Oxamniquine (BioDeep_00000003330)
Secondary id: BioDeep_00000397934
human metabolite blood metabolite
代谢物信息卡片
(7-nitro-2-{[(propan-2-yl)amino]methyl}-1,2,3,4-tetrahydroquinolin-6-yl)methanol
化学式: C14H21N3O3 (279.1583)
中文名称: 硝羟四氢喹啉胺
谱图信息:
最多检出来源 Homo sapiens(blood) 20.79%
分子结构信息
SMILES: CC(C)NCC1CCC2=CC(=C(C=C2N1)[N+](=O)[O-])CO
InChI: InChI=1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3
描述信息
An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02B - Antitrematodals > P02BA - Quinoline derivatives and related substances
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:78416
- ChEBI: CHEBI:7819
- KEGG: C07341
- KEGGdrug: D00460
- PubChem: 4612
- HMDB: HMDB0015228
- Metlin: METLIN1673
- DrugBank: DB01096
- ChEMBL: CHEMBL847
- Wikipedia: Oxamniquine
- MeSH: Oxamniquine
- chemspider: 4451
- CAS: 119678-90-9
- CAS: 119678-89-6
- CAS: 40247-39-0
- CAS: 21738-42-1
- PMhub: MS000009352
- PubChem: 9548
- NIKKAJI: J11.157K
- RefMet: Oxamniquine
- KNApSAcK: 7819
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Valentin Buchter, Yih Ching Ong, François Mouvet, Abdallah Ladaycia, Elise Lepeltier, Ursula Rothlisberger, Jennifer Keiser, Gilles Gasser. Multidisciplinary Preclinical Investigations on Three Oxamniquine Analogues as New Drug Candidates for Schistosomiasis*.
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Molecular pharmacology.
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Allergologia et immunopathologia.
1982 Mar; 10(2):105-8. doi:
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Revista do Instituto de Medicina Tropical de Sao Paulo.
1982 Jan; 24(1):40-8. doi:
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
1982; 76(6):751-5. doi:
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Bulletin de la Societe de pathologie exotique et de ses filiales.
1981 Jan; 74(1):78-83. doi:
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
1981; 75(2):234-8. doi:
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The American journal of tropical medicine and hygiene.
1980 Sep; 29(5):890-4. doi:
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Arquivos de gastroenterologia.
1980 Apr; 17(2):88-95. doi:
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Biochemical pharmacology.
1980 Feb; 29(3):429-31. doi:
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
1980; 74(4):493-500. doi:
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Revista do Instituto de Medicina Tropical de Sao Paulo.
1980 Jan; 22(1 Suppl 4):105-10, 225. doi:
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Revista do Instituto de Medicina Tropical de Sao Paulo.
1980 Jan; 22(1 Suppl 4):58-64, 175. doi:
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Revista do Instituto de Medicina Tropical de Sao Paulo.
1980 Jan; 22(1 Suppl 4):41-51, 157. doi:
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The American journal of tropical medicine and hygiene.
1980 Jan; 29(1):50-3. doi:
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Revista brasileira de pesquisas medicas e biologicas.
1979 Jun; 12(2-3):207-11. doi:
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Bulletin de la Societe de pathologie exotique et de ses filiales.
1979 Mar; 72(2):153-64. doi:
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The American journal of tropical medicine and hygiene.
1978 Nov; 27(6):1284-6. doi:
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British medical journal.
1978 Jul; 2(6131):163-5. doi:
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The Journal of the Egyptian Medical Association.
1978; 61(3-4):299-311. doi:
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
1978; 72(6):602-4. doi:
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The American journal of tropical medicine and hygiene.
1977 Mar; 26(2):234-7. doi:
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1977 Mar; 66(3):429-30. doi:
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The Journal of pharmacology and experimental therapeutics.
1977 Jan; 200(1):1-9. doi:
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Annals of tropical medicine and parasitology.
1976 Sep; 70(3):323-8. doi:
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1976 Jun; 50(27):1051-3. doi:
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Japanese journal of medical science & biology.
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