2-Phospho-D-glyceric acid (BioDeep_00000003412)
Main id: BioDeep_00000018614
Secondary id: BioDeep_00001868854
human metabolite Endogenous natural product
代谢物信息卡片
化学式: C3H7O7P (185.9929)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 49.02%
分子结构信息
SMILES: C(C(C(=O)O)OP(=O)(O)O)O
InChI: InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1
描述信息
2-Phosphoglyceric acid (2PG), or 2-phosphoglycerate, is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate.; 2-Phosphoglyceric acid (2PGA) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. Enolase catalyzes the beta-elimination reaction in a stepwise manner wherein OH- is eliminated from C3 of a discrete carbanion (enolate) intermediate. This intermediate is created by removal of the proton from C2 of 2PGA by a base in the active site. (PMID: 8994873, Wikipedia). 2-Phosphoglycerate is found in rice.
2-Phospho-D-glycerate or 2PG is an intermediate in gluconeogenesis. It is a glyceric acid which serves as the substrate in the ninth step of glycolysis. 2PG is converted by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. More specifically, 2PG can be generated from Glycerate-3-phosphate via phosphoglycerate mutase or from phosphoenolpyrvate via alpha enolase.
KEIO_ID P029
同义名列表
16 个代谢物同义名
(2R)-3-Hydroxy-2-(phosphonooxy)propanoic acid; 3-D-Hydroxy-2-phosphonooxy-propanoic acid; (2R)-3-Hydroxy-2-(phosphonooxy)propanoate; 3-D-Hydroxy-2-phosphonooxy-propanoate; D-Glyceric acid 2-phosphoric acid; D-(+)-2-Phosphoglyceric acid; D-Glyceric acid 2-phosphate; 2-Phospho-(R)-glyceric acid; 2-Phospho-D-glyceric acid; D-2-Phosphoglyceric acid; (+-)-2-phosphoglycerate; 2-Phospho-(R)-glycerate; D-Glycerate 2-phosphate; 2-phosphoglyceric acid; 2-phospho-D-Glycerate; 2-phosphoglycerate
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:17835
- KEGG: C00631
- PubChem: 439278
- HMDB: HMDB0003391
- Metlin: METLIN151
- DrugBank: DB01709
- MetaCyc: 2-PG
- KNApSAcK: C00000123
- foodb: FDB001407
- chemspider: 388411
- CAS: 3443-57-0
- CAS: 3443-58-1
- MoNA: KO003691
- MoNA: KO003694
- MoNA: KO001598
- MoNA: KO001595
- MoNA: KO003692
- MoNA: KO001597
- MoNA: KO003690
- MoNA: KO001599
- MoNA: KO003693
- MoNA: KO001596
- PubChem: 3904
- PDB-CCD: 2PG
- 3DMET: B01295
- NIKKAJI: J71.811D
- LOTUS: LTS0138738
分类词条
相关代谢途径
Reactome(0)
BioCyc(6)
PlantCyc(0)
代谢反应
103 个相关的代谢反应过程信息。
Reactome(15)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Glucose metabolism:
D-Fructose 1,6-bisphosphate + H2O ⟶ Fru(6)P + Pi - Gluconeogenesis:
D-Fructose 1,6-bisphosphate + H2O ⟶ Fru(6)P + Pi - Glycolysis:
ATP + Fru(6)P ⟶ ADP + D-Fructose 1,6-bisphosphate - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Glucose metabolism:
D-Fructose 1,6-bisphosphate + H2O ⟶ Fru(6)P + Pi - Gluconeogenesis:
D-Fructose 1,6-bisphosphate + H2O ⟶ Fru(6)P + Pi - Glycolysis:
ATP + Fru(6)P ⟶ ADP + D-Fructose 1,6-bisphosphate - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Glucose metabolism:
ADP + Glc ⟶ AMP + G6P - Gluconeogenesis:
D-Fructose 1,6-bisphosphate + H2O ⟶ Fru(6)P + Pi - Glycolysis:
ADP + Glc ⟶ AMP + G6P
BioCyc(22)
- superpathway of central carbon metabolism:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - respiration (anaerobic):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - glycolysis I:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - gluconeogenesis I:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - superpathway of glycolysis, pyruvate dehydrogenase and TCA cycle:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - D-galactarate degradation I:
ATP + D-glycerate ⟶ 2-phospho-D-glycerate + ADP + H+ - D-glucarate degradation I:
ATP + D-glycerate ⟶ 2-phospho-D-glycerate + ADP + H+ - formaldehyde assimilation I (serine pathway):
L-malyl-CoA ⟶ acetyl-CoA + glyoxylate - Bifidobacterium shunt:
ATP + acetate ⟶ ADP + H+ + acetylphosphate - sucrose degradation to ethanol and lactate (anaerobic):
NAD+ + ethanol ⟶ H+ + NADH + acetaldehyde - Entner-Doudoroff pathway III (semi-phosphorylative):
α-D-glucose ⟶ β-D-glucose - superpathway of glycolysis and Entner-Doudoroff:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - respiration (anaerobic):
D-threo-isocitrate + NADP+ ⟶ 2-oxoglutarate + CO2 + NADPH - glycolysis II:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - glycolysis III:
β-D-glucose + ATP ⟶ β-D-glucose-6-phosphate + ADP + H+ - glycolysis I:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - heterolactic fermentation:
NAD+ + ethanol ⟶ H+ + NADH + acetaldehyde - superpathway of D-glucarate and D-galactarate degradation:
ATP + D-glycerate ⟶ 2-phospho-D-glycerate + ADP + H+ - gluconeogenesis I:
ATP + H2O + pyruvate ⟶ AMP + H+ + phosphate + phosphoenolpyruvate - gluconeogenesis:
NAD+ + malate ⟶ CO2 + NADH + pyruvate - glycolysis:
3-phosphoglycerate + ATP ⟶ 1,3-diphosphateglycerate + ADP
WikiPathways(3)
- Gluconeogenesis:
malate ⟶ pyruvate - Metabolism overview:
NH3 ⟶ Glutamic acid - Disorders of fructose metabolism:
Sucrose ⟶ Fructose
Plant Reactome(0)
INOH(3)
- D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O ( Glycolysis and Gluconeogenesis ):
D-Glycerate 2-phosphate ⟶ H2O + Phosphoenol-pyruvic acid - Glycolysis and Gluconeogenesis ( Glycolysis and Gluconeogenesis ):
D-Glucose 6-phosphate + H2O ⟶ D-Glucose + Orthophosphate - D-Glycerate 2-phosphate = D-Glycerate 3-phosphate ( Glycolysis and Gluconeogenesis ):
D-Glycerate 3-phosphate ⟶ D-Glycerate 2-phosphate
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(60)
- Glycolysis:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Gluconeogenesis:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type VII. Tarui Disease:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1):
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Fructose-1,6-diphosphatase Deficiency:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Triosephosphate Isomerase Deficiency:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Fanconi-Bickel Syndrome:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Glycogenosis, Type IB:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type IC:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type IA. Von Gierke Disease:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Warburg Effect:
L-Glutamic acid + NAD + Water ⟶ Ammonia + NADH + Oxoglutaric acid - Glycolysis and Pyruvate Dehydrogenase:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycolysis:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Fructose Metabolism:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism II:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism IV (Glycerophosphoglycerol):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism V (Glycerophosphoserine):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycolysis I:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Ethanol Fermentation:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Glycolysis:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Gluconeogenesis:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type VII. Tarui Disease:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1):
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Fructose-1,6-diphosphatase Deficiency:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Triosephosphate Isomerase Deficiency:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Fanconi-Bickel Syndrome:
Adenosine triphosphate + D-Glucose ⟶ Adenosine diphosphate + Glucose 6-phosphate - Glycogenosis, Type IB:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type IC:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Glycogenosis, Type IA. Von Gierke Disease:
Glucose 1-phosphate + Water ⟶ D-Glucose + Phosphate - Warburg Effect:
L-Glutamic acid + NAD + Water ⟶ Ammonia + NADH + Oxoglutaric acid - Glycolysis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Gluconeogenesis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Warburg Effect:
L-Glutamine + Water ⟶ Ammonia + L-Glutamic acid - Glycolysis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Gluconeogenesis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Warburg Effect:
L-Glutamine + Water ⟶ Ammonia + L-Glutamic acid - Glycolysis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Warburg Effect:
L-Glutamine + Water ⟶ Ammonia + L-Glutamic acid - Glycolysis:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Warburg Effect:
L-Glutamine + Water ⟶ Ammonia + L-Glutamic acid - Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Glycogenosis, Type VII. Tarui Disease:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1):
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Fructose-1,6-diphosphatase Deficiency:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Triosephosphate Isomerase Deficiency:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Fanconi-Bickel Syndrome:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Glycogenosis, Type IB:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Glycogenosis, Type IC:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Glycogenosis, Type IA. Von Gierke Disease:
-D-Glucose + Adenosine triphosphate ⟶ -D-Glucose 6-phosphate + Adenosine diphosphate - Fructose Metabolism:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism II:
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism IV (Glycerophosphoglycerol):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - Glycerol Metabolism V (Glycerophosphoserine):
Adenosine monophosphate + Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid ⟶ Adenosine triphosphate + Pyruvic acid + Water - 2-O-alpha-Mannosyl-D-glycerate Degradation:
Adenosine triphosphate + Glyceric acid ⟶ 2-Phospho-D-glyceric acid + Adenosine diphosphate + Hydrogen Ion
PharmGKB(0)
10 个相关的物种来源信息
- 2 - Bacteria: LTS0138738
- 1890464 - Chroococcaceae: LTS0138738
- 3028117 - Cyanophyceae: LTS0138738
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 1890428 - Merismopediaceae: LTS0138738
- 1214 - Prochloron: LTS0138738
- 1142 - Synechocystis: 10.1104/PP.108.129403
- 1142 - Synechocystis: LTS0138738
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ipsita Pal Bhowmick, Nirbhay Kumar, Shobhona Sharma, Isabelle Coppens, Gotam K Jarori. Plasmodium falciparum enolase: stage-specific expression and sub-cellular localization.
Malaria journal.
2009 Jul; 8(?):179. doi:
10.1186/1475-2875-8-179. [PMID: 19642995]
