Dermorphin (BioDeep_00000002713)
PANOMIX_OTCML-2023
代谢物信息卡片
Dermorphin
化学式: C40H50N8O10 (802.364972)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 41.18%
分子结构信息
SMILES: CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CO)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)N
InChI: InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:177767
- KEGG: C20030
- PubChem: 5485199
- Metlin: METLIN73515
- ChEMBL: CHEMBL278789
- CAS: 77614-16-5
- PMhub: MS000004587
- PubChem: 135626496
- medchemexpress: HY-P0244
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 197464 Agalychnis callidryas: 10.1016/S0196-9781(96)00342-7
- 197464 Agalychnis callidryas: 10.1016/S0196-9781(96)00342-7
- 40674 Animals: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juliana de L Castro, Maria Elvira P Martucci, Henrique M G Pereira, Valéria P de Sousa. A high throughput approach for determination of dermorphin in human urine using liquid chromatography-mass spectrometry for doping control purposes.
Journal of mass spectrometry : JMS.
2020 Oct; 55(10):e4593. doi:
10.1002/jms.4593. [PMID: 32805775] - Fuyu Guan, Savannah Fay, Xiaoqing Li, Youwen You, Mary A Robinson. Identification of ex vivo catabolites of peptides with doping potential in equine plasma by HILIC-HRMS.
Drug testing and analysis.
2020 Jun; 12(6):771-784. doi:
10.1002/dta.2781. [PMID: 32100400] - Katarzyna Trzeciak, Piotr Paluch, Tomasz Pawlak, Artur Różański, Marta K Dudek, Marek J Potrzebowski. The influence of the stereochemistry and C-end chemical modification of dermorphin derivatives on the peptide-phospholipid interactions.
Biochimica et biophysica acta. Biomembranes.
2020 02; 1862(2):183066. doi:
10.1016/j.bbamem.2019.183066. [PMID: 31634444] - Oliwia Frączak, Anika Lasota, Dagmara Tymecka, Piotr Kosson, Adriana Muchowska, Aleksandra Misicka, Aleksandra Olma. Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids.
Journal of peptide science : an official publication of the European Peptide Society.
2016 Apr; 22(4):222-7. doi:
10.1002/psc.2869. [PMID: 27028206] - M A Robinson, F Guan, S McDonnell, C E Uboh, L R Soma. Pharmacokinetics and pharmacodynamics of dermorphin in the horse.
Journal of veterinary pharmacology and therapeutics.
2015 Aug; 38(4):321-9. doi:
10.1111/jvp.12179. [PMID: 25376170] - Rohan Steel, Mark Timms, Vita Levina, John Vine. A high throughput screen for 17 Dermorphin peptides in equine and human urine and equine plasma.
Drug testing and analysis.
2014 Sep; 6(9):909-21. doi:
10.1002/dta.1585. [PMID: 24259424] - Caroline C Wang, Petra Hartmann-Fischbach, Tim R Krueger, Terry L Wells, Amy R Feineman, Joanne C Compton. Fast and sensitive analysis of dermorphin and HYP6-dermorphin in equine plasma using liquid chromatography tandem mass spectrometry.
Drug testing and analysis.
2014 Apr; 6(4):342-9. doi:
10.1002/dta.1487. [PMID: 23720224] - Stacey L Richards, Adam T Cawley, Mark J Raftery. Detection and quantification of dermorphin and selected analogs in equine urine.
Bioanalysis.
2013 Dec; 5(24):2995-3007. doi:
10.4155/bio.13.281. [PMID: 24320126] - Fuyu Guan, Cornelius E Uboh, Lawrence R Soma, Mary Robinson, George A Maylin, Xiaoqing Li. Detection, quantification, and identification of dermorphin in equine plasma and urine by LC-MS/MS for doping control.
Analytical and bioanalytical chemistry.
2013 May; 405(14):4707-17. doi:
10.1007/s00216-013-6907-0. [PMID: 23571464] - Sylvia Van Dorpe, Antita Adriaens, Simon Vermeire, Ingeborgh Polis, Kathelijne Peremans, Bart De Spiegeleer. Desirability function combining metabolic stability and functionality of peptides.
Journal of peptide science : an official publication of the European Peptide Society.
2011 May; 17(5):398-404. doi:
10.1002/psc.1323. [PMID: 21294224] - Sylvia Van Dorpe, Antita Adriaens, Ingeborgh Polis, Kathelijne Peremans, Jan Van Bocxlaer, Bart De Spiegeleer. Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides.
Peptides.
2010 Jul; 31(7):1390-9. doi:
10.1016/j.peptides.2010.03.029. [PMID: 20347901] - Jian Lu, Eunjung Jeon, Bao-Shiang Lee, Hayat Onyuksel, Zaijie Jim Wang. Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes.
Journal of controlled release : official journal of the Controlled Release Society.
2006 Feb; 110(3):505-13. doi:
10.1016/j.jconrel.2005.10.025. [PMID: 16356575] - Yoshiharu Deguchi, Yu Naito, Sumio Ohtsuki, Yusaku Miyakawa, Kazuhiro Morimoto, Ken-Ichi Hosoya, Shinobu Sakurada, Tetsuya Terasaki. Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system.
The Journal of pharmacology and experimental therapeutics.
2004 Jul; 310(1):177-84. doi:
10.1124/jpet.103.064006. [PMID: 15031301] - Laura Biondi, Elisa Giannini, Fernando Filira, Marina Gobbo, Mauro Marastoni, Lucia Negri, Barbara Scolaro, Roberto Tomatisc, Raniero Rocchi. Synthesis, conformation and biological activity of dermorphin and deltorphin I analogues containing N-alkylglycine in place of residues in position 1, 3, 5 and 6.
Journal of peptide science : an official publication of the European Peptide Society.
2003 Oct; 9(10):638-48. doi:
10.1002/psc.487. [PMID: 14620129] - Bénédicte G Perret, Renaud Wagner, Sandra Lecat, Karl Brillet, Gwénaël Rabut, Bernard Bucher, Franc Pattus. Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Protein expression and purification.
2003 Sep; 31(1):123-32. doi:
10.1016/s1046-5928(03)00140-2. [PMID: 12963349] - Hironobu Tokuno, Satomi Chiken, Kiyokazu Kametani, Tetsuji Moriizumi. Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats.
Neuroscience letters.
2002 Oct; 332(1):5-8. doi:
10.1016/s0304-3940(02)00837-6. [PMID: 12377371] - K M Solaas, O Skjeldal, M L G Gardner, F B Kase, K L Reichelt. Urinary peptides in Rett syndrome.
Autism : the international journal of research and practice.
2002 Sep; 6(3):315-28. doi:
10.1177/1362361302006003008. [PMID: 12212921] - Shannon E Burgess, Luis R Gardell, Michael H Ossipov, T Philip Malan, Todd W Vanderah, Josephine Lai, Frank Porreca. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002 Jun; 22(12):5129-36. doi:
10.1523/jneurosci.22-12-05129.2002. [PMID: 12077208] - F Porreca, S E Burgess, L R Gardell, T W Vanderah, T P Malan, M H Ossipov, D A Lappi, J Lai. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001 Jul; 21(14):5281-8. doi:
10.1523/jneurosci.21-14-05281.2001. [PMID: 11438603] - O A Lebed'ko, S S Timoshin. Effects of opiate receptor ligands on DNA synthesis in tracheal epitheliocytes and smooth muscle cells of newborn albino rats.
Bulletin of experimental biology and medicine.
2001 Feb; 131(2):169-71. doi:
10.1023/a:1017504331168. [PMID: 11391405] - S F Sezen, V A Kenigs, D R Kapusta. Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats.
The Journal of pharmacology and experimental therapeutics.
1998 Oct; 287(1):238-45. doi:
NULL. [PMID: 9765343] - A M Cabral, K J Varner, D R Kapusta. Renal excretory responses produced by central administration of opioid agonists in ketamine and xylazine-anesthetized rats.
The Journal of pharmacology and experimental therapeutics.
1997 Aug; 282(2):609-16. doi:
NULL. [PMID: 9262322] - L Negri, R Lattanzi, P Melchiorri. Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors.
British journal of pharmacology.
1995 Jan; 114(1):57-66. doi:
10.1111/j.1476-5381.1995.tb14905.x. [PMID: 7712029] - E C degli Uberti, F Petraglia, M Bondanelli, A L Guo, A Valentini, S Salvadori, M Criscuolo, R E Nappi, A R Genazzani. Involvement of mu-opioid receptors in the modulation of pituitary-adrenal axis in normal and stressed rats.
Journal of endocrinological investigation.
1995 Jan; 18(1):1-7. doi:
10.1007/bf03349688. [PMID: 7759779] - D R Kapusta, E M Dzialowski. Central mu opioids mediate differential control of urine flow rate and urinary sodium excretion in conscious rats.
Life sciences.
1995; 56(14):PL243-8. doi:
10.1016/0024-3205(95)00065-e. [PMID: 7475890] - L Intorre, G Mengozzi, E Vanni, F Grassi, G Soldani. The role of peripheral opioid receptor subtypes in the modulation of gastric acid secretion and plasma gastrin in dogs.
European journal of pharmacology.
1993 Oct; 243(3):265-72. doi:
10.1016/0014-2999(93)90184-j. [PMID: 8276079] - D R Kapusta, J C Obih, G F Dibona. Central mu opioid receptor-mediated changes in renal function in conscious rats.
The Journal of pharmacology and experimental therapeutics.
1993 Apr; 265(1):134-43. doi:
NULL. [PMID: 8097241] - T N Sollertinskaia, E N Nuritdinov, M F Obukhova. [The role of dermorfin in regulating hibernation processes in mammals].
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova.
1992 Apr; 78(4):1-13. doi:
NULL. [PMID: 1334852] - D R Kapusta, S Y Jones, G F DiBona. Renal mu opioid receptor mechanisms in regulation of renal function in rats.
The Journal of pharmacology and experimental therapeutics.
1991 Jul; 258(1):111-7. doi:
NULL. [PMID: 1677034] - V M Labroo, D Hebel, K L Kirk, L A Cohen, C Lemieux, P W Schiller. Direct electrophilic fluorination of tyrosine in dermorphin analogues and its effect on biological activity, receptor affinity and selectivity.
International journal of peptide and protein research.
1991 May; 37(5):430-9. doi:
10.1111/j.1399-3011.1991.tb00758.x. [PMID: 1680830] - A L Sirén, P Paakkari, D S Goldstein, G Feuerstein. Mechanisms of central hemodynamic and sympathetic regulation by mu opioid receptors: effects of dermorphin in the conscious rat.
The Journal of pharmacology and experimental therapeutics.
1989 Feb; 248(2):596-604. doi:
. [PMID: 2563768] - G Feuerstein, Z Zukowska-Grojec. Effect of dermorphin and morphine on the sympathetic and cardiovascular system of the pithed rat.
Neuropeptides.
1987 Feb; 9(2):139-50. doi:
10.1016/0143-4179(87)90052-7. [PMID: 3574608] - S Scalia, S Salvadori, M Marastoni, F Bortolotti, R Tomatis. Reversed-phase HPLC study on the in vitro enzymic degradation of dermorphin.
Peptides.
1986 Mar; 7(2):247-51. doi:
10.1016/0196-9781(86)90221-4. [PMID: 2874548] - E C degli Uberti, E Roti, G Trasforini, S Salvadori, A Margutti, G Robuschi, R Tomatis, A Gnudi, R Pansini, L E Braverman. Somatostatin inhibits the dermorphin-stimulated thyrotropin release in man.
Hormone research.
1986; 23(4):207-12. doi:
10.1159/000180325. [PMID: 2870974] - E C Degli Uberti, F Petraglia, G Trasforini, S Salvadori, A Margutti, M Bianconi, V Teodori, F Facchinetti, R Tomatis, A R Genazzani. Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, beta-endorphin, and beta-lipotropin in man.
The Journal of clinical endocrinology and metabolism.
1985 Dec; 61(6):1018-22. doi:
10.1210/jcem-61-6-1018. [PMID: 2997256] - E C degli Uberti, G Trasforini, S Salvadori, A Margutti, C Rotola, M Bianconi, V Teodori, R Tomatis, R Pansini. Prolactin and growth hormone responses to dermorphin in patients with prolactin-secreting pituitary adenoma.
Metabolism: clinical and experimental.
1985 Sep; 34(9):874-9. doi:
10.1016/0026-0495(85)90113-1. [PMID: 4033428] - F Petraglia, E C Degli Uberti, G Trasforini, F Facchinetti, A Margutti, A Volpe, S Salvadori, R Tomatis, A R Genazzani. Dermorphin decreases plasma LH levels in human: evidence for a modulatory role of gonadal steroids.
Peptides.
1985 Sep; 6(5):869-72. doi:
10.1016/0196-9781(85)90317-1. [PMID: 3936026] - T Mitsuma, T Nogimori, M Chaya. Dermorphin inhibits basal and cold induced thyrotropin secretion in rats.
Endocrinologia experimentalis.
1985 Jun; 19(2):83-90. doi:
. [PMID: 3926450] - E C Degli Uberti, G Trasforini, S Salvadori, A Margutti, R Tomatis, R Pansini. The effects of dermorphin on the endocrine system in man.
Peptides.
1985; 6 Suppl 3(?):171-5. doi:
10.1016/0196-9781(85)90370-5. [PMID: 3008118] - M Motta. Neuroendocrine effects of some amphibian peptides.
Peptides.
1985; 6 Suppl 3(?):131-5. doi:
10.1016/0196-9781(85)90363-8. [PMID: 3938531] - L Negri, G Improta. Distribution and metabolism of dermorphin in rats.
Pharmacological research communications.
1984 Dec; 16(12):1183-91. doi:
10.1016/s0031-6989(84)80083-1. [PMID: 6522442] - D Giudici, R D'Urso, P Falaschi, L Negri, P Melchiorri, M Motta. Dermorphin stimulates prolactin secretion in the rat.
Neuroendocrinology.
1984 Sep; 39(3):236-44. doi:
10.1159/000123985. [PMID: 6504268] - E Roti, E Degli Uberti, S Salvadori, M Bianconi, R Emanuele, C Rotola, G Trasforini, G Robuschi, R Tomatis, A Gnudi. Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects.
Journal of endocrinological investigation.
1984 Jun; 7(3):211-4. doi:
10.1007/bf03348425. [PMID: 6470436] - E C Degli Uberti, G Trasforini, S Salvadori, A Margutti, R Tomatis, M Bianconi, C Rotola, R Pansini. Responses of plasma renin activity, aldosterone, adrenocorticotropin, and cortisol to dermorphin, a new synthetic potent opiate-like peptide, in man.
The Journal of clinical endocrinology and metabolism.
1983 Dec; 57(6):1179-85. doi:
10.1210/jcem-57-6-1179. [PMID: 6313731] - H G Güllner, W W Owen, V Harris, R H Unger. Dermorphin: an opioid peptide from amphibian skin which affects endocrine pancreatic function.
Archives internationales de pharmacodynamie et de therapie.
1983 Nov; 266(1):155-61. doi:
. [PMID: 6141770] - E C degli Uberti, G Trasforini, S Salvadori, A Margutti, R Tomatis, C Rotola, M Bianconi, R Pansini. Stimulatory effect of dermorphin, a new synthetic potent opiate-like peptide, on human growth hormone secretion.
Neuroendocrinology.
1983 Oct; 37(4):280-3. doi:
10.1159/000123559. [PMID: 6633818] - H G Güllner, G D Kelly. Dermorphin: effects on anterior pituitary function in the rat.
Archives internationales de pharmacodynamie et de therapie.
1983 Apr; 262(2):208-14. doi:
NULL. [PMID: 6870393] - G Feuerstein, A I Faden. Dermorphin: cardiovascular and sympathetic modulation in the anteroventral hypothalamus of conscious rats.
Life sciences.
1983; 33 Suppl 1(?):731-4. doi:
10.1016/0024-3205(83)90606-9. [PMID: 6664249]