Flavin mononucleotide (BioDeep_00000002940)

 

Secondary id: BioDeep_00000400406, BioDeep_00000407817

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


{[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid

化学式: C17H21N4O9P (456.1046106)
中文名称: 2,6-蒽二酚, 核黄素-5'-单磷酸, 黄素单核苷酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.23%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Flavin mononucleotide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/flavin_mononucleotide (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000002940). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)O)O)O)O
InChI: InChI=1/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/f/h20,27-28H

描述信息

Flavin mononucleotide, also known as riboflavin 5-monophosphate or riboflavine dihydrogen phosphate, is a member of the class of compounds known as flavin nucleotides. Flavin nucleotides are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. Flavin mononucleotide is practically insoluble (in water) and a moderately acidic compound (based on its pKa). Flavin mononucleotide can be found in a number of food items such as spinach, elliotts blueberry, tea leaf willow, and black mulberry, which makes flavin mononucleotide a potential biomarker for the consumption of these food products. Flavin mononucleotide can be found primarily in blood, as well as throughout most human tissues. Flavin mononucleotide exists in all living species, ranging from bacteria to humans. In humans, flavin mononucleotide is involved in several metabolic pathways, some of which include riboflavin metabolism, pyrimidine metabolism, beta-alanine metabolism, and doxorubicin metabolism pathway. Flavin mononucleotide is also involved in several metabolic disorders, some of which include beta ureidopropionase deficiency, UMP synthase deficiency (orotic aciduria), carnosinuria, carnosinemia, and hypophosphatasia. Moreover, flavin mononucleotide is found to be associated with anorexia nervosa. Flavin mononucleotide (FMN), or riboflavin-5′-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors. During the catalytic cycle, a reversible interconversion of the oxidized (FMN), semiquinone (FMNH•) and reduced (FMNH2) forms occurs in the various oxidoreductases. FMN is a stronger oxidizing agent than NAD and is particularly useful because it can take part in both one- and two-electron transfers. In its role as blue-light photo receptor, (oxidized) FMN stands out from the conventional photo receptors as the signaling state and not an E/Z isomerization .
Flavin mononucleotide (FMN), or riboflavin-5′-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as the prosthetic group of various oxidoreductases, including NADH dehydrogenase, as well as cofactor in biological blue-light photo receptors. During the catalytic cycle, a reversible interconversion of the oxidized (FMN), semiquinone (FMNH), and reduced (FMNH2) forms occurs in the various oxidoreductases. FMN is a stronger oxidizing agent than NAD and is particularly useful because it can take part in both one- and two-electron transfers. In its role as blue-light photo receptor, (oxidized) FMN stands out from the conventional photo receptors as the signaling state and not an E/Z isomerization. It is the principal form in which riboflavin is found in cells and tissues. It requires more energy to produce, but is more soluble than riboflavin. Flavin mononucleotide belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. Flavin mononucleotide exists in all living species, ranging from bacteria to humans. Within humans, flavin mononucleotide participates in a number of enzymatic reactions. In particular, formic acid and flavin mononucleotide can be biosynthesized from FMNH2; which is catalyzed by the enzyme lanosterol 14-alpha demethylase. In addition, formic acid and flavin mononucleotide can be biosynthesized from FMNH2 through the action of the enzyme lanosterol 14-alpha demethylase. In humans, flavin mononucleotide is involved in bloch pathway (cholesterol biosynthesis). Outside of the human body, flavin mononucleotide has been detected, but not quantified in several different foods, such as mandarin orange (clementine, tangerine), horseradish tree, black elderberries, angelica, and ostrich ferns.
Acquisition and generation of the data is financially supported in part by CREST/JST.
D018977 - Micronutrients > D014815 - Vitamins

同义名列表

46 个代谢物同义名

{[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid; Flavin mononucleotide monosodium salt, dihydrate; Riboflavin-5′-monophosphate sodium salt hydrate; Riboflavin 5-(dihydrogen phosphoric acid); Riboflavine dihydrogen phosphoric acid; Flavin mononucleotide monosodium salt; Riboflavin 5-(dihydrogen phosphate); Flavin mononucleotide disodium salt; Flavin mononucleotide sodium salt; Riboflavin 5-monophosphoric acid; Riboflavine dihydrogen phosphate; Riboflavin monophosphoric acid; Riboflavin phosphate, sodium; Flavine mononucleotide (FMN); Riboflavin-5-phosphoric acid; Riboflavin 5-phosphoric acid; Phosphate, sodium riboflavin; 5-monoPhosphate, riboflavin; Sodium riboflavin phosphate; Riboflavine 5-monophosphate; Mononucleotide, riboflavin; Riboflavin 5-monophosphate; Riboflavin 5 monophosphate; Riboflavin-5-monophosphate; Riboflavin mononucleotide; Riboflavine monophosphate; Riboflavin-5-phosphate na; Riboflavin monophosphate; Riboflavine-5-phosphate; 5-Phosphate, riboflavin; Riboflavine 5-phosphate; Riboflavin 5 phosphate; Riboflavin 5-phosphate; Flavine mononucleotide; Mononucleotide, flavin; Riboflavin-5-phosphate; Flavin mononucleotide; Riboflavine phosphate; Riboflavin phosphate; Vitamin b2 phosphate; Riboflavin; Flavol; Flanin; FMN; Riboflavin-5'-monophosphate; FMN



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(2)

PlantCyc(0)

代谢反应

319 个相关的代谢反应过程信息。

Reactome(47)

BioCyc(10)

WikiPathways(4)

Plant Reactome(231)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(27)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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