Clofilium (BioDeep_00000002984)
代谢物信息卡片
Clofilium
化学式: C21H37ClN+ (338.2614)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 79.31%
分子结构信息
SMILES: CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(C=C1)Cl
InChI: InChI=1S/C21H37ClN/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20/h14-17H,4-13,18-19H2,1-3H3/q+1
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:34649
- KEGG: C13772
- PubChem: 2798
- ChEMBL: CHEMBL9484
- CAS: 68379-02-2
- PMhub: MS000007629
- PubChem: 854018
- NIKKAJI: J354.009J
- KNApSAcK: 34649
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- H Papp, A Sarusi, A S Farkas, H Takacs, P Kui, D Vincze, E Ivany, A Varro, J G Papp, T Forster, A Farkas. Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2016 Oct; 67(5):731-737. doi:
. [PMID: 28011953] - Yanli Zhang, Thai Phung, James Dunlop, Julie Dalziel. hERG ion channel pharmacology: cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping.
European biophysics journal : EBJ.
2012 Nov; 41(11):949-58. doi:
10.1007/s00249-012-0852-2. [PMID: 22936309] - A M Neal, H C Taylor, I D Millar, J D Kibble, S J White, L Robson. Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule.
The Journal of physiology.
2011 Jul; 589(Pt 14):3595-609. doi:
10.1113/jphysiol.2011.209155. [PMID: 21576273] - Signe Skyum Kirkegaard, Ian Henry Lambert, Steen Gammeltoft, Else Kay Hoffmann. Activation of the TASK-2 channel after cell swelling is dependent on tyrosine phosphorylation.
American journal of physiology. Cell physiology.
2010 Oct; 299(4):C844-53. doi:
10.1152/ajpcell.00024.2010. [PMID: 20631251] - Marie Teixeira, Say Viengchareun, Daniel Butlen, Chrystophe Ferreira, Françoise Cluzeaud, Marcel Blot-Chabaud, Marc Lombès, Evelyne Ferrary. Functional IsK/KvLQT1 potassium channel in a new corticosteroid-sensitive cell line derived from the inner ear.
The Journal of biological chemistry.
2006 Apr; 281(15):10496-507. doi:
10.1074/jbc.m512254200. [PMID: 16478723] - Mónika Gönczi, Norbert Szentandrássy, Ian T Johnson, Anthony M Heagerty, Arthur H Weston. Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures.
British journal of pharmacology.
2006 Mar; 147(5):496-505. doi:
10.1038/sj.bjp.0706649. [PMID: 16432512] - Kellie A Davis, Elizabeth A Cowley. Two-pore-domain potassium channels support anion secretion from human airway Calu-3 epithelial cells.
Pflugers Archiv : European journal of physiology.
2006 Feb; 451(5):631-41. doi:
10.1007/s00424-005-1505-4. [PMID: 16311719] - Sang Wook Kim, Seung Dae Yang, Byung Jae Ahn, Jeong Hoon Park, Dong Soo Lee, Guido Gessner, Stefan H Heinemann, Wilhelm Herdering, Kook Hyun Yu. In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium.
Experimental & molecular medicine.
2005 Aug; 37(4):269-75. doi:
10.1038/emm.2005.36. [PMID: 16155403] - J P Barfield, C H Yeung, T G Cooper. The effects of putative K+ channel blockers on volume regulation of murine spermatozoa.
Biology of reproduction.
2005 May; 72(5):1275-81. doi:
10.1095/biolreprod.104.038448. [PMID: 15673604] - Ling Wei, Ai Ying Xiao, Chun Jin, Aizhen Yang, Zhong Yang Lu, Shan Ping Yu. Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons.
Pflugers Archiv : European journal of physiology.
2004 Jun; 448(3):325-34. doi:
10.1007/s00424-004-1277-2. [PMID: 15057559] - I D Millar, J A Hartley, C Haigh, A A Grace, S J White, J D Kibble, L Robson. Volume regulation is defective in renal proximal tubule cells isolated from KCNE1 knockout mice.
Experimental physiology.
2004 Mar; 89(2):173-80. doi:
10.1113/expphysiol.2003.026674. [PMID: 15123546] - James D Lillich, Peter C Rakestraw, Allen J Roussel, Melissa R Finley, Suhasini Ganta, Lisa C Freeman. Expression of the ether-a-go-go (ERG) potassium channel in smooth muscle of the equine gastrointestinal tract and influence on activity of jejunal smooth muscle.
American journal of veterinary research.
2003 Mar; 64(3):267-72. doi:
10.2460/ajvr.2003.64.267. [PMID: 12661864] - M I Niemeyer, L P Cid, L F Barros, F V Sepúlveda. Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume.
The Journal of biological chemistry.
2001 Nov; 276(46):43166-74. doi:
10.1074/jbc.m107192200. [PMID: 11560934] - K Finlayson, L Turnbull, C T January, J Sharkey, J S Kelly. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
European journal of pharmacology.
2001 Oct; 430(1):147-8. doi:
10.1016/s0014-2999(01)01362-0. [PMID: 11698075] - R A Li, J Miake, U C Hoppe, D C Johns, E Marbán, H B Nuss. Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes.
The Journal of physiology.
2001 May; 533(Pt 1):127-33. doi:
10.1111/j.1469-7793.2001.0127b.x. [PMID: 11351021] - R Søgaard, T Ljungstrøm, K A Pedersen, S P Olesen, B S Jensen. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
American journal of physiology. Cell physiology.
2001 Apr; 280(4):C859-66. doi:
10.1152/ajpcell.2001.280.4.c859. [PMID: 11245603] - B Attali, N Wang, A Kolot, A Sobko, V Cherepanov, B Soliven. Characterization of delayed rectifier Kv channels in oligodendrocytes and progenitor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997 Nov; 17(21):8234-45. doi:
10.1523/jneurosci.17-21-08234.1997. [PMID: 9334399] - J D Rabinowitz, P Rigler, C Carswell-Crumpton, C Beeson, H M McConnell. Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade.
Life sciences.
1997; 61(7):PL87-94. doi:
10.1016/s0024-3205(97)00543-2. [PMID: 9252253] - H Sakuta, K Okamoto, Y Watanabe. Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide-sensitive K+ currents in Xenopus oocytes.
British journal of pharmacology.
1993 Jul; 109(3):866-72. doi:
10.1111/j.1476-5381.1993.tb13655.x. [PMID: 8358576] - N Mori, M Sakagami, K Fukazawa, T Matsunaga. An immunohistochemical and electrophysiological study on Isk protein in the stria vascularis of the guinea pig.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
1993; 250(3):186-9. doi:
10.1007/bf00171709. [PMID: 8357611] - H S Young, V Skita, R P Mason, L G Herbette. Molecular basis for the inhibition of 1,4-dihydropyridine calcium channel drugs binding to their receptors by a nonspecific site interaction mechanism.
Biophysical journal.
1992 May; 61(5):1244-55. doi:
10.1016/s0006-3495(92)81933-1. [PMID: 1318093] - J Nettleton, N A Castle, G K Wang. Block of single batrachotoxin-activated Na+ channels by clofilium.
Molecular pharmacology.
1991 Mar; 39(3):352-8. doi:
". [PMID: 1848656] - D S Echt, J N Black, J T Barbey, D R Coxe, E Cato. Evaluation of antiarrhythmic drugs on defibrillation energy requirements in dogs. Sodium channel block and action potential prolongation.
Circulation.
1989 May; 79(5):1106-17. doi:
10.1161/01.cir.79.5.1106. [PMID: 2469545] - K S Su, K M Campanale, C L Gries. Nasal drug delivery system of a quaternary ammonium compound: clofilium tosylate.
Journal of pharmaceutical sciences.
1984 Sep; 73(9):1251-4. doi:
10.1002/jps.2600730915. [PMID: 6491944] - T D Lindstrom, R L Wolen. Determination of clofilium, a new antifibrillatory agent, in plasma by gas chromatography--mass spectrometry.
Journal of chromatography.
1982 Dec; 233(?):175-80. doi:
10.1016/s0378-4347(00)81744-2. [PMID: 7161331] - T D Lindstrom, P J Murphy, J K Smallwood, S A Wiest, M I Steinberg. Correlation between the disposition of [14C]clofilium and its cardiac electrophysiological effect.
The Journal of pharmacology and experimental therapeutics.
1982 Jun; 221(3):584-9. doi:
NULL. [PMID: 7086672]
