Amitrole (BioDeep_00000003030)
Secondary id: BioDeep_00000858346
natural product human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
2,3-dihydro-1H-1,2,4-triazol-3-imine
化学式: C2H4N4 (84.0436)
中文名称: 3-氨基-1,2,4-三唑, 3-氨基-s-三唑, 3-氨基-1,2,4-三氮唑, 阿米特罗
谱图信息:
最多检出来源 Homo sapiens(otcml) 48.84%
分子结构信息
SMILES: C1=NNC(=N1)N
InChI: InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 8107
CONFIDENCE standard compound; INTERNAL_ID 2792
D004791 - Enzyme Inhibitors
KEIO_ID A045
同义名列表
数据库引用编号
38 个数据库交叉引用编号
- ChEBI: CHEBI:40036
- KEGG: C11261
- PubChem: 1639
- HMDB: HMDB0245804
- Metlin: METLIN68946
- ChEMBL: CHEMBL232801
- Wikipedia: Amitrole
- MeSH: Amitrole
- MetaCyc: CPD0-1491
- chemspider: 1577
- CAS: 1346603-92-6
- CAS: 218787-12-3
- CAS: 65380-04-3
- CAS: 65312-61-0
- CAS: 155-25-9
- CAS: 61-82-5
- MoNA: KO000090
- MoNA: AU279206
- MoNA: KO002129
- MoNA: KO002132
- MoNA: KO000089
- MoNA: KO002131
- MoNA: KO000093
- MoNA: KO002128
- MoNA: KO002130
- MoNA: PS015701
- MoNA: PS015702
- MoNA: SM810703
- MoNA: KO000091
- MoNA: PS015703
- MoNA: PS015704
- MoNA: KO000092
- PMhub: MS000007774
- PubChem: 13438
- PDB-CCD: 3TR
- NIKKAJI: J2.345K
- RefMet: Amitrole
- KNApSAcK: 40036
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Louise Ramhøj, Terje Svingen, Caroline Frädrich, Eddy Rijntjes, Eva K Wirth, Katrine Pedersen, Josef Köhrle, Marta Axelstad. Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
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2014 Jun; 216(?):34-42. doi:
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PloS one.
2011; 6(11):e28207. doi:
10.1371/journal.pone.0028207. [PMID: 22140547] - Mingzhu Wu, Jingjing Huang, Sheng Xu, Tengfang Ling, Yanjie Xie, Wenbiao Shen. Haem oxygenase delays programmed cell death in wheat aleurone layers by modulation of hydrogen peroxide metabolism.
Journal of experimental botany.
2011 Jan; 62(1):235-48. doi:
10.1093/jxb/erq261. [PMID: 20797999] - Patricia Stevens, Leonard Simon van Overbeek, Jan Dirk van Elsas. Ralstonia solanacearum ΔPGI-1 strain KZR-5 is affected in growth, response to cold stress and invasion of tomato.
Microbial ecology.
2011 Jan; 61(1):101-12. doi:
10.1007/s00248-010-9728-0. [PMID: 20717661] - Rayhanur Jannat, Misugi Uraji, Miho Morofuji, Mohammad Anowar Hossain, Mohammad Muzahidul Islam, Yoshimasa Nakamura, Izumi C Mori, Yoshiyuki Murata. The roles of CATALASE2 in abscisic acid signaling in Arabidopsis guard cells.
Bioscience, biotechnology, and biochemistry.
2011; 75(10):2034-6. doi:
10.1271/bbb.110344. [PMID: 21979081] - Daisuke Ogawa, Kiyomi Abe, Akio Miyao, Mikiko Kojima, Hitoshi Sakakibara, Megumi Mizutani, Haruka Morita, Yosuke Toda, Tokunori Hobo, Yutaka Sato, Tsukaho Hattori, Hirohiko Hirochika, Shin Takeda. RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice.
Nature communications.
2011; 2(?):278. doi:
10.1038/ncomms1279. [PMID: 21505434] - David Duguay, Erika Bélanger-Nelson, Valérie Mongrain, Anna Beben, Armen Khatchadourian, Nicolas Cermakian. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
PloS one.
2011; 6(10):e26430. doi:
10.1371/journal.pone.0026430. [PMID: 22028875] - Wladimir I L Tameling, Claudia Nooijen, Nora Ludwig, Marta Boter, Erik Slootweg, Aska Goverse, Ken Shirasu, Matthieu H A J Joosten. RanGAP2 mediates nucleocytoplasmic partitioning of the NB-LRR immune receptor Rx in the Solanaceae, thereby dictating Rx function.
The Plant cell.
2010 Dec; 22(12):4176-94. doi:
10.1105/tpc.110.077461. [PMID: 21169509] - Cimen Karasu. Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.
The open cardiovascular medicine journal.
2010 Nov; 4(?):240-56. doi:
10.2174/1874192401004010240. [PMID: 21270942] - Smadar Peleg-Grossman, Naomi Melamed-Book, Gil Cohen, Alex Levine. Cytoplasmic H2O2 prevents translocation of NPR1 to the nucleus and inhibits the induction of PR genes in Arabidopsis.
Plant signaling & behavior.
2010 Nov; 5(11):1401-6. doi:
10.4161/psb.5.11.13209. [PMID: 21051935] - Elena R Álvarez-Buylla, Barbara A Ambrose, Eduardo Flores-Sandoval, Marie Englund, Adriana Garay-Arroyo, Berenice García-Ponce, Eduardo de la Torre-Bárcena, Silvia Espinosa-Matías, Esteban Martínez, Alma Piñeyro-Nelson, Peter Engström, Elliot M Meyerowitz. B-function expression in the flower center underlies the homeotic phenotype of Lacandonia schismatica (Triuridaceae).
The Plant cell.
2010 Nov; 22(11):3543-59. doi:
10.1105/tpc.109.069153. [PMID: 21119062] - Zhigang Xu, Kazuo Oshima, Stefan Heller. PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23.
BMC cell biology.
2010 Oct; 11(?):80. doi:
10.1186/1471-2121-11-80. [PMID: 20958966] - Yuji Takahashi, Takashi Soyano, Ken Kosetsu, Michiko Sasabe, Yasunori Machida. HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana.
Plant & cell physiology.
2010 Oct; 51(10):1766-76. doi:
10.1093/pcp/pcq135. [PMID: 20802223] - Seung Yoon Lee, Jung Kook Suh, Jin Hwa Choi, Woo Jae Jeon, Mi Ae Cheong. Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta.
Korean journal of anesthesiology.
2010 Sep; 59(3):196-202. doi:
10.4097/kjae.2010.59.3.196. [PMID: 20877705] - Jae Myeong Lee, Jung Kook Suh, Ji Seon Jeong, Sang Yun Cho, Dong Won Kim. Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta.
Korean journal of anesthesiology.
2010 Aug; 59(2):104-10. doi:
10.4097/kjae.2010.59.2.104. [PMID: 20740215] - Satu Ruokolainen, Yan Peng Ng, Victor A Albert, Paula Elomaa, Teemu H Teeri. Large scale interaction analysis predicts that the Gerbera hybrida floral E function is provided both by general and specialized proteins.
BMC plant biology.
2010 Jun; 10(?):129. doi:
10.1186/1471-2229-10-129. [PMID: 20579338] - Eric Soupene, Nghi Phuong Dinh, Melvin Siliakus, Frans A Kuypers. Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.
BMC biochemistry.
2010 Apr; 11(?):18. doi:
10.1186/1471-2091-11-18. [PMID: 20429931] - Christian Voigt, Ulrike Oster, Frederik Börnke, Peter Jahns, Karl-Josef Dietz, Dario Leister, Tatjana Kleine. In-depth analysis of the distinctive effects of norflurazon implies that tetrapyrrole biosynthesis, organellar gene expression and ABA cooperate in the GUN-type of plastid signalling.
Physiologia plantarum.
2010 Apr; 138(4):503-19. doi:
10.1111/j.1399-3054.2009.01343.x. [PMID: 20028479] - Wilfried Rozhon, Juliane Mayerhofer, Elena Petutschnig, Shozo Fujioka, Claudia Jonak. ASKtheta, a group-III Arabidopsis GSK3, functions in the brassinosteroid signalling pathway.
The Plant journal : for cell and molecular biology.
2010 Apr; 62(2):215-23. doi:
10.1111/j.1365-313x.2010.04145.x. [PMID: 20128883] - Lei Guo, Xiang-Yong Zeng, Deng-Yuan Wang, Guo-Qing Li. Methanol metabolism in the Asian corn borer, Ostrinia furnacalis (Guenée) (Lepidoptera: Pyralidae).
Journal of insect physiology.
2010 Mar; 56(3):260-5. doi:
10.1016/j.jinsphys.2009.10.010. [PMID: 19883652] - Guoxin Shen, Sundaram Kuppu, Sujatha Venkataramani, Jing Wang, Juqiang Yan, Xiaoyun Qiu, Hong Zhang. ANKYRIN REPEAT-CONTAINING PROTEIN 2A is an essential molecular chaperone for peroxisomal membrane-bound ASCORBATE PEROXIDASE3 in Arabidopsis.
The Plant cell.
2010 Mar; 22(3):811-31. doi:
10.1105/tpc.109.065979. [PMID: 20215589] - Chiara A Airoldi, Federica Della Rovere, Giuseppina Falasca, Giada Marino, Maarten Kooiker, Maria Maddalena Altamura, Sandra Citterio, Martin M Kater. The Arabidopsis BET bromodomain factor GTE4 is involved in maintenance of the mitotic cell cycle during plant development.
Plant physiology.
2010 Mar; 152(3):1320-34. doi:
10.1104/pp.109.150631. [PMID: 20032077] - Yeong-Tae Kim, Jonghee Oh, Kyung-Hwan Kim, Jae-Youl Uhm, Byoung-Moo Lee. Isolation and characterization of NgRLK1, a receptor-like kinase of Nicotiana glutinosa that interacts with the elicitin of Phytophthora capsici.
Molecular biology reports.
2010 Feb; 37(2):717-27. doi:
10.1007/s11033-009-9570-y. [PMID: 19449126] - Sami Banerjee, Jaroslaw W Zmijewski, Emmanuel Lorne, Gang Liu, Yonggang Sha, Edward Abraham. Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide.
The Journal of biological chemistry.
2010 Jan; 285(4):2665-75. doi:
10.1074/jbc.m109.060822. [PMID: 19933270] - Jie Xu, Caiyun Yang, Zheng Yuan, Dasheng Zhang, Martha Y Gondwe, Zhiwen Ding, Wanqi Liang, Dabing Zhang, Zoe A Wilson. The ABORTED MICROSPORES regulatory network is required for postmeiotic male reproductive development in Arabidopsis thaliana.
The Plant cell.
2010 Jan; 22(1):91-107. doi:
10.1105/tpc.109.071803. [PMID: 20118226] - Suvi K Broholm, Eija Pöllänen, Satu Ruokolainen, Sari Tähtiharju, Mika Kotilainen, Victor A Albert, Paula Elomaa, Teemu H Teeri. Functional characterization of B class MADS-box transcription factors in Gerbera hybrida.
Journal of experimental botany.
2010; 61(1):75-85. doi:
10.1093/jxb/erp279. [PMID: 19767305] - Ping Hong Meng, Cécile Raynaud, Guillaume Tcherkez, Sophie Blanchet, Kamal Massoud, Séverine Domenichini, Yves Henry, Ludivine Soubigou-Taconnat, Caroline Lelarge-Trouverie, Patrick Saindrenan, Jean Pierre Renou, Catherine Bergounioux. Crosstalks between myo-inositol metabolism, programmed cell death and basal immunity in Arabidopsis.
PloS one.
2009 Oct; 4(10):e7364. doi:
10.1371/journal.pone.0007364. [PMID: 19812700] - Andrea M Vincent, John M Hayes, Lisa L McLean, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Eva L Feldman. Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1.
Diabetes.
2009 Oct; 58(10):2376-85. doi:
10.2337/db09-0047. [PMID: 19592619] - Wei Wei, Jian Huang, Yu-Jun Hao, Hong-Feng Zou, Hui-Wen Wang, Jing-Yun Zhao, Xue-Yi Liu, Wan-Ke Zhang, Biao Ma, Jin-Song Zhang, Shou-Yi Chen. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.
PloS one.
2009 Sep; 4(9):e7209. doi:
10.1371/journal.pone.0007209. [PMID: 19789627] - Clotilde Levecque, Antonio Velayos-Baeza, Zoe G Holloway, Anthony P Monaco. The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.
American journal of physiology. Cell physiology.
2009 Jul; 297(1):C160-8. doi:
10.1152/ajpcell.00630.2008. [PMID: 19419997] - K R Shanmugam, C H Ramakrishna, K Mallikarjuna, K Sathyavelu Reddy. Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress.
Indian journal of nephrology.
2009 Jul; 19(3):101-6. doi:
10.4103/0971-4065.57106. [PMID: 20436729] - Takaaki Umano, Keiji Shiraishi, Yasushi Minobe, Kanji Yamasaki. Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the Organization for Economic Co-operation and Development draft protocols.
Archives of toxicology.
2009 May; 83(5):459-67. doi:
10.1007/s00204-008-0357-z. [PMID: 18779953] - Wei Li, Jinmiao Zha, Philip A Spear, Zhaoli Li, Lihua Yang, Zijian Wang. Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery.
Aquatic toxicology (Amsterdam, Netherlands).
2009 Apr; 92(1):50-7. doi:
10.1016/j.aquatox.2009.01.006. [PMID: 19223083] - Richard G H Immink, Isabella A N Tonaco, Stefan de Folter, Anna Shchennikova, Aalt D J van Dijk, Jacqueline Busscher-Lange, Jan W Borst, Gerco C Angenent. SEPALLATA3: the 'glue' for MADS box transcription factor complex formation.
Genome biology.
2009 Feb; 10(2):R24. doi:
10.1186/gb-2009-10-2-r24. [PMID: 19243611] - Gaiyun Zhang, Ming Chen, Liancheng Li, Zhaoshi Xu, Xueping Chen, Jiaming Guo, Youzhi Ma. Overexpression of the soybean GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought, and diseases in transgenic tobacco.
Journal of experimental botany.
2009; 60(13):3781-96. doi:
10.1093/jxb/erp214. [PMID: 19602544] - Weimin Yang, Robert M Lust, April Bofferding, Christopher J Wingard. Nitric oxide and catalase-sensitive relaxation by scutellarin in the mouse thoracic aorta.
Journal of cardiovascular pharmacology.
2009 Jan; 53(1):66-76. doi:
10.1097/fjc.0b013e318195d776. [PMID: 19129733] - Andrés P Gagete, Marta Riera, Luis Franco, M Isabel Rodrigo. Functional analysis of the isoforms of an ABI3-like factor of Pisum sativum generated by alternative splicing.
Journal of experimental botany.
2009; 60(6):1703-14. doi:
10.1093/jxb/erp038. [PMID: 19261920] - Lijun Wu, Zhijin Zhang, Haiwen Zhang, Xue-Chen Wang, Rongfeng Huang. Transcriptional modulation of ethylene response factor protein JERF3 in the oxidative stress response enhances tolerance of tobacco seedlings to salt, drought, and freezing.
Plant physiology.
2008 Dec; 148(4):1953-63. doi:
10.1104/pp.108.126813. [PMID: 18945933] - Shuang Feng, Genevieve M Okenka, Chang-Xi Bai, Andrew J Streets, Linda J Newby, Brett T DeChant, Leonidas Tsiokas, Tomoko Obara, Albert C M Ong. Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.
The Journal of biological chemistry.
2008 Oct; 283(42):28471-9. doi:
10.1074/jbc.m803834200. [PMID: 18701462] - K N Chandrashekar, Muralidhara. Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study.
Theriogenology.
2008 Jul; 70(1):97-104. doi:
10.1016/j.theriogenology.2008.02.004. [PMID: 18439665] - Bahar Tunctan, Fariborz A Yaghini, Anne Estes, Kafait U Malik. Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.
Archives of pharmacal research.
2008 Jul; 31(7):856-65. doi:
10.1007/s12272-001-1238-x. [PMID: 18704327]
