Isoflupredone (BioDeep_00000002729)

   


代谢物信息卡片


9-Fluoroprednisolone

化学式: C21H27FO5 (378.1842)
中文名称: 异氟泼尼松-d3
谱图信息: 最多检出来源 Homo sapiens(plant) 33.33%

分子结构信息

SMILES: CC12C=CC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C12F
InChI: InChI=1S/C21H27FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h5,7,9,14-16,23,25,27H,3-4,6,8,10-11H2,1-2H3

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid

同义名列表

3 个代谢物同义名

9-Fluoroprednisolone; Isoflupredone; 9-Fluoroprednisolone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AR, BIN2, IRF7, LEF1, NLRP10, NLRP9, NR3C2, RIPK2, SARM1, SYK
Peripheral membrane protein 5 BIN2, CTSB, FCN1, NLRP10, RIPK2
Endosome membrane 1 IRF7
Endoplasmic reticulum membrane 1 NR3C2
Nucleus 6 AR, FOXG1, IRF7, LEF1, NR3C2, SYK
cytosol 7 AR, IRF7, NLRP10, NR3C2, RIPK2, SARM1, SYK
dendrite 2 PRSS12, SARM1
nucleoplasm 7 ADAM12, AR, FOXG1, IRF7, LEF1, NLRP10, NR3C2
Cell membrane 4 FCN1, NLRP10, RIPK2, SYK
Cytoplasmic side 1 BIN2
Cell projection, axon 1 SARM1
Synapse 1 SARM1
cell cortex 1 BIN2
cell surface 2 CLEC1B, SARM1
glutamatergic synapse 2 PRSS12, SARM1
Golgi membrane 1 INS
neuromuscular junction 1 SARM1
Cytoplasm, cytosol 1 SYK
Lysosome 1 CTSB
Presynapse 1 PRSS12
plasma membrane 9 ADAM12, AR, BIN2, CLEC1B, FCN1, PRSS12, REN, RIPK2, SYK
terminal bouton 1 PRSS12
Membrane 4 ADAM12, AR, CLEC1B, REN
apical plasma membrane 1 CTSB
axon 2 PRSS12, SARM1
extracellular exosome 1 CTSB
endoplasmic reticulum 1 RIPK2
extracellular space 5 CLEC3A, CTSB, FCN1, INS, REN
perinuclear region of cytoplasm 1 CTSB
Schaffer collateral - CA1 synapse 1 PRSS12
mitochondrion 1 SARM1
protein-containing complex 4 AR, RIPK2, SARM1, SYK
Single-pass type I membrane protein 1 ADAM12
Secreted 4 CLEC3A, FCN1, INS, REN
extracellular region 6 ADAM12, BIN2, CTSB, FCN1, INS, REN
cytoplasmic side of plasma membrane 1 NLRP10
Single-pass membrane protein 1 CLEC1B
mitochondrial outer membrane 1 SARM1
Extracellular side 2 CTSB, FCN1
anchoring junction 1 BIN2
transcription regulator complex 1 LEF1
nuclear membrane 1 NLRP10
external side of plasma membrane 2 CTSB, FCN1
cytoplasmic vesicle 1 PRSS12
apical part of cell 1 REN
Single-pass type II membrane protein 1 CLEC1B
vesicle 1 RIPK2
Apical cell membrane 1 CTSB
microtubule 1 SARM1
collagen trimer 1 FCN1
collagen-containing extracellular matrix 2 CTSB, FCN1
nuclear speck 1 AR
Inflammasome 1 NLRP9
receptor complex 1 NR3C2
chromatin 5 AR, FOXG1, IRF7, LEF1, NR3C2
Cell projection, phagocytic cup 1 BIN2
cell projection 1 BIN2
phagocytic cup 1 BIN2
cytoskeleton 1 RIPK2
podosome 1 BIN2
Secreted, extracellular space 1 CTSB
Cytoplasm, cell cortex 1 BIN2
[Isoform 3]: Secreted 1 ADAM12
endosome lumen 1 INS
Cell projection, dendrite 1 SARM1
Melanosome 1 CTSB
ficolin-1-rich granule lumen 3 BIN2, CTSB, FCN1
secretory granule lumen 3 BIN2, FCN1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
beta-catenin-TCF complex 1 LEF1
serine-type endopeptidase complex 1 FCN1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
synaptic cleft 1 PRSS12
protein-DNA complex 1 LEF1
canonical inflammasome complex 1 NLRP9
[Isoform 4]: Secreted 1 ADAM12
early phagosome 1 SYK
peptidase inhibitor complex 1 CTSB
T cell receptor complex 1 SYK
endolysosome lumen 1 CTSB
B cell receptor complex 1 SYK
extrinsic component of synaptic membrane 1 SARM1
Cell projection, podosome membrane 1 BIN2


文献列表

  • H A Seifi, S J LeBlanc, E Vernooy, K E Leslie, T F Duffield. Effect of isoflupredone acetate with or without insulin on energy metabolism, reproduction, milk production, and health in dairy cows in early lactation. Journal of dairy science. 2007 Sep; 90(9):4181-91. doi: 10.3168/jds.2006-897. [PMID: 17699036]
  • Natalie J Coffer, Nicholas Frank, Sarah B Elliott, Charles D Young, Sarel R van Amstel. Effects of dexamethasone and isoflupredone acetate on plasma potassium concentrations and other biochemical measurements in dairy cows in early lactation. American journal of veterinary research. 2006 Jul; 67(7):1244-51. doi: 10.2460/ajvr.67.7.1244. [PMID: 16817750]
  • V Picandet, R Léguillette, J P Lavoie. Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction ('heaves'). Equine veterinary journal. 2003 Jun; 35(4):419-24. doi: 10.2746/042516403776014208. [PMID: 12880012]
  • J D Lillich, A L Bertone, L M Schmall, A J Ruggles, R A Sams. Plasma, urine, and synovial fluid disposition of methylprednisolone acetate and isoflupredone acetate after intra-articular administration in horses. American journal of veterinary research. 1996 Feb; 57(2):187-92. doi: NULL. [PMID: 8633806]
  • C D Spence, D P Campbell, J P Coghlan, D A Denton, E H Mills, M A Nelson, J A Whitworth, B A Scoggins. Structure-activity relationships for blood pressure effects of prednisolone in sheep. Clinical and experimental hypertension. Part A, Theory and practice. 1987; 9(4):773-95. doi: 10.3109/10641968709161449. [PMID: 3621626]
  • J P Coghlan, D A Denton, E H Mills, M A Nelson, C D Spence, J A Whitworth, B A Scoggins. Steroid antagonism of the 'hypertensinogenic' activity of 9 alpha-fluoroprednisolone. Life sciences. 1984 Dec; 35(26):2609-12. doi: 10.1016/0024-3205(84)90028-6. [PMID: 6513729]
  • J Montoliu, A Botey, A Trilla, L Revert. Pseudoprimary aldosteronism from the topical application of 9-alpha-fluorprednisolone to the skin. Clinical nephrology. 1984 Nov; 22(5):262-6. doi: NULL. [PMID: 6394185]
  • R Cantello, L Bergamini, M Delsedime, L Durelli, W Troni, M Gilli, D Cocito. [Hypokalemic myopathy caused by fluoroprednisolone in a nasal spray. Observations 2 cases]. Minerva medica. 1983 Jun; 74(25):1463-7. doi: NULL. [PMID: 6856155]
  • W R Adam. Aldosterone and dopamine receptors in the kidney: sites for pharmacologic manipulation of renal function. Kidney international. 1980 Nov; 18(5):623-35. doi: 10.1038/ki.1980.180. [PMID: 6257964]
  • E F Lavretskaia, Iu Sh Moshkovskii, I M Raĭkhman. [Effect of psychotropic and anticonvulsive preparations on transport ATPase in the renal tubules of the guinea pig]. Farmakologiia i toksikologiia. 1975 May; 38(3):272-5. doi: NULL. [PMID: 6303]