2-Hydroxybutyric acid (BioDeep_00000265237)
Main id: BioDeep_00000003495
Secondary id: BioDeep_00000229680
natural product PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C4H8O3 (104.0473418)
中文名称: DL-2-羟基丁酸 (含高分子酯化产品), 2-羟基丁酸, S-2-羟基丁酸
谱图信息:
最多检出来源 Homo sapiens(urine) 0.33%
分子结构信息
SMILES: CCC(C(=O)O)O
InChI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)
描述信息
A hydroxybutyric acid having a single hydroxyl group located at position 2; urinary secretion of 2-hydroxybutyric acid is increased with alcohol ingestion or vigorous physical exercise and is associated with lactic acidosis and ketoacidosis in humans and diabetes in animals.
(S)-2-Hydroxybutanoic acid is the S-enantiomer of?2-Hydroxybutanoic acid. 2-Hydroxybutanoic acid, a coproduct of protein metabolism, is an insulin resistance (IR) biomarker[1].
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:1148
- PubChem: 11266
- ChEMBL: CHEMBL567588
- KNApSAcK: C00052120
- CAS: 600-15-7
- CAS: 565-70-8
- CAS: 3347-90-8
- MoNA: CCMSLIB00005720782
- MoNA: MoNA037958
- MoNA: MoNA034278
- MoNA: MoNA034279
- MoNA: MoNA034277
- MoNA: EMBL-MCF_spec64954
- MoNA: EMBL-MCF_spec64934
- MoNA: HMDB0000008_ms_ms_12
- MoNA: HMDB0000008_ms_ms_11
- MoNA: HMDB0000008_ms_ms_10
- MoNA: CCMSLIB00000578291
- MetaboLights: MTBLC1148
- RefMet: 2-Hydroxybutyric acid
- medchemexpress: HY-W018499
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 1080010 - Aloe africana: 10.1021/JF071110T
- 593583 - Carteriospongia: 10.1055/S-2006-960851
- 3055 - Chlamydomonas reinhardtii: 10.1111/TPJ.12747
- 9606 - Homo sapiens:
- 159736 - Macrobrachium nipponense: 10.3389/FPHYS.2018.00076
- 279624 - Phyllospongia: 10.1055/S-2006-960851
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Seyed Ali Rasooli, Rozita Fathi, Farhad Ahmadi-Kani Golzar, Masoumeh Baghersalimi. The effect of circuit resistance training on plasma levels of amino acids, alpha-hydroxybutyrate, mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2021 Jun; 46(6):561-570. doi:
10.1139/apnm-2020-0171
. [PMID: 33151749] - Ding Shi, Ren Yan, Longxian Lv, Huiyong Jiang, Yingfeng Lu, Jifang Sheng, Jiaojiao Xie, Wenrui Wu, Jiafeng Xia, Kaijin Xu, Silan Gu, Yanfei Chen, Chenjie Huang, Jing Guo, Yiling Du, Lanjuan Li. The serum metabolome of COVID-19 patients is distinctive and predictive.
Metabolism: clinical and experimental.
2021 05; 118(?):154739. doi:
10.1016/j.metabol.2021.154739
. [PMID: 33662365] - Rohit Sharma, Bryn Reinstadler, Kristin Engelstad, Owen S Skinner, Erin Stackowitz, Ronald G Haller, Clary B Clish, Kerry Pierce, Melissa A Walker, Robert Fryer, Devin Oglesbee, Xiangling Mao, Dikoma C Shungu, Ashok Khatri, Michio Hirano, Darryl C De Vivo, Vamsi K Mootha. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
The Journal of clinical investigation.
2021 01; 131(2):. doi:
10.1172/jci136055
. [PMID: 33463549] - Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu. Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice.
Journal of immunology research.
2020; 2020(?):9242601. doi:
10.1155/2020/9242601
. [PMID: 32537472] - Chulhun Park, Nileshkumar Meghani, Hardik Amin, Phuong H-L Tran, Thao T-D Tran, Van H Nguyen, Beom-Jin Lee. The roles of short and long chain fatty acids on physicochemical properties and improved cancer targeting of albumin-based fattigation-platform nanoparticles containing doxorubicin.
International journal of pharmaceutics.
2019 Jun; 564(?):124-135. doi:
10.1016/j.ijpharm.2019.04.038
. [PMID: 30991133] - Matthew J Peterson, Sheena Geoghegan, Larry W Lawhorne. An Exploratory Analysis of Potential New Biomarkers of Cognitive Function.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2019 02; 74(3):299-305. doi:
10.1093/gerona/gly122
. [PMID: 29846522] - Jing Chou, Rui Liu, Jiaying Yu, Xiaowei Liu, Xinshu Zhao, Ying Li, Liyan Liu, Changhao Sun. Fasting serum α‑hydroxybutyrate and pyroglutamic acid as important metabolites for detecting isolated post-challenge diabetes based on organic acid profiles.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Nov; 1100-1101(?):6-16. doi:
10.1016/j.jchromb.2018.09.004
. [PMID: 30267980] - Wenli Li, Meiling Ji, Yandie Lin, Yi Miao, Simin Chen, Hao Li. DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 10; 32(10):5459-5469. doi:
10.1096/fj.201800357r
. [PMID: 29702025] - Prapimporn Chattranukulchai Shantavasinkul, Michael J Muehlbauer, James R Bain, Olga R Ilkayeva, Damian M Craig, Christopher B Newgard, Laura P Svetkey, Svati H Shah, Alfonso Torquati. Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
2018 Aug; 14(8):1126-1132. doi:
10.1016/j.soard.2018.03.033
. [PMID: 29805089] - Domenico Tricò, Hetty Prinsen, Cosimo Giannini, Robin de Graaf, Christoph Juchem, Fangyong Li, Sonia Caprio, Nicola Santoro, Raimund I Herzog. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents.
The Journal of clinical endocrinology and metabolism.
2017 07; 102(7):2473-2481. doi:
10.1210/jc.2017-00475
. [PMID: 28482070] - Prashant K Sarswat, Yogendra Kumar Mishra, Michael L Free. Fabrication and response of alpha-hydroxybutyrate sensors for rapid assessment of cardiometabolic disease risk.
Biosensors & bioelectronics.
2017 Mar; 89(Pt 1):334-342. doi:
10.1016/j.bios.2016.07.019
. [PMID: 27453438] - Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, Jean Tichet, Beverley Balkau, Thierry Brousseau, Marco Manca, Mario Falchi. Metabolomic Profile of Low-Copy Number Carriers at the Salivary α-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production.
Diabetes.
2016 Nov; 65(11):3362-3368. doi:
10.2337/db16-0315
. [PMID: 27436124] - Agnieszka Klupczynska, Szymon Plewa, Wojciech Dyszkiewicz, Mariusz Kasprzyk, Natalia Sytek, Zenon J Kokot. Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography-tandem mass spectrometry method.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 129(?):299-309. doi:
10.1016/j.jpba.2016.07.028
. [PMID: 27454081] - Yi Wang, Gary G Deng, Kelvin P Davies. Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
American journal of physiology. Endocrinology and metabolism.
2016 08; 311(2):E471-9. doi:
10.1152/ajpendo.00134.2016
. [PMID: 27354236] - Domenico Ciavardelli, Fabrizio Piras, Ada Consalvo, Claudia Rossi, Mirco Zucchelli, Carmine Di Ilio, Valerio Frazzini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi. Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.
Neurobiology of aging.
2016 07; 43(?):1-12. doi:
10.1016/j.neurobiolaging.2016.03.005
. [PMID: 27255810] - Jeff Cobb, Andrea Eckhart, Alison Motsinger-Reif, Bernadette Carr, Leif Groop, Ele Ferrannini. α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance.
Diabetes care.
2016 Jun; 39(6):988-95. doi:
10.2337/dc15-2752
. [PMID: 27208342] - Konrad Sarosiek, Kirk L Pappan, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Heather McMahon, Galina I Chipitsyna, David S Tichansky, Hwyda A Arafat. Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study.
Journal of diabetes research.
2016; 2016(?):3467403. doi:
10.1155/2016/3467403
. [PMID: 26881244] - Xu-guang Shi, Zhong-jie Zou, Mei-yin Wu, Yuan-gui Zeng, Zhi-cheng Lian, Man-ting Huang, Meng-juan Gong. [Metabonomics Study on Urine 1H-NMR in Chronic Superficial Gastritis Patients with Pi-qi Deficiency Syndrome/Pi-Wei Dampness-heat Syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Dec; 35(12):1427-32. doi:
. [PMID: 26882602]
- M Trent Herdman, Natthida Sriboonvorakul, Stije J Leopold, Sam Douthwaite, Sanjib Mohanty, M Mahtab Uddin Hassan, Richard J Maude, Hugh W F Kingston, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Charles J Woodrow, Aniruddha Ghose, Kesinee Chotinavich, Md Amir Hossain, M Abul Faiz, Saroj Mishra, Natchanun Leepipatpiboon, Nicholas J White, Nicholas P J Day, Joel Tarning, Arjen M Dondorp. The role of previously unmeasured organic acids in the pathogenesis of severe malaria.
Critical care (London, England).
2015 Sep; 19(?):317. doi:
10.1186/s13054-015-1023-5
. [PMID: 26343146] - Ebru Selin Selen, Zeinab Bolandnazar, Marco Tonelli, Daniel E Bütz, Julia A Haviland, Warren P Porter, Fariba M Assadi-Porter. NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.
Journal of proteome research.
2015 Aug; 14(8):3284-91. doi:
10.1021/acs.jproteome.5b00307
. [PMID: 26076986] - E Muscelli, S Frascerra, A Casolaro, S Baldi, A Mari, W Gall, J Cobb, E Ferrannini. The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment.
Diabetes, obesity & metabolism.
2014 Nov; 16(11):1140-7. doi:
10.1111/dom.12350
. [PMID: 25040945] - Elizabeth Joseloff, Wei Sha, Sara C Bell, Diana R Wetmore, Kay A Lawton, Michael V Milburn, John A Ryals, Lining Guo, Marianne S Muhlebach. Serum metabolomics indicate altered cellular energy metabolism in children with cystic fibrosis.
Pediatric pulmonology.
2014 May; 49(5):463-72. doi:
10.1002/ppul.22859
. [PMID: 23847148] - M Gołębiowski, M Cerkowniak, A Urbanek, M Dawgul, W Kamysz, M I Boguś, D Sosnowska, P Stepnowski. Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species.
Journal of applied microbiology.
2014 Feb; 116(2):269-87. doi:
10.1111/jam.12370
. [PMID: 24238211] - Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, Klaus-Peter Adam, Michael V Milburn, Gabi Kastenmüller, Jerzy Adamski, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop, Walter E Gall. Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance.
Diabetes.
2013 May; 62(5):1730-7. doi:
10.2337/db12-0707
. [PMID: 23160532] - Mainak Dutta, Mamata Joshi, Sudha Srivastava, Indrani Lodh, Baidyanath Chakravarty, Koel Chaudhury. A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis.
Molecular bioSystems.
2012 Oct; 8(12):3281-7. doi:
10.1039/c2mb25353d
. [PMID: 23079773] - Y Nedjadi, C Bailat, Y Caffari, P Froidevaux, C Wastiel, N Kivel, I Guenther-Leopold, G Triscone, F Jaquenod, F Bochud. A new measurement of the half-life of (166m)Ho.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2012 Sep; 70(9):1990-6. doi:
10.1016/j.apradiso.2012.02.063
. [PMID: 22421399] - Shanshan Chen, Junbao Du, Yinfang Liang, Rongyuan Zhang, Chaoshu Tang, Hongfang Jin. Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury.
Histology and histopathology.
2012 09; 27(9):1219-26. doi:
10.14670/hh-27.1219
. [PMID: 22806909] - Ying-ping Xiao, Tian-xing Wu, Qi-hua Hong, Jiang-ming Sun, An-guo Chen, Cai-mei Yang, Xiao-yan Li. Response to weaning and dietary L-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry.
Journal of Zhejiang University. Science. B.
2012 Jul; 13(7):567-78. doi:
10.1631/jzus.b1100343
. [PMID: 22761248] - Philip J Saylor, Edward D Karoly, Matthew R Smith. Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Jul; 18(13):3677-85. doi:
10.1158/1078-0432.ccr-11-3209
. [PMID: 22589396] - Caiping Mao, Yujuan Liu, Shan Jiang, Anwen Zhou, Peiwen Zhang, Aiping Shi, Hao Zhang, Xiaohui Xu, Zhice Xu. The effect of folic acid on ovine fetuses in utero during late gestation.
Drug and chemical toxicology.
2012 Apr; 35(2):127-33. doi:
10.3109/01480545.2011.589444
. [PMID: 21848402] - Jean-Matthieu Prot, Andrei Bunescu, Bénédicte Elena-Herrmann, Caroline Aninat, Leila Choucha Snouber, Laurent Griscom, Florence Razan, Frederic Y Bois, Cécile Legallais, Céline Brochot, Anne Corlu, Marc Emmanuel Dumas, Eric Leclerc. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.
Toxicology and applied pharmacology.
2012 Mar; 259(3):270-80. doi:
10.1016/j.taap.2011.12.017
. [PMID: 22230336] - Lay Ching Chai, Boon Hong Kong, Omar Ismail Elemfareji, Kwai Lin Thong. Variable carbon catabolism among Salmonella enterica serovar Typhi isolates.
PloS one.
2012; 7(5):e36201. doi:
10.1371/journal.pone.0036201
. [PMID: 22662115] - Shin Nishiumi, Takashi Kobayashi, Atsuki Ikeda, Tomoo Yoshie, Megumi Kibi, Yoshihiro Izumi, Tatsuya Okuno, Nobuhide Hayashi, Seiji Kawano, Tadaomi Takenawa, Takeshi Azuma, Masaru Yoshida. A novel serum metabolomics-based diagnostic approach for colorectal cancer.
PloS one.
2012; 7(7):e40459. doi:
10.1371/journal.pone.0040459
. [PMID: 22792336] - David C Nieman, Nicholas D Gillitt, Dru A Henson, Wei Sha, R Andrew Shanely, Amy M Knab, Lynn Cialdella-Kam, Fuxia Jin. Bananas as an energy source during exercise: a metabolomics approach.
PloS one.
2012; 7(5):e37479. doi:
10.1371/journal.pone.0037479
. [PMID: 22616015] - Joanna Teul, Antonia Garcia, José Tuñón, Jose Luis Martin-Ventura, Nieves Tarín, Lorenzo López Bescós, Jesús Egido, Coral Barbas, Francisco J Rupérez. Targeted and non-targeted metabolic time trajectory in plasma of patients after acute coronary syndrome.
Journal of pharmaceutical and biomedical analysis.
2011 Sep; 56(2):343-51. doi:
10.1016/j.jpba.2011.05.020
. [PMID: 21696905] - Lianzhen Yu, Jiye Aa, Jin Xu, Min Sun, Sixuan Qian, Liping Cheng, Shuping Yang, Ruihua Shi. Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry.
Journal of gastroenterology and hepatology.
2011 Aug; 26(8):1290-7. doi:
10.1111/j.1440-1746.2011.06724.x
. [PMID: 21443661] - Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart. The human serum metabolome.
PloS one.
2011 Feb; 6(2):e16957. doi:
10.1371/journal.pone.0016957
. [PMID: 21359215] - Yazmin Macotela, Brice Emanuelli, Anneli M Bång, Daniel O Espinoza, Jeremie Boucher, Kirk Beebe, Walter Gall, C Ronald Kahn. Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.
PloS one.
2011; 6(6):e21187. doi:
10.1371/journal.pone.0021187
. [PMID: 21731668] - Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.
PloS one.
2010 Dec; 5(12):e15234. doi:
10.1371/journal.pone.0015234
. [PMID: 21170321] - Alexandros Pechlivanis, Sarantos Kostidis, Ploutarchos Saraslanidis, Anatoli Petridou, George Tsalis, Vassilis Mougios, Helen G Gika, Emmanuel Mikros, Georgios A Theodoridis. (1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine.
Journal of proteome research.
2010 Dec; 9(12):6405-16. doi:
10.1021/pr100684t
. [PMID: 20932058] - Roger L Chang, Li Xie, Lei Xie, Philip E Bourne, Bernhard Ø Palsson. Drug off-target effects predicted using structural analysis in the context of a metabolic network model.
PLoS computational biology.
2010 Sep; 6(9):e1000938. doi:
10.1371/journal.pcbi.1000938
. [PMID: 20957118] - Dottie R Brundige, Elizabeth A Maga, Kirk C Klasing, James D Murray. Consumption of pasteurized human lysozyme transgenic goats' milk alters serum metabolite profile in young pigs.
Transgenic research.
2010 Aug; 19(4):563-74. doi:
10.1007/s11248-009-9334-4
. [PMID: 19847666] - Walter E Gall, Kirk Beebe, Kay A Lawton, Klaus-Peter Adam, Matthew W Mitchell, Pamela J Nakhle, John A Ryals, Michael V Milburn, Monica Nannipieri, Stefania Camastra, Andrea Natali, Ele Ferrannini. alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.
PloS one.
2010 May; 5(5):e10883. doi:
10.1371/journal.pone.0010883
. [PMID: 20526369] - Rolf Fendel, Christian Brandts, Annika Rudat, Andrea Kreidenweiss, Claudia Steur, Iris Appelmann, Bettina Ruehe, Paul Schröder, Wolfgang E Berdel, Peter G Kremsner, Benjamin Mordmüller. Hemolysis is associated with low reticulocyte production index and predicts blood transfusion in severe malarial anemia.
PloS one.
2010 Apr; 5(4):e10038. doi:
10.1371/journal.pone.0010038
. [PMID: 20386613] - Bei Yan, JiYe A, HaiPing Hao, GuangJi Wang, XuanXuan Zhu, WeiBin Zha, LinSheng Liu, EnZe Guan, Ying Zhang, ShengHua Gu, Qing Huang, YuanTing Zheng. Metabonomic phenotype and identification of "heart blood stasis obstruction pattern" and "qi and yin deficiency pattern" of myocardial ischemia rat models.
Science in China. Series C, Life sciences.
2009 Nov; 52(11):1081-90. doi:
10.1007/s11427-009-0136-y
. [PMID: 19937207] - Martin Engqvist, María F Drincovich, Ulf-Ingo Flügge, Verónica G Maurino. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.
The Journal of biological chemistry.
2009 Sep; 284(37):25026-37. doi:
10.1074/jbc.m109.021253
. [PMID: 19586914] - Xiang Li, Zhiliang Xu, Xin Lu, Xuehui Yang, Peiyuan Yin, Hongwei Kong, Ying Yu, Guowang Xu. Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus.
Analytica chimica acta.
2009 Feb; 633(2):257-62. doi:
10.1016/j.aca.2008.11.058
. [PMID: 19166731] - Huiting Liu, Linglan Ma, Jinfang Zhao, Jie Liu, Jingying Yan, Jie Ruan, Fashui Hong. Biochemical toxicity of nano-anatase TiO2 particles in mice.
Biological trace element research.
2009; 129(1-3):170-80. doi:
10.1007/s12011-008-8285-6
. [PMID: 19066734] - Gen-Fa Lv, Hong-Yi Hou, Bi Chen, Wan-Fu Zhang, Xiong-Xiang Zhu, Mao-Long Dong, Da-Hai Hu. [Effect of intensive insulin treatment on cardiac myocytes of severely scalded rats].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2008 Dec; 20(12):724-6. doi:
. [PMID: 19111118]
- Zhuo-jun Hu, Yu-Qi Zhou, Hai-bo Zhang, Li Li. [Clinical value of monitoring serum cardiac biomarkers in pulmonary thromboembolism-induced myocardial injury].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2008 Oct; 28(10):1853-5. doi:
. [PMID: 18971188]
- Rade Injac, Marija Boskovic, Martina Perse, Eva Koprivec-Furlan, Anton Cerar, Aleksandar Djordjevic, Borut Strukelj. Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress.
Pharmacological reports : PR.
2008 Sep; 60(5):742-9. doi:
. [PMID: 19066422]
- Richard S Lord, J Alexander Bralley. Clinical applications of urinary organic acids. Part I: Detoxification markers.
Alternative medicine review : a journal of clinical therapeutic.
2008 Sep; 13(3):205-15. doi:
NULL
. [PMID: 18950247] - Snezana K Bjelogrlic, Jelena Radic, Sinisa Radulovic, Milan Jokanovic, Viktor Jovic. Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo.
Experimental biology and medicine (Maywood, N.J.).
2007 Dec; 232(11):1414-24. doi:
10.3181/0705-rm-138
. [PMID: 18040065] - Iola F Duarte, Brian J Goodfellow, António Barros, John G Jones, Cristina Barosa, Luisa Diogo, Paula Garcia, Ana M Gil. Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution (1)H NMR spectroscopy.
NMR in biomedicine.
2007 Jun; 20(4):401-12. doi:
10.1002/nbm.1073
. [PMID: 17149801] - Elinor Scott, Francisc Peter, Johan Sanders. Biomass in the manufacture of industrial products--the use of proteins and amino acids.
Applied microbiology and biotechnology.
2007 Jun; 75(4):751-62. doi:
10.1007/s00253-007-0932-x
. [PMID: 17387469] - Yosuke Kato, Mitsunori Iwase, Kenji Takagi, Takao Nishizawa, Hiroaki Kanazawa, Aya Matsushita, Hisashi Umeda, Hideo Izawa, Akiko Noda, Yasuo Koike, Kohzo Nagata, Mitsuhiro Yokota. Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy: beneficial protective effect of diltiazem.
Circulation journal : official journal of the Japanese Circulation Society.
2006 Nov; 70(11):1497-502. doi:
10.1253/circj.70.1497
. [PMID: 17062977] - Ying-bin Xu, Shao-hai Qi, Ju-lin Xie, Ji-shan Yuan, Tao Zhang, Xiao-dong Chen, Bin Shu, Po Liu, Tian-zeng Li. [Protective effects of urinastatin on organ function in patients with severe burn].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2006 Jan; 18(1):39-41. doi:
. [PMID: 16464386]
- J Wojcicka, J Sienko, R Smolarczyk, E Romejko, M Grymowicz, K Czajkowski. Alpha-hydroxybutyrate dehydrogenase activity in intrahepatic cholestasis of pregnancy.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2005 Jun; 89(3):247-50. doi:
10.1016/j.ijgo.2005.02.015
. [PMID: 15919390] - Noriaki Shima, Akihiro Miki, Tooru Kamata, Munehiro Katagi, Hitoshi Tsuchihashi. Urinary endogenous concentrations of GHB and its isomers in healthy humans and diabetics.
Forensic science international.
2005 May; 149(2-3):171-9. doi:
10.1016/j.forsciint.2004.05.017
. [PMID: 15749359] - Tilmann O Kleine, Ludwig Benes, Peter Zöfel. Studies of the brain specificity of S100B and neuron-specific enolase (NSE) in blood serum of acute care patients.
Brain research bulletin.
2003 Aug; 61(3):265-79. doi:
10.1016/s0361-9230(03)00090-x
. [PMID: 12909297] - Zhan-Qin Huang, Gang-Gang Shi, Jin-Hong Zheng, Bing Liu. Effects of N-n-butyl haloperidol iodide on rat myocardial ischemia and reperfusion injury and L-type calcium current.
Acta pharmacologica Sinica.
2003 Aug; 24(8):757-63. doi:
NULL
. [PMID: 12904274] - Hitesh Shah, N Haridas. Evaluation of clinical utility of serum enzymes and troponin-T in the early stages of acute myocardial infarction.
Indian journal of clinical biochemistry : IJCB.
2003 Jul; 18(2):93-101. doi:
10.1007/bf02867373
. [PMID: 23105398] - Vincenzo Pucci, Roberto Mandrioli, Maria A Raggi. Determination of valproic acid (2-propylpentanoic acid) in human plasma by capillary electrophoresis with indirect UV detection.
Electrophoresis.
2003 Jun; 24(12-13):2076-83. doi:
10.1002/elps.200305405
. [PMID: 12858378] - Jan Hirsch, Axel Menzebach, Ingeborg Dorothea Welters, Gerald Volker Dietrich, Norbert Katz, Gunter Hempelmann. Indicators of erythrocyte damage after microwave warming of packed red blood cells.
Clinical chemistry.
2003 May; 49(5):792-9. doi:
10.1373/49.5.792
. [PMID: 12709371] - Jian-guo Zhang, Hui-ru Zhang, Xue-ying Shi, Yan Zhao, Yu Su, Xiu-zhi Li, Xiang-ci Su, Zhi-ying Miao. [Changes of myocardial enzymes in patients with acute carbon monoxide poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2003 Feb; 21(1):51-3. doi:
NULL
. [PMID: 14761575] - A Muñoz, C Riber, R Santisteban, R G Lucas, F M Castejón. Effect of training duration and exercise on blood-borne substrates, plasma lactate and enzyme concentrations in Andalusian, Anglo-Arabian and Arabian breeds.
Equine veterinary journal. Supplement.
2002 Sep; ?(34):245-51. doi:
10.1111/j.2042-3306.2002.tb05427.x
. [PMID: 12405695] - Olga Sánchez, Anna Arnau, Miguel Pareja, Enric Poch, Ignasi Ramírez, Maria Soley. Acute stress-induced tissue injury in mice: differences between emotional and social stress.
Cell stress & chaperones.
2002 Jan; 7(1):36-46. doi:
10.1379/1466-1268(2002)007<0036:asitii>2.0.co;2
. [PMID: 11892986] - J C Swaanenburg, P J Visser-VanBrummen, M J DeJongste, A T Tiebosch. The content and distribution of troponin I, troponin T, myoglobin, and alpha-hydroxybutyric acid dehydrogenase in the human heart.
American journal of clinical pathology.
2001 May; 115(5):770-7. doi:
10.1309/054c-qv78-mtvf-yacw
. [PMID: 11345843] - A R Silva, C Ruschel, C Helegda, A T Wyse, C M Wannmacher, M Wajner, C S Dutra-Filho. Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2001 May; 34(5):627-31. doi:
10.1590/s0100-879x2001000500010
. [PMID: 11323749] - M J de Groot, A M Muijtjens, M L Simoons, W T Hermens, J F Glatz. Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma.
Heart (British Cardiac Society).
2001 Mar; 85(3):278-85. doi:
10.1136/heart.85.3.278
. [PMID: 11179265] - J E Manning Fox, D Meredith, A P Halestrap. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.
The Journal of physiology.
2000 Dec; 529 Pt 2(?):285-93. doi:
10.1111/j.1469-7793.2000.00285.x
. [PMID: 11101640] - K R Kim, J Lee, D Ha, J Jeon, H G Park, J H Kim. Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.
Journal of chromatography. A.
2000 Mar; 874(1):91-100. doi:
10.1016/s0021-9673(00)00072-8
. [PMID: 10768503] - T Bamba, T Ihara. [Methionine malabsorption syndrome].
Ryoikibetsu shokogun shirizu.
1998; ?(19 Pt 2):576-7. doi:
NULL
. [PMID: 9645139] - S G Hasselbalch, G M Knudsen, J Jakobsen, L P Hageman, S Holm, O B Paulson. Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans.
The American journal of physiology.
1995 Jun; 268(6 Pt 1):E1161-6. doi:
10.1152/ajpendo.1995.268.6.e1161
. [PMID: 7611392] - V Walker, G A Mills. Effects of birth asphyxia on urinary organic acid excretion.
Biology of the neonate.
1992; 61(3):162-72. doi:
10.1159/000243739
. [PMID: 1610944] - S Klein, O B Holland, R R Wolfe. Importance of blood glucose concentration in regulating lipolysis during fasting in humans.
The American journal of physiology.
1990 Jan; 258(1 Pt 1):E32-9. doi:
10.1152/ajpendo.1990.258.1.e32
. [PMID: 2405701] - M A Staten, D E Matthews, P E Cryer, D M Bier. Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon.
The American journal of physiology.
1989 Aug; 257(2 Pt 1):E185-92. doi:
10.1152/ajpendo.1989.257.2.e185
. [PMID: 2569829] - R S Eriksson, L Thunberg, U J Eriksson. Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats.
Diabetes.
1989 Jun; 38(6):764-72. doi:
10.2337/diab.38.6.764
. [PMID: 2656344] - B M LaGrange, V L Hood. Ketoacid production in acute respiratory and metabolic acidosis and alkalosis in rats.
The American journal of physiology.
1989 Mar; 256(3 Pt 2):F437-45. doi:
10.1152/ajprenal.1989.256.3.f437
. [PMID: 2923222] - M L Halperin, B L Margolis, L A Robinson, R M Halperin, M L West, R A Bear. The urine osmolal gap: a clue to estimate urine ammonium in 'hybrid' types of metabolic acidosis.
Clinical and investigative medicine. Medecine clinique et experimentale.
1988 Jun; 11(3):198-202. doi:
NULL
. [PMID: 3135965] - D Molnár, T Decsi, G Soltész. Resting energy expenditure and food-induced thermogenesis in diabetic children receiving continuous subcutaneous insulin infusion.
Diabetes research (Edinburgh, Scotland).
1988 Mar; 7(3):117-21. doi:
NULL
. [PMID: 3046818] - M Funahashi, K Funahashi, C Wakasugi, I Shikata. Identification of alpha-hydroxybutyrate in rabbit serum after ethanol ingestion.
Nihon hoigaku zasshi = The Japanese journal of legal medicine.
1986 Dec; 40(6):821-3. doi:
NULL
. [PMID: 3560524] - T Kuhara, T Shinka, Y Inoue, M Matsumoto, M Yoshino, Y Sakaguchi, I Matsumoto. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency.
Clinica chimica acta; international journal of clinical chemistry.
1983 Sep; 133(2):133-40. doi:
10.1016/0009-8981(83)90398-4
. [PMID: 6688766] - J Kleinbaum, H Shamoon. Impaired counterregulation of hypoglycemia in insulin-dependent diabetes mellitus.
Diabetes.
1983 Jun; 32(6):493-8. doi:
10.2337/diab.32.6.493
. [PMID: 6354777] - J Feigenbaum, J Yanai, R Blass. Possible DA agonist properties of naloxone.
The International journal of neuroscience.
1982 Nov; 17(3):139-44. doi:
10.3109/00207458208985915
. [PMID: 6302020] - P Henry, R A Saunders. The performance of the 'CentrifiChem' parallel fast analyser using packaged reagents.
Annals of clinical biochemistry.
1975 May; 12(3):119-25. doi:
10.1177/000456327501200125
. [PMID: 15637919]