Enalapril (BioDeep_00000398426)
Main id: BioDeep_00000002544
代谢物信息卡片
Enalapril
化学式: C20H28N2O5 (376.1998)
中文名称: 依那普利
谱图信息:
最多检出来源 Homo sapiens(urine) 13.41%
分子结构信息
SMILES: CCOC(=O)C(CCc(c2)cccc2)NC(C)C(=O)N(C1)C(CC1)C(O)=O
InChI: InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
CONFIDENCE standard compound; INTERNAL_ID 2718
CONFIDENCE standard compound; INTERNAL_ID 8616
INTERNAL_ID 8616; CONFIDENCE standard compound
同义名列表
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:4784
- KEGG: C06977
- KEGGdrug: D07892
- PubChem: 5388962
- DrugBank: DB00584
- ChEMBL: CHEMBL578
- MeSH: Enalapril
- CAS: 75847-73-3
- MoNA: AU271806
- MoNA: AU271805
- MoNA: AU271804
- MoNA: AU271803
- MoNA: AU271802
- MoNA: AU271801
- MoNA: WA001941
- MoNA: WA001940
- MoNA: WA001939
- MoNA: WA001938
- MoNA: WA001937
- MoNA: SM861651
- MoNA: SM861601
- MoNA: CO000160
- MoNA: CO000159
- MoNA: CO000158
- MoNA: CO000157
- MoNA: CO000156
- PubChem: 9191
- NIKKAJI: J240.110J
- RefMet: Enalapril
- KNApSAcK: 4784
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yusra Habib Khan, Sumera Qasim, Ambreen Malik Uttra, Nasser H Alotaibi, Abdullah Salah Alanazi, Abdulaziz I Alzarea, Ahmed D Alatawi, Tauqeer Hussain Mallhi. Enalapril attenuated CFA provoked arthritic manifestation by modulating proinflammatory and anti-inflammatory cytokine network.
Life sciences.
2023 Jul; 324(?):121742. doi:
10.1016/j.lfs.2023.121742. [PMID: 37146938] - Bin Zhou, Cheng-Li Lin, Shinsuke Kojima, Masanori Fukushima, Chung Y Hsu. Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data.
Dementia and geriatric cognitive disorders.
2023 Mar; ?(?):. doi:
10.1159/000530102. [PMID: 36948166] - Vinicius Sepúlveda-Fragoso, Beatriz Alexandre-Santos, Emanuelle Barreto-Reis, Tiago Fernandes, Edilamar Menezes Oliveira, Soraia das Neves Vieira Cavalcanti, Georgia Correa Atella, Leandro Miranda-Alves, Manuel Vázquez-Carrera, Antonio Claudio Lucas da Nóbrega, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano. Comparison between aerobic exercise training and enalapril treatment as tools to improve diet-induced metabolic-associated fatty liver disease: Effects on endoplasmic reticulum stress markers.
Life sciences.
2022 Dec; 311(Pt A):121136. doi:
10.1016/j.lfs.2022.121136. [PMID: 36349603] - Teng Ma, Li-Ting Mu, Xin-Tong Tian, Ji Yang, Ying-Qiang Zhao. [Systematic review and sequential analysis of Tanshinone Ⅱ_A Sodium Sulfonate Injection combined with enalapril in treatment of acute exacerbation of pulmonary heart disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(24):6794-6802. doi:
10.19540/j.cnki.cjcmm.20220830.501. [PMID: 36604928] - D A Ibarrola, W Arrua, J E Gonzalez, M S Soverina Escobar, J Centurión, A M Campuzano Benitez, F M Ovando Soria, E I Rodas González, K G Arrúa, M B Acevedo Barrios, O Y Heinichen, Y Montalbetti, M A Campuzano-Bublitz, M L Kennedy, S J Figueredo Thiel, N L Alvarenga, M C Hellión-Ibarrola. The antihypertensive and diuretic effect of crude root extract and saponins from Solanum sisymbriifolium Lam., in L-NAME-induced hypertension in rats.
Journal of ethnopharmacology.
2022 Nov; 298(?):115605. doi:
10.1016/j.jep.2022.115605. [PMID: 35973627] - Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G Liu, Jie Jiang, Zugui Zhang. Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension.
BMC medicine.
2022 10; 20(1):407. doi:
10.1186/s12916-022-02601-z. [PMID: 36280851] - Zhao Jie, Wang Li, Cao Ai-Li, Wang Yun-Man, Chi Yang-Feng, Wang Yi, Wang Hao, Peng Wen. Huangqi decoction attenuates renal interstitial fibrosis transforming growth factor-β1/mitogen-activated protein kinase signaling pathways in 5/6 nephrectomy mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 10; 42(5):723-731. doi:
10.19852/j.cnki.jtcm.2022.05.006. [PMID: 36083479] - Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Marek Konop, Tomasz Hutsch, Dawid Chabowski, Marcin Ufnal. Enalapril Diminishes the Diabetes-Induced Changes in Intestinal Morphology, Intestinal RAS and Blood SCFA Concentration in Rats.
International journal of molecular sciences.
2022 May; 23(11):. doi:
10.3390/ijms23116060. [PMID: 35682739] - Cristian Sager, Carol Burek, Yesica Ruth Gomez, Santiago Weller, Javier Ruiz, Felicitas Lopez Imizcoz, Tatiana Szklarz, Nicolas Rosiere, Marta Monteverde, Liliana Campmany, Jorge Agrimbau Vazquez, Fernanda De Castro, Lorena Bernardez, Marta Adragna, Juan Pablo Corbetta. Nephro-urological outcomes of a proactive management of children with spina bifida in their first 5 Years of life.
Journal of pediatric urology.
2022 04; 18(2):181.e1-181.e7. doi:
10.1016/j.jpurol.2021.12.002. [PMID: 34991991] - Jaya Shree, Amrita Singh, Rajesh Choudhary, Devi Prasad Pandey, Surendra H Bodakhe. Topical Administration of ACE Inhibitor Interrupts the Progression of Cataract in Two Kidney One Clip Induced Hypertensive Cataract Model.
Current eye research.
2022 03; 47(3):399-408. doi:
10.1080/02713683.2021.2002911. [PMID: 34740310] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Huan Li, Panpan He, Yuanyuan Zhang, Tengfei Lin, Chengzhang Liu, Di Xie, Min Liang, Guobao Wang, Jing Nie, Yun Song, Lishun Liu, Binyan Wang, Yan Zhang, Jianping Li, Yong Huo, Xiaobin Wang, Fan Fan Hou, Xiping Xu, Xianhui Qin. Self-Perceived Psychological Stress and Risk of First Stroke in Treated Hypertensive Patients.
Psychosomatic medicine.
2022 Feb; 84(2):237-243. doi:
10.1097/psy.0000000000001030. [PMID: 34654026] - Lisette M Harteveld, Nico A Blom, Covadonga Terol Espinosa de Los Monteros, Irene M Kuipers, Lukas A J Rammeloo, Mark G Hazekamp, J Gert van Dijk, Arend D J Ten Harkel. 3-Month Enalapril Treatment in Pediatric Fontan Patients With Moderate to Good Systolic Ventricular Function.
The American journal of cardiology.
2022 01; 163(?):98-103. doi:
10.1016/j.amjcard.2021.10.013. [PMID: 34774285] - Zhuo Wang, Hai Ma, Yun Song, Tengfei Lin, Lishun Liu, Ziyi Zhou, Yaping Wei, Xiao Huang, Ping Chen, Chengzhang Liu, Youbao Li, Binyan Wang, Jianping Li, Yan Zhang, Yong Huo, Hao Zhang, Xiping Xu, Xianhui Qin, Huiyuan Guo. Plasma selenium and the risk of first stroke in adults with hypertension: a secondary analysis of the China Stroke Primary Prevention Trial.
The American journal of clinical nutrition.
2022 01; 115(1):222-231. doi:
10.1093/ajcn/nqab320. [PMID: 34549258] - Xuehui Liu, Hongjun Liu, Lijun Wang, Lei Zhang, Qiang Xu. Role of sacubitril-valsartan in the prevention of atrial fibrillation occurrence in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.
PloS one.
2022; 17(1):e0263131. doi:
10.1371/journal.pone.0263131. [PMID: 35081164] - Jorge Andrade-Sierra, Mónica Lizbeth Morales-Guillén, Andrés García-Sánchez, Elodia Nataly Díaz-de la Cruz, José Ignacio Cerrillos-Gutiérrez, Enrique Rojas-Campos, Alejandra Guillermina Miranda-Díaz. The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients.
Oxidative medicine and cellular longevity.
2022; 2022(?):5622626. doi:
10.1155/2022/5622626. [PMID: 35308174] - Yao Fu, Nan Hu, Ming Cao, Wen-Feng Li, Xin-Rui Yang, Jin-Lai Gao, Jing Zhao, Man Jiang, Ming-Hui Ma, Zhi-Jie Sun, De-Li Dong. Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice.
European journal of pharmacology.
2021 Dec; 912(?):174614. doi:
10.1016/j.ejphar.2021.174614. [PMID: 34736968] - Cristina Almengló, Marinela Couselo-Seijas, Rosa M Agra, Alfonso Varela-Román, José M García-Acuña, Mercedes González-Peteiro, José R González-Juanatey, Sonia Eiras, Ezequiel Álvarez. Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value.
Journal of molecular medicine (Berlin, Germany).
2021 12; 99(12):1741-1753. doi:
10.1007/s00109-021-02129-4. [PMID: 34529122] - Lucy H Her, Xinwen Wang, Jian Shi, Hee Jae Choi, Sun Min Jung, Logan S Smith, Audrey H Wu, Barry E Bleske, Hao-Jie Zhu. Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.
British journal of clinical pharmacology.
2021 12; 87(12):4691-4700. doi:
10.1111/bcp.14888. [PMID: 33963573] - Md Abdul Hye Khan, Sung Hee Hwang, Scott D Barnett, Anna Stavniichuk, Wojciech K Jankiewicz, Bruce D Hammock, John D Imig. Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.
British journal of pharmacology.
2021 11; 178(22):4468-4484. doi:
10.1111/bph.15623. [PMID: 34255857] - Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Chun Zhou, Panpan He, Huan Li, Jianping Li, Yan Zhang, Min Liang, Binyan Wang, Xin Xu, Xiaobin Wang, Yong Huo, Fan Fan Hou, Jing Nie, Xiping Xu, Xianhui Qin. Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients.
The British journal of nutrition.
2021 10; 126(7):1040-1047. doi:
10.1017/s000711452000505x. [PMID: 33308359] - Charlotte E Bryant, Azita Rajai, Nicholas J A Webb, Ronald J Hogg. Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria.
Pediatric nephrology (Berlin, Germany).
2021 10; 36(10):3211-3219. doi:
10.1007/s00467-021-05045-4. [PMID: 33881639] - Shuyi Liao, Wenmin Yang, Ting Yu, Lu Dai, Xiaoliang Liu, Jiangping Zhang, Jinghong Zhao, Chi Liu. Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Biomolecules.
2021 09; 11(9):. doi:
10.3390/biom11091370. [PMID: 34572583] - Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes. Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Aug; 140(?):111682. doi:
10.1016/j.biopha.2021.111682. [PMID: 34020248] - Haiyan Wang, Xianghua Fu. Effects of sacubitril/valsartan on ventricular remodeling in patents with left ventricular systolic dysfunction following acute anterior wall myocardial infarction.
Coronary artery disease.
2021 Aug; 32(5):418-426. doi:
10.1097/mca.0000000000000932. [PMID: 32732515] - Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito. High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation.
Journal of the American Heart Association.
2021 07; 10(14):e016543. doi:
10.1161/jaha.120.016543. [PMID: 34259014] - Juliana Calfa Vilhena, Letícia Lopes de Melo Cunha, Tayenne Moraes Jorge, Marcella de Lucena Machado, Ricardo de Andrade Soares, Izabelle Barcellos Santos, Graziele Freitas de Bem, Caroline Fernandes-Santos, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela de Castro Resende, Cristiane Aguiar da Costa. Açaí Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril.
Journal of cardiovascular pharmacology.
2021 05; 77(5):673-684. doi:
10.1097/fjc.0000000000001003. [PMID: 33661593] - Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia.
Urology journal.
2021 Apr; 18(3):337-342. doi:
10.22037/uj.v18i.5678. [PMID: 33840085] - Hongxu Wu, Yuanyuan Zhang, Huan Li, Jianping Li, Yan Zhang, Min Liang, Jing Nie, Binyan Wang, Xiaobin Wang, Yong Huo, Fan Fan Hou, Xiping Xu, Xianhui Qin. Interaction of serum calcium and folic acid treatment on first stroke in hypertensive males.
Clinical nutrition (Edinburgh, Scotland).
2021 04; 40(4):2381-2388. doi:
10.1016/j.clnu.2020.10.033. [PMID: 33148481] - Matthew R Veitch, Kerri Thai, Yanling Zhang, Jean-Francois Desjardins, Golam Kabir, Kim A Connelly, Richard E Gilbert. Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline.
Nephrology (Carlton, Vic.).
2021 Mar; 26(3):270-279. doi:
10.1111/nep.13828. [PMID: 33179827] - Tanja Gangnus, Bjoern B Burckhardt. Low-volume LC-MS/MS method for the pharmacokinetic investigation of carvedilol, enalapril and their metabolites in whole blood and plasma: Application to a paediatric clinical trial.
Drug testing and analysis.
2021 Mar; 13(3):694-708. doi:
10.1002/dta.2949. [PMID: 33126289] - Daniel Silva Moraes, Deborah de Farias Lelis, João Marcus Oliveira Andrade, Lara Meyer, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos. Enalapril improves obesity associated liver injury ameliorating systemic metabolic markers by modulating Angiotensin Converting Enzymes ACE/ACE2 expression in high-fat feed mice.
Prostaglandins & other lipid mediators.
2021 02; 152(?):106501. doi:
10.1016/j.prostaglandins.2020.106501. [PMID: 33049402] - Mengyi Liu, Chun Zhou, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Di Xie, Jing Nie, Min Liang, Yun Song, Chengzhang Liu, Lishun Liu, Yong Huo, Binyan Wang, Xiaobin Wang, Xiping Xu, Xianhui Qin. Relationship of visceral adiposity index with new-onset proteinuria in hypertensive patients.
Clinical nutrition (Edinburgh, Scotland).
2021 02; 40(2):438-444. doi:
10.1016/j.clnu.2020.05.031. [PMID: 32553428] - Isabele G Giori, D'Angelo C Magliano, Beatriz Alexandre-Santos, Tiago Fernandes, Edilamar M Oliveira, Carla P Vieira, Carlos A Conte-Junior, Rolando B Ceddia, Antonio C L Nobrega, Eliete D C Frantz. Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice.
Journal of cellular physiology.
2021 02; 236(2):900-910. doi:
10.1002/jcp.29900. [PMID: 32617979] - Dalia Kamal Mostafa, Mohamed Mostafa Khedr, Mervat Kamel Barakat, Amany Abdelbary Abdellatif, Amal Mohamed Elsharkawy. Autophagy blockade mechanistically links proton pump inhibitors to worsened diabetic nephropathy and aborts the renoprotection of metformin/enalapril.
Life sciences.
2021 Jan; 265(?):118818. doi:
10.1016/j.lfs.2020.118818. [PMID: 33275985] - Ajay K Medipally, Min Xiao, Brad H Rovin, Anjali A Satoskar, Iouri Ivanov, Shahzeb Qaisar, Sergey V Brodsky. Role of glomerular filtration rate-modifying drugs in the development of anticoagulant-related nephropathy.
Physiological reports.
2021 01; 9(1):e14697. doi:
10.14814/phy2.14697. [PMID: 33427414] - Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma.
Biomedical chromatography : BMC.
2020 Dec; 34(12):e4955. doi:
10.1002/bmc.4955. [PMID: 32706446] - Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae. Angiotensin inhibition and cellular senescence in the developing rat kidney.
Experimental and molecular pathology.
2020 12; 117(?):104551. doi:
10.1016/j.yexmp.2020.104551. [PMID: 33010296] - Shahid Tannu, John Allocco, Melissa Yarde, Pancras Wong, Xiuying Ma. Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice.
Journal of pharmacological and toxicological methods.
2020 Nov; 106(?):106935. doi:
10.1016/j.vascn.2020.106935. [PMID: 33096237] - Robert Greite, Katja Derlin, Bennet Hensen, Anja Thorenz, Song Rong, Rongjun Chen, Susanne Hellms, Mi-Sun Jang, Jan Hinrich Bräsen, Martin Meier, Ina Willenberg, Stephan Immenschuh, Hermann Haller, Friedrich C Luft, Dipak Panigrahy, Sung Hee Hwang, Bruce D Hammock, Nils Helge Schebb, Faikah Gueler. Early antihypertensive treatment and ischemia-induced acute kidney injury.
American journal of physiology. Renal physiology.
2020 10; 319(4):F563-F570. doi:
10.1152/ajprenal.00078.2020. [PMID: 32799675] - Rehab Werida, Ibtsam Khairat, Lamiaa Khedr, Alaa El-Din El-Sisi. Comparative effects of enalapril versus perindopril on serum levels of leptin and adiponectin in hypertensive patients.
Acta cardiologica.
2020 Oct; 75(6):551-556. doi:
10.1080/00015385.2019.1636533. [PMID: 31345107] - Congqing Wu, Dien Ye, Adam E Mullick, Zhenyu Li, A H Jan Danser, Alan Daugherty, Hong S Lu. Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19.
Hypertension (Dallas, Tex. : 1979).
2020 10; 76(4):e29-e30. doi:
10.1161/hypertensionaha.120.15782. [PMID: 32673509] - Guang Liu, Courtney M Shea, Juli E Jones, Gavrielle M Price, William Warren, Elisabeth Lonie, Shu Yan, Mark G Currie, Albert T Profy, Jaime L Masferrer, Daniel P Zimmer. Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.
American journal of physiology. Renal physiology.
2020 10; 319(4):F697-F711. doi:
10.1152/ajprenal.00003.2020. [PMID: 32865013] - Yuanyuan Zhang, Jing Nie, Yan Zhang, Jianping Li, Min Liang, Guobao Wang, Jianwei Tian, Chengzhang Liu, Binyan Wang, Yimin Cui, Xiaobin Wang, Yong Huo, Xiping Xu, Fan Fan Hou, Xianhui Qin. Degree of Blood Pressure Control and Incident Diabetes Mellitus in Chinese Adults With Hypertension.
Journal of the American Heart Association.
2020 08; 9(16):e017015. doi:
10.1161/jaha.120.017015. [PMID: 32755254] - Safirah Maheen, Akhtar Rasul, Muhammad Hanif, Hafeez Ullah Khan. Lipospheres for Simultaneous Controlled Release and Improved Pharmacokinetic Profiles of Saxagliptin-Enalapril: Formulation, Optimization, and Comparative In Vitro-In Vivo Evaluation.
AAPS PharmSciTech.
2020 Jul; 21(5):188. doi:
10.1208/s12249-020-01733-w. [PMID: 32651896] - Izabelle Barcellos Santos, Graziele Freitas de Bem, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Amanda Faria de Medeiros, Dafne Lopes Beserra Silva, Matheus Henrique Romão, Ricardo de Andrade Soares, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende. Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet-fed mice.
Nutrition research (New York, N.Y.).
2020 07; 79(?):35-49. doi:
10.1016/j.nutres.2020.05.006. [PMID: 32610256] - Trishna Bal, Sabyasachi Swain. Microwave assisted synthesis of polyacrylamide grafted polymeric blend of fenugreek seed mucilage-Polyvinyl alcohol (FSM-PVA-g-PAM) and its characterizations as tissue engineered scaffold and as a drug delivery device.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Jun; 28(1):33-44. doi:
10.1007/s40199-019-00237-8. [PMID: 30712231] - Gustavo H Marin. Facts and reflections on COVID-19 and anti-hypertensives drugs.
Drug discoveries & therapeutics.
2020 May; 14(2):105-106. doi:
10.5582/ddt.2020.01017. [PMID: 32213760] - Marcin Książczyk, Małgorzata Lelonek. Angiotensin receptor/neprilysin inhibitor-a breakthrough in chronic heart failure therapy: summary of subanalysis on PARADIGM-HF trial findings.
Heart failure reviews.
2020 05; 25(3):393-402. doi:
10.1007/s10741-019-09879-x. [PMID: 31713710] - Babatunde Alabi, Temidayo Omobowale, Joseph Badejo, Adeolu Adedapo, Oluwole Fagbemi, Olugbenga Iwalewa. Protective effects and chemical composition of Corchorus olitorius leaf fractions against isoproterenol-induced myocardial injury through p65NFkB-dependent anti-apoptotic pathway in rats.
Journal of basic and clinical physiology and pharmacology.
2020 Apr; 31(5):. doi:
10.1515/jbcpp-2019-0108. [PMID: 32319968] - Fabian Konstantin Suessenbach, Nina Makowski, Martin Feickert, Tanja Gangnus, Jutta Tins, Bjoern Bengt Burckhardt. A quality control system for ligand-binding assay of plasma renin activity: Proof-of-concept within a pharmacodynamic study.
Journal of pharmaceutical and biomedical analysis.
2020 Mar; 181(?):113090. doi:
10.1016/j.jpba.2019.113090. [PMID: 31915108] - Xianhui Qin, J David Spence, Jianping Li, Yan Zhang, Youbao Li, Ningling Sun, Min Liang, Yun Song, Yuanyuan Zhang, Binyan Wang, Xiaoshu Cheng, Lianyou Zhao, Xiaobin Wang, Xiping Xu, Yong Huo. Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke.
Neurology.
2020 03; 94(11):e1126-e1136. doi:
10.1212/wnl.0000000000008932. [PMID: 31932513] - Mengyi Liu, Zhuxian Zhang, Chun Zhou, Panpan He, Jing Nie, Min Liang, Chengzhang Liu, Fanghua Xu, Guangzhou Liao, Yan Zhang, Jianping Li, Binyan Wang, Xiaobin Wang, Yong Huo, Xiping Xu, Xianhui Qin. Relationship of Body Mass Index and Waist Circumference With Risk of New-Onset Proteinuria in Hypertensive Patients.
The Journal of clinical endocrinology and metabolism.
2020 03; 105(3):. doi:
10.1210/clinem/dgaa026. [PMID: 31976527] - Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, Xu-Wen Li. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis.
Journal of natural products.
2020 02; 83(2):362-373. doi:
10.1021/acs.jnatprod.9b00857. [PMID: 32031812] - Jesús Mario Arancón-Monge, Alicia de Castro-Cuenca, Ángel Serrano-Vázquez, Luz Campos-Díaz, Ricardo Rodríguez Barrientos, Isabel Del Cura-González. [Effects of changing the appearance of medications in safety and adherence in chronic patients over 65 years of age in primary care. CAMBIMED Study].
Atencion primaria.
2020 02; 52(2):77-85. doi:
10.1016/j.aprim.2019.06.001. [PMID: 31481266] - Ayush Gupta, Narendra Kumar Bagri, Saroj Kumar Tripathy, Adarsh Barwad, Ravi Hari Phulware, Pankaj Hari. Successful use of tocilizumab in amyloidosis secondary to systemic juvenile idiopathic arthritis.
Rheumatology international.
2020 Jan; 40(1):153-159. doi:
10.1007/s00296-019-04363-z. [PMID: 31273457] - Mojgan Mazaheri, Farahnak Assadi, Simin Sadeghi-Bojd. Adjunctive acetazolamide therapy for the treatment of Bartter syndrome.
International urology and nephrology.
2020 Jan; 52(1):121-128. doi:
10.1007/s11255-019-02351-7. [PMID: 31820361] - Olga G Kmet, Nataliia D Filipets, Taras I Kmet, Yurii M Vepriuk, Kateryna V Vlasova. BIOCHEMICAL AND MORPHOLOGICAL MARKERS OF EXPERIMENTAL SCOPOLAMINE-INDUCED NEURODEGENERATION AND THE EFFECT OF ENALAPRIL ON THEM.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2020; 73(10):2114-2119. doi:
10.36740/wlek202010102. [PMID: 33310932] - Wendy McCallum, Hocine Tighiouart, Elaine Ku, Deeb Salem, Mark J Sarnak. Trends in Kidney Function Outcomes Following RAAS Inhibition in Patients With Heart Failure With Reduced Ejection Fraction.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 01; 75(1):21-29. doi:
10.1053/j.ajkd.2019.05.010. [PMID: 31303349] - Mohamed Abouelkheir, Tarek H El-Metwally. Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme.
European journal of pharmacology.
2019 Nov; 862(?):172638. doi:
10.1016/j.ejphar.2019.172638. [PMID: 31491403] - Chirag R Parikh, Steven G Coca. 'Permissive AKI' with treatment of heart failure.
Kidney international.
2019 11; 96(5):1066-1068. doi:
10.1016/j.kint.2019.07.003. [PMID: 31648696] - Wendy McCallum, Hocine Tighiouart, Elaine Ku, Deeb Salem, Mark J Sarnak. Acute declines in estimated glomerular filtration rate on enalapril and mortality and cardiovascular outcomes in patients with heart failure with reduced ejection fraction.
Kidney international.
2019 11; 96(5):1185-1194. doi:
10.1016/j.kint.2019.05.019. [PMID: 31420191] - David A Morrow, Eric J Velazquez, Adam D DeVore, Margaret F Prescott, Carol I Duffy, Yared Gurmu, Kevin McCague, Ricardo Rocha, Eugene Braunwald. Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.
European heart journal.
2019 10; 40(40):3345-3352. doi:
10.1093/eurheartj/ehz240. [PMID: 31093657] - Larissa Russo-Vorms, Philippe Meyer, Jean-Luc Reny. [« ARNI » (Angiotensin Receptor-Neprilysin Inhibitor): when, for whom and how?].
Revue medicale suisse.
2019 Oct; 15(667):1882-1886. doi:
NULL. [PMID: 31617977] - Mari Tanaka, Sho Miki, Hirona Saita, Hiroki Shimada, Seira Nishikawa, Keisuke Taniguchi, Koichiro Hagihara, Sachio Iwanari, Masaki Ikeda, Shinji Kunishima, Hiroya Takeoka. Renin-angiotensin System Blockade Therapy for Early Renal Involvement in MYH9-related Disease with an E1841K Mutation.
Internal medicine (Tokyo, Japan).
2019 Oct; 58(20):2983-2988. doi:
10.2169/internalmedicine.2997-19. [PMID: 31243205] - Valentine Gillion, Cristina Anca Dragean, Géraldine Dahlqvist, Michel Jadoul. Intestinal angioedema from angiotensin converting enzyme inhibitor.
Kidney international.
2019 09; 96(3):798. doi:
10.1016/j.kint.2019.02.031. [PMID: 31445588] - Manar Hamed Arafa, Dalia Mohamed Amin, Ghada Mohammed Samir, Hebatallah Husseini Atteia. Protective effects of tribulus terrestris extract and angiotensin blockers on testis steroidogenesis in copper overloaded rats.
Ecotoxicology and environmental safety.
2019 Aug; 178(?):113-122. doi:
10.1016/j.ecoenv.2019.04.012. [PMID: 30999179] - Marco Betti, Daniela Catarzi, Flavia Varano, Matteo Falsini, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Lorenzo di Cesare Mannelli, Carla Ghelardini, Elena Lucarini, Diego Dal Ben, Andrea Spinaci, Gianluca Bartolucci, Marta Menicatti, Vittoria Colotta. Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.
Journal of medicinal chemistry.
2019 08; 62(15):6894-6912. doi:
10.1021/acs.jmedchem.9b00106. [PMID: 31306001] - Jean-Yu Hwang, Wei-Chih Kan, Yao-Bin Liu, Lea-Yea Chuang, Jinn-Yuh Guh, Yu-Lin Yang, Jau-Shyang Huang. Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling.
Journal of cellular physiology.
2019 08; 234(10):17473-17481. doi:
10.1002/jcp.28369. [PMID: 30825199] - Ting Deng, Xiaoman Xie, Jiufei Duan, Mingqing Chen. Exposure to diisononyl phthalate induced an increase in blood pressure through activation of the ACE/ AT1R axis and inhibition of NO production.
Toxicology letters.
2019 Jul; 309(?):42-50. doi:
10.1016/j.toxlet.2019.03.011. [PMID: 30940551] - Jingping Zhang, Jingjing Cao, Hao Zhang, Chongfei Jiang, Tengfei Lin, Ziyi Zhou, Yun Song, Youbao Li, Chengzhang Liu, Lishun Liu, Binyan Wang, Genfu Tang, Jianping Li, Yan Zhang, Yimin Cui, Yong Huo, Yan Yang, Wenhua Ling, Jingang Yang, Huiyuan Guo, Xiaobin Wang, Xiping Xu, Xianhui Qin. Plasma copper and the risk of first stroke in hypertensive patients: a nested case-control study.
The American journal of clinical nutrition.
2019 07; 110(1):212-220. doi:
10.1093/ajcn/nqz099. [PMID: 31161196] - Hui Yang, Weiru Zhang, Tingting Xie, Xuan Wang, Wangbin Ning. [Effect of enalapril on apoptosis of renal tubular epithelial cells in renal interstitial fibrosis in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2019 Jun; 44(6):614-620. doi:
10.11817/j.issn.1672-7347.2019.06.002. [PMID: 31304921] - Lihua Hu, Yuanyuan Zhang, Xiao Huang, Yun Song, Xianhui Qin, Binyan Wang, Yan Zhang, Genfu Tang, Jianping Li, Ping Li, Huihui Bao, Yong Huo, Xiaoshu Cheng. Associations between Blood Pressure Indices and Brachial-ankle Pulse Wave Velocity in Treated Hypertensive Adults: results from the China Stroke Primary Prevention Trial (CSPPT).
Scientific reports.
2019 06; 9(1):8178. doi:
10.1038/s41598-019-44740-z. [PMID: 31160658] - Zeynep Yuruk Yildirim, Melis Ozkan, Alev Yilmaz, Hülya Kayserili, Cemile Pehlivanoglu, Sevinc Emre, Ahmet Nayir. An unusual cause of nephrotic syndrome: Answers.
Pediatric nephrology (Berlin, Germany).
2019 05; 34(5):819-821. doi:
10.1007/s00467-018-4115-z. [PMID: 30406368] - Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae, Young Sook Hong. Angiotensin inhibition in the developing kidney; tubulointerstitial effect.
Pediatric research.
2019 04; 85(5):724-730. doi:
10.1038/s41390-019-0288-9. [PMID: 30700837] - Shu Zheng, Shun-Bin Luo, Yi-Bin Mei, Jing Guo, Li-Jun Tong, Qiang Zhang, Xia-Yan Ye. Simultaneous Determination of Rivaroxaban and Enalapril in Rat Plasma by UPLC-MS/MS and Its Application to A Pharmacokinetic Interaction Study.
European journal of drug metabolism and pharmacokinetics.
2019 Apr; 44(2):229-236. doi:
10.1007/s13318-018-0504-8. [PMID: 30151746] - Xiuying Ma, Shahid Tannu, John Allocco, Jie Pan, Janet Dipiero, Pancras Wong. A mouse model of heart failure exhibiting pulmonary edema and pleural effusion: Useful for testing new drugs.
Journal of pharmacological and toxicological methods.
2019 Mar; 96(?):78-86. doi:
10.1016/j.vascn.2019.02.001. [PMID: 30738210] - Dinesh Joshi, Jatinder Katyal, Sudheer Arava, Yogendra Kumar Gupta. Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.
Epilepsy & behavior : E&B.
2019 03; 92(?):345-352. doi:
10.1016/j.yebeh.2018.12.019. [PMID: 30658894] - Yaren Yu, Hao Zhang, Yun Song, Tengfei Lin, Ziyi Zhou, Huiyuan Guo, Lishun Liu, Binyan Wang, Chengzhang Liu, Jianping Li, Yan Zhang, Yong Huo, Chaofu Wang, Xiaobin Wang, Fan Fan Hou, Xianhui Qin, Xiping Xu. Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
The American journal of clinical nutrition.
2019 02; 109(2):449-456. doi:
10.1093/ajcn/nqy320. [PMID: 30624586] - Marcel Alvarez, Leopoldo Ardiles. [Prescription of renin-angiotensin-aldosterone system blockers in patients with stage 3 chronic kidney disease].
Revista medica de Chile.
2019 Feb; 147(2):173-180. doi:
10.4067/s0034-98872019000200173. [PMID: 31095165] - Chau L B Ho, Enayet K Chowdhury, Monique Breslin, Jenny Doust, Christopher M Reid, Lindon M H Wing, Mark R Nelson. Short- and long-term association of lipid-lowering drug treatment and cardiovascular disease by estimated absolute risk in the Second Australian National Blood Pressure study.
Journal of clinical lipidology.
2019 Jan; 13(1):148-155. doi:
10.1016/j.jacl.2018.08.014. [PMID: 30293937] - Huma Khan, Varun Jaiswal, Saurabh Kulshreshtha, Azhar Khan. Potential Angiotensin Converting Enzyme Inhibitors from Moringa oleifera.
Recent patents on biotechnology.
2019; 13(3):239-248. doi:
10.2174/1872208313666190211114229. [PMID: 30747089] - Karine Panico, Mariana V Abrahão, Mayra Trentin-Sonoda, Humberto Muzi-Filho, Adalberto Vieyra, Marcela S Carneiro-Ramos. Cardiac Inflammation after Ischemia-Reperfusion of the Kidney: Role of the Sympathetic Nervous System and the Renin-Angiotensin System.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 53(4):587-605. doi:
10.33594/000000159. [PMID: 31535830] - Osama M Ahmed, Tarek M Ali, Mohamed A Abdel Gaid, Ahmed A Elberry. Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats.
PloS one.
2019; 14(9):e0214349. doi:
10.1371/journal.pone.0214349. [PMID: 31527864] - Hui Yang, Weiru Zhang, Tingting Xie, Xuan Wang, Wangbin Ning. Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2019; 52(11):e8772. doi:
10.1590/1414-431x20198772. [PMID: 31664306] - M E Ougaard, H E Jensen, I D Thuen, E G Petersen, P H Kvist. Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis.
Renal failure.
2018 Nov; 40(1):640-648. doi:
10.1080/0886022x.2018.1533867. [PMID: 30403908] - Amanda M Uber, Maria E Montez-Rath, David M Kwiatkowski, Catherine D Krawczeski, Scott M Sutherland. Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.
Pediatric nephrology (Berlin, Germany).
2018 11; 33(11):2193-2199. doi:
10.1007/s00467-018-4010-7. [PMID: 29987455] - Onju Ham, William Jin, Lei Lei, Hui Hui Huang, Kenji Tsuji, Ming Huang, Jason Roh, Anthony Rosenzweig, Hua A Jenny Lu. Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril.
Scientific reports.
2018 10; 8(1):16087. doi:
10.1038/s41598-018-34216-x. [PMID: 30382174] - Md Abdul Hye Khan, Lauren Kolb, Melissa Skibba, Markus Hartmann, René Blöcher, Ewgenij Proschak, John D Imig. A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.
Diabetologia.
2018 10; 61(10):2235-2246. doi:
10.1007/s00125-018-4685-0. [PMID: 30032428] - Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado. Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: Are they safe?.
Environmental toxicology and pharmacology.
2018 Oct; 63(?):1-5. doi:
10.1016/j.etap.2018.08.005. [PMID: 30107356] - Jeppe B Rosenbaek, Erling B Pedersen, Jesper N Bech. The effect of sodium nitrite infusion on renal function, brachial and central blood pressure during enzyme inhibition by allopurinol, enalapril or acetazolamide in healthy subjects: a randomized, double-blinded, placebo-controlled, crossover study.
BMC nephrology.
2018 09; 19(1):244. doi:
10.1186/s12882-018-1035-x. [PMID: 30241504] - Hiroko Hamatani, Diana G Eng, Natalya V Kaverina, Kenneth W Gross, Benjamin S Freedman, Jeffrey W Pippin, Stuart J Shankland. Lineage tracing aged mouse kidneys shows lower number of cells of renin lineage and reduced responsiveness to RAAS inhibition.
American journal of physiology. Renal physiology.
2018 07; 315(1):F97-F109. doi:
10.1152/ajprenal.00570.2017. [PMID: 29412700] - Milton Packer, Brian Claggett, Martin P Lefkowitz, John J V McMurray, Jean L Rouleau, Scott D Solomon, Michael R Zile. Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial.
The lancet. Diabetes & endocrinology.
2018 07; 6(7):547-554. doi:
10.1016/s2213-8587(18)30100-1. [PMID: 29661699] - Kevin Damman, Mauro Gori, Brian Claggett, Pardeep S Jhund, Michele Senni, Martin P Lefkowitz, Margaret F Prescott, Victor C Shi, Jean L Rouleau, Karl Swedberg, Michael R Zile, Milton Packer, Akshay S Desai, Scott D Solomon, John J V McMurray. Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure.
JACC. Heart failure.
2018 06; 6(6):489-498. doi:
10.1016/j.jchf.2018.02.004. [PMID: 29655829] - Vidushi Mahajan, Sanjay D'Cruz, Ritambara Nada, Atul Sachdev. Successful Use of Entecavir in Hepatitis B-associated Membranous Nephropathy.
Journal of tropical pediatrics.
2018 Jun; 64(3):249-252. doi:
10.1093/tropej/fmx058. [PMID: 28977667] - Marek Konop, Marek Radkowski, Marta Grochowska, Karol Perlejewski, Emilia Samborowska, Marcin Ufnal. Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2018 May; 23(4):380-385. doi:
10.1080/1354750x.2018.1432689. [PMID: 29363331] - F Lu, L-Y Zhao, Z-M Zhang, Q Zou, X-L Yu, C-Y Wei. The intervention of enalapril maleate and folic acid tablet on the expressions of the GRP78 and CHOP and vascular remodeling in the vascular smooth muscle cells of H-hypertensive rats with homocysteine.
European review for medical and pharmacological sciences.
2018 04; 22(7):2160-2168. doi:
10.26355/eurrev_201804_14750. [PMID: 29687876] - Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae, Young Sook Hong. Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney.
Journal of molecular histology.
2018 Apr; 49(2):219-228. doi:
10.1007/s10735-018-9762-7. [PMID: 29442209] - Eric J Velazquez, David A Morrow, Adam D DeVore, Andrew P Ambrosy, Carol I Duffy, Kevin McCague, Adrian F Hernandez, Ricardo A Rocha, Eugene Braunwald. Rationale and design of the comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode (PIONEER-HF) trial.
American heart journal.
2018 04; 198(?):145-151. doi:
10.1016/j.ahj.2018.01.004. [PMID: 29653636]
