Pemoline (BioDeep_00000002741)

 

Secondary id: BioDeep_00000406162

human metabolite blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


2-amino-5-phenyl-4,5-dihydro-1,3-oxazol-4-one

化学式: C9H8N2O2 (176.0585748)
中文名称: 匹莫林, 培脑灵
谱图信息: 最多检出来源 Mentha canadensis(plant) 15%

分子结构信息

SMILES: C1=CC=C(C=C1)C2C(=O)N=C(O2)N
InChI: InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics > N06BA - Centrally acting sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant

同义名列表

33 个代谢物同义名

2-amino-5-phenyl-4,5-dihydro-1,3-oxazol-4-one; 2-Imino-4-keto-5-phenyltetrahydrooxazole; 5-Phenyl-2-imino-4-oxooxazolidine; 2-Amino-5-phenyl-4(5H)-oxazolone; 5-Phenyl-2-imino-4-oxazolidinone; 2-Imino-5-phenyl-4-oxazolidinone; Mallinckrodt brand OF pemoline; Abbott brand OF pemoline; Lilly brand OF pemoline; Pheniminooxazolidinone; Phenylpseudohydantoin; 5-Phenylisohydantion; Magnesium, pemoline; Compounds, pemoline; Pemoline compounds; Phenylisohydantoin; Pemoline magnesium; Phenoxazole; Dantromin; Betanamin; Deltamine; Pemolinum; Azoxodon; Pemolina; pemoline; Cylert; Notair; Myamin; Tradon; PemADD; Nitan; Hyton; Pemoline



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shohei Takai, Shingo Oda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. Journal of applied toxicology : JAT. 2016 Jan; 36(1):35-47. doi: 10.1002/jat.3141. [PMID: 25900201]
  • Martin Mücke, Henning Cuhls, Vera Peuckmann-Post, Ollie Minton, Patrick Stone, Lukas Radbruch. Pharmacological treatments for fatigue associated with palliative care. The Cochrane database of systematic reviews. 2015 May; ?(5):CD006788. doi: 10.1002/14651858.cd006788.pub3. [PMID: 26026155]
  • Cornelius Hess, Natalie Ritke, Konrad Sydow, Lena-Maria Mehling, Hauke Ruehs, Burkhard Madea, Frank Musshoff. Determination of levamisole, aminorex, and pemoline in plasma by means of liquid chromatography-mass spectrometry and application to a pharmacokinetic study of levamisole. Drug testing and analysis. 2014 Oct; 6(10):1049-54. doi: 10.1002/dta.1619. [PMID: 24574157]
  • Vera Peuckmann, Frank Elsner, Norbert Krumm, Peter Trottenberg, Lukas Radbruch. Pharmacological treatments for fatigue associated with palliative care. The Cochrane database of systematic reviews. 2010 Nov; ?(11):CD006788. doi: 10.1002/14651858.cd006788.pub2. [PMID: 21069692]
  • Nina Oestreicher, Gary D Friedman, Sheng-Fang Jiang, Jim Chan, Charles Quesenberry, Laurel A Habel. Methylphenidate use in children and risk of cancer at 18 sites: results of surveillance analyses. Pharmacoepidemiology and drug safety. 2007 Dec; 16(12):1268-72. doi: 10.1002/pds.1519. [PMID: 18041106]
  • M Huber, E Kirchler, M Karner, R Pycha. Delusional parasitosis and the dopamine transporter. A new insight of etiology?. Medical hypotheses. 2007; 68(6):1351-8. doi: 10.1016/j.mehy.2006.07.061. [PMID: 17134847]
  • Ronald T Brown, Robert W Amler, Wendy S Freeman, James M Perrin, Martin T Stein, Heidi M Feldman, Karen Pierce, Mark L Wolraich. Treatment of attention-deficit/hyperactivity disorder: overview of the evidence. Pediatrics. 2005 Jun; 115(6):e749-57. doi: 10.1542/peds.2004-2560. [PMID: 15930203]
  • C Abbiati, M Vecchi, G Rossi, M F Donata, R de Franchis. Inappropriate pemoline therapy leading to acute liver failure and liver transplantation. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2002 Jun; 34(6):447-51. doi: 10.1016/s1590-8658(02)80043-3. [PMID: 12132793]
  • Hidefumi Nakamura, Jeffrey L Blumer, Michael D Reed. Pemoline ingestion in children: a report of five cases and review of the literature. Journal of clinical pharmacology. 2002 Mar; 42(3):275-82. doi: 10.1177/00912700222011292. [PMID: 11865963]
  • P J Marotta, E A Roberts. Pemoline hepatotoxicity in children. The Journal of pediatrics. 1998 May; 132(5):894-7. doi: 10.1016/s0022-3476(98)70329-4. [PMID: 9602211]
  • J A Hochman, S A Woodard, M B Cohen. Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy. Pediatrics. 1998 Jan; 101(1 Pt 1):106-8. doi: 10.1542/peds.101.1.106. [PMID: 9417161]
  • S P Cudia, R H Poppenga, W J Birdsall. Pemoline toxicosis in a dog. Journal of the American Veterinary Medical Association. 1998 Jan; 212(1):74-6. doi: NULL. [PMID: 9426782]
  • A Margolin, S K Avants, T R Kosten. Pemoline for the treatment of cocaine dependence in methadone-maintained patients. Journal of psychoactive drugs. 1996 Jul; 28(3):301-4. doi: 10.1080/02791072.1996.10472491. [PMID: 8895115]
  • F R Sallee, R L Stiller, J M Perel. Pharmacodynamics of pemoline in attention deficit disorder with hyperactivity. Journal of the American Academy of Child and Adolescent Psychiatry. 1992 Mar; 31(2):244-51. doi: 10.1097/00004583-199203000-00010. [PMID: 1564025]
  • X Jin, Z H Zhou, X F He, Z H Zhang, M Z Wang. [Solid-phase extraction and RP-HPLC screening procedure for diuretics, probenecid, caffeine and pemoline in urine]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(11):875-80. doi: . [PMID: 1300035]
  • F R Sallee, R L Stiller, J M Perel, G Everett. Pemoline-induced abnormal involuntary movements. Journal of clinical psychopharmacology. 1989 Apr; 9(2):125-9. doi: 10.1097/00004714-198904000-00010. [PMID: 2723130]
  • H Kotaki, T Aoyama, F Nakazato, Y Saitoh, F Nakagawa. Interactions in tissue distribution between methylphenidate and pemoline. II. Effects of methylphenidate or its metabolite on plasma and tissue concentrations of pemoline in the rat. Chemical & pharmaceutical bulletin. 1988 Nov; 36(11):4560-6. doi: 10.1248/cpb.36.4560. [PMID: 3246025]
  • T Aoyama, H Kotaki, Y Saitoh, F Nakagawa. Determination of pemoline in plasma, urine and tissues by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1988 Sep; 430(2):351-60. doi: 10.1016/s0378-4347(00)83170-9. [PMID: 3235508]
  • K Slais, M W Nielen, U A Brinkman, R W Frei. Screening of amphetamines by gradient microbore liquid chromatography and pre-column technology. Journal of chromatography. 1987 Apr; 393(1):57-68. doi: 10.1016/s0021-9673(01)94204-9. [PMID: 3597599]
  • A J Zametkin, M Linnoila, F Karoum, R Sallee. Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder. The American journal of psychiatry. 1986 Mar; 143(3):359-62. doi: 10.1176/ajp.143.3.359. [PMID: 2420216]
  • F Sallee, R Stiller, J Perel, T Bates. Oral pemoline kinetics in hyperactive children. Clinical pharmacology and therapeutics. 1985 Jun; 37(6):606-9. doi: 10.1038/clpt.1985.96. [PMID: 4006361]
  • C P Collier, S J Soldin, J M Swanson, S M MacLeod, F Weinberg, J G Rochefort. Pemoline pharmacokinetics and long term therapy in children with attention deficit disorder and hyperactivity. Clinical pharmacokinetics. 1985 May; 10(3):269-78. doi: 10.2165/00003088-198510030-00006. [PMID: 4017397]
  • K Nishihara, Y Kohda, Y Saitoh, F Nakagawa, Y Honda. Determination of pemoline in plasma, plasma water, mixed saliva, and urine by high-performance liquid chromatography. Therapeutic drug monitoring. 1984; 6(2):232-7. doi: 10.1097/00007691-198406000-00018. [PMID: 6740743]
  • O J Igwe, J W Blake. The pharmacokinetics, plasma protein binding and time response relationships of 2-amino-5-phenyl-2-oxazolin-4-one (pemoline) in the horse. Drug metabolism and disposition: the biological fate of chemicals. 1983 Mar; 11(2):120-5. doi: . [PMID: 6133715]
  • A I Krylov, N S Khlebnikova. Quantitative gas-liquid chromatographic determination of pemoline using trimethylanilinium hydroxide. Journal of chromatography. 1982 Dec; 252(?):319-24. doi: 10.1016/s0021-9673(01)88426-0. [PMID: 7182415]
  • W Gielsdorf. Determination of the psychostimulants pemoline, fenozolone and thozalinone in human urine by gas chromatography/mass spectrometry and thin layer chromatography. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1982 Feb; 20(2):65-8. doi: 10.1515/cclm.1982.20.2.65. [PMID: 6121837]
  • O J Igwe, J W Blake. Gas/liquid chromatographic analysis of pemoline in biological fluids using electron capture detection. Journal of chromatographic science. 1981 Dec; 19(12):617-24. doi: 10.1093/chromsci/19.12.617. [PMID: 7328158]
  • J Kocián, J Kociánová, V Brodan. [Effect of a combined geriatric preparation on serum proteins and liver tests (author's transl)]. Ceskoslovenska gastroenterologie a vyziva. 1981 Mar; 35(2):49-53. doi: NULL. [PMID: 7214561]
  • G P Cartoni, M Ciardi, A Giarrusso, F Rosati. Reversed-phase high-performance liquid chromatographic detection of pemoline in doping control. Journal of chromatography. 1980 Dec; 202(1):131-3. doi: 10.1016/s0021-9673(00)80087-4. [PMID: 7217245]
  • C P Tomkins, S J Soldin, S M MacLeod, J G Rochefort, J M Swanson. Analysis of pemoline in serum by high performance liquid chromatography: clinical application to optimize treatment of hyperactive children. Therapeutic drug monitoring. 1980; 2(3):255-60. doi: 10.1097/00007691-198007000-00009. [PMID: 7222180]
  • N P Vermeulen, M W Teunissen, D D Breimer. Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration. British journal of clinical pharmacology. 1979 Nov; 8(5):459-63. doi: 10.1111/j.1365-2125.1979.tb01026.x. [PMID: 508551]
  • L C Dickinson, J Lee, I C Ringdahl, H K Schedewie, B S Kilgore, M J Elders. Impaired growth in hyperkinetic children receiving pemoline. The Journal of pediatrics. 1979 Apr; 94(4):538-41. doi: 10.1016/s0022-3476(79)80006-2. [PMID: 430289]
  • D J Hoffman. Sensitive GLC assay for pemoline in biological fluids using nitrogen-specific detection. Journal of pharmaceutical sciences. 1979 Apr; 68(4):445-7. doi: 10.1002/jps.2600680413. [PMID: 438965]
  • J Kocián, V Brodan, J Kociánová. [Influencing cholesterol and other lipid parameters in the serum using a combined geriatric preparation (author's transl)]. Ceskoslovenska gastroenterologie a vyziva. 1979; 33(8):507-15. doi: NULL. [PMID: 535057]
  • N P Vermeulen, M W Teunissen, D D Breimer. Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. Journal of chromatography. 1978 Sep; 157(?):133-40. doi: 10.1016/s0021-9673(00)92329-x. [PMID: 701438]
  • J C Libeer, P Schepens. GLC determination of pemoline in biological fluids. Journal of pharmaceutical sciences. 1978 Mar; 67(3):419-21. doi: 10.1002/jps.2600670343. [PMID: 641739]
  • D I Margolin. The hyperkinetic child syndrome and brain monoamines: pharmacology and therapeutic implications. The Journal of clinical psychiatry. 1978 Feb; 39(2):120-3, 7. doi: NULL. [PMID: 344302]
  • W Röper. The effects of pemoline on nuclear fusion, karyokinesis, and cytokinesis in caffeine treated cells. Arzneimittel-Forschung. 1978; 28(6):949-52. doi: . [PMID: 582003]
  • S Goenechea, G M Wagner. [Thin layer chromatographic determination of pemoline in urine after therapeutic doses]. Journal of chromatography. 1977 Oct; 140(1):134-5. doi: 10.1016/s0021-9673(00)83616-x. [PMID: 893629]
  • N P Vermeulen, D de Roode, D D Breimer. Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine. Journal of chromatography. 1977 Jul; 137(2):333-42. doi: 10.1016/s0021-9673(00)81356-4. [PMID: 881457]
  • S Y Chu, S T Sennello. Gas chromatographic determination of pemoline in biological fluids using electron capture detection. Journal of chromatography. 1977 Jul; 137(2):343-50. doi: 10.1016/s0021-9673(00)81357-6. [PMID: 881458]
  • M Van Boven, P Daenens. Combined gas-liquid chromatographic-mass spectrometric analysis of pemoline in biological samples. Journal of chromatography. 1977 Apr; 134(2):415-21. doi: 10.1016/s0021-9673(00)88540-4. [PMID: 858763]
  • S Goenechea, G M Wagner. [Quantitative determination of pemoline in serum and urine after ingestion of therapeutic doses (author's transl)]. Arzneimittel-Forschung. 1977; 27(8):1604-5. doi: NULL. [PMID: 578754]
  • G P Cartoni, F Natalizia. Determination of pemoline high-pressure liquid chromatography. Journal of chromatography. 1976 Aug; 123(2):474-8. doi: 10.1016/s0021-9673(00)82224-4. [PMID: 956318]
  • F Brabec, W Röper. [The effect of pemolin on the mitotic activity of Vicia faba L (author's transl)]. Arzneimittel-Forschung. 1976 Feb; 26(2):180-4. doi: ". [PMID: 947197]
  • B Mütze. [No stimulation of the growth of microorganisms by repair-substances (author's transl)]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abt.: Allgemeine, landwirtschaftliche und technische Mikrobiologie. 1976; 131(8):673-7. doi: ". [PMID: 798454]
  • R M Knights, C A Viets. Effects of pemoline on hyperactive boys. Pharmacology, biochemistry, and behavior. 1975 Nov; 3(6):1107-14. doi: 10.1016/0091-3057(75)90024-6. [PMID: 772696]
  • H H Gierlich, H J Heinen, H D Beckey. The application of quadrupole mass filters in field desorption mass spectrometry. Biomedical mass spectrometry. 1975 Feb; 2(1):31-5. doi: 10.1002/bms.1200020107. [PMID: 1131391]
  • J J Boitano, G A Patrissi, S A Simone. Effects of magnesium pemoline in dimethylsulfoxide on reversal learning, motor activity, and water intake. Psychological reports. 1971 Feb; 28(1):71-9. doi: 10.2466/pr0.1971.28.1.71. [PMID: 5552765]
  • N Plotnikoff, F Will, W Ditzler. Stimulant activity of pemoline and magnesium hydroxide. Archives internationales de pharmacodynamie et de therapie. 1969 Oct; 181(2):441-58. doi: . [PMID: 4397542]
  • H LeVan, P Burlakow. Magnesium pemoline and Ehrlich tumor: tumor animal versus tumor cell survivals. Experientia. 1969 Sep; 25(9):973-4. doi: 10.1007/bf01898097. [PMID: 5371441]
  • L M Cummins, J E Perry. Spectrophotometric determination of pemoline and mandelic acid in biological fluids. Journal of pharmaceutical sciences. 1969 Jun; 58(6):762-3. doi: 10.1002/jps.2600580627. [PMID: 5799771]
  • H LeVan. Short-term and long-term radioprotective effect of magnesium pemoline. Experientia. 1968 May; 24(5):477-9. doi: 10.1007/bf02144404. [PMID: 5674992]
  • H LeVan. Effect of pre- and post-irradiation administration of magnesium pemoline on radioresistance. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology. 1968; 1(6):514-6. doi: ". [PMID: 4388453]
  • J J Brink, D G Stein. Pemoline levels in brain: enhancement by dimethyl sulfoxide. Science (New York, N.Y.). 1967 Dec; 158(3807):1479-80. doi: 10.1126/science.158.3807.1479. [PMID: 6058689]
  • J Bojanovský, Z Hánysová. [Comparison of Pondex, methylphenidate and placebo during short term administration and the effect on serum potassium, calcium and sodium levels in neurotic patients]. Activitas nervosa superior. 1967 Nov; 9(4):375-6. doi: NULL. [PMID: 4388631]
  • G Beach, D P Kimble. Activity and responsivity in rats after magnesium pemoline injections. Science (New York, N.Y.). 1967 Feb; 155(3763):698-701. doi: 10.1126/science.155.3763.698. [PMID: 4381057]