prazosin (BioDeep_00000398448)

Main id: BioDeep_00000002066

 

Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


prazosin

化学式: C19H21N5O4 (383.15934660000005)
中文名称: 哌唑嗪
谱图信息: 最多检出来源 Bos taurus(endogenous) 42.86%

分子结构信息

SMILES: COc(c1)c(OC)cc(c(N)4)c1nc(n4)N(C3)CCN(C3)C(=O)c(c2)occ2
InChI: InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.767
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.759
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.760
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

同义名列表

3 个代谢物同义名

prazosin; Prazosin; Prazosin



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of ethnopharmacology. 2024 Mar; 321(?):117500. doi: 10.1016/j.jep.2023.117500. [PMID: 38030022]
  • Fatemeh Khajepour, Fariba Mahmoodpoor, Elmira Jafari, Farzad Kakaei, Farina Bahraminia, Shadi Aghajani, Sepideh Zununi Vahed, Yasin Bagheri. Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats. Drug research. 2023 Mar; ?(?):. doi: 10.1055/a-2015-7976. [PMID: 36940722]
  • Zahra Malekinejad, Shadi Aghajani, Mostafa Jeddi, Reihane Qahremani, Sina Shahbazi, Yasin Bagheri, Elham Ahmadian. Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion. Drug research. 2022 Jul; 72(6):336-342. doi: 10.1055/a-1806-1453. [PMID: 35426094]
  • Min Wang, Yingying Sun, Bingying Hu, Zhisheng He, Shanshan Chen, Dake Qi, Hai An, Yang Wei. Organic Cation Transporters are Involved in Fluoxetine Transport Across the Blood-Brain Barrier In Vivo and In Vitro. Current drug delivery. 2022; 19(4):508-517. doi: 10.2174/1567201818666210708122326. [PMID: 34238184]
  • Lian-Lian Fan, Mu-Peng Li, Tong Wu, Chun-Yan Gan, Pei-Wen Zhang, Gang Mai, Jian-Zhong Shen-Tu. Bioequivalence study of two formulations of terazosin hydrochloride capsule in healthy Chinese subjects under fasting and fed conditions. International journal of clinical pharmacology and therapeutics. 2022 Jan; 60(1):57-66. doi: 10.5414/cp204018. [PMID: 34672254]
  • Sreenivasulu Kilari, Amit Sharma, Chenglei Zhao, Avishek Singh, Chuanqi Cai, Michael Simeon, Andre J van Wijnen, Sanjay Misra. Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. Translational research : the journal of laboratory and clinical medicine. 2021 09; 235(?):32-47. doi: 10.1016/j.trsl.2021.03.005. [PMID: 33711514]
  • M M Rahimi, A Bagheri, Y Bagheri, E Fathi, S Bagheri, A V Nia, S Jafari, S Montazersaheb. Renoprotective effects of prazosin on ischemia-reperfusion injury in rats. Human & experimental toxicology. 2021 Aug; 40(8):1263-1273. doi: 10.1177/0960327121993224. [PMID: 33559503]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. Urology journal. 2021 Apr; 18(3):337-342. doi: 10.22037/uj.v18i.5678. [PMID: 33840085]
  • Doran J Satanove, Simon Rahman, T M Vanessa Chan, Suelynn Ren, Paul B S Clarke. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology. 2021 Feb; 238(2):475-486. doi: 10.1007/s00213-020-05696-5. [PMID: 33150479]
  • Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 02; 77(2):178-189.e1. doi: 10.1053/j.ajkd.2020.07.018. [PMID: 32920153]
  • Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Loke Meng Ong, Ru Shing Ng, Hong Chin Wee, Kok Khiang Peh. Simple and fast LC-MS/MS method for quantification of terazosin in human plasma and application to bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jan; 1163(?):122517. doi: 10.1016/j.jchromb.2020.122517. [PMID: 33429127]
  • Jin Hee Jeong, Michelle L Brown, Gaston Kapuku, Gregory A Harshfield, Jeanie Park. α-Adrenergic receptor blockade attenuates pressor response during mental stress in young black adults. Physiological reports. 2021 01; 8(24):e14642. doi: 10.14814/phy2.14642. [PMID: 33356011]
  • Diogo A Fonseca, Mónica Ferreira, Maria Graça Campos, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim. Vascular effects of a polyphenolic fraction from Oxalis pes-caprae L.: role of α-adrenergic receptors Sub-types. Natural product research. 2020 Dec; 34(23):3369-3372. doi: 10.1080/14786419.2018.1564291. [PMID: 30698035]
  • Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults. The Cochrane database of systematic reviews. 2020 11; 11(?):CD013393. doi: 10.1002/14651858.cd013393.pub2. [PMID: 33179245]
  • Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loic Laplanche, Mario Mezler. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening. Pharmaceutical research. 2020 Sep; 37(10):194. doi: 10.1007/s11095-020-02895-9. [PMID: 32918191]
  • Vojtěch Škop, Naili Liu, Juen Guo, Oksana Gavrilova, Marc L Reitman. The contribution of the mouse tail to thermoregulation is modest. American journal of physiology. Endocrinology and metabolism. 2020 08; 319(2):E438-E446. doi: 10.1152/ajpendo.00133.2020. [PMID: 32691633]
  • Atsunori Yamamoto, Kengo Matsumoto, Kiko Hori, Satoshi Kameshima, Naoko Yamaguchi, Shoshiro Okada, Muneyoshi Okada, Hideyuki Yamawaki. Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. Pflugers Archiv : European journal of physiology. 2020 06; 472(6):673-681. doi: 10.1007/s00424-020-02391-4. [PMID: 32462328]
  • Aaron J Horsey, Deborah A Briggs, Nicholas D Holliday, Stephen J Briddon, Ian D Kerr. Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2. Biochimica et biophysica acta. Biomembranes. 2020 06; 1862(6):183218. doi: 10.1016/j.bbamem.2020.183218. [PMID: 32057756]
  • Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122125. doi: 10.1016/j.jchromb.2020.122125. [PMID: 32371329]
  • Johns T Johnson, Kripa Elizabeth Cherian, Nitin Kapoor, Thomas Vizhalil Paul. Micturition syncope secondary to urinary bladder paraganglioma. BMJ case reports. 2020 Mar; 13(3):. doi: 10.1136/bcr-2019-233556. [PMID: 32169989]
  • Yaser Pashaei, Bahram Daraei, Maryam Shekarchi. Magnetic-Dispersive Solid Phase Extraction Based on Graphene Oxide-Fe3O4 Nanocomposites Followed by High Performance Liquid Chromatography-Fluorescence for the Preconcentration and Determination of Terazosin Hydrochloride in Human Plasma. Journal of chromatographic science. 2020 Jan; 58(2):178-186. doi: 10.1093/chromsci/bmz085. [PMID: 31746326]
  • Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry. 2020 01; 63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. [PMID: 31834797]
  • Christine C Orozco, Karen Atkinson, Sangwoo Ryu, George Chang, Christopher Keefer, Jian Lin, Keith Riccardi, Robert K Mongillo, David Tess, Kevin J Filipski, Amit S Kalgutkar, John Litchfield, Dennis Scott, Li Di. Structural attributes influencing unbound tissue distribution. European journal of medicinal chemistry. 2020 Jan; 185(?):111813. doi: 10.1016/j.ejmech.2019.111813. [PMID: 31732255]
  • Samra Sulaiman, Mazhar Hussain, Muhammad Nauman Shad, Sadia Chiragh. Hepatoprotective Effect Of Prazosin Is Comparable To N-Acetylcysteine In Acetaminophen Induced Hepatotoxicity In Mice. Journal of Ayub Medical College, Abbottabad : JAMC. 2020 Jan; 32(1):28-32. doi: NULL. [PMID: 32468750]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Biebele Abel, Dilip K Tosh, Stewart R Durell, Megumi Murakami, Shahrooz Vahedi, Kenneth A Jacobson, Suresh V Ambudkar. Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1). Molecular pharmacology. 2019 08; 96(2):180-192. doi: 10.1124/mol.118.115295. [PMID: 31127007]
  • Monika Kubacka, Monika Zadrożna, Barbara Nowak, Magdalena Kotańska, Barbara Filipek, Anna Maria Waszkielewicz, Henryk Marona, Szczepan Mogilski. Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 08; 42(8):1125-1141. doi: 10.1038/s41440-019-0239-1. [PMID: 30872813]
  • Monika Kubacka, Magdalena Kotańska, Małgorzata Szafarz, Krzysztof Pociecha, Anna M Waszkielewicz, Henryk Marona, Barbara Filipek, Szczepan Mogilski. Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 07; 29(7):751-760. doi: 10.1016/j.numecd.2019.04.003. [PMID: 31133498]
  • Courtney A Marshall, Zachary D Brodnik, Ole V Mortensen, Maarten E A Reith, Jed S Shumsky, Barry D Waterhouse, Rodrigo A España, Sandhya Kortagere. Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention. Neuropharmacology. 2019 04; 148(?):178-188. doi: 10.1016/j.neuropharm.2019.01.003. [PMID: 30633928]
  • Rei Miyamoto, Takashi Nozawa, Koichi Shiozuka, Kenji Tabata. The Impact of Endogenous Breast Cancer Resistance Protein on Human P-Glycoprotein-Mediated Transport Assays Using LLC-PK1 Cells Transfected With Human P-Glycoprotein. Journal of pharmaceutical sciences. 2019 Mar; 108(3):1085-1089. doi: 10.1016/j.xphs.2018.10.012. [PMID: 30339864]
  • Olanrewaju A Salako, Abidemi J Akindele, Aishat O Balogun, Olufunmilayo O Adeyemi. Investigation of Antidepressant, Anxiolytic and Sedative Activities of the Aqueous Leaf Extract of Musa sapientum Linn. (Banana; Musaceae). Drug research. 2019 Feb; 69(3):136-143. doi: 10.1055/a-0651-7978. [PMID: 30075482]
  • Mahmoud Roushani, Zeynab Jalilian, Azizollah Nezhadali. A novel electrochemical sensor based on electrode modified with gold nanoparticles and molecularly imprinted polymer for rapid determination of trazosin. Colloids and surfaces. B, Biointerfaces. 2018 Dec; 172(?):594-600. doi: 10.1016/j.colsurfb.2018.09.015. [PMID: 30218985]
  • Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma. Luminescence : the journal of biological and chemical luminescence. 2018 Nov; 33(7):1226-1234. doi: 10.1002/bio.3539. [PMID: 30094938]
  • Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Apr; 195(?):215-222. doi: 10.1016/j.saa.2018.01.077. [PMID: 29414581]
  • Jun-Jun Huang, Zhi-Han Zhang, Fei He, Xia-Wen Liu, Xing-Jie Xu, Li-Jun Dai, Qi-Meng Liu, Mu Yuan. Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α1D/1A-adrenoreceptor subtypes. Bioorganic & medicinal chemistry letters. 2018 02; 28(4):547-551. doi: 10.1016/j.bmcl.2018.01.068. [PMID: 29422390]
  • Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui. Prazosin protects myocardial cells against anoxia-reoxygenation injury via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports. 2018 Feb; 17(2):2145-2152. doi: 10.3892/mmr.2017.8175. [PMID: 29207167]
  • Zhe-Xian Deng, Ling-Xiao Ji, Yi-Rong Zhang, Cheng-di Li, Jian Cai, Hai-Hong Jiang. [Ningmitai Capsules relieve lower urinary tract symptoms in patients with benign prostatic hyperplasia : A short-term clinical observation]. Zhonghua nan ke xue = National journal of andrology. 2018 Jan; 24(1):72-77. doi: . [PMID: 30157365]
  • Feipeng Zhu, Qihui Wu, Jie Li, Katarzyna Grycel, Bing Liu, Xiaoxuan Sun, Li Zhou, Ruiyin Jiao, Rui Song, Younus M Khan, Qinglong Wang, Lun Wang, Yongxin Xu, Jin Li, Bo Zhang, Zhuan Zhou. A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell calcium. 2017 11; 67(?):11-20. doi: 10.1016/j.ceca.2017.07.007. [PMID: 29029785]
  • Tong-Xin Yang, Bang-Hua Liao, Yun-Tian Chen, Hong Li, Qing He, Qin-Yu Liu, Kun-Jie Wang. A network meta-analysis on the beneficial effect of medical expulsive therapy after extracorporeal shock wave lithotripsy. Scientific reports. 2017 10; 7(1):14429. doi: 10.1038/s41598-017-14862-3. [PMID: 29089544]
  • Mohamed A Hammad, Mahmoud A Omar, Baher I Salman. Utility of Hantzsch reaction for development of highly sensitive spectrofluorimetric method for determination of alfuzosin and terazosin in bulk, dosage forms and human plasma. Luminescence : the journal of biological and chemical luminescence. 2017 Sep; 32(6):1066-1071. doi: 10.1002/bio.3292. [PMID: 28303653]
  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):450-458. doi: 10.1124/jpet.117.241406. [PMID: 28630284]
  • Ruxia Liu, Qianlong Zhang, Qian Luo, Hui Qiao, Peng Wang, Juan Yu, Yonggang Cao, Bo Lu, Lihui Qu. Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling. The international journal of biochemistry & cell biology. 2017 07; 88(?):100-112. doi: 10.1016/j.biocel.2017.05.001. [PMID: 28476501]
  • G O Isehunwa, O T Oladun, J E Akpan, A R A Alada. Effect of Cortisol on Plasma Lactate Levels following Cortisolinduced Hyperglycaemia in Common African Toad, Bufo regularis. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2017 Jun; 32(1):21-25. doi: NULL. [PMID: 29134973]
  • Yasaman Sefid-Sefidehkhan, Khadijeh Nekoueian, Mandana Amiri, Mika Sillanpaa, Habibollah Eskandari. Palladium nanoparticles in electrochemical sensing of trace terazosin in human serum and pharmaceutical preparations. Materials science & engineering. C, Materials for biological applications. 2017 Jun; 75(?):368-374. doi: 10.1016/j.msec.2017.02.061. [PMID: 28415474]
  • Bryan K Becker, Joshua S Speed, Mackenzie Powell, David M Pollock. Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors. Physiological reports. 2017 Feb; 5(4):. doi: 10.14814/phy2.13077. [PMID: 28219980]
  • Katsunori Nonogaki, Takao Kaji. α1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice. Neuroscience letters. 2017 01; 638(?):35-38. doi: 10.1016/j.neulet.2016.12.008. [PMID: 27939978]
  • Hafiz Mohammad Rashid Nadeem, Ejaz Mohiuddin, Shahab UdDin, Muhammad Daniyal, Khan Usmanghani. Comparison of Anti BPH capsule (herbal) and Terazosin HCl in the treatment of benign prostate hyperplasia. Pakistan journal of pharmaceutical sciences. 2017 Jan; 30(1 Suppl):289-293. doi: ". [PMID: 28625956]
  • Jocelyn Fotso Soh, Hilary R Strong, Noriko Daneshtalab, Reza Tabrizchi. The effect of inflammation on sympathetic nerve mediated contractions in rat isolated caudal artery. European journal of pharmacology. 2016 Dec; 792(?):54-62. doi: 10.1016/j.ejphar.2016.10.030. [PMID: 27793651]
  • Jian-Ming Sun, Peng Liu, Wen-Jun Han. [Efficacy and safety of Tonglin Powder in the treatment of benign prostatic hyperplasia]. Zhonghua nan ke xue = National journal of andrology. 2016 Oct; 22(10):897-901. doi: . [PMID: 29278471]
  • Jianying Tao, Juanxiu Lv, Weisheng Li, Pengjie Zhang, Caiping Mao, Zhice Xu. Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways. Reproductive biology. 2016 Sep; 16(3):212-217. doi: 10.1016/j.repbio.2016.06.001. [PMID: 27692363]
  • Fuju Chen, Aikebaier Reheman, Jing Cao, Zixu Wang, Yulan Dong, Yuxian Zhang, Yaoxing Chen. Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens. Journal of photochemistry and photobiology. B, Biology. 2016 Aug; 161(?):9-16. doi: 10.1016/j.jphotobiol.2016.05.001. [PMID: 27203566]
  • Ping Xu, Zhao-Li Ling, Ji Zhang, Ying Li, Nan Shu, Ze-Yu Zhong, Yang Chen, Xin-Yu Di, Zhong-Jian Wang, Li Liu, Xiao-Dong Liu. Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats. Acta pharmacologica Sinica. 2016 Aug; 37(8):1129-40. doi: 10.1038/aps.2016.25. [PMID: 27180978]
  • Qian Du, De-zhi Kong, Pan-pan Zhang, Lei-ming Ren. [Quantification of (-)doxazosin at very low concentration in rat plasma samples by SPE-LC-MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 07; 51(7):1125-9. doi: NULL. [PMID: 29897217]
  • Tetsuya Nakamura, Jun Kamishikiryo, Tetsuo Morita. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II. Pharmacological reports : PR. 2016 Jun; 68(3):649-53. doi: 10.1016/j.pharep.2016.02.001. [PMID: 27031052]
  • Samuel A Onasanwo, Rume A Rotu. Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action. Journal of basic and clinical physiology and pharmacology. 2016 Jun; 27(4):363-70. doi: 10.1515/jbcpp-2015-0075. [PMID: 26812784]
  • Ewa Obuchowicz, Agnieszka Prymus, Anna M Bielecka, Łukasz Drzyzga, Monika Paul-Samojedny, Marta Kot, Władysława A Daniel. Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1β in the brain and plasma of rats. Cytokine. 2016 Apr; 80(?):26-34. doi: 10.1016/j.cyto.2015.10.012. [PMID: 26937856]
  • Bruna Kalil, Aline B Ribeiro, Cristiane M Leite, Ernane T Uchôa, Ruither O Carolino, Thais S R Cardoso, Lucila L K Elias, José A Rodrigues, Tony M Plant, Maristela O Poletini, Janete A Anselmo-Franci. The Increase in Signaling by Kisspeptin Neurons in the Preoptic Area and Associated Changes in Clock Gene Expression That Trigger the LH Surge in Female Rats Are Dependent on the Facilitatory Action of a Noradrenaline Input. Endocrinology. 2016 Jan; 157(1):323-35. doi: 10.1210/en.2015-1323. [PMID: 26556532]
  • Mindi Zhao, Jianqiang Wu, Youhe Gao. The Specific α1-Adrenergic Receptor Antagonist Prazosin Influences the Urine Proteome. PloS one. 2016; 11(10):e0164796. doi: 10.1371/journal.pone.0164796. [PMID: 27780262]
  • Patrícia de Souza Rossignoli, Fernanda Zocatelli Yamamoto, Oduvaldo Câmara Marques Pereira, Agnaldo Bruno Chies. Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids. Vascular pharmacology. 2015 Sep; 72(?):93-100. doi: 10.1016/j.vph.2015.06.017. [PMID: 26141930]
  • Herman Burger, Alexander T den Dekker, Sandra Segeletz, Antonius W M Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H J Mathijssen, Erik A C Wiemer. Lysosomal Sequestration Determines Intracellular Imatinib Levels. Molecular pharmacology. 2015 Sep; 88(3):477-87. doi: 10.1124/mol.114.097451. [PMID: 26108972]
  • Ai Ping Li, Huanjun Peng, Jing Dong Peng, Ming Qiong Zhou, Jing Zhang. Rayleigh light scattering detection of three α1-adrenoceptor antagonists coupled with high performance liquid chromatograph. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Aug; 147(?):178-84. doi: 10.1016/j.saa.2015.02.062. [PMID: 25840026]
  • J Kaufmann, P Martinka, O Moede, M Sendeski, A Steege, M Fähling, M Hultström, M Gaestel, I C Moraes-Silva, T Nikitina, Z Z Liu, O Zavaritskaya, A Patzak. Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries. Acta physiologica (Oxford, England). 2015 Apr; 213(4):920-32. doi: 10.1111/apha.12457. [PMID: 25594617]
  • I O Ishola, S O Olayemi, O K Yemitan, E A Umeh. Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems. Drug research. 2015 Apr; 65(4):205-13. doi: 10.1055/s-0034-1376963. [PMID: 24886981]
  • Jasdeep Kaur, Marty D Spranger, Robert L Hammond, Abhinav C Krishnan, Alberto Alvarez, Robert A Augustyniak, Donal S O'Leary. Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation. American journal of physiology. Heart and circulatory physiology. 2015 Mar; 308(5):H524-9. doi: 10.1152/ajpheart.00648.2014. [PMID: 25539712]
  • Mouna B Sassi, Emna Gaies, Issam Salouage, Sameh Trabelsi, Mohamed Lakhal, Anis Klouz. Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. Current drug safety. 2015; 10(3):254-6. doi: 10.2174/1574886310666150512105459. [PMID: 25968921]
  • Pierre Mugabo, Alvenia Philander, Ismaila Raji, Daneel Dietrich, Ivan Green. Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. Journal of ethnopharmacology. 2014 Dec; 158 Pt A(?):123-31. doi: 10.1016/j.jep.2014.10.011. [PMID: 25456427]
  • Maysaa B Zubairi, Jawad H Ahmed, Sawsan S Al-Haroon. Effect of adrenergic blockers, carvedilol, prazosin, metoprolol and combination of prazosin and metoprolol on paracetamol-induced hepatotoxicity in rabbits. Indian journal of pharmacology. 2014 Nov; 46(6):644-8. doi: 10.4103/0253-7613.144937. [PMID: 25538338]
  • Miyu Sekio, Kenjiro Seki. Lipopolysaccharide-induced depressive-like behavior is associated with α₁-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area. The international journal of neuropsychopharmacology. 2014 Oct; 18(1):. doi: 10.1093/ijnp/pyu005. [PMID: 25539502]
  • Yusuke Murahata, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine, and prazosin on xylazine-induced diuresis in clinically normal cats. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2014 Oct; 78(4):304-15. doi: . [PMID: 25356000]
  • Jacqueline M Ho, Vishwanath T Anekonda, Benjamin W Thompson, Mingyan Zhu, Robert W Curry, Bang H Hwang, Gregory J Morton, Michael W Schwartz, Denis G Baskin, Suzanne M Appleyard, James E Blevins. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014 Aug; 155(8):2845-57. doi: 10.1210/en.2014-1148. [PMID: 24877632]
  • Linda T Tran, Kathleen M MacLeod, John H McNeill. Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension. Molecular and cellular biochemistry. 2014 Jul; 392(1-2):205-11. doi: 10.1007/s11010-014-2031-5. [PMID: 24682694]
  • Maliheh Keshvari Shirvan, Mohammad Reza Darabi Mahboob, Mehdi Masuminia, Shabnam Mohammadi. Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. JPMA. The Journal of the Pakistan Medical Association. 2014 Jun; 64(6):683-5. doi: . [PMID: 25252490]
  • Meng Ning, Jing-Hui Huang, Yan-Fang Zhang, Wen-Yu Cui, Hai Wang. [Novel drug composition ameliorating thrombosis and its molecular mechanisms]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2014 Mar; 30(2):184-8. doi: . [PMID: 25016879]
  • Yusuke Murahata, Asami Yamamoto, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats. The Journal of veterinary medical science. 2014 Mar; 76(2):173-82. doi: 10.1292/jvms.13-0398. [PMID: 24107430]
  • Andrea Luiza de Oliveira, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Adelar Bracht. The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca(2+)-mobilization and cAMP production. Molecular and cellular biochemistry. 2014 Mar; 388(1-2):135-47. doi: 10.1007/s11010-013-1905-2. [PMID: 24287564]
  • Sae Uchida, Fusako Kagitani. Effects of electrical stimulation of autonomic nerves to the ovary on the ovarian testosterone secretion rate in rats. Autonomic neuroscience : basic & clinical. 2014 Feb; 180(?):48-52. doi: 10.1016/j.autneu.2013.10.007. [PMID: 24220239]
  • Xiaohui Yu, Baoyin Jia, Faqiang Wang, Xiuxiu Lv, Xuemei Peng, Yiyang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Huadong Wang. α₁ adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-α production via modulating ERK1/2 and NF-κB pathway. Journal of cellular and molecular medicine. 2014 Feb; 18(2):263-73. doi: 10.1111/jcmm.12184. [PMID: 24304472]
  • Shuhei Kobuchi, Ryosuke Tanaka, Asami Funai, Rie Suzuki, Maki Yazawa, Hidenobu Tsutsui, Mamoru Ohkita, Kazuhide Ayajiki, Yasuo Matsumura. Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats. Journal of cardiovascular pharmacology. 2014 Jan; 63(1):9-15. doi: 10.1097/fjc.0000000000000016. [PMID: 24084211]
  • Barbara Gzyl-Malcher, Jadwiga Handzlik, Ewelina Klekowska. Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers. Colloids and surfaces. B, Biointerfaces. 2013 Dec; 112(?):171-6. doi: 10.1016/j.colsurfb.2013.07.030. [PMID: 23973675]
  • Feng Shao, Tian Zhu, Feng Tang, Xin Liu. Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2013 Jul; 81-82(?):50-5. doi: 10.1016/j.jpba.2013.02.041. [PMID: 23624508]
  • L Villa, R Buono, N Fossati, P Rigatti, F Montorsi, F Benigni, P Hedlund. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters. British journal of pharmacology. 2013 May; 169(1):230-8. doi: 10.1111/bph.12123. [PMID: 23373675]
  • D Mitropoulos, E Patris, G Deliconstantinos, A Kyroudi-Voulgari, I Anastasiou, D Perea. Terazosin-induced alterations in catalase expression and lipid peroxidation in the rat seminal vesicles. Andrologia. 2013 Apr; 45(2):128-34. doi: 10.1111/j.1439-0272.2012.01324.x. [PMID: 22731390]
  • Minoru Miyazato, Takuma Oshiro, Michael B Chancellor, William C de Groat, Naoki Yoshimura, Seiichi Saito. An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats. Life sciences. 2013 Feb; 92(2):125-30. doi: 10.1016/j.lfs.2012.11.006. [PMID: 23178151]
  • Sushmita Purkayastha, Ashwini Saxena, Wendy L Eubank, Besim Hoxha, Peter B Raven. α1-Adrenergic receptor control of the cerebral vasculature in humans at rest and during exercise. Experimental physiology. 2013 Feb; 98(2):451-61. doi: 10.1113/expphysiol.2012.066118. [PMID: 23024369]
  • Naoki Ishiguro, Hidetada Shimizu, Wataru Kishimoto, Thomas Ebner, Olaf Schaefer. Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug metabolism and disposition: the biological fate of chemicals. 2013 Jan; 41(1):149-58. doi: 10.1124/dmd.112.048470. [PMID: 23073734]
  • Man Liu, Dan Zhang, Man Yang, Ting Zhao, Xiaolin Wang, Yanan Zhang, Jing Han, Huichen Liu. Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. Chirality. 2012 Dec; 24(12):1047-50. doi: 10.1002/chir.22095. [PMID: 22887707]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Xinfeng Zhao, Qian Li, Liujiao Bian, Xiaohui Zheng, Jianbin Zheng, Youyi Zhang, Zijian Li. Using immobilized G-protein coupled receptors to screen bioactive traditional Chinese medicine compounds with multiple targets. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):549-52. doi: 10.1016/j.jpba.2012.05.004. [PMID: 22651959]
  • Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein, Ismael J Hidalgo. The role of a basolateral transporter in rosuvastatin transport and its interplay with apical breast cancer resistance protein in polarized cell monolayer systems. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2102-8. doi: 10.1124/dmd.112.045666. [PMID: 22855735]
  • Britta J Veitenheimer, William C Engeland, Pilar A Guzman, Gregory D Fink, John W Osborn. Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats. American journal of physiology. Heart and circulatory physiology. 2012 Oct; 303(8):H1022-34. doi: 10.1152/ajpheart.00413.2012. [PMID: 22904160]
  • Barbara Gzyl-Malcher, Jadwiga Handzlik, Ewelina Klekowska. Interaction of prazosin with model membranes--a Langmuir monolayer study. Bioelectrochemistry (Amsterdam, Netherlands). 2012 Oct; 87(?):96-103. doi: 10.1016/j.bioelechem.2011.12.005. [PMID: 22260980]
  • André R S Colla, Daniele G Machado, Luis E B Bettio, Guilherme Colla, Michele D A Magina, Inês M C Brighente, Ana Lúcia S Rodrigues. Involvement of monoaminergic systems in the antidepressant-like effect of Eugenia brasiliensis Lam. (Myrtaceae) in the tail suspension test in mice. Journal of ethnopharmacology. 2012 Sep; 143(2):720-31. doi: 10.1016/j.jep.2012.07.038. [PMID: 22884868]
  • Ying-Jin Zhang, Wei Huang, Xi Huang, Yang Wang, Zhe Wang, Cheng Wang, Bing-Wu Zhong, Chen-Xia Sheng, Bing Wang, Si-Fang Zhang, Nan-Xiang Su, Zhao-Qian Liu, Hong-Hao Zhou, Ping Ren. Fructus Aurantii induced antidepressant effect via its monoaminergic mechanism and prokinetic action in rat. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Sep; 19(12):1101-7. doi: 10.1016/j.phymed.2012.05.015. [PMID: 22770641]
  • Arzu Onay-Besikci, Elif Suzmecelik, A Tanju Ozcelikay. Carvedilol suppresses fatty acid oxidation and stimulates glycolysis in C2C12 cells. Canadian journal of physiology and pharmacology. 2012 Aug; 90(8):1087-93. doi: 10.1139/y2012-015. [PMID: 22524679]
  • Pallavi B Shewale, Rupali A Patil, Yogesh A Hiray. Antidepressant-like activity of anthocyanidins from Hibiscus rosa-sinensis flowers in tail suspension test and forced swim test. Indian journal of pharmacology. 2012 Jul; 44(4):454-7. doi: 10.4103/0253-7613.99303. [PMID: 23087504]
  • Jerzy Jochem, Zbigniew Kalarus, Luca Spaccapelo, Fabrizio Canalini, Alessandra Ottani, Daniela Giuliani, Salvatore Guarini. Centrally acting leptin induces a resuscitating effect in haemorrhagic shock in rats. Regulatory peptides. 2012 Jun; 176(1-3):45-50. doi: 10.1016/j.regpep.2012.03.003. [PMID: 22465165]
  • Chun-Yu Deng, Su-Juan Kuang, Fang Rao, Hui Yang, Xian-Hong Fang, Zhi-Xin Shan, Xiao-Hong Li, Zhi-Ling Zhou, Qiu-Xiong Lin, Min Yang, Shu-Lin Wu, Xi-Yong Yu, Shu-Guang Lin. Effect of ranolazine on rat intrarenal arteries in vitro. European journal of pharmacology. 2012 May; 683(1-3):211-6. doi: 10.1016/j.ejphar.2012.03.010. [PMID: 22449375]
  • Xingrong Liu, Xiao Ding, Gauri Deshmukh, Bianca M Liederer, Cornelis E C A Hop. Use of the cassette-dosing approach to assess brain penetration in drug discovery. Drug metabolism and disposition: the biological fate of chemicals. 2012 May; 40(5):963-9. doi: 10.1124/dmd.111.044420. [PMID: 22328585]