Chalepensin (BioDeep_00000003775)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-(alpha,alpha-dimethylallyl)psoralen

化学式: C16H14O3 (254.0943)
中文名称: 状芸香素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 68.75%

分子结构信息

SMILES: C=CC(C)(C)c1cc2cc3ccoc3cc2oc1=O
InChI: InChI=1S/C16H14O3/c1-4-16(2,3)12-8-11-7-10-5-6-18-13(10)9-14(11)19-15(12)17/h4-9H,1H2,2-3H3

描述信息

D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins

同义名列表

3 个代谢物同义名

Chalepensin; 3-(alpha,alpha-dimethylallyl)psoralen; Chalepensin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANXA5, BCL2, BCL2L1, BIRC5, CASP3, CASP9, CYP1A1, CYP2A13, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4, NR1I3, XIAP
Peripheral membrane protein 5 ANXA5, CYP1A1, CYP1B1, CYP2B6, CYP2E1
Endoplasmic reticulum membrane 10 BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Mitochondrion membrane 1 BCL2L1
Nucleus 7 BCL2, BIRC5, CASP3, CASP9, NR1I3, PARP1, XIAP
cytosol 9 ANXA5, BCL2, BCL2L1, BIRC5, CASP3, CASP9, NR1I3, PARP1, XIAP
nuclear body 1 PARP1
centrosome 1 BCL2L1
nucleoplasm 5 BIRC5, CASP3, NR1I3, PARP1, XIAP
Cytoplasmic side 1 BCL2L1
glutamatergic synapse 1 CASP3
mitochondrial inner membrane 3 BCL2L1, CYP1A1, CYP2E1
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 BCL2L1, PARP1
plasma membrane 1 CYP2C9
synaptic vesicle membrane 1 BCL2L1
Membrane 6 ANXA5, BCL2, CYP1B1, CYP2D6, CYP3A4, PARP1
extracellular exosome 1 ANXA5
endoplasmic reticulum 3 BCL2, BCL2L1, CYP2D6
mitochondrion 7 BCL2, BCL2L1, CASP9, CYP1A1, CYP1B1, CYP2D6, PARP1
protein-containing complex 4 BCL2, BIRC5, CASP9, PARP1
intracellular membrane-bounded organelle 9 CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Microsome membrane 8 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
postsynaptic density 1 CASP3
extracellular region 1 ANXA5
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 3 BCL2, BCL2L1, CYP2D6
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 1 ANXA5
microtubule cytoskeleton 1 BIRC5
nucleolus 1 PARP1
midbody 1 BIRC5
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 NR1I3
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 ANXA5
microtubule 1 BIRC5
spindle 1 BIRC5
collagen-containing extracellular matrix 1 ANXA5
interphase microtubule organizing center 1 BIRC5
Zymogen granule membrane 1 ANXA5
chromatin 2 NR1I3, PARP1
Chromosome 2 BIRC5, PARP1
cytoskeleton 1 NR1I3
centriole 1 BIRC5
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 BIRC5
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
myelin sheath 1 BCL2
kinetochore 1 BIRC5
apoptosome 1 CASP9
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 PARP1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Lutfun Nahar, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul, Satyajit D Sarker. Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061609. [PMID: 33799365]
  • Ramiro Quintanilla-Licea, Benito David Mata-Cárdenas, Javier Vargas-Villarreal, Aldo Fabio Bazaldúa-Rodríguez, Isvar Kavimngeles-Hernández, Jesús Norberto Garza-González, Magda Elizabeth Hernández-García. Antiprotozoal activity against Entamoeba histolytica of plants used in northeast Mexican traditional medicine. Bioactive compounds from Lippia graveolens and Ruta chalepensis. Molecules (Basel, Switzerland). 2014 Dec; 19(12):21044-65. doi: 10.3390/molecules191221044. [PMID: 25517343]
  • Wei-Sheng Lo, Yun-Ping Lim, Chien-Chih Chen, Chih-Chien Hsu, Pavel Souček, Chul-Ho Yun, Wen Xie, Yune-Fang Ueng. A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation. Archives of toxicology. 2012 Dec; 86(12):1927-38. doi: 10.1007/s00204-012-0902-7. [PMID: 22790670]
  • J Yamahara, S Miki, H Murakami, H Matsuda, H Fujimura. [Screening test for calcium antagonists in natural products. The active principles of Boenninghausenia albiflora var. japonica]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1987 Oct; 107(10):823-6. doi: 10.1248/yakushi1947.107.10_823. [PMID: 3440926]