N(6)-Methyllysine (BioDeep_00000003152)

 

Secondary id: BioDeep_00001869037

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


epsilon-N-Methyllysine hydrochloride, (L-lys)-isomer

化学式: C7H16N2O2 (160.1212)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 13.33%

分子结构信息

SMILES: CNCCCCC(C(=O)O)N
InChI: InChI=1S/C7H16N2O2/c1-9-5-3-2-4-6(8)7(10)11/h6,9H,2-5,8H2,1H3,(H,10,11)/t6-/m0/s1

描述信息

N(6)-Methyllysine is a naturally occurring amino acid found in human biofluids. N-monomethyl-lysine is generated by metabolic transmethylation of endogenous lysine. Lysine methylation displays the highest degree of complexity among known covalent histone modifications, with each site of methylation regulating the association of different effector molecules. The versatility of lysine methylation marks is perhaps best exemplified by modifications implicated in transcriptional regulation as well as being required for double-strand break repair in several organisms. Identification of the numerous biological functions encoded by histone lysine methylation is a major area of research interest, as these mechanisms are intimately associated with cellular senescence, genomic instability, and leukemogenesis. While multiple sites of lysine methylation have been linked with gene activation, each modification is distributed to unique positions across the active gene. (PMID: 17030614, 1122639, 15756599, 3111294).
N(6)-Methyllysine is a naturally occurring amino acid found in human biofluids. N-monomethyl-lysine is generated by metabolic transmethylation of endogenous lysine.

同义名列表

21 个代谢物同义名

epsilon-N-Methyllysine hydrochloride, (L-lys)-isomer; (2S)-2-amino-6-(methylamino)Hexanoic acid; epsilon-N-Methyllysine, (DL-lys)-isomer; (S)-2-Amino-6-methylaminohexanoic acid; (2S)-2-amino-6-(methylamino)Hexanoate; (S)-2-Amino-6-methylaminohexanoate; N(epsilon)-Monomethyl-lysine; N(epsilon)-Methyl-L-lysine; Epsilon-N-Methyllysine; N-Epsilon-Methyllysine; epsilon-Methyllysine; N(zeta)-Methyllysine; N(6)-Methyl-L-lysine; N6-Methyl-L-lysine; Ne-Methyl-L-lysine; N(Z)-Methyllysine; N-Methyl-L-lysine; N(6)-Methyllysine; N(Ζ)-methyllysine; N-Methyl-lysine; MeLys



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 G6PD, HIF1AN, MYLK, RPS6
Peripheral membrane protein 1 G6PD
Nucleus 12 CBX5, KDM1A, KDM2B, KDM4A, KDM4E, KDM5A, KDM5C, KDM5D, PHF8, RPS6, SETD7, SETDB2
cytosol 9 G6PD, GPT, HIF1AN, KDM4A, KDM5C, MYLK, RCCD1, RPS6, SETDB2
dendrite 1 RPS6
nucleoplasm 13 CBX5, HIF1AN, KDM1A, KDM2B, KDM4A, KDM4E, KDM5A, KDM5C, KDM5D, PHF8, RPS6, SETD7, SETDB2
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Synapse 1 MYLK
Cytoplasm, cytosol 1 G6PD
plasma membrane 2 MYLK, RCCD1
Membrane 2 G6PD, RPS6
extracellular exosome 3 CPVL, G6PD, GPT
endoplasmic reticulum 1 RPS6
extracellular space 2 CXCL8, IL6
perinuclear region of cytoplasm 2 HIF1AN, RPS6
protein-containing complex 2 CBX5, KDM1A
intracellular membrane-bounded organelle 1 G6PD
pericentric heterochromatin 2 CBX5, KDM4A
Secreted 2 CXCL8, IL6
extracellular region 2 CXCL8, IL6
cytoplasmic side of plasma membrane 1 G6PD
transcription regulator complex 1 KDM1A
centriolar satellite 1 G6PD
nuclear membrane 1 PHF8
actin cytoskeleton 1 MYLK
nucleolus 6 CBX5, KDM2B, KDM5A, PHF8, RPS6, SETD7
Cell projection, lamellipodium 1 MYLK
heterochromatin 1 CBX5
chromatin 6 KDM1A, KDM4A, KDM4E, KDM5A, KDM5C, KDM5D
Chromosome 6 CBX5, KDM1A, KDM2B, RCCD1, SETD7, SETDB2
cytoplasmic ribonucleoprotein granule 1 RPS6
Nucleus, nucleolus 4 KDM2B, KDM5A, PHF8, RPS6
chromosome, telomeric region 2 CBX5, KDM1A
fibrillar center 2 KDM4A, KDM5D
nuclear envelope 1 CBX5
Chromosome, centromere 1 CBX5
cell body 1 RPS6
stress fiber 1 MYLK
endoplasmic reticulum lumen 1 IL6
histone methyltransferase complex 1 CBX5
transcription repressor complex 1 CBX5
PcG protein complex 1 KDM2B
kinetochore 1 CBX5
histone deacetylase complex 1 CBX5
small-subunit processome 1 RPS6
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ribonucleoprotein complex 2 CBX5, RPS6
protein-DNA complex 1 KDM5A
chromocenter 1 CBX5
DNA repair complex 1 KDM1A
cytosolic ribosome 1 RPS6
site of DNA damage 1 CBX5
ribosome 1 RPS6
interleukin-6 receptor complex 1 IL6
cytosolic small ribosomal subunit 1 RPS6
small ribosomal subunit 1 RPS6


文献列表

  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Agnes M Móricz, Péter G Ott, Klára H Otta, Erno Tyihák. Investigation of the antibacterial mechanism of aflatoxins in the BioArena system. Natural product communications. 2011 May; 6(5):657-60. doi: ". [PMID: 21615027]
  • H Kalász, Z Szücs, M Tihanyi, A Szilágyi, J Lengyel. Detection of Nepsilon-monomethyllysine using high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry. Journal of chromatography. A. 2005 Jun; 1079(1-2):208-12. doi: 10.1016/j.chroma.2005.03.079. [PMID: 16038306]
  • Huba Kalász, Imre Klebovich, Katalin Balogh-Nemes, Agnes Szilágyi, Mária Tihanyi, Tibor Szarvas, József Lengyel. Detection of N-monomethyl-lysine generated by metabolic transmethylation. Analytical and bioanalytical chemistry. 2005 Jun; 382(3):760-4. doi: 10.1007/s00216-005-3089-4. [PMID: 15756599]
  • H Kalász, A Benkö, Z Szücsp, A Szilágyi, T Szarvas, J Lengyel. HPLC and HPLC-MS analysis of urinary N(epsilon)-monomethyl-lysine. Journal of chromatographic science. 2005 Apr; 43(4):165-8. doi: 10.1093/chromsci/43.4.165. [PMID: 15975230]
  • Raymond C Trievel, E Megan Flynn, Robert L Houtz, James H Hurley. Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nature structural biology. 2003 Jul; 10(7):545-52. doi: 10.1038/nsb946. [PMID: 12819771]
  • M Kushiro, K Shikata, H Sugimoto, K Ikeda, S Horiuchi, H Makino. Accumulation of Nsigma-(carboxy-methyl)lysine and changes in glomerular extracellular matrix components in Otsuka Long-Evans Tokushima fatty rat: a model of spontaneous NIDDM. Nephron. 1998 Aug; 79(4):458-68. doi: 10.1159/000045093. [PMID: 9689163]
  • K MURRAY. THE OCCURRENCE OF EPSILON-N-METHYL LYSINE IN HISTONES. Biochemistry. 1964 Jan; 3(?):10-5. doi: 10.1021/bi00889a003. [PMID: 14114491]