Pyridostigmine (BioDeep_00000002991)
Secondary id: BioDeep_00001868399
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C9H13N2O2+ (181.0977)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 21.59%
分子结构信息
SMILES: CN(C)C(=O)OC1=C[N+](C)=CC=C1
InChI: InChI=1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1
描述信息
Pyridostigmine is only found in individuals that have used or taken this drug. It is a cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. [PubChem]Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine.
N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics > N07AA - Anticholinesterases
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:8665
- KEGG: C07410
- PubChem: 4991
- HMDB: HMDB0014685
- DrugBank: DB00545
- ChEMBL: CHEMBL1115
- ChEMBL: CHEMBL812
- Wikipedia: Pyridostigmine
- MeSH: Pyridostigmine Bromide
- chemspider: 4817
- CAS: 155-97-5
- PMhub: MS000007640
- PubChem: 9614
- NIKKAJI: J10.938J
- RefMet: Pyridostigmine
- KNApSAcK: 8665
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Runqing Xue, Qing Wu, Lulu Guo, Dan Ye, Qing Cao, Meng Zhang, Yushan Xian, Minchun Chen, Kangkang Yan, Jie Zheng. Pyridostigmine attenuated high-fat-diet induced liver injury by the reduction of mitochondrial damage and oxidative stress via α7nAChR and M3AChR.
Journal of biochemical and molecular toxicology.
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Scandinavian journal of rheumatology.
2023 Nov; 52(6):627-636. doi:
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Life sciences.
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Autoimmune diseases.
2011; 2011(?):404101. doi:
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Arquivos de neuro-psiquiatria.
2010 Dec; 68(6):849-54. doi:
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International journal of general medicine.
2010 Nov; 3(?):375-8. doi:
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Journal of neuroinflammation.
2010 Sep; 7(?):52. doi:
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Journal of the American Veterinary Medical Association.
2010 Mar; 236(6):664-8. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2010 Mar; 30(3):271-4. doi:
"
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Clinics (Sao Paulo, Brazil).
2010; 65(1):85-92. doi:
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Journal of AOAC International.
2009 Nov; 92(6):1631-8. doi:
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Oral diseases.
2009 Oct; 15(7):478-83. doi:
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The Journal of pharmacy and pharmacology.
2009 Sep; 61(9):1187-96. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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AIDS research and human retroviruses.
2009 Aug; 25(8):749-55. doi:
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Cases journal.
2009 Jun; 2(?):7394. doi:
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Journal of clinical neurology (Seoul, Korea).
2009 Jun; 5(2):53-64. doi:
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Fertility and sterility.
2009 Mar; 91(3):842-50. doi:
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La Revue du praticien.
2008 Dec; 58(20):2217-24. doi:
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Chemico-biological interactions.
2008 Sep; 175(1-3):380-6. doi:
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Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2008 Sep; 6(9):988-92. doi:
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Rinsho shinkeigaku = Clinical neurology.
2008 Sep; 48(9):666-9. doi:
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2008 Sep; 6(9):964-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Journal of medical case reports.
2008 Mar; 2(?):89. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2008 Mar; 38(3):294-313. doi:
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Arthritis and rheumatism.
2008 Feb; 58(2):612-22. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2008 Feb; 24(1):19-23. doi:
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Southern medical journal.
2008 Jan; 101(1):63-9. doi:
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Parkinsonism & related disorders.
2008; 14(2):164-5. doi:
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Autonomic neuroscience : basic & clinical.
2007 Dec; 137(1-2):19-26. doi:
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Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2007 Dec; 27(12):901-3. doi:
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BMC musculoskeletal disorders.
2007 Nov; 8(?):119. doi:
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Biological psychiatry.
2007 Nov; 62(10):1175-8. doi:
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Orphanet journal of rare diseases.
2007 Nov; 2(?):44. doi:
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Journal of the International Society of Sports Nutrition.
2007 Oct; 4(?):14. doi:
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Pediatric neurology.
2007 Jun; 36(6):421-3. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2007 Jun; 4(2):195-202. doi:
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Archives of toxicology.
2007 May; 81(5):353-9. doi:
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Neuropsychiatric disease and treatment.
2007; 3(5):539-44. doi:
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International immunopharmacology.
2006 Dec; 6(12):1765-79. doi:
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Psychoneuroendocrinology.
2006 Nov; 31(10):1181-9. doi:
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Gastroenterology.
2006 Nov; 131(5):1592-6. doi:
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Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.
2006 Oct; 23(5):476-81. doi:
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Brain : a journal of neurology.
2006 Aug; 129(Pt 8):2061-76. doi:
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