Pergolide (BioDeep_00000398568)

Main id: BioDeep_00000003164

 


代谢物信息卡片


Pergolide

化学式: C19H26N2S (314.18165960000005)
中文名称: 培高利特
谱图信息: 最多检出来源 Homo sapiens(blood) 60%

分子结构信息

SMILES: CCCN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CSC
InChI: InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1

描述信息

N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BC - Dopamine agonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.736
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.732
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.731

同义名列表

1 个代谢物同义名

Pergolide



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A B Miller, A T Loynachan, H M Bush, K A Hart, V D Barker, A G Campana-Emard, S T Grubbs, A A Adams. Effects of pituitary pars intermedia dysfunction and Prascend (pergolide tablets) treatment on endocrine and immune function in horses. Domestic animal endocrinology. 2021 01; 74(?):106531. doi: 10.1016/j.domaniend.2020.106531. [PMID: 32942194]
  • R C Tatum, C M McGowan, J L Ireland. Efficacy of pergolide for the management of equine pituitary pars intermedia dysfunction: A systematic review. Veterinary journal (London, England : 1997). 2020 Dec; 266(?):105562. doi: 10.1016/j.tvjl.2020.105562. [PMID: 33323174]
  • D I Rendle, G Doran, J Ireland, S Edwards. Pharmacokinetics and pharmacodynamics of pergolide mesylate after oral administration in horses with pituitary pars intermedia dysfunction. Domestic animal endocrinology. 2019 07; 68(?):135-141. doi: 10.1016/j.domaniend.2019.01.008. [PMID: 31082785]
  • Garance Christen, Vinzenz Gerber, Johannes Hermanus van der Kolk, Caroline Franziska Frey, Nathalie Fouché. Fecal strongyle egg counts in horses with suspected pre-clinical pituitary pars intermedia dysfunction before and after treatment with pergolide. Veterinary journal (London, England : 1997). 2018 05; 235(?):60-62. doi: 10.1016/j.tvjl.2018.03.007. [PMID: 29704940]
  • D McFarlane, H Banse, H K Knych, L K Maxwell. Pharmacokinetic and pharmacodynamic properties of pergolide mesylate following long-term administration to horses with pituitary pars intermedia dysfunction. Journal of veterinary pharmacology and therapeutics. 2017 Apr; 40(2):158-164. doi: 10.1111/jvp.12339. [PMID: 27301465]
  • David I Rendle, Kris J Hughes, Gregory S Doran, Scott H Edwards. Pharmacokinetics of pergolide after intravenous administration to horses. American journal of veterinary research. 2015 Feb; 76(2):155-60. doi: 10.2460/ajvr.76.2.155. [PMID: 25629913]
  • Glenn A Jacobson, Adam Pirie, Scott Edwards, Kristopher J Hughes, David I Rendle, Noel W Davies. Determination of pergolide in horse plasma by UPLC-MS/MS for pharmacokinetic applications. Journal of pharmaceutical and biomedical analysis. 2014 Jun; 94(?):54-7. doi: 10.1016/j.jpba.2014.01.016. [PMID: 24549007]
  • Gregory Doran, Kristopher Hughes, David Rendle, Scott Edwards. The analysis of pergolide residues in horse plasma by LC with fluorescence detection. Journal of AOAC International. 2013 Nov; 96(6):1487-93. doi: 10.5740/jaoacint.12-282. [PMID: 24645533]
  • Lucian Hritcu, Alin Ciobica. Intranigral lipopolysaccharide administration induced behavioral deficits and oxidative stress damage in laboratory rats: relevance for Parkinson's disease. Behavioural brain research. 2013 Sep; 253(?):25-31. doi: 10.1016/j.bbr.2013.07.006. [PMID: 23850357]
  • Rupali A Patil, Yogesh A Hiray, Sanjay B Kasture. Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi. Indian journal of pharmacology. 2012 May; 44(3):340-4. doi: 10.4103/0253-7613.96307. [PMID: 22701243]
  • Alin Ciobica, Zenovia Olteanu, Manuela Padurariu, Lucian Hritcu. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. Journal of physiology and biochemistry. 2012 Mar; 68(1):59-69. doi: 10.1007/s13105-011-0119-x. [PMID: 22006204]
  • Motomi Arai. Levodopa in combination with carbidopa does not affect plasma arginine vasopressin levels in treatment-naïve older patients with Parkinson's disease: A before-after study. Neuro endocrinology letters. 2012; 33(1):34-6. doi: . [PMID: 22467109]
  • Bogdan Brodacki, Małgorzata Chalimoniuk, Jowita Wesołowska, Jacek Staszewski, Stanisław J Chrapusta, Adam Stępień, Józef Langfort. cGMP level in idiopathic Parkinson's disease patients with and without cardiovascular disease - A pilot study. Parkinsonism & related disorders. 2011 Nov; 17(9):689-92. doi: 10.1016/j.parkreldis.2011.07.003. [PMID: 21802341]
  • Kamal S Bhatia, Steven T Szabo, J Corey Fowler, William C Wetsel, Tong H Lee. Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine. Behavioural brain research. 2011 Sep; 223(1):227-32. doi: 10.1016/j.bbr.2011.04.045. [PMID: 21571009]
  • Monica A James-Smith, Brittney Hellner, Nancy Annunziato, Samir Mitragotri. Effect of surfactant mixtures on skin structure and barrier properties. Annals of biomedical engineering. 2011 Apr; 39(4):1215-23. doi: 10.1007/s10439-010-0190-4. [PMID: 21063778]
  • Motomi Arai. Increased plasma arginine vasopressin levels in dopamine agonist-treated Parkinson's disease patients. Neuro endocrinology letters. 2011; 32(1):39-43. doi: . [PMID: 21407160]
  • Angelo Antonini, Daniela Calandrella. Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson's disease: implications for patients. Neuropsychiatric disease and treatment. 2011; 7(?):297-302. doi: 10.2147/ndt.s10097. [PMID: 21654875]
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  • Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna Marrosu. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo). Neuropsychiatric disease and treatment. 2010 Sep; 6(?):483-90. doi: 10.2147/ndt.s5190. [PMID: 20856911]
  • Bernardo Soares, Anelise Arl Lima Reisser, Michael Farrell, Mauricio Silva de Lima. WITHDRAWN: Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. 2010 Feb; ?(2):CD003352. doi: 10.1002/14651858.cd003352.pub2. [PMID: 20166066]
  • Ronette Gehring, Laurie Beard, Abra Wright, Johann Coetzee, James Havel, Michael Apley. Single-dose oral pharmacokinetics of pergolide mesylate in healthy adult mares. Veterinary therapeutics : research in applied veterinary medicine. 2010; 11(1):E1-8. doi: . [PMID: 20949429]
  • Arnt F A Schellekens, K P Grootens, C Neef, Kris L L Movig, J K Buitelaar, B Ellenbroek, R J Verkes. Effect of apomorphine on cognitive performance and sensorimotor gating in humans. Psychopharmacology. 2010 Jan; 207(4):559-69. doi: 10.1007/s00213-009-1686-1. [PMID: 19834690]
  • Shin-ichi Ono, Kohji Hirai, Ei-ichi Tokuda. Effects of pergolide mesilate on metallothionein mRNAs expression in a mouse model for Parkinson disease. Biological & pharmaceutical bulletin. 2009 Oct; 32(10):1813-7. doi: 10.1248/bpb.32.1813. [PMID: 19801850]
  • Sanjeev Bhattacharyya, Anthony H Schapira, Dimitri P Mikhailidis, Joseph Davar. Drug-induced fibrotic valvular heart disease. Lancet (London, England). 2009 Aug; 374(9689):577-85. doi: 10.1016/s0140-6736(09)60252-x. [PMID: 19683643]
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  • Hideki Ohno, Masashi Nakajima, Shinsuke Fujioka, Kohnosuke Iwamoto, Mitsuru Kawamura. Overnight switching from ergot-derived dopamine agonists to pramipexole in patients with Parkinson's disease: an open preliminary trial in Japan. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2009 Jun; 16(6):790-2. doi: 10.1016/j.jocn.2008.09.001. [PMID: 19286385]
  • Narong Simakajornboon, Leila Kheirandish-Gozal, David Gozal. Diagnosis and management of restless legs syndrome in children. Sleep medicine reviews. 2009 Apr; 13(2):149-56. doi: 10.1016/j.smrv.2008.12.002. [PMID: 19186083]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • H Watanabe, M Hirayama, A Noda, M Ito, N Atsuta, J Senda, T Kaga, A Yamada, M Katsuno, T Niwa, F Tanaka, G Sobue. B-type natriuretic peptide and cardiovalvulopathy in Parkinson disease with dopamine agonist. Neurology. 2009 Feb; 72(7):621-6. doi: 10.1212/01.wnl.0000342467.47860.f2. [PMID: 19221295]
  • Muhammad M Nashatizadeh, Kelly E Lyons, Rajesh Pahwa. A review of ropinirole prolonged release in Parkinson's disease. Clinical interventions in aging. 2009; 4(?):179-86. doi: 10.2147/cia.s3358. [PMID: 19503779]
  • Motomi Arai, Masayasu Iwabuchi. Pramipexole as a possible cause of the syndrome of inappropriate antidiuresis. BMJ case reports. 2009; 2009(?):. doi: 10.1136/bcr.01.2009.1484. [PMID: 21687007]
  • S J A Haritou, R Zylstra, C Ralli, S Turner, D J Tortonese. Seasonal changes in circadian peripheral plasma concentrations of melatonin, serotonin, dopamine and cortisol in aged horses with Cushing's disease under natural photoperiod. Journal of neuroendocrinology. 2008 Aug; 20(8):988-96. doi: 10.1111/j.1365-2826.2008.01751.x. [PMID: 18540997]
  • David J Brooks. Optimizing levodopa therapy for Parkinson's disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective. Neuropsychiatric disease and treatment. 2008 Feb; 4(1):39-47. doi: 10.2147/ndt.s1660. [PMID: 18728816]
  • Philip Seeman. Antiparkinson therapeutic potencies correlate with their affinities at dopamine D2(High) receptors. Synapse (New York, N.Y.). 2007 Dec; 61(12):1013-8. doi: 10.1002/syn.20453. [PMID: 17853435]
  • Ubaldo Bonuccelli, Nicola Pavese. Role of dopamine agonists in Parkinson's disease: an update. Expert review of neurotherapeutics. 2007 Oct; 7(10):1391-9. doi: 10.1586/14737175.7.10.1391. [PMID: 17939774]
  • Andrzej Bogucki, Agata Gajos. [Choosing a dopamine agonist in Parkinson's disease]. Neurologia i neurochirurgia polska. 2007 Mar; 41(2 Suppl 1):S14-21. doi: . [PMID: 17941454]
  • Joseph Jankovic, Mark Stacy. Medical management of levodopa-associated motor complications in patients with Parkinson's disease. CNS drugs. 2007; 21(8):677-92. doi: 10.2165/00023210-200721080-00005. [PMID: 17630819]
  • Guy H Neild, Manuel Rodriguez-Justo, Catherine Wall, John O Connolly. Hyper-IgG4 disease: report and characterisation of a new disease. BMC medicine. 2006 Oct; 4(?):23. doi: 10.1186/1741-7015-4-23. [PMID: 17026742]
  • Dag Nyholm. Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update. Clinical pharmacokinetics. 2006; 45(2):109-36. doi: 10.2165/00003088-200645020-00001. [PMID: 16485914]
  • Miklos Z Molnar, Marta Novak, Istvan Mucsi. Management of restless legs syndrome in patients on dialysis. Drugs. 2006; 66(5):607-24. doi: 10.2165/00003495-200666050-00003. [PMID: 16620140]
  • Michal Pohanka, Petr Kanovský, Martin Bares, Jiri Pulkrábek, Ivan Rektor. The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson's disease induced by pergolide: evidence from the results of an open, prospective, one-year trial. Parkinsonism & related disorders. 2005 Dec; 11(8):509-12. doi: 10.1016/j.parkreldis.2005.03.004. [PMID: 15994112]
  • F Galluzzi, R Salti, S Stagi, F La Cauza, F Chiarelli. Reversible weight gain and prolactin levels--long-term follow-up in childhood. Journal of pediatric endocrinology & metabolism : JPEM. 2005 09; 18(9):921-4. doi: 10.1515/jpem.2005.18.9.921. [PMID: 16279371]
  • Tatyana D Sotnikova, Jean-Martin Beaulieu, Larry S Barak, William C Wetsel, Marc G Caron, Raul R Gainetdinov. Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS biology. 2005 Aug; 3(8):e271. doi: 10.1371/journal.pbio.0030271. [PMID: 16050778]
  • Claire Thalamas, Iris Rajman, Jaime Kulisevsky, Alberto Lledó, Alison E Mackie, Olivier Blin, Todd A Gillespie, Mary Seger, Olivier Rascol. Pergolide: multiple-dose pharmacokinetics in patients with mild to moderate Parkinson disease. Clinical neuropharmacology. 2005 May; 28(3):120-5. doi: 10.1097/01.wnf.0000168581.97083.9c. [PMID: 15965310]
  • D McFarlane, N Dybdal, M T Donaldson, L Miller, A E Cribb. Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction. Journal of neuroendocrinology. 2005 Feb; 17(2):73-80. doi: 10.1111/j.1365-2826.2005.01277.x. [PMID: 15796757]
  • G R A Focchi, M C Leite, A G Andrade, S Scivoletto. Use of dopamine agonist pergolide in outpatient treatment of cocaine dependence. Substance use & misuse. 2005; 40(8):1169-77. doi: 10.1081/ja-200030552. [PMID: 16040376]
  • M Chalimoniuk, A Stepień. Influence of the therapy with pergolide mesylate plus L-DOPA and with L-DOPA alone on serum cGMP level in PD patients. Polish journal of pharmacology. 2004 Sep; 56(5):647-50. doi: NULL. [PMID: 15591656]
  • Malgorzata Chalimoniuk, A Stepień, J B Strosznajder. Pergolide mesylate, a dopaminergic receptor agonist, applied with L-DOPA enhances serum antioxidant enzyme activity in Parkinson disease. Clinical neuropharmacology. 2004 Sep; 27(5):223-9. doi: 10.1097/01.wnf.0000145509.84389.ce. [PMID: 15602103]
  • M Pohanka, P Kanovský, M Bares, J Pulkrábek, I Rektor. Pergolide mesylate can improve sexual dysfunction in patients with Parkinson's disease: the results of an open, prospective, 6-month follow-up. European journal of neurology. 2004 Jul; 11(7):483-8. doi: 10.1111/j.1468-1331.2004.00820.x. [PMID: 15257688]
  • Serhat Ozkan, Omer Colak, Ceyhan Kutlu, Melek Ertan, Ozkan Alatas. Plasma homocysteine levels in pergolide-treated Parkinson disease patients. Clinical neuropharmacology. 2004 Jul; 27(4):163-5. doi: 10.1097/01.wnf.0000136890.78887.b9. [PMID: 15319701]
  • Mark T Donaldson, Alec J R Jorgensen, Jill Beech. Evaluation of suspected pituitary pars intermedia dysfunction in horses with laminitis. Journal of the American Veterinary Medical Association. 2004 Apr; 224(7):1123-7. doi: 10.2460/javma.2004.224.1123. [PMID: 15074858]
  • Olivier Blin. The pharmacokinetics of pergolide in Parkinson's disease. Current opinion in neurology. 2003 Dec; 16 Suppl 1(?):S9-12. doi: 10.1097/00019052-200312001-00003. [PMID: 15180132]
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  • Nicola Hughes, Witold Winnik, Jean-Jacques Dunyach, Ma'an Amad, Maurizio Splendore, Gary Paul. High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities. Journal of mass spectrometry : JMS. 2003 Jul; 38(7):743-51. doi: 10.1002/jms.489. [PMID: 12898654]
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  • Mark T Donaldson, Bernadette H LaMonte, Peter Morresey, Gary Smith, Jill Beech. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease). Journal of veterinary internal medicine. 2002 Nov; 16(6):742-6. doi: 10.1892/0891-6640(2002)016<0742:twpoco>2.3.co;2. [PMID: 12465775]
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