Quinine (BioDeep_00000398542)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Quinine

化学式: C20H24N2O2 (324.1838)
中文名称: 奎宁, DSSTox_GSID_44280
谱图信息: 最多检出来源 Viridiplantae(plant) 65.99%

分子结构信息

SMILES: C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5966; ORIGINAL_PRECURSOR_SCAN_NO 5964
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BC - Methanolquinolines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5977; ORIGINAL_PRECURSOR_SCAN_NO 5975
CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5998; ORIGINAL_PRECURSOR_SCAN_NO 5996
CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5996; ORIGINAL_PRECURSOR_SCAN_NO 5994
CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6003; ORIGINAL_PRECURSOR_SCAN_NO 6001
CONFIDENCE standard compound; INTERNAL_ID 270; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6016; ORIGINAL_PRECURSOR_SCAN_NO 6013
Origin: Plant; SubCategory_DNP: Monoterpenoid indole alkaloids, Cinchona alkaloids, Indole alkaloids
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.728
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.722
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.721
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].

同义名列表

3 个代谢物同义名

Quinine; Quinine; DSSTox_GSID_44280



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

83 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ALB, AXIN2, CAT, CYP1A1, CYP2C19, CYP2D6, CYP3A4, G6PD
Peripheral membrane protein 3 CYP1A1, CYP1B1, G6PD
Endoplasmic reticulum membrane 6 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4
Nucleus 3 ALB, AXIN2, FOS
cytosol 5 ALB, AXIN2, CAT, FOS, G6PD
centrosome 2 ALB, AXIN2
nucleoplasm 1 FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 3 ABCB1, GJD2, TNF
Multi-pass membrane protein 4 ABCB1, GJD2, KCNA3, TAS2R38
Synapse 1 GJD2
cell surface 3 ABCB1, ITGA2B, TNF
glutamatergic synapse 1 KCNA3
Golgi apparatus 2 ALB, TAS1R3
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 TNF
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 1 G6PD
plasma membrane 10 ABCB1, AXIN2, CYP2C19, GCG, GJD2, ITGA2B, KCNA3, TAS1R3, TAS2R38, TNF
Membrane 10 ABCB1, CAT, CYP1B1, CYP2D6, CYP3A4, G6PD, ITGA2B, KCNA3, TAS1R3, TAS2R38
apical plasma membrane 1 ABCB1
axon 1 KCNA3
extracellular exosome 5 ABCB1, ALB, CAT, G6PD, ITGA2B
endoplasmic reticulum 3 ALB, CYP2D6, FOS
extracellular space 4 ALB, GCG, INS, TNF
perinuclear region of cytoplasm 1 KCNA3
mitochondrion 4 CAT, CYP1A1, CYP1B1, CYP2D6
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 8 CAT, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, G6PD
Microsome membrane 5 CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
Single-pass type I membrane protein 1 ITGA2B
Secreted 3 ALB, GCG, INS
extracellular region 5 ALB, CAT, GCG, INS, TNF
cytoplasmic side of plasma membrane 1 G6PD
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
centriolar satellite 1 G6PD
external side of plasma membrane 2 ITGA2B, TNF
beta-catenin destruction complex 1 AXIN2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 2 KCNA3, TNF
focal adhesion 2 CAT, ITGA2B
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Cell junction, gap junction 1 GJD2
connexin complex 1 GJD2
ciliary basal body 1 ALB
chromatin 1 FOS
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, ITGA2B
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 1 INS
voltage-gated potassium channel complex 1 KCNA3
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, GCG, INS
nuclear matrix 1 FOS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calyx of Held 1 KCNA3
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 KCNA3
platelet alpha granule membrane 1 ITGA2B
integrin complex 1 ITGA2B
transcription factor AP-1 complex 1 FOS
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
integrin alphaIIb-beta3 complex 1 ITGA2B
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
sweet taste receptor complex 1 TAS1R3


文献列表

  • Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds. Insect science. 2024 Apr; 31(2):448-468. doi: 10.1111/1744-7917.13301. [PMID: 38010036]
  • Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects]. Medecine tropicale et sante internationale. 2023 06; 3(2):. doi: 10.48327/mtsi.v3i2.2023.378. [PMID: 37525671]
  • Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine. The American journal of tropical medicine and hygiene. 2023 01; 108(1):7-11. doi: 10.4269/ajtmh.22-0404. [PMID: 36410328]
  • Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization. Journal of chromatography. A. 2022 Nov; 1683(?):463550. doi: 10.1016/j.chroma.2022.463550. [PMID: 36219969]
  • Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats. BMC immunology. 2022 10; 23(1):50. doi: 10.1186/s12865-022-00519-y. [PMID: 36261807]
  • M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001). Die Pharmazie. 2022 09; 77(7):278-285. doi: 10.1691/ph.2022.2034. [PMID: 36199186]
  • Peyman Rezaie, Vida Bitarafan, Braden D Rose, Kylie Lange, Jens F Rehfeld, Michael Horowitz, Christine Feinle-Bisset. Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex. The Journal of clinical endocrinology and metabolism. 2022 06; 107(7):e2870-e2881. doi: 10.1210/clinem/dgac182. [PMID: 35325161]
  • Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092662. [PMID: 35566014]
  • Teerachat Sae-Heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang, Kesara Na-Bangchang. Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. CPT: pharmacometrics & systems pharmacology. 2022 01; 11(1):104-115. doi: 10.1002/psp4.12737. [PMID: 34730282]
  • Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen. PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice. Frontiers in endocrinology. 2022; 13(?):781404. doi: 10.3389/fendo.2022.781404. [PMID: 35340329]
  • Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang, Tian-Lin Wu, Yu Sun, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids. Journal of agricultural and food chemistry. 2021 Oct; 69(41):12156-12170. doi: 10.1021/acs.jafc.1c05677. [PMID: 34623798]
  • Daniel M Gelfman. Reflections on quinine and its importance in dermatology today. Clinics in dermatology. 2021 Sep; 39(5):900-903. doi: 10.1016/j.clindermatol.2021.08.017. [PMID: 34785019]
  • M G Semedo, A L Pereira, J R Pita. The influence of German science on Cinchona and quinine research in Portugal in the second half of the 19th century. Die Pharmazie. 2021 08; 76(8):396-402. doi: 10.1691/ph.2021.1050. [PMID: 34412740]
  • Wout Verbeure, Eveline Deloose, Joran Tóth, Jens F Rehfeld, Lukas Van Oudenhove, Inge Depoortere, Jan Tack. The endocrine effects of bitter tastant administration in the gastrointestinal system: intragastric versus intraduodenal administration. American journal of physiology. Endocrinology and metabolism. 2021 07; 321(1):E1-E10. doi: 10.1152/ajpendo.00636.2020. [PMID: 34029163]
  • Inoussa Sanané, Judith Legrand, Christine Dillmann, Frédéric Marion-Poll. High-Throughput Feeding Bioassay for Lepidoptera Larvae. Journal of chemical ecology. 2021 Jul; 47(7):642-652. doi: 10.1007/s10886-021-01290-x. [PMID: 34331170]
  • Braden D Rose, Vida Bitarafan, Peyman Rezaie, Penelope C E Fitzgerald, Michael Horowitz, Christine Feinle-Bisset. Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying. The Journal of nutrition. 2021 06; 151(6):1453-1461. doi: 10.1093/jn/nxab020. [PMID: 33704459]
  • Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba, Ekkehard Brysch, Michael Schindler, Ulrich Schubert. Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2. Viruses. 2021 04; 13(4):. doi: 10.3390/v13040647. [PMID: 33918670]
  • Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, Sarah E O'Connor. Early and Late Steps of Quinine Biosynthesis. Organic letters. 2021 03; 23(5):1793-1797. doi: 10.1021/acs.orglett.1c00206. [PMID: 33625237]
  • Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste. Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041992. [PMID: 33671466]
  • Wei Wei, Xingyue Wu, Chaoyuan Jin, Tong Mu, Guorong Gu, Min Min, Sucheng Mu, Yi Han. Predictive Significance of the Prognostic Nutritional Index (PNI) in Patients with Severe COVID-19. Journal of immunology research. 2021; 2021(?):9917302. doi: 10.1155/2021/9917302. [PMID: 34337084]
  • Andrew D S Duncan, Simona Hapca, Nicosha De Souza, Daniel Morales, Samira Bell. Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people. Age and ageing. 2020 10; 49(6):1042-1047. doi: 10.1093/ageing/afaa079. [PMID: 32463438]
  • Aurelie Vandenbeuch, Courtney E Wilson, Sue C Kinnamon. Optogenetic Activation of Type III Taste Cells Modulates Taste Responses. Chemical senses. 2020 10; 45(7):533-539. doi: 10.1093/chemse/bjaa044. [PMID: 32582939]
  • Ingrid Berling, Joshua D King, Greene Shepherd, Robert S Hoffman, Badria Alhatali, Valery Lavergne, Darren M Roberts, Sophie Gosselin, Gabrielle Wilson, Thomas D Nolin, Marc Ghannoum. Extracorporeal Treatment for Chloroquine, Hydroxychloroquine, and Quinine Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Journal of the American Society of Nephrology : JASN. 2020 10; 31(10):2475-2489. doi: 10.1681/asn.2020050564. [PMID: 32963091]
  • A G Tolkushin, E A Luchinin, M E Kholovnya-Voloskova, A A Zavyalov. [History of aminoquinoline preparations: from cinchona bark to chloroquine and hydroxychloroquinon]. Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny. 2020 Oct; 28(Special Issue):1118-1122. doi: 10.32687/0869-866x-2020-28-s2-1118-1122. [PMID: 33219768]
  • Davoud Kianifard, Seyyed Maysam Mousavi Shoar, Ahmed Aly, Leila Kianifard, Farhad Rezaee. Administration of Nicotine Exacerbates the Quinine-induced Structural and Functional Alterations of Testicular Tissue in Adult Rats: An Experimental Study. Urology journal. 2020 Jul; 18(1):103-110. doi: 10.22037/uj.v16i7.5884. [PMID: 32748385]
  • Victoria V Golovchenko, Shinen Naranmandakh, Jamsranjav Ganbaatar, Artur Yu Prilepskii, Gennady L Burygin, Alexander O Chizhov, Alexander S Shashkov. Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk. Phytochemistry. 2020 Jul; 175(?):112313. doi: 10.1016/j.phytochem.2020.112313. [PMID: 32353551]
  • X J Wang, Y S Yang, K Shen, J Wang, F Han, G F Wu, Y Li, X Z Bai, L Luo, D H Hu. [Effects and mechanism of pyrroloquinoline quinine on mitochondrial function and cell survival of rat bone marrow mesenchymal stem cells under oxidative stress]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2020 May; 36(5):378-387. doi: 10.3760/cma.j.cn501120-20190806-00335. [PMID: 32456375]
  • Nataly Allasi Canales, Tobias Nikolaj Gress Hansen, Claus Cornett, Kim Walker, Felix Driver, Alexandre Antonelli, Carla Maldonado, Mark Nesbitt, Christopher J Barnes, Nina Rønsted. Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies. Journal of ethnopharmacology. 2020 Mar; 249(?):112375. doi: 10.1016/j.jep.2019.112375. [PMID: 31698039]
  • Vida Bitarafan, Penelope C E Fitzgerald, Tanya J Little, Wolfgang Meyerhof, Karen L Jones, Tongzhi Wu, Michael Horowitz, Christine Feinle-Bisset. Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 02; 318(2):R263-R273. doi: 10.1152/ajpregu.00294.2019. [PMID: 31774306]
  • Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. European journal of medicinal chemistry. 2020 Jan; 185(?):111857. doi: 10.1016/j.ejmech.2019.111857. [PMID: 31734022]
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  • Zhiping Che, Jinming Yang, Di Sun, Yuee Tian, Shengming Liu, Xiaomin Lin, Jia Jiang, Genqiang Chen. Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents. Combinatorial chemistry & high throughput screening. 2020; 23(2):111-118. doi: 10.2174/1386207323666200120112714. [PMID: 31958039]
  • Julie Iven, Jessica R Biesiekierski, Dongxing Zhao, Eveline Deloose, Owen G O'Daly, Inge Depoortere, Jan Tack, Lukas Van Oudenhove. Intragastric quinine administration decreases hedonic eating in healthy women through peptide-mediated gut-brain signaling mechanisms. Nutritional neuroscience. 2019 Dec; 22(12):850-862. doi: 10.1080/1028415x.2018.1457841. [PMID: 29607741]
  • Kanae Nishimura, Noboru Okamura, Tetsutaro Kimachi, Jun Haginaka. Evaluation of molecularly imprinted polymers for chlorpromazine and bromopromazine prepared by multi-step swelling and polymerization method-The application for the determination of chlorpromazine and its metabolites in rat plasma by column-switching LC. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):248-255. doi: 10.1016/j.jpba.2019.05.063. [PMID: 31181487]
  • Anna Svedberg, Svante Vikingsson, Anders Vikström, Niels Hornstra, Magnus Kentson, Eva Branden, Hirsh Koyi, Bengt Bergman, Henrik Gréen. Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients. British journal of clinical pharmacology. 2019 08; 85(8):1704-1709. doi: 10.1111/bcp.13953. [PMID: 30945322]
  • F Azadmehr, K Zarei. Fabrication of an imprinted electrochemical sensor from l-tyrosine, 3-methyl-4-nitrophenol and gold nanoparticles for quinine determination. Bioelectrochemistry (Amsterdam, Netherlands). 2019 Jun; 127(?):59-67. doi: 10.1016/j.bioelechem.2019.01.001. [PMID: 30703737]
  • Kai Wu, Yi Yao, Fang Chen, Mingxing Xu, Guangquan Lu, Tingting Jiang, Ziyu Liu, Weixing Du, Fang Li, Rugui Li, Huabing Tan, Jian Li. Analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe1) polymorphisms among imported African malaria parasites isolated in Wuhan, Central China. BMC infectious diseases. 2019 Apr; 19(1):354. doi: 10.1186/s12879-019-3921-7. [PMID: 31035938]
  • Dietrich Mebs, Cora Wunder, Stefan W Toennes. Coping with noxious effects of quinine by praying mantids (Mantodea) and spiders (Araneae). Toxicon : official journal of the International Society on Toxinology. 2019 Apr; 162(?):57-60. doi: 10.1016/j.toxicon.2019.03.017. [PMID: 30904569]
  • Shoji Maehara, Andria Agusta, Yoshimi Tokunaga, Hirotaka Shibuya, Toshiyuki Hata. Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan. Journal of natural medicines. 2019 Mar; 73(2):431-438. doi: 10.1007/s11418-018-1273-z. [PMID: 30552602]
  • Jinrong Li, Christian H Lemon. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 02; 39(9):1631-1648. doi: 10.1523/jneurosci.2000-18.2018. [PMID: 30606758]
  • Naohiro Imura, Masamichi Ae, Rin Hoshino, Masami Abe, Tatsuya Yamamuro, Keisuke Oyama, Yasuo Oyama. Membrane hyperpolarization and depolarization of rat thymocytes by azoxystrobin, a post harvest fungicide. Chemico-biological interactions. 2019 Feb; 300(?):35-39. doi: 10.1016/j.cbi.2019.01.006. [PMID: 30629953]
  • Chee Tung Tai, Hong Heng See. Rapid quantification of quinine by multi-stacking in a portable microchip electrophoresis system. Electrophoresis. 2019 02; 40(3):455-461. doi: 10.1002/elps.201800398. [PMID: 30450561]
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