Digitin (BioDeep_00000003838)
Main id: BioDeep_00000230831
PANOMIX_OTCML-2023
代谢物信息卡片
(25R)-2alpha,15beta-dihydroxy-5alpha-spirostan-3beta-yl beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranoside
化学式: C56H92O29 (1228.5724)
中文名称: 毛地黃皂苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(C(C3C(O2)C(C4C3(CCC5C4CCC6C5(CC(C(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)CO)O)OC9C(C(C(CO9)O)O)O)OC2C(C(C(C(O2)CO)O)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O)C)C)O)C)OC1
InChI: InChI=1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19?,20-,21-,22+,23-,24+,25+,26+,27+,28+,29+,30+,31-,32+,33-,34+,35-,36+,37-,38-,39+,40+,41+,42+,43+,44-,45+,46-,47-,48+,49-,50+,51-,52-,53-,54+,55-,56+/m0/s1
描述信息
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth[1]. Digitonin is an natural detergent[2].
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth[1]. Digitonin is an natural detergent[2].
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- KEGG: C00765
- PubChem: 439305
- PubChem: 409778
- Metlin: METLIN43702
- MeSH: Digitonin
- KNApSAcK: C00003574
- CAS: 11024-24-1
- PMhub: MS000012152
- ChEBI: CHEBI:27729
- PubChem: 4027
- LipidMAPS: LMST01080003
- 3DMET: B04721
- NIKKAJI: J42.102B
- medchemexpress: HY-N4000
- KNApSAcK: 27729
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daria V Grigorieva, Irina V Gorudko, Natalia A Grudinina, Oleg M Panasenko, Igor V Semak, Alexey V Sokolov, Alexander V Timoshenko. Lactoferrin modified by hypohalous acids: Partial loss in activation of human neutrophils.
International journal of biological macromolecules.
2022 Jan; 195(?):30-40. doi:
10.1016/j.ijbiomac.2021.11.165. [PMID: 34863835] - André T Graça, Michael Hall, Karina Persson, Wolfgang P Schröder. High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction.
Scientific reports.
2021 07; 11(1):15534. doi:
10.1038/s41598-021-94914-x. [PMID: 34330992] - Lindsey R Hayes, Lauren Duan, Svetlana Vidensky, Petr Kalab. Nuclear Transport Assays in Permeabilized Mouse Cortical Neurons.
Journal of visualized experiments : JoVE.
2021 07; ?(173):. doi:
10.3791/62710. [PMID: 34309603] - Alexander G Ball, Maura C Belanger, Rebecca R Pompano. Detergent wash improves vaccinated lymph node handling ex vivo.
Journal of immunological methods.
2021 02; 489(?):112943. doi:
10.1016/j.jim.2020.112943. [PMID: 33333059] - Raymond Malabed, Shinya Hanashima, Michio Murata, Kaori Sakurai. Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin.
Langmuir : the ACS journal of surfaces and colloids.
2020 04; 36(13):3600-3610. doi:
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Scientific reports.
2019 04; 9(1):6726. doi:
10.1038/s41598-019-43143-4. [PMID: 31040365] - Acidália Carine Vieira Santos, Francianne Oliveira Santos, Hélimar Gonçalves Lima, Gisele Dias Da Silva, Rosangela Soares Uzêda, Êuder Reis Dias, Alexsandro Branco, Klauber Viana Cardoso, Jorge Mauricio David, Mariana Borges Botura, Silvia Lima Costa, Maria José Moreira Batatinha. In vitro ovicidal and larvicidal activities of some saponins and flavonoids against parasitic nematodes of goats.
Parasitology.
2018 12; 145(14):1884-1889. doi:
10.1017/s0031182018000689. [PMID: 29781423] - Jonas M la Cour, Pernille Winding Gojkovic, Sophie E B Ambjørner, Jonas Bagge, Simone M Jensen, Svetlana Panina, Martin W Berchtold. ALG-2 participates in recovery of cells after plasma membrane damage by electroporation and digitonin treatment.
PloS one.
2018; 13(9):e0204520. doi:
10.1371/journal.pone.0204520. [PMID: 30240438] - Raymond Malabed, Shinya Hanashima, Michio Murata, Kaori Sakurai. Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins.
Biochimica et biophysica acta. Biomembranes.
2017 Dec; 1859(12):2516-2525. doi:
10.1016/j.bbamem.2017.09.019. [PMID: 28947142] - Helen Y Fan, Heiko Heerklotz. Digitonin does not flip across cholesterol-poor membranes.
Journal of colloid and interface science.
2017 Oct; 504(?):283-293. doi:
10.1016/j.jcis.2017.05.034. [PMID: 28551523] - M Orczyk, K Wojciechowski, G Brezesinski. Disordering Effects of Digitonin on Phospholipid Monolayers.
Langmuir : the ACS journal of surfaces and colloids.
2017 04; 33(15):3871-3881. doi:
10.1021/acs.langmuir.6b04613. [PMID: 28333465] - Aleksey V Zholobenko, Ange Mouithys-Mickalad, Zdenek Dostal, Didier Serteyn, Martin Modriansky. On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells.
PloS one.
2017; 12(10):e0185691. doi:
10.1371/journal.pone.0185691. [PMID: 28977033] - Kamil Wojciechowski, Marta Orczyk, Thomas Gutberlet, Gerald Brezesinski, Thomas Geue, Philippe Fontaine. On the Interaction between Digitonin and Cholesterol in Langmuir Monolayers.
Langmuir : the ACS journal of surfaces and colloids.
2016 09; 32(35):9064-73. doi:
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The Journal of biological chemistry.
2016 Feb; 291(8):4178-84. doi:
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Molecules (Basel, Switzerland).
2015 Nov; 20(11):20146-60. doi:
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2012 Dec; 1818(12):3000-9. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Nov; 19(14):1307-14. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Nov; 19(14):1288-97. doi:
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Pest management science.
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PloS one.
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Cloning and stem cells.
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