Amitrole (BioDeep_00000003030)

 

Secondary id: BioDeep_00000858346

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2,3-dihydro-1H-1,2,4-triazol-3-imine

化学式: C2H4N4 (84.0435944)
中文名称: 3-氨基-1,2,4-三唑, 3-氨基-s-三唑, 3-氨基-1,2,4-三氮唑
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 11.11%

分子结构信息

SMILES: C1=NNC(=N1)N
InChI: InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 8107
CONFIDENCE standard compound; INTERNAL_ID 2792
D004791 - Enzyme Inhibitors
KEIO_ID A045

同义名列表

9 个代谢物同义名

2,3-dihydro-1H-1,2,4-triazol-3-imine; 1H-1,2,4-Triazol-3-ylamine; 3-amino-1,2,4-triazole; 2-Amino-1,3,4-triazole; 3-Amino-S-triazole; 3-AMINOTRIAZOLE; Aminotriazole; Amitrole; 3-AT



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Louise Ramhøj, Terje Svingen, Caroline Frädrich, Eddy Rijntjes, Eva K Wirth, Katrine Pedersen, Josef Köhrle, Marta Axelstad. Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring. Toxicology letters. 2022 Jan; 354(?):44-55. doi: 10.1016/j.toxlet.2021.10.010. [PMID: 34757178]
  • Huaming He, Jordi Denecker, Katrien Van Der Kelen, Patrick Willems, Robin Pottie, Su Yin Phua, Matthew A Hannah, Didier Vertommen, Frank Van Breusegem, Amna Mhamdi. The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses. The Plant cell. 2021 07; 33(6):2032-2057. doi: 10.1093/plcell/koab079. [PMID: 33713138]
  • Yun Chen, Yuanhua Chen, Yajun Zhang, Dongping Zhang, Guoming Li, Jiali Wei, Xia Hua, Bing Lv, Lijun Liu. Heterotrimeric G protein γ subunit DEP1 is involved in hydrogen peroxide signaling and promotes aerenchyma formation in rice roots. Plant signaling & behavior. 2021 05; 16(5):1889251. doi: 10.1080/15592324.2021.1889251. [PMID: 33632064]
  • Mariana R Lauar, Graziela T Blanch, Débora S A Colombari, Eduardo Colombari, Patrícia M De Paula, Laurival A De Luca, José V Menani. Anti-hypertensive effect of hydrogen peroxide acting centrally. Hypertension research : official journal of the Japanese Society of Hypertension. 2020 11; 43(11):1192-1203. doi: 10.1038/s41440-020-0474-5. [PMID: 32461634]
  • Lauren E Stanley, Baoqing Ding, Wei Sun, Fengjuan Mou, Connor Hill, Shilin Chen, Yao-Wu Yuan. A Tetratricopeptide Repeat Protein Regulates Carotenoid Biosynthesis and Chromoplast Development in Monkeyflowers (Mimulus). The Plant cell. 2020 05; 32(5):1536-1555. doi: 10.1105/tpc.19.00755. [PMID: 32132132]
  • Oly Banerjee, Siddhartha Singh, Shilpi Kumari Prasad, Ankita Bhattacharjee, Arnab Banerjee, Anindita Banerjee, Adipa Saha, Bithin Kumar Maji, Sandip Mukherjee. Inhibition of catalase activity with 3-amino-1,2,4-triazole intensifies bisphenol A (BPA)-induced toxicity in granulosa cells of female albino rats. Toxicology and industrial health. 2018 Nov; 34(11):787-797. doi: 10.1177/0748233718795744. [PMID: 30269681]
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  • Marie-Sylviane Rahantaniaina, Shengchun Li, Gilles Chatel-Innocenti, Andrée Tuzet, Amna Mhamdi, Hélène Vanacker, Graham Noctor. Glutathione oxidation in response to intracellular H2O2: Key but overlapping roles for dehydroascorbate reductases. Plant signaling & behavior. 2017 08; 12(8):e1356531. doi: 10.1080/15592324.2017.1356531. [PMID: 28782990]
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  • John M Clough, Richard P Dale, Barry Elsdon, Timothy R Hawkes, Bridget V Hogg, Anushka Howell, Daniel P Kloer, Karine Lecoq, Matthew Mw McLachlan, Phillip J Milnes, Timothy Jc O'Riordan, Saranga Ranasinghe, Stephen E Shanahan, Karen D Sumner, Shanaaz Tayab. Synthesis and evaluation of hydroxyazolopyrimidines as herbicides; the generation of amitrole in planta. Pest management science. 2016 Dec; 72(12):2254-2272. doi: 10.1002/ps.4264. [PMID: 26918632]
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  • Danuta Cembrowska-Lech, Marek Koprowski, Jan Kępczyński. Germination induction of dormant Avena fatua caryopses by KAR(1) and GA(3) involving the control of reactive oxygen species (H2O2 and O2(·-)) and enzymatic antioxidants (superoxide dismutase and catalase) both in the embryo and the aleurone layers. Journal of plant physiology. 2015 Mar; 176(?):169-79. doi: 10.1016/j.jplph.2014.11.010. [PMID: 25618514]
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  • Long-Chi Wang, Fernando Montalvo-Munoz, Yuan-Chan Tsai, Chung-Yi Liang, Chun-Chuan Chang, Wan-Sheng Lo. The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae. BioMed research international. 2015; 2015(?):284692. doi: 10.1155/2015/284692. [PMID: 25922832]
  • Yuping Jing, Kunwei Wu, Jiashuo Liu, Qing Ai, Pu Ge, Jie Dai, Rong Jiang, Dan Zhou, Qian Che, Jingyuan Wan, Li Zhang. Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation. PloS one. 2015; 10(4):e0122781. doi: 10.1371/journal.pone.0122781. [PMID: 25884831]
  • Svetlana Ivanović-Matić, Desanka Bogojević, Vesna Martinović, Anja Petrović, Sofija Jovanović-Stojanov, Goran Poznanović, Ilijana Grigorov. Catalase inhibition in diabetic rats potentiates DNA damage and apoptotic cell death setting the stage for cardiomyopathy. Journal of physiology and biochemistry. 2014 Dec; 70(4):947-59. doi: 10.1007/s13105-014-0363-y. [PMID: 25298180]
  • Jie Dai, Mingwei Liu, Qing Ai, Ling Lin, Kunwei Wu, Xinyu Deng, Yuping Jing, Mengying Jia, Jingyuan Wan, Li Zhang. Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. Chemico-biological interactions. 2014 Jun; 216(?):34-42. doi: 10.1016/j.cbi.2014.03.013. [PMID: 24717679]
  • Yansha Li, Lichao Chen, Jinye Mu, Jianru Zuo. LESION SIMULATING DISEASE1 interacts with catalases to regulate hypersensitive cell death in Arabidopsis. Plant physiology. 2013 Oct; 163(2):1059-70. doi: 10.1104/pp.113.225805. [PMID: 23958864]
  • Fuqiang Xing, Zhe Li, Aizhen Sun, Da Xing. Reactive oxygen species promote chloroplast dysfunction and salicylic acid accumulation in fumonisin B1-induced cell death. FEBS letters. 2013 Jul; 587(14):2164-72. doi: 10.1016/j.febslet.2013.05.034. [PMID: 23711368]
  • Vicente Sánchez-Valle, Mahara Valverde, Leticia Carrizale, Jesus Mejía, Nahum Zepeta, Emilio Rojas. A metal mixture induces transformation upon antioxidant depletion in a hepatic cell line. Annals of hepatology. 2013 Mar; 12(2):315-24. doi: . [PMID: 23396744]
  • E V Pradedova, I S Trukhan, O D Nimaeva, R K Salyaev. Hydrogen peroxide generation in the vacuoles of red beet root cells. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2013 Mar; 449(?):106-9. doi: 10.1134/s0012496613020129. [PMID: 23652440]
  • Hyunjin Hong, Kyung Sook Bae, Yeonhee Lee. New bacteria Bacillus nitroreducens PLC9 with hydrogen peroxide-degrading activity with high survival rate in hydrogen peroxide. Applied biochemistry and biotechnology. 2013 Feb; 169(3):701-11. doi: 10.1007/s12010-012-0034-9. [PMID: 23271626]
  • Leonardo M Cardoso, Eduardo Colombari, Glenn M Toney. Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamate. Journal of applied physiology (Bethesda, Md. : 1985). 2012 Nov; 113(9):1423-31. doi: 10.1152/japplphysiol.00912.2012. [PMID: 22984242]
  • Nikolay Mehterov, Salma Balazadeh, Jacques Hille, Valentina Toneva, Bernd Mueller-Roeber, Tsanko Gechev. Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes. Plant physiology and biochemistry : PPB. 2012 Oct; 59(?):20-9. doi: 10.1016/j.plaphy.2012.05.024. [PMID: 22710144]
  • Xinyu Deng, Kunwei Wu, Jingyuan Wan, Longjiang Li, Rong Jiang, Mengying Jia, Yuping Jing, Li Zhang. Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3073-8. doi: 10.1016/j.fct.2012.05.052. [PMID: 22687551]
  • Bianka Steffens, Alexander Kovalev, Stanislav N Gorb, Margret Sauter. Emerging roots alter epidermal cell fate through mechanical and reactive oxygen species signaling. The Plant cell. 2012 Aug; 24(8):3296-306. doi: 10.1105/tpc.112.101790. [PMID: 22904148]
  • Rayhanur Jannat, Misugi Uraji, Mohammad Anowar Hossain, Mohammad Muzahidul Islam, Yoshimasa Nakamura, Izumi C Mori, Yoshiyuki Murata. Catalases negatively regulate methyl jasmonate signaling in guard cells. Journal of plant physiology. 2012 Jul; 169(10):1012-6. doi: 10.1016/j.jplph.2012.03.006. [PMID: 22525681]
  • S Gayatridevi, S K Jayalakshmi, K Sreeramulu. Salicylic acid is a modulator of catalase isozymes in chickpea plants infected with Fusarium oxysporum f. sp. ciceri. Plant physiology and biochemistry : PPB. 2012 Mar; 52(?):154-61. doi: 10.1016/j.plaphy.2011.12.005. [PMID: 22245913]
  • Paloma Rueda-Romero, Cristina Barrero-Sicilia, Aurelio Gómez-Cadenas, Pilar Carbonero, Luis Oñate-Sánchez. Arabidopsis thaliana DOF6 negatively affects germination in non-after-ripened seeds and interacts with TCP14. Journal of experimental botany. 2012 Mar; 63(5):1937-49. doi: 10.1093/jxb/err388. [PMID: 22155632]
  • Verena Ibl, Edina Csaszar, Nicole Schlager, Susanne Neubert, Christoph Spitzer, Marie-Theres Hauser. Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana. Journal of proteome research. 2012 Jan; 11(1):397-411. doi: 10.1021/pr200845n. [PMID: 22010978]
  • Jian-fei Kuang, Jian-ye Chen, Ming Luo, Ke-qiang Wu, Wei Sun, Yue-ming Jiang, Wang-jin Lu. Histone deacetylase HD2 interacts with ERF1 and is involved in longan fruit senescence. Journal of experimental botany. 2012 Jan; 63(1):441-54. doi: 10.1093/jxb/err290. [PMID: 21926091]
  • Lu Liu, Chang Liu, Xingliang Hou, Wanyan Xi, Lisha Shen, Zhen Tao, Yue Wang, Hao Yu. FTIP1 is an essential regulator required for florigen transport. PLoS biology. 2012; 10(4):e1001313. doi: 10.1371/journal.pbio.1001313. [PMID: 22529749]
  • Gavin Anderson, Renyuan Wang, Anindya Bandyopadhyay, Michael Goodin. The Nucleocapsid Protein of Potato Yellow dwarf Virus: Protein Interactions and Nuclear Import Mediated by a Non-Canonical Nuclear Localization Signal. Frontiers in plant science. 2012; 3(?):14. doi: 10.3389/fpls.2012.00014. [PMID: 22645569]
  • Katalin Tóth, Thomas F Stratil, Esben B Madsen, Juanying Ye, Claudia Popp, Meritxell Antolín-Llovera, Christina Grossmann, Ole N Jensen, Arthur Schüssler, Martin Parniske, Thomas Ott. Functional domain analysis of the Remorin protein LjSYMREM1 in Lotus japonicus. PloS one. 2012; 7(1):e30817. doi: 10.1371/journal.pone.0030817. [PMID: 22292047]
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