N-acetyl-aspartyl-glutamate (NAAG) (BioDeep_00000002799)

 

Secondary id: BioDeep_00000015163, BioDeep_00000181527

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2S)-2-[(2S)-3-carboxy-2-acetamidopropanamido]pentanedioic acid

化学式: C11H16N2O8 (304.0907)
中文名称: N-乙酰基谷氨酸, N-乙酰基-L-天冬氨酰-L-谷氨酸, 异冬谷酸
谱图信息: 最多检出来源 Homo sapiens(feces) 13.27%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

N-acetyl-aspartyl-glutamate (NAAG). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/n-acetyl-aspartyl-glutamate_(naag) (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002799). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)

描述信息

N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in millimolar concentrations in the brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca(2+)-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders (PMID:9361299). N-Acetylaspartylglutamic acid (NAAG) is a purported precursor of N-acetylaspartic acid (NAA) and is present at about one-tenth of the concentration of NAA in the brain. NAAG has been reported to activate N-methyl-D-aspartic acid (NMDA) receptors in neurons. Previous immunohistochemical studies in the vertebrate central nervous system (CNS) have suggested that NAAG is exclusively localized to neurons. Recent evidence, however, indicates that NAAG might also be localized to nonneuronal cells within the CNS. Only traces of NAA and NAAG are detectable in other tissues. Some compounds can change levels of NAA and NAAG in the brain. For example, methylphenidate increases the levels of NAA and NAAG in the cerebral cortex; amphetamine also increases NAA concentration in a mature brain by 26\\\%, raising the possibility that other neurochemical systems might be involved in the clinical effects of stimulants (PMID:10603234).
N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in millimolar concentrations in brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca(2+)-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders. (PMID 9361299)
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D009676 - Noxae > D009498 - Neurotoxins
D018926 - Anti-Allergic Agents
D020011 - Protective Agents
Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.

同义名列表

38 个代谢物同义名

(2S)-2-[(2S)-3-carboxy-2-acetamidopropanamido]pentanedioic acid; 2-(3-carboxy-2-acetamidopropanamido)pentanedioic acid; N-(N-Acetyl-L-alpha-aspartyl)-L-glutamic acid; N-Acetyl-alpha-L-aspartyl-L-glutamic acid; N-Acetyl-L-alpha-aspartyl-L-glutamic acid; N-Acetyl-L-alpha-aspartylglutamic acid; N-Acetyl-α-L-aspartyl-L-glutamic acid; N-Acetyl-L-α-aspartyl-L-glutamic acid; N-Acetyl-a-L-aspartyl-L-glutamic acid; Acetyl-alpha-L-aspartylglutamic acid; N-Acetyl-alpha-aspartylglutamic acid; N-Acetyl-L-aspartyl-L-glutamic acid; N-(N-Acetylaspartyl)glutamic acid; Acetyl-a-L-aspartylglutamic acid; Acetyl-α-L-aspartylglutamic acid; N-Acetyl-α-aspartylglutamic acid; N-Acetyl-a-aspartylglutamic acid; N-Acetyl-1-aspartylglutamic acid; N-Acetyl-aspartyl-glutamic acid; N-acetyl-L-aspartyl-L-glutamate; N-Acetylaspartylglutamic acid; N-Acetyl-1-aspartylglutamate; N-Acetyl-aspartyl-glutamate; N-Acetylaspartylglutamate; alpha-Spaglumic acid; N-Acetyl-L-asp-L-glu; N-Acetyl-1-asp-glu; Isospaglumic acid; a-Spaglumic acid; Α-spaglumic acid; spaglumic acid; Isospaglumate; N-Ac-D-e; Naaxia; NAAGA; NAAG; N-Acetylaspartylglutamic acid (NAAG); N-Acetylaspartylglutamate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CRK, CRKL, PDPK1, PTK2, RHOA
Peripheral membrane protein 1 PTK2
Endosome membrane 1 INSR
Endoplasmic reticulum membrane 1 RHOA
Nucleus 4 CRK, PDPK1, PTK2, RHOA
cytosol 6 CRK, CRKL, PDPK1, PTK2, PXN, RHOA
centrosome 1 PTK2
nucleoplasm 1 CRKL
Cell membrane 4 CRK, INSR, PTK2, RHOA
Lipid-anchor 1 RHOA
Cytoplasmic side 2 PTK2, RHOA
Cleavage furrow 1 RHOA
lamellipodium 2 PXN, RHOA
ruffle membrane 1 RHOA
cell cortex 3 PTK2, PXN, RHOA
cell junction 1 RHOA
glutamatergic synapse 1 RHOA
Golgi membrane 1 INS
neuromuscular junction 2 CRK, CRKL
postsynapse 1 RHOA
Lysosome 1 INSR
endosome 1 RHOA
plasma membrane 6 CRK, INSR, PDPK1, PTK2, PXN, RHOA
Membrane 2 CRK, INSR
axon 1 INSR
caveola 1 INSR
extracellular exosome 3 CRK, INSR, RHOA
extracellular space 1 INS
perinuclear region of cytoplasm 1 PTK2
protein-containing complex 2 CRK, CRKL
intracellular membrane-bounded organelle 1 PTK2
postsynaptic density 1 PDPK1
Single-pass type I membrane protein 1 INSR
Secreted 1 INS
extracellular region 1 INS
cytoplasmic side of plasma membrane 1 RHOA
neuronal cell body membrane 1 INSR
anchoring junction 1 PTK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
external side of plasma membrane 1 INSR
actin cytoskeleton 1 CRK
dendritic spine 2 PTK2, RHOA
cytoplasmic vesicle 1 PDPK1
midbody 1 RHOA
cell-cell junction 1 PXN
vesicle 1 RHOA
Cell projection, lamellipodium 1 RHOA
Cytoplasm, perinuclear region 1 PTK2
Cell junction, focal adhesion 2 PTK2, PXN
Cytoplasm, cytoskeleton 2 PTK2, PXN
focal adhesion 4 PDPK1, PTK2, PXN, RHOA
Late endosome 1 INSR
receptor complex 1 INSR
ciliary basal body 1 PTK2
microtubule associated complex 1 PXN
cell projection 2 PDPK1, PTK2
cell periphery 1 RHOA
cytoskeleton 3 PTK2, PXN, RHOA
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
Cytoplasm, cell cortex 3 PTK2, PXN, RHOA
endosome lumen 1 INS
Cell projection, dendrite 1 RHOA
stress fiber 2 PTK2, PXN
secretory granule lumen 1 INS
secretory granule membrane 1 RHOA
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 RHOA
apical junction complex 1 RHOA
dendrite membrane 1 INSR
extrinsic component of postsynaptic membrane 1 CRKL
insulin receptor complex 1 INSR


文献列表

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