Phenylacetylglycine (BioDeep_00000002795)

 

Secondary id: BioDeep_00000405375

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


[(Phenylacetyl)amino]acetic acid

化学式: C10H11NO3 (193.0739)
中文名称: 苯乙酰甘氨酸
谱图信息: 最多检出来源 Homo sapiens(plant) 9.85%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(=O)NCC(=O)O
InChI: InChI=1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)

描述信息

Phenylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. Phenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis. Urinary PAG is elevated in animals exhibiting abnormal phospholipid accumulation in many tissues and may thus be useful as a surrogate biomarker for phospholipidosis. (PMID: 15764292) The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial. GC-MS studies have not found this compound (PMID: 7492634) while NMR studies claimed to have identified it (PMID: 21167146). It appears that phenylacetylglycine may sometimes be mistaken for phenylacetylglutamine via NMR.
Phenylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion[1].
Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion[1].

同义名列表

20 个代谢物同义名

[(Phenylacetyl)amino]acetic acid; ((Phenylacetyl)amino)acetic acid; 2-(2-phenylacetamido)acetic acid; [(Phenylacetyl)amino]acetate; N-(Phenylacetyl)-glycine; N-(Phenylacetyl)glycine; N-Phenylacetylglycine; Phenylacetyl glycine; Phenylacetylglycine; N-Phenacetylglycine; Phenacetylglycine; Phenaceturic acid; Phenacetic acid; Phenaceturate; Phenacetate; PAA; PAG; Phenylacetylglycine; Phenylacetylglycine; Phenylacetylglycine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 APOE, PIK3CA, PNPLA2, PPARG, TXN
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 2 AGPAT1, PNPLA2
Nucleus 6 ADRB2, APOE, EBF1, GABPA, PPARG, TXN
cytosol 7 GPCPD1, GPT, LIPE, PIK3CA, PNPLA2, PPARG, TXN
dendrite 2 APOE, OPRM1
nucleoplasm 4 GABPA, PNPLA2, PPARG, TXN
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 ADRB2, LIPE, OPRM1, PNPLA2
lamellipodium 1 PIK3CA
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 4 ADRB2, AGPAT1, OPRM1, PNPLA2
Synapse 1 OPRM1
cell surface 2 ADIPOQ, PLA2G1B
glutamatergic synapse 1 APOE
Golgi apparatus 3 ADRB2, APOE, OPRM1
Golgi membrane 1 INS
neuronal cell body 1 APOE
Cytoplasm, cytosol 2 GPCPD1, LIPE
Lysosome 1 ADRB2
endosome 2 ADRB2, OPRM1
plasma membrane 7 ADRB2, APOE, ENPP2, IGHE, OPRM1, PIK3CA, PNPLA2
Membrane 8 ADRB2, AGPAT1, APOE, ENPP2, LCAT, LIPE, OPRM1, PNPLA2
apical plasma membrane 1 ADRB2
axon 1 OPRM1
caveola 1 LIPE
extracellular exosome 4 APOE, GPT, LCAT, TXN
endoplasmic reticulum 4 ADIPOQ, AGPAT1, APOE, OPRM1
extracellular space 8 ADIPOQ, APOE, ENPP2, IGHE, IL6, INS, LCAT, PLA2G1B
perinuclear region of cytoplasm 2 PIK3CA, PPARG
intercalated disc 1 PIK3CA
intracellular membrane-bounded organelle 1 PPARG
Single-pass type I membrane protein 1 IGHE
Secreted 8 ADIPOQ, APOE, ENPP2, IL6, INS, LCAT, PLA2G1B, TXN
extracellular region 9 ADIPOQ, APOE, ENPP2, IGHE, IL6, INS, LCAT, PLA2G1B, TXN
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 2 APOE, LCAT
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
perikaryon 1 OPRM1
Early endosome 2 ADRB2, APOE
extracellular matrix 1 APOE
collagen trimer 1 ADIPOQ
collagen-containing extracellular matrix 2 ADIPOQ, APOE
receptor complex 2 ADRB2, PPARG
neuron projection 1 OPRM1
chromatin 3 EBF1, GABPA, PPARG
IgE immunoglobulin complex 1 IGHE
Secreted, extracellular space 1 APOE
blood microparticle 1 APOE
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
Lipid droplet 2 LIPE, PNPLA2
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 OPRM1
Melanosome 1 APOE
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 APOE, IL6, INS, PNPLA2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 ADRB2
clathrin-coated endocytic vesicle membrane 2 ADRB2, APOE
synaptic cleft 1 APOE
[Isoform 3]: Cell membrane 1 IGHE
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
interleukin-6 receptor complex 1 IL6
[Isoform 12]: Cytoplasm 1 OPRM1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

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