Piperacillin (BioDeep_00000003414)

 

Secondary id: BioDeep_00000016600

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antibiotics


代谢物信息卡片


(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C23H27N5O7S (517.1631)
中文名称: 哌拉西林
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 32.48%

分子结构信息

SMILES: CCN(C4)C(=O)C(=O)N(C4)C(=O)NC(c(c3)cccc3)C(=O)NC(C(=O)1)C(S2)N1C(C(O)=O)C(C)(C)2
InChI: InChI=1/C23H27N5O7S/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34)/t13-,14+,15-,20+/m0/s1/f/h24-25,33H

描述信息

Piperacillin is only found in individuals that have used or taken this drug. It is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
Acquisition and generation of the data is financially supported in part by CREST/JST.
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Same as: D08380
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

36 个代谢物同义名

(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-6-[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Ratiopharm brand OF piperacillin sodium; Fresenius brand OF piperacillin sodium; Astrapin brand OF piperacillin sodium; Curasan brand OF piperacillin sodium; Lederle brand OF pipracillin sodium; Wyeth brand OF piperacillin sodium; Hexal brand OF piperacillin sodium; AHP brand OF piperacillin sodium; Salt, piperacillin monosodium; Monosodium salt, piperacillin; Piperacillin monosodium salt; Piperacillin sodium salt; Piperacillin-ratiopharm; Piperacillin ratiopharm; Piperacillin fresenius; Piperacillin anhydrous; Curasan, piperacillin; Piperacillin curasan; Sodium, piperacillin; Piperacillin Sodium; Piperacillin hexal; AB piperacillin; AB-piperacillin; Pipera hameln; Pipera-hameln; Piperacillin; Pipercillin; Pipracil; Peracin; Pipcil; Pipril; PIPC; Piperacillin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 ALB, CST3
Peripheral membrane protein 1 CYP27A1
Endoplasmic reticulum membrane 2 CD4, MOXD1
Mitochondrion membrane 1 CYP27A1
Nucleus 1 ALB
cytosol 3 ALB, GPT, LIPE
centrosome 1 ALB
Cell membrane 4 CD4, CD8A, LIPE, TNF
Multi-pass membrane protein 2 SLC22A6, SLC22A8
cell surface 2 C3, TNF
Golgi apparatus 2 ALB, CST3
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 LIPE
plasma membrane 8 C3, CD4, CD8A, CST3, IGHE, SLC22A6, SLC22A8, TNF
Membrane 2 LIPE, SLC22A6
apical plasma membrane 1 SLC22A8
basolateral plasma membrane 2 SLC22A6, SLC22A8
caveola 2 LIPE, SLC22A6
extracellular exosome 6 ALB, C3, CST3, GPT, SLC22A6, SLC22A8
endoplasmic reticulum 2 ALB, CST3
extracellular space 11 ALB, C3, CPZ, CRP, CSF3, CST3, IGHE, IL6, MOXD1, RNASE3, TNF
lysosomal lumen 1 CSF3
mitochondrion 1 CYP27A1
protein-containing complex 3 ALB, C3, SLC22A6
Single-pass type I membrane protein 4 CD4, CD8A, IGHE, MOXD1
Secreted 7 ALB, C3, CRP, CSF3, CST3, HTRA3, IL6
extracellular region 11 ALB, C3, CD8A, CRP, CSF3, CST3, HTRA3, IGHE, IL6, RNASE3, TNF
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, CD8A, TNF
Secreted, extracellular space, extracellular matrix 1 CPZ
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 CST3
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 2 CD4, TNF
lateral plasma membrane 1 SLC22A8
receptor complex 1 CD8A
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, C3
Basolateral cell membrane 2 SLC22A6, SLC22A8
[Isoform 2]: Cell membrane 1 IGHE
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
basal plasma membrane 1 SLC22A6
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CST3
secretory granule lumen 1 C3
secretory granule membrane 1 MOXD1
endoplasmic reticulum lumen 5 ALB, C3, CD4, CST3, IL6
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 CST3
azurophil granule lumen 2 C3, RNASE3
clathrin-coated endocytic vesicle membrane 1 CD4
Basal cell membrane 1 SLC22A6
[Isoform 1]: Cell membrane 1 CD8A
[Isoform 3]: Cell membrane 1 IGHE
endocytic vesicle lumen 1 CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhang Ruijuan, Xiao Li, Wang Yingjie, Wang Rui, Lu Chunqing. Effects of Catheter Tracking Management on Urinary Tract Function and Infection Rates in Patients With Spinal Cord Injury. Alternative therapies in health and medicine. 2023 Jan; ?(?):. doi: . [PMID: 36634314]
  • Wei Zhang, Chun-Yu Yan, Shu-Rui Li, Ting-Ting Fan, Shan-Shan Cao, Bin Cui, Meng-Ying Li, Bo-Yuan Fan, Bo Ji, Li Wang, Fei Cui, Jia Cui, Lei Wang, Yue Guan, Jing-Wen Wang. Efficacy and safety of piperacillin-tazobactam compared with meropenem in treating complicated urinary tract infections including acute pyelonephritis due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Frontiers in cellular and infection microbiology. 2023; 13(?):1093842. doi: 10.3389/fcimb.2023.1093842. [PMID: 37207190]
  • Shungo Imai, Shota Kadomura, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Yoh Takekuma. Using Japanese big data to investigate novel factors and their high-risk combinations that affect vancomycin-induced nephrotoxicity. British journal of clinical pharmacology. 2022 07; 88(7):3241-3255. doi: 10.1111/bcp.15252. [PMID: 35106797]
  • Robert Strengen Bigseth, Håkon Sandholdt, Andreas Petersen, Christian Østergaard, Thomas Benfield, Louise Thorlacius-Ussing. Comparable Effectiveness of Cefuroxime and Piperacillin-Tazobactam as Empirical Therapy for Methicillin-Susceptible Staphylococcus aureus Bacteremia. Microbiology spectrum. 2022 06; 10(3):e0153021. doi: 10.1128/spectrum.01530-21. [PMID: 35438533]
  • Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients. European journal of clinical pharmacology. 2022 Jun; 78(6):989-1001. doi: 10.1007/s00228-022-03307-0. [PMID: 35275224]
  • Eveline Wallenburg, Rob Ter Heine, Jeroen A Schouten, Jelmer Raaijmakers, Jaap Ten Oever, Eva Kolwijck, David M Burger, Peter Pickkers, Tim Frenzel, Roger J M Brüggemann. An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients. Clinical pharmacokinetics. 2022 06; 61(6):907-918. doi: 10.1007/s40262-022-01113-6. [PMID: 35377133]
  • Wei-Chun Huang, Mei-Tzu Wang, Tai-Shuan Lai, Kuo-Hua Lee, Shih-Chieh Shao, Chien-Hao Chen, Chien-Hao Su, Yih-Ting Chen, Junne-Ming Sung, Yung-Chang Chen. Nephrotoxins and acute kidney injury - The consensus of the Taiwan acute kidney injury Task Force. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 May; 121(5):886-895. doi: 10.1016/j.jfma.2021.12.007. [PMID: 34998658]
  • Yong Kyun Kim, Hyoung Soo Kim, Sunghoon Park, Hwan-Il Kim, Sun Hee Lee, Dong-Hwan Lee. Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation. The Journal of antimicrobial chemotherapy. 2022 04; 77(5):1353-1364. doi: 10.1093/jac/dkac059. [PMID: 35224630]
  • Ping Li, Zengsheng Chen, Rong Wang, Changfeng Shao, Yan Liu, Qiang Ju, Peng Zong, Haiyan Wang. Pancytopenia in a newborn due to maternal piperacillin and human leukocyte antigen antibodies. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2022 Apr; 61(2):103324. doi: 10.1016/j.transci.2021.103324. [PMID: 34865972]
  • Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem. Journal of chemotherapy (Florence, Italy). 2022 Apr; 34(2):103-109. doi: 10.1080/1120009x.2021.1965334. [PMID: 34424136]
  • Stefan Hagel, Friedhelm Bach, Thorsten Brenner, Hendrik Bracht, Alexander Brinkmann, Thorsten Annecke, Andreas Hohn, Markus Weigand, Guido Michels, Stefan Kluge, Axel Nierhaus, Dominik Jarczak, Christina König, Dirk Weismann, Otto Frey, Dominic Witzke, Carsten Müller, Michael Bauer, Michael Kiehntopf, Sophie Neugebauer, Thomas Lehmann, Jason A Roberts, Mathias W Pletz. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive care medicine. 2022 Mar; 48(3):311-321. doi: 10.1007/s00134-021-06609-6. [PMID: 35106617]
  • Mitchell S Buckley, Ivan A Komerdelj, Paul A D'Alessio, Pooja Rangan, Sumit K Agarwal, Nicole C Tinta, Brandon K Martinez, Delia S Ziadat, Melanie J Yerondopoulos, Emir Kobic, Sandra L Kane-Gill. Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study. Journal of critical care. 2022 02; 67(?):134-140. doi: 10.1016/j.jcrc.2021.10.018. [PMID: 34768175]
  • Hadrien Winiszewski, Cyrielle Despres, Marc Puyraveau, Jennifer Lagoutte-Renosi, Damien Montange, Guillaume Besch, Sebastien Pili Floury, Claire Chaignat, Guylaine Labro, Lucie Vettoretti, Anne-Laure Clairet, Gilles Capellier, Berengère Vivet, Gael Piton. β-lactam dosing at the early phase of sepsis: Performance of a pragmatic protocol for target concentration achievement in a prospective cohort study. Journal of critical care. 2022 02; 67(?):141-146. doi: 10.1016/j.jcrc.2021.10.023. [PMID: 34768176]
  • Robert Włodarski, Karolina Żuchowska, Wojciech Filipiak. Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry. Molecules (Basel, Switzerland). 2022 Jan; 27(3):. doi: 10.3390/molecules27030926. [PMID: 35164191]
  • Chi-Hao Shao, Chih-Hsun Tai, Fang-Ju Lin, Chien-Chih Wu, Jann-Tay Wang, Chi-Chuan Wang. Comparison of risk of acute kidney injury between patients receiving the combination of teicoplanin and piperacillin/tazobactam versus vancomycin and piperacillin/tazobactam. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 Jan; 121(1 Pt 1):117-125. doi: 10.1016/j.jfma.2021.02.004. [PMID: 33637370]
  • Y Al-Jebawi, K Karalic, P Shekhawat, M J Mhanna. The concomitant use of vancomycin and piperacillin-tazobactam is associated with acute kidney injury (AKI) in extremely low birth weight infants (ELBW). Journal of neonatal-perinatal medicine. 2022; 15(2):303-309. doi: 10.3233/npm-210866. [PMID: 34864693]
  • Brian Pacca Elliott, Michael M Tang, Joshua Alexander Madden, Ronald James Markert, Steven Dale Burdette, Craig Matthew Pleiman, Emily Claire Speelmon. A retrospective cohort study assessing acute kidney injury and renal recovery among septic patients empirically treated with vancomycin piperacillin-tazobactam versus vancomycin cefepime. Internal and emergency medicine. 2022 Jan; 17(1):91-99. doi: 10.1007/s11739-021-02772-2. [PMID: 34089468]
  • Jongsung Hahn, Kyoung Lok Min, Soyoung Kang, Seungwon Yang, Min Soo Park, Jin Wi, Min Jung Chang. Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy. Microbiology spectrum. 2021 12; 9(3):e0063321. doi: 10.1128/spectrum.00633-21. [PMID: 34937189]
  • Kohei Sazanami, Ryo Inose, Tatsuya Yagi, Satoshi Dote, Nozomu Horiuchi, Yuka Kobayashi, Yuichi Muraki. Incidence of acute kidney injury after teicoplanin- or vancomycin- and piperacillin/tazobactam combination therapy: A comparative study using propensity score matching analysis. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021 Dec; 27(12):1723-1728. doi: 10.1016/j.jiac.2021.08.012. [PMID: 34446352]
  • Sofie Colman, Sofie Dhaese, Veronique Stove, Jan J De Waele, Alain G Verstraete. Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit. Clinica chimica acta; international journal of clinical chemistry. 2021 Dec; 523(?):72-76. doi: 10.1016/j.cca.2021.09.005. [PMID: 34508687]
  • Alfredo Traversa, Drayton A Hammond, Gary D Peksa, Joshua M DeMott. Short Versus Extended Duration Vancomycin and Piperacillin/Tazobactam and the Incidence of Acute Kidney Injury in Noncritically Ill Patients. Journal of pharmacy practice. 2021 Dec; 34(6):882-887. doi: 10.1177/0897190020933488. [PMID: 32578474]
  • Yuma Yamashita, Hiroshi Kawaguchi, Tsubasa Yano, Norihiro Sakurai, Wataru Shibata, Kazuhiro Oshima, Takumi Imai, Koichi Yamada, Yasutaka Nakamura, Katsuya Nagayama, Hiroshi Kakeya. Risk factors for acute kidney injury in vancomycin and piperacillin/tazobactam combination therapy: A retrospective study. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021 Nov; 27(11):1614-1620. doi: 10.1016/j.jiac.2021.07.017. [PMID: 34366231]
  • Naoto Okada, Yuki Izumi, Aki Nakamoto, Masayuki Chuma, Mitsuhiro Goda, Kenta Yagi, Fuka Aizawa, Hirofumi Hamano, Yoshito Zamami, Momoyo Azuma, Keisuke Ishizawa. Impact of Area Under the Concentration-Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study. Clinical therapeutics. 2021 11; 43(11):1910-1920.e3. doi: 10.1016/j.clinthera.2021.09.007. [PMID: 34642081]
  • Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M Jakob, Hyung-Sook Kim, Bianca J Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, John F Fraser, Kiran Shekar, Jason A Roberts. Population Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: an ASAP ECMO Study. Antimicrobial agents and chemotherapy. 2021 10; 65(11):e0143821. doi: 10.1128/aac.01438-21. [PMID: 34460303]
  • Jazmin D Lee, Brett H Heintz, Hilary J Mosher, Daniel J Livorsi, Jason A Egge, Brian C Lund. Risk of Acute Kidney Injury and Clostridioides difficile Infection With Piperacillin/Tazobactam, Cefepime, and Meropenem With or Without Vancomycin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 10; 73(7):e1579-e1586. doi: 10.1093/cid/ciaa1902. [PMID: 33382398]
  • Kang Liu, Ying Zhang, Xueqiang Xu, Buyun Wu, Juan Ni, Ting Li, Changying Xing, Huijuan Mao. Comparative Prevalence of Acute Kidney Injury in Chinese Patients Receiving Vancomycin with Concurrent β-Lactam Antibiotics: A Retrospective Cohort Study. Clinical therapeutics. 2021 10; 43(10):e319-e351. doi: 10.1016/j.clinthera.2021.08.008. [PMID: 34579971]
  • Martin Knudsen, Mats Bue, Louise L Pontoppidan, Magnus A Hvistendahl, Kjeld Søballe, Maiken Stilling, Pelle Hanberg. Evaluation of Benzylpenicillin as an Internal Standard for Measurement of Piperacillin Bone Concentrations Via Microdialysis. Journal of pharmaceutical sciences. 2021 10; 110(10):3500-3506. doi: 10.1016/j.xphs.2021.06.008. [PMID: 34102200]
  • Sarah Van Vooren, Jan J De Waele, Jerina Boelens, Michael Polet, Veronique Stove, Lynn Vanhaecke, Alain G Verstraete. Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces. Analytica chimica acta. 2021 Sep; 1177(?):338760. doi: 10.1016/j.aca.2021.338760. [PMID: 34482897]
  • Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum. The journal of applied laboratory medicine. 2021 09; 6(5):1202-1212. doi: 10.1093/jalm/jfab036. [PMID: 34086904]
  • Orlando Salinas-Jaramillo, Alejandra Monroy-Arreola, Sebastian Herrera-Noreña, Ana L Guzmán-Ortiz, Abrahan Hernández-Hernández, Silvia Méndez-Flores, Judith Domínguez-Cherit, Noe V Duran-Figueroa, Dean J Naisbitt, Pedro Cortes-Reynosa, Eduardo Perez Salazar, Héctor Quezada, J Luis Castrejón-Flores. Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. Chemical research in toxicology. 2021 07; 34(7):1738-1748. doi: 10.1021/acs.chemrestox.1c00047. [PMID: 34142820]
  • Adrien Contejean, Caroline Charlier, Jean-Marc Treluyer, Solen Kernéis, Laurent Chouchana. A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem. The Journal of antimicrobial chemotherapy. 2021 07; 76(8):2221-2223. doi: 10.1093/jac/dkab144. [PMID: 34008026]
  • Joseph M Yabes, Laveta Stewart, Faraz Shaikh, Paul M Robben, Joseph L Petfield, Anuradha Ganesan, Wesley R Campbell, David R Tribble, Dana M Blyth. Risk of Acute Kidney Injury in Combat-Injured Patients Associated With Concomitant Vancomycin and Extended-Spectrum β-Lactam Antibiotic Use. Journal of intensive care medicine. 2021 Jul; 36(7):818-827. doi: 10.1177/0885066620930994. [PMID: 32508215]
  • Tatchanapong Chongcharoenyanon, Noppadol Wacharachaisurapol, Suvaporn Anugulruengkitt, Passara Maimongkol, Orawan Anunsittichai, Jiratchaya Sophonphan, Tanittha Chatsuwan, Thanyawee Puthanakit. Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in paediatric patients. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Jul; 108(?):102-108. doi: 10.1016/j.ijid.2021.05.044. [PMID: 34029707]
  • Dušan Krnáč, Katarína Reiffová, Boris Rolinski. A new HPLC-MS/MS analytical method for quantification of tazobactam, piperacillin, and meropenem in human plasma. Journal of separation science. 2021 Jul; 44(14):2744-2753. doi: 10.1002/jssc.202100067. [PMID: 33988308]
  • Irene Krämer, Jelena Rosentreter, Marius Fried, Michael Kühn. Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an osteosarcoma patient. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2021 Jun; 27(4):1000-1004. doi: 10.1177/1078155220953878. [PMID: 32878553]
  • Sînziana Cristea, Elke H J Krekels, Karel Allegaert, Peter De Paepe, Annick de Jaeger, Pieter De Cock, Catherijne A J Knibbe. Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3. The AAPS journal. 2021 05; 23(3):65. doi: 10.1208/s12248-021-00595-9. [PMID: 33948771]
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