocrinology.
2016 07; 230(1):105-23. doi:
10.1530/joe-16-0038. [PMID: 27390301] - Feng-Yan Yu, Shao-Gang Huang, Hai-Yan Zhang, Hua Ye, Hong-Gang Chi, Ying Zou, Ru-Xi Lv, Xue-Bao Zheng. Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis.
World journal of gastroenterology.
2016 Mar; 22(12):3451-9. doi:
10.3748/wjg.v22.i12.3451. [PMID: 27022227] - Lucyna Konieczna, Anna Roszkowska, Maciej Niedźwiecki, Tomasz Bączek. Hydrophilic interaction chromatography combined with dispersive liquid-liquid microextraction as a preconcentration tool for the simultaneous determination of the panel of underivatized neurotransmitters in human urine samples.
Journal of chromatography. A.
2016 Jan; 1431(?):111-121. doi:
10.1016/j.chroma.2015.12.062. [PMID: 26747692] - Marta Rysz, Ewa Bromek, Władysława A Daniel. Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450.
Biochemical pharmacology.
2016 Jan; 99(?):113-22. doi:
10.1016/j.bcp.2015.11.014. [PMID: 26581122] - Olle Eriksson, Anders Wall, Ulf Olsson, Ina Marteinsdottir, Maria Holstad, Hans Ågren, Per Hartvig, Bengt Långström, Tord Naessén. Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms.
PloS one.
2016; 11(9):e0159538. doi:
10.1371/journal.pone.0159538. [PMID: 27617751] - Yohei Sakaguchi, Jun Ikenaga, Hideyuki Yoshida, Tadashi Hayama, Miki Itoyama, Kenichiro Todoroki, Osamu Imakyure, Masatoshi Yamaguchi, Hitoshi Nohta. Selective and sensitive liquid chromatographic determination method of 5-hydroxyindoles with fluorous and fluorogenic derivatization.
Journal of pharmaceutical and biomedical analysis.
2015 Oct; 114(?):348-54. doi:
10.1016/j.jpba.2015.06.003. [PMID: 26112924] - D Keszthelyi, F J Troost, D M Jonkers, H M van Eijk, J Dekker, W A Buurman, A A M Masclee. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2015 Aug; 27(8):1127-37. doi:
10.1111/nmo.12600. [PMID: 26031193] - Andreas Frick, Fredrik Åhs, Jonas Engman, My Jonasson, Iman Alaie, Johannes Björkstrand, Örjan Frans, Vanda Faria, Clas Linnman, Lieuwe Appel, Kurt Wahlstedt, Mark Lubberink, Mats Fredrikson, Tomas Furmark. Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.
JAMA psychiatry.
2015 Aug; 72(8):794-802. doi:
10.1001/jamapsychiatry.2015.0125. [PMID: 26083190] - Maria Esposito, Francesco Precenzano, Michele Sorrentino, Deborah Avolio, Marco Carotenuto. A Medical Food Formulation of Griffonia simplicifolia/Magnesium for Childhood Periodic Syndrome Therapy: An Open-Label Study on Motion Sickness.
Journal of medicinal food.
2015 Aug; 18(8):916-20. doi:
10.1089/jmf.2014.0113. [PMID: 25590358] - Yun-Yun Shao, Jing Huang, Yan-Rong Ma, Miao Han, Kang Ma, Hong-Yan Qin, Zhi Rao, Xin-An Wu. Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Canadian journal of physiology and pharmacology.
2015 Aug; 93(8):633-9. doi:
10.1139/cjpp-2015-0039. [PMID: 26053941] - Jimena Laporta, Spencer A E Moore, Samantha R Weaver, Callyssa M Cronick, Megan Olsen, Austin P Prichard, Brian P Schnell, Thomas D Crenshaw, Francisco Peñagaricano, Rupert M Bruckmaier, Laura L Hernandez. Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows.
The Journal of endocrinology.
2015 Jul; 226(1):43-55. doi:
10.1530/joe-14-0693. [PMID: 26099356] - Bingjuan Han, Hui Zou, Bingchao Han, Weiwei Zhu, Zhiyang Cao, Yingxia Liu. Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China.
Brain & development.
2015 Jun; 37(6):592-8. doi:
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