Tropisetron (BioDeep_00000003187)
代谢物信息卡片
8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
化学式: C17H20N2O2 (284.1525)
中文名称: 托烷司琼
谱图信息:
最多检出来源 Viridiplantae(plant) 16.1%
分子结构信息
SMILES: CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
InChI: InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
A - Alimentary tract and metabolism > A04 - Antiemetics and antinauseants > A04A - Antiemetics and antinauseants > A04AA - Serotonin (5ht3) antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
Same as: D02130
Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. IC50 value: 70.1 ± 0.9 nM [1] Target: 5-HT3 receptor in vitro: Tropisetron specifically inhibited both IL-2 gene transcription and IL-2 synthesis in stimulated T cells. tropisetron inhibited both the binding to DNA and the transcriptional activity of NFAT and AP-1. We also observed that tropisetron is a potent inhibitor of PMA plus ionomycin-induced NF-(kappa)B activation but in contrast TNF(alpha)-mediated NF-(kappa)B activation was not affected by this antagonist [2]. Tropisetron prevents the phosphorylation and thus activation of the p38 MAPK, which is involved in post-transcriptional regulation of various cytokines [3]. in vivo: Two different doses of tropisetron (5 and 10 mg/kg) or vehicle were administered intraperitoneally 30 min before pMCAO. Neurological deficit scores, mortality rate and infarct volume were determined 24 h after permanent focal cerebral ischemia [4].
同义名列表
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:91913
- ChEBI: CHEBI:94647
- ChEBI: CHEBI:32269
- KEGG: C13666
- KEGGdrug: D02130
- PubChem: 5595
- PubChem: 656665
- Metlin: METLIN69620
- DrugBank: DB11699
- ChEMBL: CHEMBL8197
- ChEMBL: CHEMBL1289230
- ChEMBL: CHEMBL56564
- MeSH: Tropisetron
- CAS: 124583-47-7
- CAS: 89565-68-4
- CAS: 89565-86-6
- MoNA: FiehnHILIC003028
- MoNA: FiehnHILIC002389
- MoNA: FiehnHILIC001551
- MoNA: FiehnHILIC000821
- PMhub: MS000008432
- PubChem: 586259
- PDB-CCD: TKT
- NIKKAJI: J22.211I
- RefMet: Tropisetron
- medchemexpress: HY-B0072
- KNApSAcK: 32269
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongbin Zhang, ShangKun Si, WeiXun Shang, Xi Zhou. Effect of preoperative tropisetron treatment on postoperative cognitive function: A retrospective cohort study.
Medicine.
2022 Dec; 101(52):e32562. doi:
10.1097/md.0000000000032562. [PMID: 36596014] - Shiva Gholizadeh-Ghaleh Aziz, Roya Naderi, Nima Mahmodian. Ameliorative effects of tropisetron on liver injury in streptozotocin-induced diabetic rats.
Archives of physiology and biochemistry.
2021 Aug; 127(4):367-372. doi:
10.1080/13813455.2019.1640743. [PMID: 31306054] - Qiuju Xiong, Su Min, Ke Wei, Yanmei Yang, Jingyue Ma, Dan Liu, Menghua Zeng, Lei Zou. Transcutaneous Electrical Acupoint Stimulation Combined with Dexamethasone and Tropisetron Prevents Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Sleeve Gastrectomy: a Prospective, Randomized Controlled Trial.
Obesity surgery.
2021 05; 31(5):1912-1920. doi:
10.1007/s11695-020-05205-9. [PMID: 33650089] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Bagher Pourheydar, Mahrokh Samadi, Parisa Habibi, Ahmad Ali Nikibakhsh, Roya Naderi. Renoprotective effects of tropisetron through regulation of the TGF-β1, p53 and matrix metalloproteinases in streptozotocin-induced diabetic rats.
Chemico-biological interactions.
2021 Feb; 335(?):109332. doi:
10.1016/j.cbi.2020.109332. [PMID: 33387473] - Mahrokh Samadi, Shiva Gholizadeh-Ghaleh Aziz, Roya Naderi. The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats.
Cell stress & chaperones.
2021 01; 26(1):217-227. doi:
10.1007/s12192-020-01170-5. [PMID: 33047279] - Roya Naderi, Alireza Shirpoor, Mahrokh Samadi, Bagher Pourheydar, Azam Moslehi. Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling.
Pharmacological reports : PR.
2020 Dec; 72(6):1657-1665. doi:
10.1007/s43440-020-00146-7. [PMID: 32725585] - Ashkan Divanbeigi, Mohammad Nasehi, Salar Vaseghi, Sepideh Amiri, Mohammad-Reza Zarrindast. Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion.
Neurochemical research.
2020 Nov; 45(11):2631-2640. doi:
10.1007/s11064-020-03110-2. [PMID: 32797381] - Yi Sun, Dandan Lin, Jing Wang, Mengwen Geng, Mei Xue, Yayun Lang, Lina Cui, Yanan Hao, Shanshan Mu, Dan Wu, Lirong Liang, Anshi Wu. Effect of Tropisetron on Prevention of Emergence Delirium in Patients After Noncardiac Surgery: A Trial Protocol.
JAMA network open.
2020 10; 3(10):e2013443. doi:
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European journal of pharmacology.
2020 Sep; 883(?):173310. doi:
10.1016/j.ejphar.2020.173310. [PMID: 32619674] - Roya Naderi, Alireza Shirpoor, Mahrokh Samadi, Bagher Pourheydar, Azam Moslehi. Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ-induced diabetic rats: involvement of UCP2/ZnT8 pathway.
The Journal of pharmacy and pharmacology.
2020 Aug; 72(8):1082-1091. doi:
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Hormone molecular biology and clinical investigation.
2020 May; 41(3):. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2020 02; 48(2):93-105. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):50-58. doi:
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2017 Sep; 13(5):313-318. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Sep; 93(?):589-595. doi:
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Metabolic brain disease.
2017 06; 32(3):819-826. doi:
10.1007/s11011-017-9976-5. [PMID: 28243846] - Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, Allen H Li, Huang-Ping Yu. Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways.
BioMed research international.
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European journal of pharmacology.
2015 Nov; 767(?):152-9. doi:
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Clinical and experimental pharmacology & physiology.
2015 Apr; 42(4):361-8. doi:
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European journal of pharmacology.
2014 Sep; 738(?):222-9. doi:
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Neurotoxicology.
2014 Mar; 41(?):1-8. doi:
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Minerva anestesiologica.
2013 Feb; 79(2):130-6. doi:
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Cardiovascular toxicology.
2012 Dec; 12(4):318-25. doi:
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The pharmacogenomics journal.
2012 Feb; 12(1):22-9. doi:
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PloS one.
2012; 7(12):e53203. doi:
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2011 Dec; 339(3):790-8. doi:
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International immunopharmacology.
2011 Dec; 11(12):2073-8. doi:
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Pain.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Anaesthesia and intensive care.
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American journal of physiology. Gastrointestinal and liver physiology.
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Cancer management and research.
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European journal of pharmacology.
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European journal of clinical investigation.
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Journal of ethnopharmacology.
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Scandinavian journal of rheumatology. Supplement.
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Scandinavian journal of rheumatology. Supplement.
2004; 119(?):34-40. doi:
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Scandinavian journal of rheumatology. Supplement.
2004; 119(?):33. doi:
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Scandinavian journal of rheumatology. Supplement.
2004; 119(?):59-62. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Sep; 35(9):511-6. doi:
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Journal of pharmacological sciences.
2003 Sep; 93(1):74-9. doi:
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European journal of clinical pharmacology.
2003 Jun; 59(2):111-6. doi:
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American journal of physiology. Heart and circulatory physiology.
2003 Mar; 284(3):H867-75. doi:
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Clinical nephrology.
2003 Feb; 59(2):124-9. doi:
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The Journal of physiology.
2002 11; 544(3):897-912. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2002 Jun; 20(12):2805-11. doi:
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Brain research.
2002 May; 934(2):157-61. doi:
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Biomedical chromatography : BMC.
2002 May; 16(3):187-90. doi:
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Alimentary pharmacology & therapeutics.
2002 Jan; 16(1):119-27. doi:
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British journal of clinical pharmacology.
2001 Dec; 52(6):705-7. doi:
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European journal of anaesthesiology.
2001 Dec; 18(12):833-5. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2001 Oct; 281(4):L931-40. doi:
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Digestive diseases and sciences.
2001 Feb; 46(2):250-6. doi:
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European journal of pharmacology.
2000 Jul; 399(2-3):97-106. doi:
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Scandinavian journal of rheumatology. Supplement.
2000; 113(?):46-8. doi:
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The European respiratory journal.
1999 Sep; 14(3):642-9. doi:
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European journal of pharmacology.
1998 Oct; 359(2-3):185-90. doi:
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The Journal of physiology.
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Peptides.
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Drug metabolism and disposition: the biological fate of chemicals.
1996 May; 24(5):602-9. doi:
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European journal of clinical pharmacology.
1996; 50(5):371-3. doi:
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European journal of drug metabolism and pharmacokinetics.
1996 Jan; 21(1):43-50. doi:
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Molecular pharmacology.
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Gan to kagaku ryoho. Cancer & chemotherapy.
1995 Aug; 22(9):1209-21. doi:
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Biochemical pharmacology.
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British journal of pharmacology.
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Brain research.
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Cancer chemotherapy and pharmacology.
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General pharmacology.
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1994 Oct; 11(2):101-6. doi:
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European journal of clinical investigation.
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European journal of cancer (Oxford, England : 1990).
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European journal of pharmacology.
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Cancer.
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Life sciences.
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Drug metabolism and disposition: the biological fate of chemicals.
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