prazosin (BioDeep_00000398448)
Main id: BioDeep_00000002066
Chemicals and Drugs
代谢物信息卡片
prazosin
化学式: C19H21N5O4 (383.1593)
中文名称: 哌唑嗪
谱图信息:
最多检出来源 Bos taurus(endogenous) 42.86%
分子结构信息
SMILES: COc(c1)c(OC)cc(c(N)4)c1nc(n4)N(C3)CCN(C3)C(=O)c(c2)occ2
InChI: InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.767
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.759
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.760
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.
同义名列表
数据库引用编号
35 个数据库交叉引用编号
- ChEBI: CHEBI:8364
- KEGG: C07368
- KEGGdrug: D08411
- PubChem: 4893
- DrugBank: DB00457
- ChEMBL: CHEMBL2
- MeSH: Prazosin
- CAS: 19216-56-9
- MoNA: WA002468
- MoNA: WA002467
- MoNA: WA002466
- MoNA: WA002465
- MoNA: WA002464
- MoNA: FiehnHILIC002942
- MoNA: FiehnHILIC002273
- MoNA: FiehnHILIC000705
- MoNA: BML81998
- MoNA: BML81997
- MoNA: BML81996
- MoNA: BML81995
- MoNA: BML00725
- MoNA: BML00717
- MoNA: BML00708
- MoNA: BML00699
- MoNA: CO000355
- MoNA: CO000354
- MoNA: CO000353
- MoNA: CO000352
- MoNA: CO000351
- PubChem: 9572
- PDB-CCD: XRA
- NIKKAJI: J10.000E
- RefMet: Prazosin
- medchemexpress: HY-B0193
- KNApSAcK: 8364
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.
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2024 Mar; 321(?):117500. doi:
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Drug research.
2023 Mar; ?(?):. doi:
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2022 Jul; 72(6):336-342. doi:
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International journal of clinical pharmacology and therapeutics.
2022 Jan; 60(1):57-66. doi:
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Human & experimental toxicology.
2021 Aug; 40(8):1263-1273. doi:
10.1177/0960327121993224. [PMID: 33559503] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
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2016 07; 51(7):1125-9. doi:
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Pharmacological reports : PR.
2016 Jun; 68(3):649-53. doi:
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Journal of basic and clinical physiology and pharmacology.
2016 Jun; 27(4):363-70. doi:
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Cytokine.
2016 Apr; 80(?):26-34. doi:
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Endocrinology.
2016 Jan; 157(1):323-35. doi:
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PloS one.
2016; 11(10):e0164796. doi:
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Vascular pharmacology.
2015 Sep; 72(?):93-100. doi:
10.1016/j.vph.2015.06.017. [PMID: 26141930] - Herman Burger, Alexander T den Dekker, Sandra Segeletz, Antonius W M Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H J Mathijssen, Erik A C Wiemer. Lysosomal Sequestration Determines Intracellular Imatinib Levels.
Molecular pharmacology.
2015 Sep; 88(3):477-87. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Aug; 147(?):178-84. doi:
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Acta physiologica (Oxford, England).
2015 Apr; 213(4):920-32. doi:
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Drug research.
2015 Apr; 65(4):205-13. doi:
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American journal of physiology. Heart and circulatory physiology.
2015 Mar; 308(5):H524-9. doi:
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Current drug safety.
2015; 10(3):254-6. doi:
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Journal of ethnopharmacology.
2014 Dec; 158 Pt A(?):123-31. doi:
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Indian journal of pharmacology.
2014 Nov; 46(6):644-8. doi:
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The international journal of neuropsychopharmacology.
2014 Oct; 18(1):. doi:
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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):304-15. doi:
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Endocrinology.
2014 Aug; 155(8):2845-57. doi:
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Molecular and cellular biochemistry.
2014 Jul; 392(1-2):205-11. doi:
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JPMA. The Journal of the Pakistan Medical Association.
2014 Jun; 64(6):683-5. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 Mar; 30(2):184-8. doi:
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The Journal of veterinary medical science.
2014 Mar; 76(2):173-82. doi:
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Molecular and cellular biochemistry.
2014 Mar; 388(1-2):135-47. doi:
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Autonomic neuroscience : basic & clinical.
2014 Feb; 180(?):48-52. doi:
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Journal of cellular and molecular medicine.
2014 Feb; 18(2):263-73. doi:
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Journal of cardiovascular pharmacology.
2014 Jan; 63(1):9-15. doi:
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Colloids and surfaces. B, Biointerfaces.
2013 Dec; 112(?):171-6. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Jul; 81-82(?):50-5. doi:
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British journal of pharmacology.
2013 May; 169(1):230-8. doi:
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Andrologia.
2013 Apr; 45(2):128-34. doi:
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Life sciences.
2013 Feb; 92(2):125-30. doi:
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Experimental physiology.
2013 Feb; 98(2):451-61. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2013 Jan; 41(1):149-58. doi:
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Chirality.
2012 Dec; 24(12):1047-50. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):549-52. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Nov; 40(11):2102-8. doi:
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American journal of physiology. Heart and circulatory physiology.
2012 Oct; 303(8):H1022-34. doi:
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Bioelectrochemistry (Amsterdam, Netherlands).
2012 Oct; 87(?):96-103. doi:
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Journal of ethnopharmacology.
2012 Sep; 143(2):720-31. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Sep; 19(12):1101-7. doi:
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Canadian journal of physiology and pharmacology.
2012 Aug; 90(8):1087-93. doi:
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Indian journal of pharmacology.
2012 Jul; 44(4):454-7. doi:
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Regulatory peptides.
2012 Jun; 176(1-3):45-50. doi:
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European journal of pharmacology.
2012 May; 683(1-3):211-6. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 May; 40(5):963-9. doi:
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