Neostigmine (BioDeep_00000002980)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(m-Hydroxyphenyl)trimethylammonium dimethylcarbamic acid

化学式: C12H19N2O2+ (223.1446454)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90.91%

分子结构信息

SMILES: CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C
InChI: InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1

描述信息

Neostigmine is only found in individuals that have used or taken this drug. It is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. [PubChem]Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degredation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction. It does not cross the blood-brain barrier.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics > N07AA - Anticholinesterases
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

22 个代谢物同义名

(m-Hydroxyphenyl)trimethylammonium dimethylcarbamic acid; (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate; 3-Trimethylammoniumphenyl N,N-dimethylcarbamic acid; 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium; 3-Trimethylammoniumphenyl N,N-dimethylcarbamate; m-Trimethylammoniumphenyldimethylcarbamic acid; m-Trimethylammoniumphenyldimethylcarbamate; Methylsulfate, neostigmine; Neostigmine Methylsulfate; Bromide, neostigmine; Neostigmine Bromide; Syntostigmine; Vagostigmine; Prostigmine; NEOSTIGMINE; Polstigmine; Synstigmin; Eustigmine; Prostigmin; Proserine; Eustigmin; Prozerin

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:7514
KEGG: C07258
KEGGdrug: D08261
PubChem: 4456
HMDB: HMDB0015472
DrugBank: DB01400
ChEMBL: CHEMBL278020
Wikipedia: Neostigmine
MeSH: Neostigmine
chemspider: 4301
CAS: 59-99-4
PMhub: MS000007610
PubChem: 9467
NIKKAJI: J4.797J
RefMet: Neostigmine

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jing Tan, Jianhua He, Lijun Wang, Jia Fang, Pengyi Li, Zhenghuan Song, Qingming Bian. Analysis of the association of sugammadex with the length of hospital stay in patients undergoing abdominal surgery: a retrospective study. BMC anesthesiology. 2023 01; 23(1):32. doi: 10.1186/s12871-023-01979-4. [PMID: 36698080]
Yuan Feng, Wan Dai, Junyu Ke, Yong Cui, Shuang Li, Jingjing Ma, Wenfeng Guo, Gang Chen, Ning Li, Yanwu Li. Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder. Pharmaceutical biology. 2022 Dec; 60(1):1095-1105. doi: 10.1080/13880209.2022.2071449. [PMID: 35658820]
Chen Xu, Jiying Cong, Tingting Liu, Chenmeng Jiao, Mingsen Li, Yongjun Yu, Zhao Zhang, Shiwu Zhang, Yuwei Li. The colonic motility and classification of patients with slow transit constipation by high-resolution colonic manometry. Clinics and research in hepatology and gastroenterology. 2022 11; 46(9):101998. doi: 10.1016/j.clinre.2022.101998. [PMID: 35863732]
Myung Ah Lee, Chonghwee Lee, Jung Hyun Park, Jung Hwan Lee. Early-Onset Myasthenia Gravis Following COVID-19 Vaccination. Journal of Korean medical science. 2022 Mar; 37(10):e50. doi: 10.3346/jkms.2022.37.e50. [PMID: 35289135]
Wenhua He, Peng Chen, Yupeng Lei, Liang Xia, Pi Liu, Yong Zhu, Hao Zeng, Yao Wu, Huajing Ke, Xin Huang, Wenhao Cai, Xin Sun, Wei Huang, Robert Sutton, Yin Zhu, Nonghua Lu. Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis. Critical care (London, England). 2022 03; 26(1):52. doi: 10.1186/s13054-022-03922-4. [PMID: 35241135]
Fang Yu, Aisha Saand, Changhong Xing, Jong Woo Lee, Liangge Hsu, Octavia P Palmer, Vanessa Jackson, Lu Tang, MingMing Ning, Rose Du, Patrick M Kochanek, Eng H Lo, Sherry H-Y Chou. CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 10; 41(10):2524-2533. doi: 10.1177/0271678x211012110. [PMID: 33951946]
Mennatallah A Gowayed, Amany Abdel-Bary, Rasha A El-Tahan. The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. BMC pharmacology & toxicology. 2021 05; 22(1):24. doi: 10.1186/s40360-021-00488-9. [PMID: 33933169]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Maria Vargas, Pasquale Buonanno, Andrea Sica, Emanuele Sabatella, Francesco P D'Alessio, Simone Alfieri, Carmine Iacovazzo, Rosa Carrano, Giuseppe Servillo. Effects of Sugammadex Plus Rocuronium vs Neostigmine Plus Cisatracurium During Renal Transplantation on Graft Function: A Retrospective, Case-Control Study. Transplantation proceedings. 2021 Apr; 53(3):818-824. doi: 10.1016/j.transproceed.2020.09.012. [PMID: 33069485]
Stephen Adeniyi Adefegha, Ganiyu Oboh, Bathlomew Maduka Okeke. Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine. Journal of complementary & integrative medicine. 2021 Jan; 18(3):491-497. doi: 10.1515/jcim-2020-0055. [PMID: 33544523]
Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia. Journal of pharmacological sciences. 2021 Jan; 145(1):122-129. doi: 10.1016/j.jphs.2020.10.006. [PMID: 33357770]
Stephania Paredes, Steven B Porter, Ivan E Porter, J Ross Renew. Sugammadex use in patients with end-stage renal disease: a historical cohort study. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2020 Dec; 67(12):1789-1797. doi: 10.1007/s12630-020-01812-3. [PMID: 32949009]
Y F Ba, Y N Liu, S H He, H M Li, H R Wang, J P Zhu, W Q Xing, C S Li. [Analysis of sugammadex for antagonistic neuromuscular block in patients with radical resection of lung cancer under thoracoscope]. Zhonghua yi xue za zhi. 2020 Jan; 100(3):213-219. doi: 10.3760/cma.j.issn.0376-2491.2020.03.011. [PMID: 32008289]
Reyhan Arslantas, Banu Eler Cevik. Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex. Transplantation proceedings. 2019 Sep; 51(7):2265-2267. doi: 10.1016/j.transproceed.2019.03.051. [PMID: 31400973]
Matthieu Cachemaille, Magnus Olofsson, Françoise Livio, Patrizio Pascale, Tobias Zingg, Yann Boegli. Recurrent Asystole After Neostigmine in a Heart Transplant Recipient With End-Stage Renal Disease. Journal of cardiothoracic and vascular anesthesia. 2017 04; 31(2):653-656. doi: 10.1053/j.jvca.2016.06.020. [PMID: 27663634]
Nao Nagata, Takuma Miyoshi, Yuzo Otake, Hitomi Suzuki, Yumiko Kagawa, Tetsushi Yamagami, Mitsuhiro Irie. Temporal deterioration of neurological symptoms and increase of serum acetylcholine receptor antibody levels after thymectomy: a case report of a cat with myasthenia gravis. The Journal of veterinary medical science. 2017 Jan; 78(12):1893-1896. doi: 10.1292/jvms.16-0134. [PMID: 27593682]
Zhe-Qi Xu, Bo-Zong Shao, Ping Ke, Jian-Guo Liu, Guo-Ku Liu, Xiong-Wen Chen, Ding-Feng Su, Chong Liu. Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling. Scientific reports. 2016 11; 6(?):37709. doi: 10.1038/srep37709. [PMID: 27874086]
Alexandre Kanashiro, Jhimmy Talbot, Raphael S Peres, Larissa G Pinto, Gabriel S Bassi, Thiago M Cunha, Fernando Q Cunha. Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis are Modulated by the Cholinergic Anti-Inflammatory Pathway. Basic & clinical pharmacology & toxicology. 2016 Nov; 119(5):453-457. doi: 10.1111/bcpt.12611. [PMID: 27098245]
Gulay Gunduz Gul, Ayse B Ozer, Ismail Demirel, Ahmet Aksu, Omer L Erhan. The effect of sugammadex on steroid hormones: A randomized clinical study. Journal of clinical anesthesia. 2016 Nov; 34(?):62-7. doi: 10.1016/j.jclinane.2016.03.039. [PMID: 27687347]
A Sen, B Erdivanli, Y Tomak, A Pergel. Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility. Journal of clinical anesthesia. 2016 Aug; 32(?):208-13. doi: 10.1016/j.jclinane.2016.03.010. [PMID: 27290978]
Kiran Bamel, Rajendra Gupta, Shirish C Gupta. Acetylcholine suppresses shoot formation and callusing in leaf explants of in vitro raised seedlings of tomato, Lycopersicon esculentum Miller var. Pusa Ruby. Plant signaling & behavior. 2016 06; 11(6):e1187355. doi: 10.1080/15592324.2016.1187355. [PMID: 27348536]
Yasemin Isik, Onur Palabiyik, Bilal Muhammed Cegin, Ugur Goktas, Ismail Kati. Effects of Sugammadex and Neostigmine on Renal Biomarkers. Medical science monitor : international medical journal of experimental and clinical research. 2016 Mar; 22(?):803-9. doi: 10.12659/msm.897608. [PMID: 26963316]
Jeung Hui Pyo, Yang Won Min, Poong-Lyul Rhee. Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2016 Feb; 67(2):103-6. doi: 10.4166/kjg.2016.67.2.103. [PMID: 26907487]
J Tack, E Deloose, D Ang, E Scarpellini, T Vanuytsel, L Van Oudenhove, I Depoortere. Motilin-induced gastric contractions signal hunger in man. Gut. 2016 Feb; 65(2):214-24. doi: 10.1136/gutjnl-2014-308472. [PMID: 25539673]
Szilvia Berkó, Kálmán F Szűcs, Boglárka Balázs, Erzsébet Csányi, Gábor Varju, Anita Sztojkov-Ivanov, Mária Budai-Szűcs, Judit Bóta, Róbert Gáspár. Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration. Drug design, development and therapy. 2016; 10(?):1695-701. doi: 10.2147/dddt.s102959. [PMID: 27274203]
Friederike Haerter, Jeroen Cedric Peter Simons, Urs Foerster, Ingrid Moreno Duarte, Daniel Diaz-Gil, Shweta Ganapati, Katharina Eikermann-Haerter, Cenk Ayata, Ben Zhang, Manfred Blobner, Lyle Isaacs, Matthias Eikermann. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. Anesthesiology. 2015 Dec; 123(6):1337-49. doi: 10.1097/aln.0000000000000868. [PMID: 26418697]
Li Ruihong, Li Dechun, Shao Guoqing, Du Hongtao, Luo Wei. Treatment of Intestinal Paralysis Using Revised Major Purgative Decoction Combined with Nasointestinal Decompression: Experience with 31 Patients. Cell biochemistry and biophysics. 2015 Nov; 73(2):285-289. doi: 10.1007/s12013-015-0623-7. [PMID: 25733335]
Imtiaz Khan, Aliya Ibrar, Sumera Zaib, Sarfraz Ahmad, Norbert Furtmann, Shahid Hameed, Jim Simpson, Jürgen Bajorath, Jamshed Iqbal. Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis. Bioorganic & medicinal chemistry. 2014 Nov; 22(21):6163-73. doi: 10.1016/j.bmc.2014.08.026. [PMID: 25257911]
ZiHuan Yang, Ao Pan, WuLin Zuo, JingHui Guo, WenLiang Zhou. Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle. Journal of ethnopharmacology. 2014 Sep; 155(2):1177-83. doi: 10.1016/j.jep.2014.06.053. [PMID: 24997391]
Niels Steinebrunner, Carolin Mogler, Spiros Vittas, Birgit Hoyler, Catharina Sandig, Wolfgang Stremmel, Christoph Eisenbach. Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse. BMC gastroenterology. 2014 Aug; 14(?):148. doi: 10.1186/1471-230x-14-148. [PMID: 25139304]
Zhuo Qu, Jingze Zhang, Wenyuan Gao, Huimin Guo, Changxiao Liu. Bidirectional effects of methanol extract of Wei-Chang-An pill on gastrointestinal transit and the spasmolytic activity on isolated rat jejunum. Journal of ethnopharmacology. 2014 Aug; 155(1):203-12. doi: 10.1016/j.jep.2014.05.017. [PMID: 24928825]
Imtiaz Khan, Sumera Zaib, Aliya Ibrar, Nasim Hasan Rama, Jim Simpson, Jamshed Iqbal. Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. European journal of medicinal chemistry. 2014 May; 78(?):167-77. doi: 10.1016/j.ejmech.2014.03.046. [PMID: 24681981]
Machika Moriya, Shinya Oda, Masaki Nakane, Kaneyuki Kawamae. [Severe asthmatic crisis during general anesthesia in a patient with IgG4 related disease]. Masui. The Japanese journal of anesthesiology. 2014 Apr; 63(4):418-22. doi: NULL. [PMID: 24783608]
Di Cao, Wenxue Li, Xin Zhao, Xiaolan Ye, Fanlu Sun, Jinying Li, Fenyun Song, Guorong Fan. Development and validation of a rapid and high-sensitivity liquid chromatography-tandem mass spectrometry assay for the determination of neostigmine in small-volume beagle dog plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2014 Mar; 28(3):354-61. doi: 10.1002/bmc.3028. [PMID: 24115102]
A F Khorshid, Y M Issa. Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine. Biosensors & bioelectronics. 2014 Jan; 51(?):143-9. doi: 10.1016/j.bios.2013.07.018. [PMID: 23948245]
Chong-Hui Li, Xuan Zhang, Xin-Lan Ge, Xin Huang, Ai-Qun Zhang, Wan-Qing Gu. Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy. BioMed research international. 2014; 2014(?):362024. doi: 10.1155/2014/362024. [PMID: 25478569]
Helle Bosselmann, Michael Egstrup, Kasper Rossing, Ida Gustafsson, Finn Gustafsson, Niels Tonder, Caroline N Kistorp, Jens P Goetze, Morten Schou. Prognostic significance of cardiovascular biomarkers and renal dysfunction in outpatients with systolic heart failure: a long term follow-up study. International journal of cardiology. 2013 Dec; 170(2):202-7. doi: 10.1016/j.ijcard.2013.10.064. [PMID: 24182673]
Diane I Bitzinger, York A Zausig, Christoph Paech, Michael Gruber, Hendrik Busse, Barbara Sinner, Bernhard M Graf, Benedikt Trabold. Modulation of immune functions in polymorphonuclear neutrophils induced by physostigmine, but not neostigmine, independent of cholinergic neurons. Immunobiology. 2013 Aug; 218(8):1049-54. doi: 10.1016/j.imbio.2013.01.003. [PMID: 23434434]
Jorge E Nieto, Betina Morales, Sawsan Z Yamout, Scott D Stanley, Faye A Harmon, Jack R Snyder. In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses. American journal of veterinary research. 2013 Apr; 74(4):579-88. doi: 10.2460/ajvr.74.4.579. [PMID: 23531066]
Martijn Boon, Christian H Martini, Leon P H J Aarts, Rob F M Bevers, Albert Dahan. Effect of variations in depth of neuromuscular blockade on rating of surgical conditions by surgeon and anesthesiologist in patients undergoing laparoscopic renal or prostatic surgery (BLISS trial): study protocol for a randomized controlled trial. Trials. 2013 Mar; 14(?):63. doi: 10.1186/1745-6215-14-63. [PMID: 23452344]
Wen Luo, Qun-You Tan, Hua-Rong Xiong, Chun-Jing Zhao, Jing-Qing Zhang. [Correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2013 Jan; 44(1):80-3. doi: NULL. [PMID: 23600216]
Oyun Khookhor, Hiroyuki Umegaki. The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system. Neuro endocrinology letters. 2013; 34(1):58-61. doi: NULL. [PMID: 23524625]
Alexander Kalb, Clarissa von Haefen, Marco Sifringer, Annalena Tegethoff, Nadine Paeschke, Mariya Kostova, Aarne Feldheiser, Claudia D Spies. Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model. PloS one. 2013; 8(5):e62679. doi: 10.1371/journal.pone.0062679. [PMID: 23671623]
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Bing-Liang Ma, Yue-Ming Ma, Cheng-Lu Gao, Jia-Sheng Wu, Fu-Rong Qiu, Chang-Hong Wang, Xin-Hong Wang. Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma coptidis alkaloids. Journal of ethnopharmacology. 2011 Oct; 138(1):169-74. doi: 10.1016/j.jep.2011.08.074. [PMID: 21924335]
Sharique A Ali, Keisham V Meitei. On the action and mechanism of withaferin-A from Withania somnifera, a novel and potent melanin dispersing agent in frog melanophores. Journal of receptor and signal transduction research. 2011 Oct; 31(5):359-66. doi: 10.3109/10799893.2011.602414. [PMID: 21848494]
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Abeed H Chowdhury, David J Humes, Susan E Pritchard, Luca Marciani, Penny A Gowland, John Simpson, Dileep N Lobo. The effects of morphine-neostigmine and secretin provocation on pancreaticobiliary morphology in healthy subjects: a randomized, double-blind crossover study using serial MRCP. World journal of surgery. 2011 Sep; 35(9):2102-9. doi: 10.1007/s00268-011-1162-z. [PMID: 21656308]
Hua-Rong Xiong, Qun-You Tan, Bi-Lin Liu, Wen Luo, Jing-Qing Zhang. [Pharmacokinetics and relative bioavailability of neostigmine bromide sustained-release tablets]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2011 Sep; 42(5):657-60. doi: NULL. [PMID: 22007493]
Amira M El-Kosasy, Marianne Nebsen, Mohamed K Abd El-Rahman, Maissa Y Salem, Mohamed G El-Bardicy. Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. Talanta. 2011 Aug; 85(2):913-8. doi: 10.1016/j.talanta.2011.04.071. [PMID: 21726718]
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