pyrazole (BioDeep_00000003039)
Secondary id: BioDeep_00001867786
human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
1H-pyrazole
化学式: C3H4N2 (68.0374)
中文名称: 吡唑
谱图信息:
最多检出来源 Homo sapiens(blood) 21.37%
分子结构信息
SMILES: C1=CNN=C1
InChI: InChI=1S/C3H4N2/c1-2-4-5-3-1/h1-3H,(H,4,5)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 8154
D004791 - Enzyme Inhibitors
KEIO_ID P095
1H-pyrazole is an endogenous metabolite.
同义名列表
8 个代谢物同义名
1H-pyrazole; 1,2-Diazole; 1H-Pyrazol; pyrazole; Pyrazol; Hpz; Pyrazole; Pyrazole
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:17241
- KEGG: C00481
- KEGGdrug: D78528
- PubChem: 1048
- HMDB: HMDB0256947
- Metlin: METLIN65516
- DrugBank: DB02757
- ChEMBL: CHEMBL15967
- Wikipedia: Pyrazole
- MetaCyc: PYRAZOLE
- KNApSAcK: C00057519
- chemspider: 1019
- CAS: 105809-46-9
- CAS: 288-13-1
- MoNA: KO003863
- MoNA: KO003866
- MoNA: KO003867
- MoNA: SM815402
- MoNA: KO003865
- MoNA: KO003864
- PMhub: MS000007791
- PubChem: 3764
- PDB-CCD: PZO
- NIKKAJI: J5.452F
- RefMet: 1H-pyrazole
- medchemexpress: HY-76228
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-24
- KNApSAcK: 17241
分类词条
相关代谢途径
Reactome(0)
BioCyc(6)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- β-pyrazole-1-ylalanine biosynthesis:
O-acetyl-L-serine + pyrazole ⟶ 3-(pyrazol-1-yl)-L-alanine + H+ + acetate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(3)
- β-pyrazole-1-ylalanine biosynthesis:
O-acetyl-L-serine + pyrazole ⟶ 3-(pyrazol-1-yl)-L-alanine + H+ + acetate - β-pyrazole-1-ylalanine biosynthesis:
O-acetyl-L-serine + pyrazole ⟶ 3-(pyrazol-1-yl)-L-alanine + H+ + acetate - β-pyrazole-1-ylalanine biosynthesis:
O-acetyl-L-serine + pyrazole ⟶ 3-(pyrazol-1-yl)-L-alanine + H+ + acetate
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 49827 - Glycyrrhiza glabra: 10.1021/JF60214A042
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bo Luo, Yuerui Wu, Xinran Ren, Huimin Li, Xuanru Li, Gege Wang, Mengjia Wang, Luqi Dong, Mengxing Liu, Wei Zhou, Lailiang Qu. Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control Rhizoctonia solani.
Journal of agricultural and food chemistry.
2024 May; 72(17):9599-9610. doi:
10.1021/acs.jafc.3c06811. [PMID: 38646697] - Tongchao Zhao, Yuyao Sun, Yufei Meng, Lifang Liu, Jingwen Dai, Guoan Yan, Xiaohong Pan, Xiong Guan, Liyan Song, Ran Lin. Design, Synthesis and Antifungal Activities of Novel Pyrazole Analogues Containing the Aryl Trifluoromethoxy Group.
Molecules (Basel, Switzerland).
2023 Aug; 28(17):. doi:
10.3390/molecules28176279. [PMID: 37687108] - Vesna Rastija, Karolina Vrandečić, Jasenka Ćosić, Gabriella Kanižai Šarić, Ivana Majić, Dejan Agić, Domagoj Šubarić, Maja Karnaš, Drago Bešlo, Harshad Brahmbhatt, Mario Komar. Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119335. [PMID: 37298285] - Rebecca L Mattison, Roland Beffa, Guido Bojack, Birgit Bollenbach-Wahl, Christine Dörnbrack, Nicole Dorn, Jörg Freigang, Elmar Gatzweiler, Rahel Getachew, Claudia Hartfiel, Ines Heinemann, Hendrik Helmke, Sabine Hohmann, Harald Jakobi, Gudrun Lange, Peter Lümmen, Lothar Willms, Jens Frackenpohl. Design, synthesis, and screening of herbicidal activity of new phenyl pyrazole-based protoporphyrinogen oxidase-inhibitors (PPO) overcoming resistance issues.
Pest management science.
2023 Feb; ?(?):. doi:
10.1002/ps.7425. [PMID: 36815643] - Ze Zhang, Pengwei Sun, Jiahui Zhao, Hongyuan Zhang, Xinyao Wang, Linshan Li, Lixia Xiong, Na Yang, Yuxin Li, Zhiguang Yuchi, Zhengming Li. Design, synthesis and biological activity of diamide compounds based on 3-substituent of the pyrazole ring†.
Pest management science.
2022 May; 78(5):2022-2033. doi:
10.1002/ps.6826. [PMID: 35122377] - Guang-Hao Zheng, Jian Liu, Fang Yan Guo, Zhi-Hong Zhang, Yin-Jing Jiang, Yong-Ce Lin, Xiao-Qi Lan, Jie Ren, Yan-Ling Wu, Ji-Xing Nan, Cheng Hua Jin, Li-Hua Lian. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis.
Bioorganic chemistry.
2022 05; 122(?):105715. doi:
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Epilepsia.
2022 04; 63(4):1003-1015. doi:
10.1111/epi.17190. [PMID: 35179226] - Haibo Huo, Weiqi Jiang, Feifei Sun, Jian Li, Baojun Shi. Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents.
Steroids.
2021 12; 176(?):108931. doi:
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European journal of medicinal chemistry.
2021 Jul; 219(?):113402. doi:
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Chemical communications (Cambridge, England).
2021 Apr; 57(33):4039-4042. doi:
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Journal of biochemical and molecular toxicology.
2021 Mar; 35(3):e22656. doi:
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Bioorganic chemistry.
2020 07; 100(?):103936. doi:
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2020 Jul; 84(7):1427-1435. doi:
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Biochemistry.
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The international journal of biochemistry & cell biology.
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Chemical research in toxicology.
2009 Sep; 22(9):1603-12. doi:
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Bioorganic & medicinal chemistry letters.
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Proceedings of the National Academy of Sciences of the United States of America.
2009 Mar; 106(13):5400-5. doi:
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Free radical biology & medicine.
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Free radical biology & medicine.
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