L-Targinine (BioDeep_00000003180)
Secondary id: BioDeep_00001868765
human metabolite Endogenous
代谢物信息卡片
(2S)-2-amino-5-(3-methylcarbamimidamido)pentanoic acid
化学式: C7H16N4O2 (188.12731960000002)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(feces) 0.22%
分子结构信息
SMILES: CN=C(N)NCCCC(C(=O)O)N
InChI: InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)
描述信息
L-Targinine is found in pulses. L-Targinine is isolated from broad bean seed L-Targinine has been identified in the human placenta (PMID: 32033212).
C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
41 个代谢物同义名
(2S)-2-amino-5-(3-methylcarbamimidamido)pentanoic acid; Acide (2S)-2-amino-5-(3-methylguanidino)pentanoique; N(5)-[Imino(methylamino)methyl]-L-ornithine; N5-[imino(methylamino)methyl]-L-ornithine; N(5)-(N-Methylcarbamimidoyl)-L-ornithine; N5-(N-Methylcarbamimidoyl)-L-ornithine; N(5)-(Methylamidino)-L-ornithine; N(Omega)-monomethyl-L-arginine; N(5)-(Metilamidino)-L-ornitina; N-Omega-monomethyl-L-arginine; Ngamma-monomethyl-L-arginine; Omega-N-monomethylarginine; N(g)-Monomethyl-L-arginine; N(g)-Monomethyl-D-arginine; N(Omega)-methyl-L-arginine; Arginine, L-NG-monomethyl; N-Omega-methyl-L-arginine; L NG Monomethyl arginine; L-NG-Monomethyl arginine; NG-Monomethyl-L-arginine; NG Monomethyl L arginine; N-Monomethyl-L-arginine; N(g)-Monomethylarginine; NG-Monomethyl-L-argine; Omega-N-methylarginine; Omega N methylarginine; Ng-METHYL-L-ARGININE; L-Monomethylarginine; L Monomethylarginine; N-Methyl-L-arginine; N(g)-Methylarginine; Methylarginine; Tilargininum; L-Targinine; Tilarginina; Tilarginine; Targininum; Targinine; Targinina; D-NMMA; L-NMMA
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:124959
- ChEBI: CHEBI:28229
- KEGG: C03884
- PubChem: 132862
- PubChem: 4366
- HMDB: HMDB0029416
- Metlin: METLIN44311
- DrugBank: DB11815
- ChEMBL: CHEMBL1835117
- ChEMBL: CHEMBL312870
- ChEMBL: CHEMBL256147
- Wikipedia: Methylarginine
- MeSH: omega-N-Methylarginine
- foodb: FDB000510
- chemspider: 117259
- PMhub: MS000008407
- PubChem: 6617
- PDB-CCD: NMM
- NIKKAJI: J264.000G
- LOTUS: LTS0058526
- wikidata: Q99615184
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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2022 01; 85(1):185-195. doi:
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Clinical laboratory.
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2021 05; 84(5):1598-1606. doi:
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Bioorganic & medicinal chemistry letters.
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The Journal of biological chemistry.
2020 12; 295(51):17441-17459. doi:
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The Journal of physiology.
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2020 May; 25(9):. doi:
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Diabetes, obesity & metabolism.
2019 02; 21(2):397-401. doi:
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2018 10; 81(10):2163-2168. doi:
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2018 09; 81(9):2129-2133. doi:
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Hypertension (Dallas, Tex. : 1979).
2018 09; 72(3):667-675. doi:
10.1161/hypertensionaha.118.11071. [PMID: 30012866] - Xiaohong Liu, Xin Xu, Ruru Shang, Yingjie Chen. Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease.
Nitric oxide : biology and chemistry.
2018 08; 78(?):113-120. doi:
10.1016/j.niox.2018.06.004. [PMID: 29928990] - Kongara Damodar, Jeong Tae Lee, Jin-Kyung Kim, Jong-Gab Jun. Synthesis and in vitro evaluation of homoisoflavonoids as potent inhibitors of nitric oxide production in RAW-264.7 cells.
Bioorganic & medicinal chemistry letters.
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Clinical research in cardiology : official journal of the German Cardiac Society.
2018 Mar; 107(3):201-213. doi:
10.1007/s00392-017-1172-4. [PMID: 29101459] - Gui-Min Xue, Xiao-Qing Li, Chen Chen, Kang Chen, Xiao-Bing Wang, Yu-Cheng Gu, Jian-Guang Luo, Ling-Yi Kong. Highly Oxidized Guaianolide Sesquiterpenoids with Potential Anti-inflammatory Activity from Chrysanthemum indicum.
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2018 02; 81(2):378-386. doi:
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High altitude medicine & biology.
2017 Sep; 18(3):226-233. doi:
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2017 08; 80(8):2204-2214. doi:
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Kidney international.
2017 06; 91(6):1426-1435. doi:
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The Journal of clinical endocrinology and metabolism.
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Diabetes.
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PloS one.
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Psychiatry research.
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Amino acids.
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Bioorganic & medicinal chemistry letters.
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Analytical biochemistry.
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British journal of clinical pharmacology.
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Journal of natural products.
2015 Jun; 78(6):1322-9. doi:
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2015 May; 78(5):1093-100. doi:
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Journal of natural products.
2015 May; 78(5):1174-8. doi:
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PloS one.
2015; 10(5):e0127221. doi:
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Bioorganic & medicinal chemistry letters.
2015 Jan; 25(1):96-9. doi:
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European journal of clinical investigation.
2014 Dec; 44(12):1177-88. doi:
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British journal of clinical pharmacology.
2014 Oct; 78(4):789-99. doi:
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Hypertension (Dallas, Tex. : 1979).
2014 Oct; 64(4):867-74. doi:
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Journal of natural products.
2014 Aug; 77(8):1955-61. doi:
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Journal of separation science.
2014 Aug; 37(16):2087-94. doi:
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BMC nephrology.
2014 Jun; 15(?):100. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2014 Feb; 34(2):211-9. doi:
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Scandinavian journal of clinical and laboratory investigation.
2014 Jan; 74(1):8-19. doi:
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Natural product research.
2014; 28(17):1409-12. doi:
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Journal of cardiac failure.
2013 Nov; 19(11):776-85. doi:
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Hypertension (Dallas, Tex. : 1979).
2013 Nov; 62(5):920-6. doi:
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Planta.
2013 Oct; 238(4):727-37. doi:
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Neurological research.
2013 Sep; 35(7):709-12. doi:
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Scandinavian journal of clinical and laboratory investigation.
2013 Aug; 73(5):436-43. doi:
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Asian journal of andrology.
2013 Jul; 15(4):503-7. doi:
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Electrophoresis.
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Diabetes care.
2013 May; 36(5):1290-6. doi:
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Bioorganic & medicinal chemistry letters.
2013 Apr; 23(7):2140-4. doi:
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American journal of physiology. Heart and circulatory physiology.
2013 Apr; 304(7):H994-H1001. doi:
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Bioorganic & medicinal chemistry letters.
2013 Mar; 23(6):1771-5. doi:
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The Journal of physiology.
2013 Mar; 591(6):1475-87. doi:
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The Journal of clinical endocrinology and metabolism.
2013 Mar; 98(3):1235-41. doi:
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Journal of natural products.
2013 Feb; 76(2):237-42. doi:
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Gut.
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PloS one.
2013; 8(6):e65458. doi:
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Bioorganic & medicinal chemistry letters.
2012 Dec; 22(24):7465-70. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Dec; 60(6):1415-21. doi:
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Environmental toxicology and pharmacology.
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American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Oct; 303(7):R710-8. doi:
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The Journal of physiology.
2012 Sep; 590(17):4391-400. doi:
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Plant physiology.
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Obesity (Silver Spring, Md.).
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American journal of physiology. Renal physiology.
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Experimental biology and medicine (Maywood, N.J.).
2012 May; 237(5):570-7. doi:
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Cardiovascular therapeutics.
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The Journal of physiology.
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Circulation.
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International journal of molecular sciences.
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PloS one.
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BMJ open.
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