Isoguvacine (BioDeep_00000003397)

 

Secondary id: BioDeep_00000400412, BioDeep_00001874274

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


1,2,3,6-tetrahydropyridine-4-carboxylic acid

化学式: C6H9NO2 (127.0633)
中文名称: 1,2,3,6-四氢-吡啶-4-羧酸盐酸盐, 1,2,3,6-四氢-吡啶-4-羧酸
谱图信息: 最多检出来源 Homo sapiens(blood) 24.77%

分子结构信息

SMILES: C1CNCC=C1C(=O)O
InChI: InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)

描述信息

Acquisition and generation of the data is financially supported in part by CREST/JST.
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists

同义名列表

5 个代谢物同义名

1,2,3,6-tetrahydropyridine-4-carboxylic acid; Isoguvacine hydrochloride; Isoguvacine hydrobromide; isoguvacine; Isoguvacine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, CA1, CA3, GFAP, IKBKG, POMC, PRL
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 1 GABBR1
Nucleus 3 AXIN2, IKBKG, PRL
cytosol 6 AXIN2, CA1, CA3, CLCN5, GFAP, IKBKG
mitochondrial membrane 1 GABBR1
centrosome 1 AXIN2
nucleoplasm 2 IKBKG, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 7 AGTR1, CLCN5, GABBR1, GLRA2, GRID1, SLC12A2, SLC12A5
Multi-pass membrane protein 7 AGTR1, CLCN5, GABBR1, GLRA2, GRID1, SLC12A2, SLC12A5
Golgi apparatus membrane 1 CLCN5
Synapse 3 CRH, GLRA2, TAC1
dendritic shaft 1 GABBR1
glutamatergic synapse 3 GABBR1, GRID1, SLC12A5
Golgi apparatus 2 CLCN5, NPY
Golgi membrane 1 CLCN5
lysosomal membrane 1 CLCN5
neuronal cell body 4 GABBR1, SLC12A2, SLC12A5, TAC1
presynaptic membrane 1 GABBR1
synaptic vesicle 2 CLCN5, GABBR1
plasma membrane 9 AGTR1, AXIN2, CLCN5, GABBR1, GLRA2, GRID1, KNG1, SLC12A2, SLC12A5
Membrane 6 AGTR1, CLCN5, GABBR1, GLRA2, SLC12A2, SLC12A5
apical plasma membrane 1 SLC12A2
axon 1 TAC1
basolateral plasma membrane 1 SLC12A2
extracellular exosome 4 CA1, GRID1, KNG1, SLC12A2
extracellular space 7 CRH, GABBR1, KNG1, NPY, POMC, PRL, TAC1
Schaffer collateral - CA1 synapse 1 GABBR1
mitochondrion 1 ABAT
protein-containing complex 1 IKBKG
intracellular membrane-bounded organelle 1 GLRA2
Secreted 5 CRH, NPY, POMC, PRL, TRH
extracellular region 7 CRH, KNG1, NPY, POMC, PRL, TAC1, TRH
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 ABAT
varicosity 1 CRH
Extracellular vesicle 1 SLC12A2
dendritic spine 1 GABBR1
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, SLC12A5
beta-catenin destruction complex 1 AXIN2
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
postsynaptic membrane 2 GABBR1, GRID1
axolemma 1 GABBR1
G protein-coupled GABA receptor complex 1 GABBR1
GABA-ergic synapse 4 GABBR1, GLRA2, GRID1, NPY
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 POMC, TRH
intermediate filament 1 GFAP
lateral plasma membrane 1 SLC12A2
Postsynaptic cell membrane 3 GABBR1, GLRA2, GRID1
neuron projection 3 GLRA2, SLC12A2, SLC12A5
chromatin 1 PRL
cell projection 3 GFAP, GLRA2, SLC12A2
cell periphery 2 SLC12A2, SLC12A5
mitotic spindle 1 IKBKG
Secreted, extracellular space 1 KNG1
spindle pole 1 IKBKG
blood microparticle 1 KNG1
transmembrane transporter complex 1 GLRA2
Basolateral cell membrane 1 SLC12A2
endosome lumen 1 PRL
chloride channel complex 1 GLRA2
Cytoplasmic vesicle membrane 1 SLC12A2
Cell projection, dendrite 2 GABBR1, SLC12A5
cell body 2 GFAP, SLC12A2
intermediate filament cytoskeleton 1 GFAP
ubiquitin ligase complex 1 IKBKG
basal plasma membrane 1 SLC12A2
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 1 KNG1
platelet alpha granule lumen 1 KNG1
postsynaptic density membrane 1 GRID1
neuronal dense core vesicle 1 NPY
IkappaB kinase complex 1 IKBKG
postsynaptic specialization membrane 2 GLRA2, SLC12A5
dendrite membrane 1 SLC12A5
G protein-coupled receptor heterodimeric complex 1 GABBR1
cytoplasmic side of lysosomal membrane 1 GFAP
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
glycinergic synapse 1 GLRA2
cell body membrane 1 SLC12A2
cell projection membrane 1 SLC12A2
4-aminobutyrate transaminase complex 1 ABAT
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Lei Ding, Run Gao, Xiao-Qing Xiong, Xing-Ya Gao, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. GABA in Paraventricular Nucleus Regulates Adipose Afferent Reflex in Rats. PloS one. 2015; 10(8):e0136983. doi: 10.1371/journal.pone.0136983. [PMID: 26317425]
  • Laurence Desrues, Thomas Lefebvre, Céline Lecointre, Marie-Thérèse Schouft, Jérôme Leprince, Vincent Compère, Fabrice Morin, François Proust, Pierrick Gandolfo, Marie-Christine Tonon, Hélène Castel. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PloS one. 2012; 7(5):e36319. doi: 10.1371/journal.pone.0036319. [PMID: 22563490]
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