prazosin (BioDeep_00000398448)

Main id: BioDeep_00000002066

 

Chemicals and Drugs


代谢物信息卡片


prazosin

化学式: C19H21N5O4 (383.15934660000005)
中文名称: 哌唑嗪
谱图信息: 最多检出来源 Bos taurus(endogenous) 42.86%

分子结构信息

SMILES: COc(c1)c(OC)cc(c(N)4)c1nc(n4)N(C3)CCN(C3)C(=O)c(c2)occ2
InChI: InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.767
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.759
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.760
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

同义名列表

1 个代谢物同义名

prazosin



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of ethnopharmacology. 2024 Mar; 321(?):117500. doi: 10.1016/j.jep.2023.117500. [PMID: 38030022]
  • Fatemeh Khajepour, Fariba Mahmoodpoor, Elmira Jafari, Farzad Kakaei, Farina Bahraminia, Shadi Aghajani, Sepideh Zununi Vahed, Yasin Bagheri. Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats. Drug research. 2023 Mar; ?(?):. doi: 10.1055/a-2015-7976. [PMID: 36940722]
  • Zahra Malekinejad, Shadi Aghajani, Mostafa Jeddi, Reihane Qahremani, Sina Shahbazi, Yasin Bagheri, Elham Ahmadian. Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion. Drug research. 2022 Jul; 72(6):336-342. doi: 10.1055/a-1806-1453. [PMID: 35426094]
  • Min Wang, Yingying Sun, Bingying Hu, Zhisheng He, Shanshan Chen, Dake Qi, Hai An, Yang Wei. Organic Cation Transporters are Involved in Fluoxetine Transport Across the Blood-Brain Barrier In Vivo and In Vitro. Current drug delivery. 2022; 19(4):508-517. doi: 10.2174/1567201818666210708122326. [PMID: 34238184]
  • Lian-Lian Fan, Mu-Peng Li, Tong Wu, Chun-Yan Gan, Pei-Wen Zhang, Gang Mai, Jian-Zhong Shen-Tu. Bioequivalence study of two formulations of terazosin hydrochloride capsule in healthy Chinese subjects under fasting and fed conditions. International journal of clinical pharmacology and therapeutics. 2022 Jan; 60(1):57-66. doi: 10.5414/cp204018. [PMID: 34672254]
  • Sreenivasulu Kilari, Amit Sharma, Chenglei Zhao, Avishek Singh, Chuanqi Cai, Michael Simeon, Andre J van Wijnen, Sanjay Misra. Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. Translational research : the journal of laboratory and clinical medicine. 2021 09; 235(?):32-47. doi: 10.1016/j.trsl.2021.03.005. [PMID: 33711514]
  • M M Rahimi, A Bagheri, Y Bagheri, E Fathi, S Bagheri, A V Nia, S Jafari, S Montazersaheb. Renoprotective effects of prazosin on ischemia-reperfusion injury in rats. Human & experimental toxicology. 2021 Aug; 40(8):1263-1273. doi: 10.1177/0960327121993224. [PMID: 33559503]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. Urology journal. 2021 Apr; 18(3):337-342. doi: 10.22037/uj.v18i.5678. [PMID: 33840085]
  • Doran J Satanove, Simon Rahman, T M Vanessa Chan, Suelynn Ren, Paul B S Clarke. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology. 2021 Feb; 238(2):475-486. doi: 10.1007/s00213-020-05696-5. [PMID: 33150479]
  • Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 02; 77(2):178-189.e1. doi: 10.1053/j.ajkd.2020.07.018. [PMID: 32920153]
  • Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Loke Meng Ong, Ru Shing Ng, Hong Chin Wee, Kok Khiang Peh. Simple and fast LC-MS/MS method for quantification of terazosin in human plasma and application to bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jan; 1163(?):122517. doi: 10.1016/j.jchromb.2020.122517. [PMID: 33429127]
  • Jin Hee Jeong, Michelle L Brown, Gaston Kapuku, Gregory A Harshfield, Jeanie Park. α-Adrenergic receptor blockade attenuates pressor response during mental stress in young black adults. Physiological reports. 2021 01; 8(24):e14642. doi: 10.14814/phy2.14642. [PMID: 33356011]
  • Diogo A Fonseca, Mónica Ferreira, Maria Graça Campos, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim. Vascular effects of a polyphenolic fraction from Oxalis pes-caprae L.: role of α-adrenergic receptors Sub-types. Natural product research. 2020 Dec; 34(23):3369-3372. doi: 10.1080/14786419.2018.1564291. [PMID: 30698035]
  • Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults. The Cochrane database of systematic reviews. 2020 11; 11(?):CD013393. doi: 10.1002/14651858.cd013393.pub2. [PMID: 33179245]
  • Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loic Laplanche, Mario Mezler. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening. Pharmaceutical research. 2020 Sep; 37(10):194. doi: 10.1007/s11095-020-02895-9. [PMID: 32918191]
  • Vojtěch Škop, Naili Liu, Juen Guo, Oksana Gavrilova, Marc L Reitman. The contribution of the mouse tail to thermoregulation is modest. American journal of physiology. Endocrinology and metabolism. 2020 08; 319(2):E438-E446. doi: 10.1152/ajpendo.00133.2020. [PMID: 32691633]
  • Atsunori Yamamoto, Kengo Matsumoto, Kiko Hori, Satoshi Kameshima, Naoko Yamaguchi, Shoshiro Okada, Muneyoshi Okada, Hideyuki Yamawaki. Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. Pflugers Archiv : European journal of physiology. 2020 06; 472(6):673-681. doi: 10.1007/s00424-020-02391-4. [PMID: 32462328]
  • Aaron J Horsey, Deborah A Briggs, Nicholas D Holliday, Stephen J Briddon, Ian D Kerr. Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2. Biochimica et biophysica acta. Biomembranes. 2020 06; 1862(6):183218. doi: 10.1016/j.bbamem.2020.183218. [PMID: 32057756]
  • Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122125. doi: 10.1016/j.jchromb.2020.122125. [PMID: 32371329]
  • Johns T Johnson, Kripa Elizabeth Cherian, Nitin Kapoor, Thomas Vizhalil Paul. Micturition syncope secondary to urinary bladder paraganglioma. BMJ case reports. 2020 Mar; 13(3):. doi: 10.1136/bcr-2019-233556. [PMID: 32169989]
  • Yaser Pashaei, Bahram Daraei, Maryam Shekarchi. Magnetic-Dispersive Solid Phase Extraction Based on Graphene Oxide-Fe3O4 Nanocomposites Followed by High Performance Liquid Chromatography-Fluorescence for the Preconcentration and Determination of Terazosin Hydrochloride in Human Plasma. Journal of chromatographic science. 2020 Jan; 58(2):178-186. doi: 10.1093/chromsci/bmz085. [PMID: 31746326]
  • Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry. 2020 01; 63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. [PMID: 31834797]
  • Christine C Orozco, Karen Atkinson, Sangwoo Ryu, George Chang, Christopher Keefer, Jian Lin, Keith Riccardi, Robert K Mongillo, David Tess, Kevin J Filipski, Amit S Kalgutkar, John Litchfield, Dennis Scott, Li Di. Structural attributes influencing unbound tissue distribution. European journal of medicinal chemistry. 2020 Jan; 185(?):111813. doi: 10.1016/j.ejmech.2019.111813. [PMID: 31732255]
  • Samra Sulaiman, Mazhar Hussain, Muhammad Nauman Shad, Sadia Chiragh. Hepatoprotective Effect Of Prazosin Is Comparable To N-Acetylcysteine In Acetaminophen Induced Hepatotoxicity In Mice. Journal of Ayub Medical College, Abbottabad : JAMC. 2020 Jan; 32(1):28-32. doi: NULL. [PMID: 32468750]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Biebele Abel, Dilip K Tosh, Stewart R Durell, Megumi Murakami, Shahrooz Vahedi, Kenneth A Jacobson, Suresh V Ambudkar. Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1). Molecular pharmacology. 2019 08; 96(2):180-192. doi: 10.1124/mol.118.115295. [PMID: 31127007]
  • Monika Kubacka, Monika Zadrożna, Barbara Nowak, Magdalena Kotańska, Barbara Filipek, Anna Maria Waszkielewicz, Henryk Marona, Szczepan Mogilski. Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 08; 42(8):1125-1141. doi: 10.1038/s41440-019-0239-1. [PMID: 30872813]
  • Monika Kubacka, Magdalena Kotańska, Małgorzata Szafarz, Krzysztof Pociecha, Anna M Waszkielewicz, Henryk Marona, Barbara Filipek, Szczepan Mogilski. Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 07; 29(7):751-760. doi: 10.1016/j.numecd.2019.04.003. [PMID: 31133498]
  • Courtney A Marshall, Zachary D Brodnik, Ole V Mortensen, Maarten E A Reith, Jed S Shumsky, Barry D Waterhouse, Rodrigo A España, Sandhya Kortagere. Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention. Neuropharmacology. 2019 04; 148(?):178-188. doi: 10.1016/j.neuropharm.2019.01.003. [PMID: 30633928]
  • Rei Miyamoto, Takashi Nozawa, Koichi Shiozuka, Kenji Tabata. The Impact of Endogenous Breast Cancer Resistance Protein on Human P-Glycoprotein-Mediated Transport Assays Using LLC-PK1 Cells Transfected With Human P-Glycoprotein. Journal of pharmaceutical sciences. 2019 Mar; 108(3):1085-1089. doi: 10.1016/j.xphs.2018.10.012. [PMID: 30339864]
  • Olanrewaju A Salako, Abidemi J Akindele, Aishat O Balogun, Olufunmilayo O Adeyemi. Investigation of Antidepressant, Anxiolytic and Sedative Activities of the Aqueous Leaf Extract of Musa sapientum Linn. (Banana; Musaceae). Drug research. 2019 Feb; 69(3):136-143. doi: 10.1055/a-0651-7978. [PMID: 30075482]
  • Mahmoud Roushani, Zeynab Jalilian, Azizollah Nezhadali. A novel electrochemical sensor based on electrode modified with gold nanoparticles and molecularly imprinted polymer for rapid determination of trazosin. Colloids and surfaces. B, Biointerfaces. 2018 Dec; 172(?):594-600. doi: 10.1016/j.colsurfb.2018.09.015. [PMID: 30218985]
  • Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma. Luminescence : the journal of biological and chemical luminescence. 2018 Nov; 33(7):1226-1234. doi: 10.1002/bio.3539. [PMID: 30094938]
  • Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Apr; 195(?):215-222. doi: 10.1016/j.saa.2018.01.077. [PMID: 29414581]
  • Jun-Jun Huang, Zhi-Han Zhang, Fei He, Xia-Wen Liu, Xing-Jie Xu, Li-Jun Dai, Qi-Meng Liu, Mu Yuan. Novel naftopidil derivatives containing methyl phenylacetate and their blocking effects on α1D/1A-adrenoreceptor subtypes. Bioorganic & medicinal chemistry letters. 2018 02; 28(4):547-551. doi: 10.1016/j.bmcl.2018.01.068. [PMID: 29422390]
  • Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui. Prazosin protects myocardial cells against anoxia-reoxygenation injury via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports. 2018 Feb; 17(2):2145-2152. doi: 10.3892/mmr.2017.8175. [PMID: 29207167]
  • Zhe-Xian Deng, Ling-Xiao Ji, Yi-Rong Zhang, Cheng-di Li, Jian Cai, Hai-Hong Jiang. [Ningmitai Capsules relieve lower urinary tract symptoms in patients with benign prostatic hyperplasia : A short-term clinical observation]. Zhonghua nan ke xue = National journal of andrology. 2018 Jan; 24(1):72-77. doi: . [PMID: 30157365]
  • Feipeng Zhu, Qihui Wu, Jie Li, Katarzyna Grycel, Bing Liu, Xiaoxuan Sun, Li Zhou, Ruiyin Jiao, Rui Song, Younus M Khan, Qinglong Wang, Lun Wang, Yongxin Xu, Jin Li, Bo Zhang, Zhuan Zhou. A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell calcium. 2017 11; 67(?):11-20. doi: 10.1016/j.ceca.2017.07.007. [PMID: 29029785]
  • Tong-Xin Yang, Bang-Hua Liao, Yun-Tian Chen, Hong Li, Qing He, Qin-Yu Liu, Kun-Jie Wang. A network meta-analysis on the beneficial effect of medical expulsive therapy after extracorporeal shock wave lithotripsy. Scientific reports. 2017 10; 7(1):14429. doi: 10.1038/s41598-017-14862-3. [PMID: 29089544]
  • Mohamed A Hammad, Mahmoud A Omar, Baher I Salman. Utility of Hantzsch reaction for development of highly sensitive spectrofluorimetric method for determination of alfuzosin and terazosin in bulk, dosage forms and human plasma. Luminescence : the journal of biological and chemical luminescence. 2017 Sep; 32(6):1066-1071. doi: 10.1002/bio.3292. [PMID: 28303653]
  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):450-458. doi: 10.1124/jpet.117.241406. [PMID: 28630284]
  • Ruxia Liu, Qianlong Zhang, Qian Luo, Hui Qiao, Peng Wang, Juan Yu, Yonggang Cao, Bo Lu, Lihui Qu. Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling. The international journal of biochemistry & cell biology. 2017 07; 88(?):100-112. doi: 10.1016/j.biocel.2017.05.001. [PMID: 28476501]
  • G O Isehunwa, O T Oladun, J E Akpan, A R A Alada. Effect of Cortisol on Plasma Lactate Levels following Cortisolinduced Hyperglycaemia in Common African Toad, Bufo regularis. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2017 Jun; 32(1):21-25. doi: NULL. [PMID: 29134973]
  • Yasaman Sefid-Sefidehkhan, Khadijeh Nekoueian, Mandana Amiri, Mika Sillanpaa, Habibollah Eskandari. Palladium nanoparticles in electrochemical sensing of trace terazosin in human serum and pharmaceutical preparations. Materials science & engineering. C, Materials for biological applications. 2017 Jun; 75(?):368-374. doi: 10.1016/j.msec.2017.02.061. [PMID: 28415474]
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  • Tetsuya Nakamura, Jun Kamishikiryo, Tetsuo Morita. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II. Pharmacological reports : PR. 2016 Jun; 68(3):649-53. doi: 10.1016/j.pharep.2016.02.001. [PMID: 27031052]
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