Isoguvacine (BioDeep_00000003397)
Secondary id: BioDeep_00000400412, BioDeep_00001874274
natural product human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
化学式: C6H9NO2 (127.0633)
中文名称: 1,2,3,6-四氢-吡啶-4-羧酸盐酸盐, 1,2,3,6-四氢-吡啶-4-羧酸
谱图信息:
最多检出来源 Homo sapiens(blood) 24.77%
分子结构信息
SMILES: C1CNCC=C1C(=O)O
InChI: InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
描述信息
Acquisition and generation of the data is financially supported in part by CREST/JST.
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:200075
- ChEBI: CHEBI:34799
- KEGG: C13694
- PubChem: 3765
- HMDB: HMDB0253644
- Metlin: METLIN69641
- ChEMBL: CHEMBL39071
- Wikipedia: Isoguvacine
- chemspider: 3633
- CAS: 64603-90-3
- CAS: 74719-31-6
- MoNA: PS026104
- MoNA: PS026102
- MoNA: PS026103
- MoNA: PR100576
- MoNA: PS026106
- MoNA: PS026101
- PMhub: MS000009604
- PubChem: 586283
- NIKKAJI: J668.315K
- KNApSAcK: 34799
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Lei Ding, Run Gao, Xiao-Qing Xiong, Xing-Ya Gao, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. GABA in Paraventricular Nucleus Regulates Adipose Afferent Reflex in Rats.
PloS one.
2015; 10(8):e0136983. doi:
10.1371/journal.pone.0136983
. [PMID: 26317425] - Laurence Desrues, Thomas Lefebvre, Céline Lecointre, Marie-Thérèse Schouft, Jérôme Leprince, Vincent Compère, Fabrice Morin, François Proust, Pierrick Gandolfo, Marie-Christine Tonon, Hélène Castel. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
PloS one.
2012; 7(5):e36319. doi:
10.1371/journal.pone.0036319
. [PMID: 22563490] - Muhammad Nabeel Ghayur, Syed Faraz Kazim, Huma Rasheed, Asaad Khalid, Maliha Iqbal Jumani, Muhammad Iqbal Choudhary, Anwarul Hassan Gilani. Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2011 Jun; 9(6):619-25. doi:
10.3736/jcim20110607
. [PMID: 21669165] - Ming-Kui Zhong, Zhen Shi, Li-Min Zhou, Juan Gao, Zhao-Hui Liao, Wei Wang, Xing-Ya Gao, Guo-Qing Zhu. Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.
The European journal of neuroscience.
2008 Jun; 27(12):3226-32. doi:
10.1111/j.1460-9568.2008.06261.x
. [PMID: 18554298] - V R Antunes, S T Yao, A E Pickering, D Murphy, J F R Paton. A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympathoexcitation.
The Journal of physiology.
2006 Oct; 576(Pt 2):569-83. doi:
10.1113/jphysiol.2006.115766
. [PMID: 16873404] - Martin Mortensen, Uffe Kristiansen, Bjarke Ebert, Bente Frølund, Povl Krogsgaard-Larsen, Trevor G Smart. Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists.
The Journal of physiology.
2004 Jun; 557(Pt 2):389-413. doi:
10.1113/jphysiol.2003.054734
. [PMID: 14990676] - M N Ritta, D E Bas, C M Tartaglione. In vitro effect of gamma-aminobutyric acid on bovine spermatozoa capacitation.
Molecular reproduction and development.
2004 Apr; 67(4):478-86. doi:
10.1002/mrd.20038
. [PMID: 14991740] - Christof Geigerseder, Richard F G Doepner, Andrea Thalhammer, Annette Krieger, Artur Mayerhofer. Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA.
Reproductive biology and endocrinology : RB&E.
2004 Mar; 2(?):13. doi:
10.1186/1477-7827-2-13
. [PMID: 15040802] - K Z Shen, S W Johnson. Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain.
European journal of pharmacology.
2001 Sep; 428(1):1-7. doi:
10.1016/s0014-2999(01)01218-3
. [PMID: 11779025] - M N Ritta, J C Calamera, D E Bas. Occurrence of GABA and GABA receptors in human spermatozoa.
Molecular human reproduction.
1998 Aug; 4(8):769-73. doi:
10.1093/molehr/4.8.769
. [PMID: 9733434] - C Dominguez-Perrot, P Feltz, M O Poulter. Recombinant GABAA receptor desensitization: the role of the gamma 2 subunit and its physiological significance.
The Journal of physiology.
1996 Nov; 497 ( Pt 1)(?):145-59. doi:
10.1113/jphysiol.1996.sp021756
. [PMID: 8951718] - E J Wagner, J L Goudreau, K E Moore, K J Lookingland. GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat.
Brain research.
1994 Oct; 659(1-2):194-200. doi:
10.1016/0006-8993(94)90878-8
. [PMID: 7820661] - E Falch, P Krogsgaard-Larsen, A N Christensen. Esters of isoguvacine as potential prodrugs.
Journal of medicinal chemistry.
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. [PMID: 7265114]