phosphoramidon (BioDeep_00000003416)
代谢物信息卡片
phosphoramidon
化学式: C23H34N3O10P (543.1982)
中文名称: 磷酰二肽
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CC(C)CC(NP(=O)(O)OC1OC(C)C(O)C(O)C1O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O
InChI: InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1
描述信息
A dipeptide isolated from the cultures of Streptomyces tanashiensis.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
KEIO_ID P122
同义名列表
3 个代谢物同义名
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:45353
- KEGG: C00563
- PubChem: 445114
- Metlin: METLIN65521
- DrugBank: DB02557
- ChEMBL: CHEMBL479579
- KNApSAcK: C00017972
- CAS: 119942-99-3
- CAS: 36357-77-4
- MoNA: KO001731
- MoNA: KO009148
- MoNA: KO001733
- MoNA: KO003891
- MoNA: KO001730
- MoNA: KO001732
- MoNA: KO001734
- MoNA: KO003889
- MoNA: KO003890
- MoNA: KO003888
- PMhub: MS000009641
- MetaboLights: MTBLC45353
- PubChem: 3843
- PDB-CCD: RDF
- NIKKAJI: J18.388A
- RefMet: Phosphoramidon
- KNApSAcK: 45353
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 67367 - Streptomyces tanashiensis: 10.1016/S0040-4039(01)84249-0
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Aikaterini Kaloudi, Berthold A Nock, Emmanouil Lymperis, Eric P Krenning, Marion de Jong, Theodosia Maina. Improving the In Vivo Profile of Minigastrin Radiotracers: A Comparative Study Involving the Neutral Endopeptidase Inhibitor Phosphoramidon.
Cancer biotherapy & radiopharmaceuticals.
2016 Feb; 31(1):20-8. doi:
10.1089/cbr.2015.1935. [PMID: 26844849] - A Kaloudi, B A Nock, E P Krenning, T Maina, M De Jong. Radiolabeled gastrin/CCK analogs in tumor diagnosis: towards higher stability and improved tumor targeting.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....
2015 Sep; 59(3):287-302. doi:
. [PMID: 26158215] - Panteleimon J Marsouvanidis, Marleen Melis, Erik de Blois, Wout A P Breeman, Eric P Krenning, Theodosia Maina, Berthold A Nock, Marion de Jong. In vivo enzyme inhibition improves the targeting of [177Lu]DOTA-GRP(13-27) in GRPR-positive tumors in mice.
Cancer biotherapy & radiopharmaceuticals.
2014 Nov; 29(9):359-67. doi:
10.1089/cbr.2014.1706. [PMID: 25286347] - Tatsuo Sakamoto, Michihiro Kamijima, Mio Miyake. Neurogenic airway microvascular leakage induced by toluene inhalation in rats.
European journal of pharmacology.
2012 Jun; 685(1-3):180-5. doi:
10.1016/j.ejphar.2012.04.035. [PMID: 22554773] - Maria Luisa Sirico, Bruna Guida, Alfredo Procino, Andrea Pota, Maurizio Sodo, Giuseppe Grandaliano, Simona Simone, Giovanni Pertosa, Eleonora Riccio, Bruno Memoli. Human mature adipocytes express albumin and this expression is not regulated by inflammation.
Mediators of inflammation.
2012; 2012(?):236796. doi:
10.1155/2012/236796. [PMID: 22675238] - Yung-Hua Koh, Shabbir Moochhala, Madhav Bhatia. The role of neutral endopeptidase in caerulein-induced acute pancreatitis.
Journal of immunology (Baltimore, Md. : 1950).
2011 Nov; 187(10):5429-39. doi:
10.4049/jimmunol.1102011. [PMID: 22013111] - Markus Hoenicka, Andreas Keyser, Leopold Rupprecht, Thomas Puehler, Stephan Hirt, Christof Schmid. Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?.
The Annals of thoracic surgery.
2011 Oct; 92(4):1299-306. doi:
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Journal of molecular and cellular cardiology.
2011 Jul; 51(1):67-71. doi:
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PloS one.
2011; 6(11):e26994. doi:
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British journal of pharmacology.
2010 Feb; 159(4):812-9. doi:
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Peptides.
2010 Feb; 31(2):346-53. doi:
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International archives of allergy and immunology.
2010; 152(3):295-300. doi:
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Magnesium research.
2009 Sep; 22(3):167S-173S. doi:
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Regulatory peptides.
2008 Nov; 151(1-3):7-13. doi:
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Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2008 Jul; 57(7):300-5. doi:
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Hypertension (Dallas, Tex. : 1979).
2007 Jul; 50(1):110-5. doi:
10.1161/hypertensionaha.106.085761. [PMID: 17470724] - Wanda Nowak, Ezequiel Dario Goldschmidt, Alejandra Georgina Falcioni, Mariana Ines Pugliese, Andrea Emilse Errasti, Facundo German Pelorosso, Federico Manuel Daray, Juan Ezequiel Gago, Rodolfo Pedro Rothlin. Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.
Naunyn-Schmiedeberg's archives of pharmacology.
2007 May; 375(3):221-9. doi:
10.1007/s00210-007-0145-y. [PMID: 17372720] - Mohamed Anwar Abdelhalim. Effects of big endothelin-1 in comparison with endothelin-1 on the microvascular blood flow velocity and diameter of rat mesentery in vivo.
Microvascular research.
2006 Nov; 72(3):108-12. doi:
10.1016/j.mvr.2006.04.007. [PMID: 17028040] - Carlos R Tirapelli, Marie-Helene Fecteau, Jean-Claude Honore, Eurode Legros, Fernand Gobeil, Pedro D'Orleans-Juste. Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta.
British journal of pharmacology.
2006 Jun; 148(4):527-35. doi:
10.1038/sj.bjp.0706735. [PMID: 16633356] - Jerzy Beltowski, Anna Jamroz-Wisniewska, Ewelina Borkowska, Andrzej Marciniak. Phosphodiesterase 5 inhibitor ameliorates renal resistance to atrial natriuretic peptide associated with obesity and hyperleptinemia.
Archives of medical research.
2006 Apr; 37(3):307-15. doi:
10.1016/j.arcmed.2005.06.008. [PMID: 16513477] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Francesca Restivo, Giulio Mengozzi, Antonina Smedile, Floriano Rosina, Oliviero Danni, Maurizio Parola, Mario Rizzetto. Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?.
Journal of hepatology.
2005 Nov; 43(5):791-8. doi:
10.1016/j.jhep.2005.04.017. [PMID: 16085334] - Adnan Dibas, Ganesh Prasanna, Thomas Yorio. Localization of endothelin-converting enzyme in bovine optic nerve and retina.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2005 Aug; 21(4):288-97. doi:
10.1089/jop.2005.21.288. [PMID: 16117692] - M Cemazar, I Wilson, V E Prise, K M Bell, S A Hill, G M Tozer. The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification.
British journal of cancer.
2005 Jul; 93(1):98-106. doi:
10.1038/sj.bjc.6602672. [PMID: 15970923] - Marie-Hélène Fecteau, Jean-Claude Honoré, Mirco Plante, Julie Labonté, Giles A Rae, Pedro D'Orléans-Juste. Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Hypertension (Dallas, Tex. : 1979).
2005 Jul; 46(1):87-92. doi:
10.1161/01.hyp.0000170460.24604.23. [PMID: 15956117] - Adnan Dibas, Ganesh Prasanna, Thomas Yorio. Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2005 Jun; 21(3):196-204. doi:
10.1089/jop.2005.21.196. [PMID: 15969636] - Fumihiro Teramachi, Takashi Koyano, Thaworn Kowithayakorn, Masahiko Hayashi, Kanki Komiyama, Masami Ishibashi. Collagenase inhibitory quinic acid esters from Ipomoea pes-caprae.
Journal of natural products.
2005 May; 68(5):794-6. doi:
10.1021/np0500631. [PMID: 15921434] - Bruno D'Agostino, Giuseppina Marrocco, Marilisa De Nardo, Girolamo Calò, Remo Guerrini, Luca Gallelli, Charles Advenier, Francesco Rossi. Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.
British journal of pharmacology.
2005 Mar; 144(6):813-20. doi:
10.1038/sj.bjp.0706066. [PMID: 15685213] - Igor Ryndin, Frederick A Gulmi, Shyan-Yih Chou, Unni M M Mooppan, Hong Kim. Renal responses to atrial natriuretic peptide are preserved in bilateral ureteral obstruction and augmented by neutral endopeptidase inhibition.
The Journal of urology.
2005 Feb; 173(2):651-6. doi:
10.1097/01.ju.0000150532.61780.1f. [PMID: 15643282] - Vladimir Kuklin, Mikhail Sovershaev, Thomas Andreasen, Vegard Skogen, Kirsti Ytrehus, Lars Bjertnaes. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture.
Critical care (London, England).
2005; 9(6):R677-86. doi:
10.1186/cc3882. [PMID: 16280068] - B M R Quinto, M A Juliano, I Hirata, A K Carmona, L Juliano, D E Casarini. Specificity comparison of a serine endopeptidase (SH1) and a serine thiol endopeptidase (STH2) purified from human urine.
The international journal of biochemistry & cell biology.
2004 Oct; 36(10):1933-44. doi:
10.1016/j.biocel.2004.02.011. [PMID: 15203108] - Akanksha Gupta, Avadhesh C Sharma. Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases.
Molecular and cellular biochemistry.
2004 Oct; 265(1-2):47-56. doi:
10.1023/b:mcbi.0000044314.29395.fb. [PMID: 15543933] - Alexander I Kuklin, Randall L Mynatt, Mitchell L Klebig, Laura L Kiefer, William O Wilkison, Richard P Woychik, Edward J Michaud. Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes.
Molecular cancer.
2004 Jun; 3(?):17. doi:
10.1186/1476-4598-3-17. [PMID: 15175105] - Kenichi Shirai, Takeshi Nakanishi, Yoshihiro Takamitsu. [Endothelin].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Jun; 62 Suppl 6(?):194-200. doi:
NULL. [PMID: 15250294] - Céline Rouget, Yong Yao Cui, Bruno D'Agostino, Christophe Faisy, Emmanuel Naline, Marc Bardou, Charles Advenier. Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.
British journal of pharmacology.
2004 Mar; 141(6):1077-83. doi:
10.1038/sj.bjp.0705704. [PMID: 14993101] - Arundhathi Jeyabalan, Jacqueline Novak, Lee A Danielson, Laurie J Kerchner, Shannon L Opett, Kirk P Conrad. Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries.
Circulation research.
2003 Dec; 93(12):1249-57. doi:
10.1161/01.res.0000104086.43830.6c. [PMID: 14593002] - Fei He, Ming Sun, Rong Guo. [Protective effects of phosphoramidon on the experimental myocardial injury in rats].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2003 Dec; 28(6):572-4. doi:
NULL. [PMID: 15804063] - Joachim F Schindler. Aminopeptidases function as endocytic receptors in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes).
Journal of experimental zoology. Part A, Comparative experimental biology.
2003 Oct; 299(2):213-22. doi:
10.1002/jez.a.10282. [PMID: 12975809] - Akanksha Gupta, Avadhesh C Sharma. Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia.
Shock (Augusta, Ga.).
2003 Oct; 20(4):375-81. doi:
10.1097/01.shk.0000087202.34916.0c. [PMID: 14501953] - Cristina T Navarrete, Carlos Devia, Andrea C Lessa, Dorothy Hehre, Karen Young, Octavio Martinez, Eduardo Bancalari, Cleide Suguihara. The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn piglets.
Pediatric research.
2003 Sep; 54(3):387-92. doi:
10.1203/01.pdr.0000078272.77816.1e. [PMID: 12788984] - Alexey A Lagunin, Oleg A Gomazkov, Dmitrii A Filimonov, Tatyana A Gureeva, Elvira A Dilakyan, Elena V Kugaevskaya, Yulia E Elisseeva, Nina I Solovyeva, Vladimir V Poroikov. Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.
Journal of medicinal chemistry.
2003 Jul; 46(15):3326-32. doi:
10.1021/jm021089h. [PMID: 12852763] - Catherine Rougeot, Michaël Messaoudi, Véronique Hermitte, Anne Gaëlle Rigault, Thierry Blisnick, Christophe Dugave, Didier Desor, François Rougeon. Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Proceedings of the National Academy of Sciences of the United States of America.
2003 Jul; 100(14):8549-54. doi:
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The journal of medical investigation : JMI.
2003 Feb; 50(1-2):87-94. doi:
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Journal of nephrology.
2003 Jan; 16(1):63-74. doi:
NULL. [PMID: 12649537] - Kazushige Dobashi, Inderjit Singh, John K Orak, Kohtaro Asayama, Avtar K Singh. Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney.
Molecular and cellular biochemistry.
2002 Nov; 240(1-2):9-17. doi:
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Molecular and cellular biochemistry.
2002 Nov; 240(1-2):19-29. doi:
10.1023/a:1020675721351. [PMID: 12487368] - Stéphanie G Dubois, Andréa Frota Ruchon, Aline Delalandre, Guy Boileau, Daniel Lajeunesse. Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.
American journal of physiology. Cell physiology.
2002 Nov; 283(5):C1414-21. doi:
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Phytotherapy research : PTR.
2002 Sep; 16(6):545-9. doi:
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Clinical and experimental pharmacology & physiology.
2002 Aug; 29(8):679-83. doi:
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The European respiratory journal.
2002 Aug; 20(2):268-73. doi:
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FEBS letters.
2002 May; 519(1-3):181-4. doi:
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American journal of respiratory and critical care medicine.
2002 Feb; 165(3):398-405. doi:
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The Journal of clinical endocrinology and metabolism.
2002 Jan; 87(1):322-8. doi:
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Archives of biochemistry and biophysics.
2001 Dec; 396(2):178-86. doi:
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The American journal of medicine.
2001 Dec; 111 Suppl 8A(?):25S-30S. doi:
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Analytical biochemistry.
2001 Oct; 297(1):52-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2001 Oct; 299(1):372-6. doi:
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European journal of pharmacology.
2001 Aug; 425(3):219-27. doi:
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Phytotherapy research : PTR.
2001 Aug; 15(5):444-6. doi:
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Canadian journal of physiology and pharmacology.
2001 Aug; 79(8):715-22. doi:
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Biology of reproduction.
2001 Aug; 65(2):538-43. doi:
10.1095/biolreprod65.2.538. [PMID: 11466223] - S J Wort, M Woods, T D Warner, T W Evans, J A Mitchell. Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling.
American journal of respiratory cell and molecular biology.
2001 Jul; 25(1):104-10. doi:
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2001 May; 31(5-6):499-511. doi:
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