Flindersine (BioDeep_00000003610)

   

natural product


代谢物信息卡片


Flindersine

化学式: C14H13NO2 (227.0946)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 8.87%

分子结构信息

SMILES: CC1(C)C=Cc2c(O)nc3ccccc3c2O1
InChI: InChI=1S/C14H13NO2/c1-14(2)8-7-10-12(17-14)9-5-3-4-6-11(9)15-13(10)16/h3-8H,1-2H3,(H,15,16)

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 1.139
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.140

同义名列表

2 个代谢物同义名

Flindersine; Flindersine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

68 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 MX1, PPARG, PRKAA2, PRKX, TNK1
Peripheral membrane protein 2 MX1, TNK1
Endoplasmic reticulum membrane 1 MX1
Nucleus 4 MX1, PPARG, PRKAA2, PRKX
cytosol 5 MX1, NGF, PPARG, PRKAA2, SLC2A4
dendrite 2 NGF, PRKAA2
trans-Golgi network 1 SLC2A4
nucleoplasm 3 PPARG, PRKAA2, PRKX
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 2 SLC2A4, TNF
Multi-pass membrane protein 1 SLC2A4
cell surface 1 TNF
Golgi apparatus 1 PRKAA2
Golgi membrane 1 INS
neuronal cell body 2 PRKAA2, TNF
sarcolemma 1 SLC2A4
synaptic vesicle 1 NGF
Presynapse 1 SLC2A4
plasma membrane 3 SLC2A4, TNF, TNK1
Membrane 4 MX1, PRKAA2, SLC2A4, TNK1
axon 2 NGF, PRKAA2
extracellular exosome 1 SLC2A4
extracellular space 3 INS, NGF, TNF
perinuclear region of cytoplasm 3 MX1, PPARG, SLC2A4
intracellular membrane-bounded organelle 1 PPARG
Secreted 2 INS, NGF
extracellular region 3 INS, NGF, TNF
nuclear membrane 1 MX1
external side of plasma membrane 2 SLC2A4, TNF
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
clathrin-coated pit 1 SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 MX1, SLC2A4
Membrane raft 2 SLC2A4, TNF
microtubule 1 MX1
sarcoplasmic reticulum 1 SLC2A4
nuclear speck 1 PRKAA2
receptor complex 1 PPARG
chromatin 1 PPARG
phagocytic cup 1 TNF
Endomembrane system 1 SLC2A4
endosome lumen 2 INS, NGF
Cytoplasmic vesicle membrane 1 SLC2A4
cytoplasmic stress granule 1 PRKAA2
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
Golgi lumen 2 INS, NGF
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 MX1
vesicle membrane 1 SLC2A4
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
insulin-responsive compartment 1 SLC2A4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Santiagu Stephen Irudayaraj, Jacob Jincy, Christudas Sunil, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu, Govindasamy Chandramohan, Soosaimanickam Maria Packiam. Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. Journal of ethnopharmacology. 2022 Mar; 285(?):114883. doi: 10.1016/j.jep.2021.114883. [PMID: 34861363]
  • Elaine Torres Suarez, Diana Susana Granados-Falla, Sara María Robledo, Javier Murillo, Yulieth Upegui, Gabriela Delgado. Antileishmanial activity of synthetic analogs of the naturally occurring quinolone alkaloid N-methyl-8-methoxyflindersin. PloS one. 2020; 15(12):e0243392. doi: 10.1371/journal.pone.0243392. [PMID: 33370295]
  • Rodrigo Sant'Ana Cabral, Pierre-Marie Allard, Laurence Marcourt, Maria Cláudia Marx Young, Emerson Ferreira Queiroz, Jean-Luc Wolfender. Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks. Journal of natural products. 2016 09; 79(9):2270-8. doi: 10.1021/acs.jnatprod.6b00379. [PMID: 27557347]
  • Santiagu Stephen Irudayaraj, Christudas Sunil, Veeramuthu Duraipandiyan, Savarimuthu Ignacimuthu. Antidiabetic and antioxidant activities of Toddalia asiatica (L.) Lam. leaves in streptozotocin induced diabetic rats. Journal of ethnopharmacology. 2012 Sep; 143(2):515-23. doi: 10.1016/j.jep.2012.07.006. [PMID: 22842651]
  • Veeramuthu Duraipandiyan, Naif Abdullah Al-Harbi, Savarimuthu Ignacimuthu, Chinnasamy Muthukumar. Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm. BMC complementary and alternative medicine. 2012 Mar; 12(?):13. doi: 10.1186/1472-6882-12-13. [PMID: 22397713]
  • M Karunai Raj, C Balachandran, V Duraipandiyan, P Agastian, S Ignacimuthu. Antimicrobial activity of Ulopterol isolated from Toddalia asiatica (L.) Lam.: a traditional medicinal plant. Journal of ethnopharmacology. 2012 Mar; 140(1):161-5. doi: 10.1016/j.jep.2012.01.005. [PMID: 22265751]
  • Pegah Varamini, Katayoun Javidnia, Mohammad Soltani, Ahmad Reza Mehdipour, Abbas Ghaderi. Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss. Planta medica. 2009 Nov; 75(14):1509-16. doi: 10.1055/s-0029-1185807. [PMID: 19551611]
  • V Duraipandiyan, S Ignacimuthu. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. Journal of ethnopharmacology. 2009 Jun; 123(3):494-8. doi: 10.1016/j.jep.2009.02.020. [PMID: 19481384]
  • Cheng-Hui Yang, Ming-Jen Cheng, Shiow-Ju Lee, Cheng-Wei Yang, Hsun-Shuo Chang, Ih-Sheng Chen. Secondary metabolites and cytotoxic activities from the stem bark of Zanthoxylum nitidum. Chemistry & biodiversity. 2009 Jun; 6(6):846-57. doi: 10.1002/cbdv.200800107. [PMID: 19551734]
  • Pier Luigi Gentili, Fausto Ortica, Gianna Favaro. Static and dynamic interaction of a naturally occurring photochromic molecule with bovine serum albumin studied by UV-visible absorption and fluorescence spectroscopy. The journal of physical chemistry. B. 2008 Dec; 112(51):16793-801. doi: 10.1021/jp805922g. [PMID: 19367911]
  • Pier Luigi Gentili. Boolean and fuzzy logic gates based on the interaction of flindersine with bovine serum albumin and tryptophan. The journal of physical chemistry. A. 2008 Nov; 112(47):11992-7. doi: 10.1021/jp806772m. [PMID: 18973319]
  • C L Cantrell, K K Schrader, L K Mamonov, G T Sitpaeva, T S Kustova, C Dunbar, D E Wedge. Isolation and identification of antifungal and antialgal alkaloids from Haplophyllum sieversii. Journal of agricultural and food chemistry. 2005 Oct; 53(20):7741-8. doi: 10.1021/jf051478v. [PMID: 16190626]
  • Fujinori Hanawa, Nikolas Fokialakis, Alexios-Leandros Skaltsounis. Photo-activated DNA binding and antimicrobial activities of furoquinoline and pyranoquinolone alkaloids from rutaceae. Planta medica. 2004 Jun; 70(6):531-5. doi: 10.1055/s-2004-827153. [PMID: 15229804]