Vancomycin (BioDeep_00000002635)

 

Secondary id: BioDeep_00000422588

human metabolite blood metabolite Chemicals and Drugs Antibiotics


代谢物信息卡片


(1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-5,47-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2^{3,6}.2^{14,17}.1^{8,12}.1^{29,33}.0^{10,25}.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid

化学式: C66H75Cl2N9O24 (1447.4302)
中文名称: 万古霉素
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O
InChI: InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)

描述信息

Vancomycin is only found in individuals that have used or taken this drug. It is an antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. [PubChem]The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls. The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Normally this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis. There is no cross-resistance between vancomycin and other antibiotics. Vancomycin is not active in vitro against gram-negative bacilli, mycobacteria, or fungi.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01X - Other antibacterials > J01XA - Glycopeptide antibacterials
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
C254 - Anti-Infective Agent > C258 - Antibiotic > C61101 - Glycopeptide Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
Vancomycin is an antibiotic for the treatment of bacterial infections.

同义名列表

56 个代谢物同义名

(1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-5,47-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2^{3,6}.2^{14,17}.1^{8,12}.1^{29,33}.0^{10,25}.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid; (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-5,47-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2³,⁶.2¹⁴,¹⁷.1⁸,¹².1²⁹,³³.0¹⁰,²⁵.0³⁴,³⁹]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate; (1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate; (2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]; (2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-b-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-b-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]; (2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-β-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-β-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]; 4-Methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44; Cell pharm brand OF vancomycin hydrochloride; Ratiopharm brand OF vancomycin hydrochloride; Eli lilly brand OF vancomycin hydrochloride; Azupharma brand OF vancomycin hydrochloride; Combino brand OF vancomycin hydrochloride; Curasan brand OF vancomycin hydrochloride; Abbott brand OF vancomycin hydrochloride; Dakota brand OF vancomycin hydrochloride; Chiesi brand OF vancomycin hydrochloride; Norman brand OF vancomycin hydrochloride; Dista brand OF vancomycin hydrochloride; Lilly brand OF vancomycin hydrochloride; Vancomycin phosphate (1:2), decahydrate; Hexal brand OF vancomycin hydrochloride; MIP brand OF vancomycin hydrochloride; Vancomycin phosphate (1:2); Hydrochloride, vancomycin; Vancomycin Hydrochloride; Vancomicina combino phar; Vancomycin-ratiopharm; Sulfate, vancomycin; Vancomicina norman; Vancomicina abbott; Vancomycin sulfate; Vancomycine dakota; Vancomicina chiesi; Vancomycin hexal; Vancomycin lilly; Vanco azupharma; Vancomycin HCL; AB-vancomycin; Vancomycinum; Vancocin HCL; Vancomicina; SCHEMBL3178; Vancomycine; Vanco-saar; Vancomycin; Vancomicin; Vanco-cell; Diatracin; Vancocine; Vancocin; Vancomycin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CAT, DHFR, MSRA, NAP1L1
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 2 CD4, CYP1B1
Nucleus 1 NAP1L1
cytosol 6 CAT, DHFR, GPT, LIPE, MSRA, PRF1
phagocytic vesicle 1 CD82
nucleoplasm 1 MSRA
Cell membrane 3 CD4, LIPE, PRF1
Lipid-anchor 1 MSRA
Multi-pass membrane protein 3 ATP4A, CD82, PRF1
cell surface 1 TNR
glutamatergic synapse 1 TNR
Golgi membrane 1 INS
Cytoplasm, cytosol 1 LIPE
plasma membrane 6 ATP4A, CD4, CD82, F2, MSRA, PRF1
Membrane 8 ATP4A, CAT, CD82, CYP1B1, LIPE, MSRA, NAP1L1, PRF1
apical plasma membrane 1 ATP4A
caveola 1 LIPE
extracellular exosome 6 CAT, CD82, F2, GPT, LYZ, MSRA
extracellular space 8 ATP4A, CSF3, F2, IL10, IL24, INS, LYZ, TNR
lysosomal lumen 1 CSF3
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 5 CAT, CLPP, CYP1B1, DHFR, MSRA
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 CAT, CYP1B1, MSRA
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 CD4
Secreted 6 CSF3, F2, IL10, IL24, INS, PRF1
extracellular region 9 CAT, CSF3, F2, IL10, IL24, INS, LYZ, PRF1, TNR
Mitochondrion matrix 1 CLPP
mitochondrial matrix 2 CAT, CLPP
external side of plasma membrane 1 CD4
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 MSRA
midbody 1 MSRA
Early endosome 1 CD4
Apical cell membrane 1 ATP4A
Membrane raft 2 CD4, TNR
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 F2, TNR
chromatin 1 NAP1L1
blood microparticle 1 F2
endosome lumen 2 INS, PRF1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 NAP1L1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 CD4, F2, INS
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRF1
perineuronal net 1 TNR
clathrin-coated endocytic vesicle membrane 1 CD4
Cytoplasmic vesicle, phagosome 1 CD82
endopeptidase Clp complex 1 CLPP
endocytic vesicle lumen 1 CSF3
T cell receptor complex 1 CD4
catalase complex 1 CAT
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
potassium:proton exchanging ATPase complex 1 ATP4A
tenascin complex 1 TNR


文献列表

  • Zhihui Liu, Meizi Zeng, Yuquan Xiao, Xiaohua Zhu, Meiling Liu, Ying Long, Haitao Li, Youyu Zhang, Shouzhuo Yao. Surface-mediated fluorescent sensor array for identification of gut microbiota and monitoring of colorectal cancer. Talanta. 2024 Jul; 274(?):126081. doi: 10.1016/j.talanta.2024.126081. [PMID: 38613947]
  • Julia Werner, Florian Umstätter, Tobias Hertlein, Eric Mühlberg, Barbro Beijer, Sabrina Wohlfart, Stefan Zimmermann, Uwe Haberkorn, Knut Ohlsen, Gert Fricker, Walter Mier, Philipp Uhl. Oral Delivery of the Vancomycin Derivative FU002 by a Surface-Modified Liposomal Nanocarrier. Advanced healthcare materials. 2024 Jun; 13(14):e2303654. doi: 10.1002/adhm.202303654. [PMID: 38387090]
  • Hai Bang Pan, Yan Cui, Zhi Hang Wu, Ying Meng, Tian Ming Wang, Qi Fu, Qian Chen, Quan Xin Chen, Bo Wang. Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis. Advances in skin & wound care. 2024 Apr; 37(4):216-223. doi: 10.1097/asw.0000000000000094. [PMID: 38353666]
  • Liqiang Zhou, Shuxing Xing. A meta-analysis examining the impact of intrawound treatment on reducing deep surgical site infections during instrumented spine surgery. International wound journal. 2024 Apr; 21(4):e14554. doi: 10.1111/iwj.14554. [PMID: 38151914]
  • Jee Hoon Park, Rachel E Reviello, Patrick J Loll. Crystal structure of vancomycin bound to the resistance determinant D-alanine-D-serine. IUCrJ. 2024 Mar; ?(?):. doi: 10.1107/s2052252524000289. [PMID: 38277167]
  • Yuquan Xiao, Pei Cheng, Xiaohua Zhu, Maotian Xu, Meiling Liu, Haitao Li, Youyu Zhang, Shouzhuo Yao. Antimicrobial Agent Functional Gold Nanocluster-Mediated Multichannel Sensor Array for Bacteria Sensing. Langmuir : the ACS journal of surfaces and colloids. 2024 01; 40(4):2369-2376. doi: 10.1021/acs.langmuir.3c03612. [PMID: 38230676]
  • Atul Kumar Tiwari, Munesh Kumar Gupta, Hari Prakash Yadav, Roger J Narayan, Prem C Pandey. Aggregation-Resistant, Turn-On-Off Fluorometric Sensing of Glutathione and Nickel (II) Using Vancomycin-Conjugated Gold Nanoparticles. Biosensors. 2024 Jan; 14(1):. doi: 10.3390/bios14010049. [PMID: 38248426]
  • Jian Hu, Xinjun Han, Xiaoxue Ma, Xutao Chen, Zhenping Zhou, Peilan Peng, Zhao Yu, Yongzhi Hou, Peiru Han, Long Pang, Yali Yang, Jia Xu, Wenhui Wu. Comparative proteomic analysis of vancomycin-sensitive and vancomycin-intermediate resistant Staphylococcus aureus. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2024 Jan; 43(1):139-153. doi: 10.1007/s10096-023-04709-3. [PMID: 37985551]
  • Rouba Yasser Al-Sroji, Shaza Al-Laham, Ahmad Almandili. Protective effects of vitamin D3 (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats. Pharmaceutical biology. 2023 Dec; 61(1):755-766. doi: 10.1080/13880209.2023.2204916. [PMID: 37139624]
  • Mathias H Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max J Cryle, Nadine Ziemert. Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides. Nature communications. 2023 Nov; 14(1):7842. doi: 10.1038/s41467-023-43451-4. [PMID: 38030603]
  • Rouhallah Ramezanifard, Yekaterina A Golubeva, Alexander D Palmer, James M Slauch. TamAB is regulated by PhoPQ and functions in outer membrane homeostasis during Salmonella pathogenesis. Journal of bacteriology. 2023 10; 205(10):e0018323. doi: 10.1128/jb.00183-23. [PMID: 37728604]
  • Yunxiang Yan, Yong Liu, Juanjuan Li, Ye Li, Haoheng Wu, Hong Li, Xiang Ma, Yanqiong Tang, Yuan Tong, Kexian Yi, Quanfeng Liang, Zhu Liu. A Molecular Switch-Integrated Nanoplatform Enables Photo-Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy. Advanced healthcare materials. 2023 10; 12(27):e2301157. doi: 10.1002/adhm.202301157. [PMID: 37392145]
  • Anaëlle Fait, Dan I Andersson, Hanne Ingmer. Evolutionary history of Staphylococcus aureus influences antibiotic resistance evolution. Current biology : CB. 2023 Jul; ?(?):. doi: 10.1016/j.cub.2023.06.082. [PMID: 37494936]
  • Zhenwei Yu, Jieqiong Liu, Haitao Yu, Ling Zhou, Yuhua Zhao, Lin Zhong, Jianping Zhu, Gang Liang, Yi Yang, Ying Zheng, Lingyan Yu, Gang Han. Should the trough concentration of vancomycin be abandoned in therapeutic drug monitoring? A multicentre, retrospective study of critically ill patients without any form of dialysis. International journal of antimicrobial agents. 2023 Jun; 61(6):106812. doi: 10.1016/j.ijantimicag.2023.106812. [PMID: 37037321]
  • Yong Lin, Liangbin Zhao, Dengpiao Xie, Lizeyu Lv, Yu Zhang, Ling Wu, Mingquan Li. Biopsy-proven granulomatous interstitial nephritis associated with vancomycin in an adult patient: a case report. The Journal of international medical research. 2023 Jun; 51(6):3000605231180052. doi: 10.1177/03000605231180052. [PMID: 37309693]
  • Gil Belofsky, Hyojin Ahn, Maxwell Zapata, Dominique Wilcox, Christine E Salomon, P Clint Spiegel. Antimicrobial Isoflavans and Other Metabolites of Dalea jamesii. Planta medica. 2023 Jun; 89(7):754-763. doi: 10.1055/a-2013-3008. [PMID: 36863394]
  • Mahir Mohammed, Usri H Ibrahim, Aimen Aljoundi, Calvin A Omolo, Nikita Devnarain, Mohammed A Gafar, Chunderika Mocktar, Thirumala Govender. Enzyme-responsive biomimetic solid lipid nanoparticles for antibiotic delivery against hyaluronidase-secreting bacteria. International journal of pharmaceutics. 2023 Apr; ?(?):122967. doi: 10.1016/j.ijpharm.2023.122967. [PMID: 37084831]
  • Santhni Subramaniam, Paul Joyce, Clive A Prestidge. Liquid crystalline lipid nanoparticles improve the antibacterial activity of tobramycin and vancomycin against intracellular Pseudomonas aeruginosa and Staphylococcus aureus. International journal of pharmaceutics. 2023 Apr; 639(?):122927. doi: 10.1016/j.ijpharm.2023.122927. [PMID: 37059243]
  • Alessandra Ottonello, Jessica A Wyllie, Oussama Yahiaoui, Shoujun Sun, Rebecca A Koelln, Joshua A Homer, Robert M Johnson, Ewan Murray, Paul Williams, Jani R Bolla, Carol V Robinson, Thomas Fallon, Tatiana P Soares da Costa, John E Moses. Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr; 120(15):e2208737120. doi: 10.1073/pnas.2208737120. [PMID: 37011186]
  • Zhihui Liu, Xiaohua Zhu, Qiujun Lu, Meiling Liu, Haitao Li, Youyu Zhang, Yang Liu, Shouzhuo Yao. Recognition Engineering-Mediated Multichannel Sensor Array for Gut Microbiota Sensing. Analytical chemistry. 2023 Mar; ?(?):. doi: 10.1021/acs.analchem.2c04997. [PMID: 36975193]
  • Ashelyn E Sidders, Katarzyna M Kedziora, Melina Arts, Jan-Martin Daniel, Stefania de Benedetti, Jenna E Beam, Duyen T Bui, Joshua B Parsons, Tanja Schneider, Sarah E Rowe, Brian P Conlon. Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations. eLife. 2023 Mar; 12(?):. doi: 10.7554/elife.80246. [PMID: 36876902]
  • Kern Hast, M Rhia L Stone, Zhaojun Jia, Melih Baci, Tushar Aggarwal, Enver Cagri Izgu. Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules. ACS applied materials & interfaces. 2023 Feb; 15(4):4996-5009. doi: 10.1021/acsami.2c20942. [PMID: 36649474]
  • Mia Dželalija, Marija Kvesić, Anita Novak, Željana Fredotović, Hrvoje Kalinić, Ivica Šamanić, Marin Ordulj, Slaven Jozić, Ivana Goić Barišić, Marija Tonkić, Ana Maravić. Microbiome profiling and characterization of virulent and vancomycin-resistant Enterococcus faecium from treated and untreated wastewater, beach water and clinical sources. The Science of the total environment. 2023 Feb; 858(Pt 1):159720. doi: 10.1016/j.scitotenv.2022.159720. [PMID: 36306843]
  • Lingbing Zhang, Yandan Zhang, Xuejun Jiang, Lejiao Mao, Yinyin Xia, Yinzhen Fan, Na Li, Ziqi Jiang, Xia Qin, Yu Jiang, Gang Liu, Feng Qiu, Jun Zhang, Zhen Zou, Chengzhi Chen. Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles. Toxicology. 2023 02; 485(?):153390. doi: 10.1016/j.tox.2022.153390. [PMID: 36535435]
  • Acharya Balkrishna, Sonam Sharma, Vivek Gohel, Ankita Kumari, Malini Rawat, Madhulina Maity, Sandeep Sinha, Rishabh Dev, Anurag Varshney. Renogrit attenuates Vancomycin-induced nephrotoxicity in human renal spheroids and in Sprague-Dawley rats by regulating kidney injury biomarkers and creatinine/urea clearance. PloS one. 2023; 18(11):e0293605. doi: 10.1371/journal.pone.0293605. [PMID: 37939153]
  • Paula V Huertas-Abril, María-José Prieto-Álamo, Juan Jurado, Tamara García-Barrera, Nieves Abril. A selenium-enriched diet helps to recover liver function after antibiotic administration in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113519. doi: 10.1016/j.fct.2022.113519. [PMID: 36464106]
  • Xuedong Yin, Qiaoling Yang, Hongjing Li, Yulin Kang, Zhiling Li. Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides. Drug design, development and therapy. 2023; 17(?):283-295. doi: 10.2147/dddt.s392813. [PMID: 36756189]
  • Ming Wei, Peng Wang, Tianmeng Li, Qiangyi Wang, Mingze Su, Li Gu, Shuai Wang. Antimicrobial and antibiofilm effects of essential fatty acids against clinically isolated vancomycin-resistant Enterococcus faecium. Frontiers in cellular and infection microbiology. 2023; 13(?):1266674. doi: 10.3389/fcimb.2023.1266674. [PMID: 37842001]
  • Qiaoling Yang, Xuedong Yin, Hongjing Li, Lili Ding, Huajun Sun, Li Yang, Zhiling Li. Analysis of kidney proteomes to identify biological pathways associated with vancomycin-induced nephrotoxicity in mice by tandem mass tag-labeled quantitative and parallel reaction monitoring phosphoproteomics. Human & experimental toxicology. 2023 Jan; 42(?):9603271231183885. doi: 10.1177/09603271231183885. [PMID: 37340591]
  • Y T Candace Ho, Ralf B Schittenhelm, Dumitrita Iftime, Evi Stegmann, Julien Tailhades, Max J Cryle. Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones. Chembiochem : a European journal of chemical biology. 2022 Dec; ?(?):e202200686. doi: 10.1002/cbic.202200686. [PMID: 36534957]
  • Liming Wang, Xiaolan Lin, Ling Wang, Hong Ye, Yuxing Lin, Junshan Ruan, Songqing Shi. Clinical validation of the two-point method for predicting vancomycin AUC based on peak and trough plasma concentrations. International journal of clinical pharmacy. 2022 Dec; 44(6):1325-1331. doi: 10.1007/s11096-022-01474-9. [PMID: 36136207]
  • Varsha Saini, Devashish Mehta, Siddhi Gupta, Sandeep Kumar, Parul Rani, Kajal Rana, Kajal Rajput, Dolly Jain, Garima Pal, Bharti Aggarwal, Sanjay Pal, Sonu K Gupta, Yashwant Kumar, Vemanna S Ramu, Avinash Bajaj. Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates. Journal of medicinal chemistry. 2022 11; 65(22):15312-15326. doi: 10.1021/acs.jmedchem.2c01293. [PMID: 36331380]
  • Sifiso S Makhathini, Calvin A Omolo, Lucy W Kiruri, Pavan Walvekar, Nikita Devnarain, Chunderika Mocktar, Thirumala Govender. Synthesis of pH-responsive dimethylglycine surface-modified branched lipids for targeted delivery of antibiotics. Chemistry and physics of lipids. 2022 11; 249(?):105241. doi: 10.1016/j.chemphyslip.2022.105241. [PMID: 36152880]
  • Fanxin Kong, Liling Li, Daxue Zhang, Baorong Lian, Xudong Liu, Shuqun Ren, Yu Zhang, Liming Cao. Healthy adults with Streptococcus pneumoniae meningitis and Streptococcus pneumoniae subdural abscess: two case reports and a literature review. The Journal of international medical research. 2022 Nov; 50(11):3000605221137470. doi: 10.1177/03000605221137470. [PMID: 36396983]
  • Rutan Zhang, Hari Polenakovik, Ismael A Barreras Beltran, Adam Waalkes, Stephen J Salipante, Libin Xu, Brian J Werth. Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated With Dalbavancin: Case Report and Isolate Characterization. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 10; 75(9):1641-1644. doi: 10.1093/cid/ciac341. [PMID: 35510938]
  • Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance. Journal of natural products. 2022 10; 85(10):2413-2423. doi: 10.1021/acs.jnatprod.2c00621. [PMID: 36222797]
  • Ya-Xin Fan, Meng-Ting Chen, Nan-Yang Li, Xiao-Fen Liu, Min-Jie Yang, Yuan-Cheng Chen, Xiao-Yu Liang, Ju-Fang Wu, Bei-Ning Guo, Si-Chao Song, Yong-Qiang Zhu, Feng-Ying Zhang, Jing-Qing Hang, Sheng-Bin Wu, Bo Shen, Hua-Yin Li, Qin Wang, Xu-Ming Luo, Qing-Ge Chen, Hui-Fang Zhang, Rui-Lan Wang, Li-Hua Shen, Feng-Ming Fu, Xiao-Lian Song, Jing Zhang. Sequence Type 5 (ST5) as a Possible Predictor of Bacterial Persistence in Adult Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia Treated with Vancomycin. Microbiology spectrum. 2022 10; 10(5):e0134822. doi: 10.1128/spectrum.01348-22. [PMID: 36094217]
  • Wenliang Feng, Xuebin Jiang, Rujiang Zhang, Zhendong Guo, Daiquan Gao. Diagnosis of an Acinetobacter pittii from a patient in China with a multiplex PCR-based targeted gene sequencing platform of the cerebrospinal fluid: A case report with literature review. Medicine. 2022 Oct; 101(42):e31130. doi: 10.1097/md.0000000000031130. [PMID: 36281177]
  • Yue Liu, Xiaoxia Sun, Jincan Zhang, Feng Gao, Leilei Yu, Lina Dong, Gangli Zhang, Changxin Wu. Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. FEMS microbiology letters. 2022 10; 369(1):. doi: 10.1093/femsle/fnac089. [PMID: 36073496]
  • Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria. ACS infectious diseases. 2022 10; 8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. [PMID: 36098580]
  • M N Tosun, G Taylan, N N Demirel Zorba. Antibacterial and antibiofilm activities of some plant essential oils and synergistic effects of cinnamon essential oil with vancomycin against Clostridioides difficile: in vitro study. Letters in applied microbiology. 2022 Sep; 75(3):598-606. doi: 10.1111/lam.13747. [PMID: 35611552]
  • Takashi Furukawa, Tohru Mekata, Mohan Amarasiri, Kazunari Sei. Concentration and reduction efficiency of vancomycin-resistant heterotrophic bacteria and vanA and vanB genes in wastewater treatment unit processes. Journal of global antimicrobial resistance. 2022 09; 30(?):340-347. doi: 10.1016/j.jgar.2022.07.008. [PMID: 35830952]
  • Ayman Al-Eyadhy, Muneera R Al-Jelaify. Suboptimal vancomycin levels in critically ill children with sickle cell disease and acute chest syndrome. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022 Sep; 28(9):1304-1309. doi: 10.1016/j.jiac.2022.05.017. [PMID: 35688759]
  • Mohammed A Samad, Md Shahjalal Sagor, Muhammad Sazzad Hossain, Md Rezaul Karim, Mohammad Asheak Mahmud, Md Samun Sarker, Fahria A Shownaw, Zakaria Mia, Roderick M Card, Agnes Agunos, Lindahl Johanna. High prevalence of vancomycin non-susceptible and multi-drug resistant enterococci in farmed animals and fresh retail meats in Bangladesh. Veterinary research communications. 2022 Sep; 46(3):811-822. doi: 10.1007/s11259-022-09906-7. [PMID: 35338457]
  • Adel Attia M Ahmad, Ahlam A Gharib, Ibrahim Elshorbgy, Omnia A Elewasy, Gamal A Elmowalid. Nigella sativa oil extract: A natural novel specific conjugal transfer inhibitor of vancomycin resistance from vanA/B-resistant Enterococcus faecium to Staphylococcus aureus. Journal of applied microbiology. 2022 Aug; 133(2):619-629. doi: 10.1111/jam.15567. [PMID: 35395119]
  • Takashi Niwa, Moeka Yasue, Saki Harada, Yuto Yamada, Manami Otsubo, Michi Yamada, Serika Matsuoka, Taishi Yamamoto, Yurika Mizusaki, Akio Suzuki. Comparison of single trough-based area under the concentration-time curve versus trough concentration for the incidence of vancomycin-associated nephrotoxicity. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022 Jul; 28(7):923-928. doi: 10.1016/j.jiac.2022.03.019. [PMID: 35379525]
  • Guang-Ming Huang, Yue Qiu, Tao-Tao Liu, Jie-Jiu Lu. Comparison of Vancomycin Clearance Between Augmented Renal Clearance and Normal Renal Function in Critically Ill Infants: A Population Pharmacokinetics Study. Journal of clinical pharmacology. 2022 Jul; 62(7):863-872. doi: 10.1002/jcph.2029. [PMID: 35049078]
  • Xinran Chen, Liying Du, Mingfeng Liu. Development, validation, and application of an UPLC-MS/MS method for vancomycin, norvancomycin, methotrexate, paclitaxel, and imatinib analysis in human plasma. Annals of clinical biochemistry. 2022 07; 59(4):253-263. doi: 10.1177/00045632221077183. [PMID: 35209719]
  • Shungo Imai, Shota Kadomura, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Yoh Takekuma. Using Japanese big data to investigate novel factors and their high-risk combinations that affect vancomycin-induced nephrotoxicity. British journal of clinical pharmacology. 2022 07; 88(7):3241-3255. doi: 10.1111/bcp.15252. [PMID: 35106797]
  • Anish Zacharia, Ritesh Ranjan Pal, Naama Katsowich, Chanchal Thomas Mannully, Aida Ibrahim, Sivan Alfandary, Raphael Serruya, Amit K Baidya, Sigal Ben-Yehuda, Ilan Rosenshine, Arieh Moussaieff. Activation of the Type III Secretion System of Enteropathogenic Escherichia coli Leads to Remodeling of Its Membrane Composition and Function. mSystems. 2022 06; 7(3):e0020222. doi: 10.1128/msystems.00202-22. [PMID: 35477304]
  • Rubén Cebrián, Qian Li, Pablo Peñalver, Efres Belmonte-Reche, María Andrés-Bilbao, Ricardo Lucas, María Violante de Paz, Oscar P Kuipers, Juan Carlos Morales. Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. Journal of natural products. 2022 06; 85(6):1459-1473. doi: 10.1021/acs.jnatprod.1c01107. [PMID: 35621995]
  • Taizong Wu, Angela A Salim, Zeinab G Khalil, Paul V Bernhardt, Robert J Capon. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. Journal of natural products. 2022 06; 85(6):1641-1657. doi: 10.1021/acs.jnatprod.2c00444. [PMID: 35640100]
  • Kai Tong, Jian Wei, Hanwen Gu, Qingyi Hu, Hui Wang, Yinxian Wen, Liaobin Chen. Evaluation of Experimental and Clinical Efficacy on Surgical Debridement and Systemic Antibiotics Treatment for Early Knee Infection after Anterior Cruciate Ligament Reconstruction. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0011222. doi: 10.1128/aac.00112-22. [PMID: 35499314]
  • Sheryl A Zelenitsky, Robert E Ariano. An updated vancomycin dosing protocol for initiating therapy in patients undergoing intermittent high-flux hemodialysis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2022 06; 79(12):1006-1010. doi: 10.1093/ajhp/zxac066. [PMID: 35234825]
  • Masashi Uchida, Mifuyu Sawada, Shingo Yamazaki, Tatsuya Suzuki, Takaaki Suzuki, Itsuko Ishii. Contribution of diafiltration and adsorption to vancomycin clearance in a continuous hemodiafiltration circuit model in vitro. Artificial organs. 2022 Jun; 46(6):1086-1096. doi: 10.1111/aor.14178. [PMID: 35048387]
  • Akio Ogawa, Daiki Hira, Masayuki Tsujimoto, Kohshi Nishiguchi, Masanori Endo, Toshiaki Ono, Tsuguru Hatta, Tomohiro Terada, Shin-Ya Morita. Optimal Sampling Strategy and Threshold of Serum Vancomycin Concentration in Elderly Japanese Patients Undergoing High-Flux Hemodialysis. Therapeutic drug monitoring. 2022 06; 44(3):396-403. doi: 10.1097/ftd.0000000000000920. [PMID: 34407000]
  • Wanqing Zhou, Shuo Gao, Jie Zheng, Yan Zhang, Hui Zhou, Zhifeng Zhang, Xiaoli Cao, Han Shen. Identification of an Aerococcus urinaeequi isolate by whole genome sequencing and average nucleotide identity analysis. Journal of global antimicrobial resistance. 2022 06; 29(?):353-359. doi: 10.1016/j.jgar.2022.04.013. [PMID: 35477007]
  • Bolette Skive, Andreas Christian Lawaetz, Anette M Hammerum, Henrik Hasman, Mette Pinholt, Christian Stab Jensen, Jenny Dahl Knudsen, Anne Kjerulf, Hanne Ingmer. Survival of hospital- and community-associated Enterococcus faecium following exposure to in-use concentrations of the biocide sodium dichloroisocyanurate (NaDCC). Journal of global antimicrobial resistance. 2022 Jun; 29(?):281-288. doi: 10.1016/j.jgar.2022.03.020. [PMID: 35358701]
  • Mazen Almehmadi, Osama Abdulaziz, Muhannad Alenazi, Ebtisam Alosimi, Fatimah Rebh, Ayman Al-Hazmi, Naif Alsiwiehri, Abdullah Turjoman, Abdulelah Aljuaid, Mamdouh Allahyani, Mustafa Halawi. Evaluation of Renal Function in COVID-19 Patients by Using Urinalysis Following the Administration of Vancomycin. Clinical laboratory. 2022 Jun; 68(6):. doi: 10.7754/clin.lab.2021.211032. [PMID: 35704713]
  • Akihiro Sonoda, Yoshitaka Iwashita, Yukina Takada, Ryu Hamazono, Kazuhisa Ishida, Hiroshi Imamura. Prediction Accuracy of Area under the Concentration-Time Curve of Vancomycin by Bayesian Approach Using Creatinine-Based Equations of Estimated Kidney Function in Bedridden Elderly Japanese Patients. Biological & pharmaceutical bulletin. 2022 Jun; 45(6):763-769. doi: 10.1248/bpb.b22-00070. [PMID: 35370223]
  • Lewis F Neville, Itamar Shalit, Peter A Warn, Jacob T Rendell. Vancomycin-arginine (STM-001) abrogates ESBL carrier and carbapenem-resistant Escherichia coli burden in a murine complicated urinary tract infection model. The Journal of antimicrobial chemotherapy. 2022 05; 77(6):1706-1709. doi: 10.1093/jac/dkac063. [PMID: 35229156]
  • Sean N Avedissian, Gwendolyn M Pais, Michelle Pham, Jiajun Liu, Jack Chang, Khrystyna Hlukhenka, Walter Prozialeck, Brooke Griffin, Anil Gulati, Medha D Joshi, Ying Mu, Marc H Scheetz. Vancomycin Pharmacokinetics in a Pregnancy Rat Model. Antimicrobial agents and chemotherapy. 2022 05; 66(5):e0005622. doi: 10.1128/aac.00056-22. [PMID: 35446134]
  • Khyati Girdhar, Marion Soto, Qian Huang, Lucie Orliaguet, Carly Cederquist, Bharathi Sundaresh, Jiang Hu, Maximilian Figura, Amol Raisingani, Emanuel E Canfora, Ercument Dirice, Shiho Fujisaka, Gijs H Goossens, Ellen E Blaak, Rohit N Kulkarni, C Ronald Kahn, Emrah Altindis. Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones. Diabetes. 2022 05; 71(5):945-960. doi: 10.2337/db21-0382. [PMID: 35212729]
  • Masayuki Ishikawa, Masashi Uchida, Shingo Yamazaki, Yuki Shiko, Yohei Kawasaki, Takaaki Suzuki, Yasuo Iwadate, Itsuko Ishii. Evaluation of association between parameters related to penetration into cerebrospinal fluid and the microbiological efficacy of vancomycin in patients with bacterial meningitis. Journal of chemotherapy (Florence, Italy). 2022 May; 34(3):157-165. doi: 10.1080/1120009x.2021.2012326. [PMID: 34913849]
  • Stuart Johnson, Dale N Gerding, Xue Li, Domenic J Reda, Curtis J Donskey, Kalpana Gupta, Matthew Bidwell Goetz, Michael W Climo, Fred M Gordin, Robert Ringer, Neil Johnson, Michelle Johnson, Lawrence A Calais, Alexa M Goldberg, Ling Ge, Tamara Haegerich. Defining optimal treatment for recurrent Clostridioides difficile infection (OpTION study): A randomized, double-blind comparison of three antibiotic regimens for patients with a first or second recurrence. Contemporary clinical trials. 2022 05; 116(?):106756. doi: 10.1016/j.cct.2022.106756. [PMID: 35398532]
  • Shahbaz Ahmad, Farooq Ali, Sadaf Anwar Qureshi, Bibi Uzma, Qismat Shakeela, Muhammad Shehryar Sabir, Sajjad Ahmad, Ijazul Haq, Atia Rasheed, Shehzad Ahmed, Muhammad Farooq. The evaluation of antibiotic susceptibility pattern and associated risk factors of UTI in tertiary care hospital of Peshawar. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3(Special)):897-903. doi: NULL. [PMID: 35791585]
  • Marissa R Rees, Dustin R Carr, Tamara Trienski, Carley Buchanan, Kara White, Derek N Bremmer. Outpatient vancomycin therapy: Acute kidney injury in individualized AUC-based goal trough ranges versus traditional trough dosing. Journal of the American Pharmacists Association : JAPhA. 2022 May; 62(3):706-710. doi: 10.1016/j.japh.2021.11.031. [PMID: 34920955]
  • Quanyao Chen, Jun Wan, Wei Shen, Wanlong Lin, Xiuxian Lin, Zhiyi Huang, Min Lin, Yao Chen. Optimal exposure targets for vancomycin in the treatment of neonatal coagulase-negative Staphylococcus infection: A retrospective study based on electronic medical records. Pediatrics and neonatology. 2022 05; 63(3):247-254. doi: 10.1016/j.pedneo.2021.11.010. [PMID: 35190273]
  • Mark J Spangehl, Henry D Clarke, Grant A Moore, Mei Zhang, Nick E Probst, Simon W Young. Higher Tissue Concentrations of Vancomycin Achieved With Low-Dose Intraosseous Injection Versus Intravenous Despite Limited Tourniquet Duration in Primary Total Knee Arthroplasty: A Randomized Trial. The Journal of arthroplasty. 2022 05; 37(5):857-863. doi: 10.1016/j.arth.2022.01.057. [PMID: 35091036]
  • Gwendolyn M Pais, Jack Chang, Jiajun Liu, Marc H Scheetz. A translational rat model to assess glomerular function changes with vancomycin. International journal of antimicrobial agents. 2022 May; 59(5):106583. doi: 10.1016/j.ijantimicag.2022.106583. [PMID: 35378229]
  • Wei-Chun Huang, Mei-Tzu Wang, Tai-Shuan Lai, Kuo-Hua Lee, Shih-Chieh Shao, Chien-Hao Chen, Chien-Hao Su, Yih-Ting Chen, Junne-Ming Sung, Yung-Chang Chen. Nephrotoxins and acute kidney injury - The consensus of the Taiwan acute kidney injury Task Force. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 May; 121(5):886-895. doi: 10.1016/j.jfma.2021.12.007. [PMID: 34998658]
  • Jingpeng Yang, Lingtong Meng, Hong Yang. Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model. Microbiology spectrum. 2022 04; 10(2):e0067222. doi: 10.1128/spectrum.00672-22. [PMID: 35311540]
  • Francesca Sivori, Ilaria Cavallo, Daniela Kovacs, Maria Guembe, Isabella Sperduti, Mauro Truglio, Martina Pasqua, Grazia Prignano, Arianna Mastrofrancesco, Luigi Toma, Fulvia Pimpinelli, Aldo Morrone, Fabrizio Ensoli, Enea Gino Di Domenico. Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections. Microbiology spectrum. 2022 04; 10(2):e0035122. doi: 10.1128/spectrum.00351-22. [PMID: 35416701]
  • Yuhuai Liu, Qinghua Tan, Jie Qin, Yan Cai, Ning Ning, Rui Zhang, Bo Dong, Xijing He, Dong Wang, Bo Zhao. Prophylactic Use of Antibiotics for Fever After Drainage Removal Following a Dural Tear During Lumbar Spinal Surgery: A Retrospective Study. Medical science monitor : international medical journal of experimental and clinical research. 2022 Apr; 28(?):e936652. doi: 10.12659/msm.936652. [PMID: 35462392]
  • Praneeth Jarugula, Ayse Akcan-Arikan, Flor Munoz-Rivas, Brady S Moffett, Vijay Ivaturi, Danielle Rios. Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling. Antimicrobial agents and chemotherapy. 2022 04; 66(4):e0189921. doi: 10.1128/aac.01899-21. [PMID: 35293782]
  • Rikeshwer Prasad Dewangan, Devesh Pratap Verma, Neeraj Kumar Verma, Ankit Gupta, Garima Pant, Kalyan Mitra, Saman Habib, Jimut Kanti Ghosh. Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents. Journal of medicinal chemistry. 2022 04; 65(7):5433-5448. doi: 10.1021/acs.jmedchem.1c01809. [PMID: 35297625]
  • Dan F Smelter, Michael J Trisler, Erin K McCreary, Matthew Baker, Kenneth Copeland, Thomas J Dilworth, Warren E Rose. Long-Acting Lipoglycopeptides Can Interfere With Vancomycin Therapeutic Drug Monitoring. Journal of clinical pharmacology. 2022 04; 62(4):472-478. doi: 10.1002/jcph.1975. [PMID: 34564865]
  • Mariawy Riollano Cruz, Damodara Rao Mendu, Michael F Tosi. Falsely Undetectable Vancomycin Levels in a Pediatric Patient With Chronic Granulomatous Disease. The Pediatric infectious disease journal. 2022 04; 41(4):302-303. doi: 10.1097/inf.0000000000003412. [PMID: 34803136]
  • M Hamdi Abdulkareem, I Abbas Abood, M Munis Dakheel. Antimicrobial Resistance of Tannin Extract against E. coli Isolates from Sheep. Archives of Razi Institute. 2022 Apr; 77(2):697-701. doi: 10.22092/ari.2022.356982.1955. [PMID: 36284977]
  • Gro Grimnes, Soerajja Bhoelan, Kristian Hindberg, Mark Davids, Max Nieuwdorp, Tom E Mollnes, Annika E Michelsen, Thor Ueland, Sigrid K Brækkan, John-Bjarne Hansen, Vladimir Tichelaar. Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial. Thrombosis and haemostasis. 2022 Apr; 122(4):540-551. doi: 10.1055/s-0041-1733906. [PMID: 34428832]
  • Rui Shen, Lixin Ke, Qiao Li, Xi Dang, Shunli Shen, Jianming Shen, Shaoqiang Li, Lijian Liang, Baogang Peng, Ming Kuang, Yi Ma, Zhonghan Yang, Yunpeng Hua. Abnormal bile acid-microbiota crosstalk promotes the development of hepatocellular carcinoma. Hepatology international. 2022 Apr; 16(2):396-411. doi: 10.1007/s12072-022-10299-7. [PMID: 35211843]
  • Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem. Journal of chemotherapy (Florence, Italy). 2022 Apr; 34(2):103-109. doi: 10.1080/1120009x.2021.1965334. [PMID: 34424136]
  • Shengtang Li, Xuewen Shi, Bo Xu, Jian Wang, Peng Li, Xin Wang, Jinpeng Lou, Ziyao Li, Chengwei Yang, Songkai Li, Ping Zhen. In vitro drug release and antibacterial activity evaluation of silk fibroin coated vancomycin hydrochloride loaded poly (lactic-co-glycolic acid) (PLGA) sustained release microspheres. Journal of biomaterials applications. 2022 04; 36(9):1676-1688. doi: 10.1177/08853282211064098. [PMID: 35015589]
  • Nadezda Petejova, Arnost Martinek, Josef Zadrazil, Viktor Klementa, Lenka Pribylova, Radim Bris, Marcela Kanova, Radka Sigutova, Ivana Kacirova, Zdenek Svagera, Eva Bace, David Stejskal. Expression and 7-day time course of circulating microRNAs in septic patients treated with nephrotoxic antibiotic agents. BMC nephrology. 2022 03; 23(1):111. doi: 10.1186/s12882-022-02726-6. [PMID: 35305556]
  • Jack Chang, Gwendolyn M Pais, Kimberly Valdez, Sylwia Marianski, Erin F Barreto, Marc H Scheetz. Glomerular Function and Urinary Biomarker Changes between Vancomycin and Vancomycin plus Piperacillin-Tazobactam in a Translational Rat Model. Antimicrobial agents and chemotherapy. 2022 03; 66(3):e0213221. doi: 10.1128/aac.02132-21. [PMID: 35007142]
  • Inga Mauliņa, Karīna Darbiniece, Lāsma Miķelsone-Jansone, Renārs Erts, Dace Bandere, Angelika Krūmiņa. Experience of Vancomycin Therapeutic Drug Monitoring in Two Multidisciplinary Hospitals in Latvia. Medicina (Kaunas, Lithuania). 2022 Mar; 58(3):. doi: 10.3390/medicina58030370. [PMID: 35334546]
  • Rasoul Mirzaei, Mohammad Yousef Alikhani, Carla Renata Arciola, Iraj Sedighi, Rasoul Yousefimashouf, Kamran Pooshang Bagheri. Prevention, inhibition, and degradation effects of melittin alone and in combination with vancomycin and rifampin against strong biofilm producer strains of methicillin-resistant Staphylococcus epidermidis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Mar; 147(?):112670. doi: 10.1016/j.biopha.2022.112670. [PMID: 35123230]
  • Wui Ming Chang, Elaine Cheng, Karen Shalansky, Suneet R Singh. Evaluation of intraperitoneal vancomycin in peritoneal dialysis-associated peritonitis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2022 03; 42(2):171-176. doi: 10.1177/08968608211051579. [PMID: 34674576]
  • Phuc Le, Sankar Dass Navaneethan, Pei-Chun Yu, Andrea M Pallotta, Radhika Rastogi, Preethi Patel, Andrei Brateanu, Peter B Imrey, Michael B Rothberg. Association of antibiotic use and acute kidney injury in patients hospitalized with community-acquired pneumonia. Current medical research and opinion. 2022 Mar; 38(3):443-450. doi: 10.1080/03007995.2021.2000716. [PMID: 34714213]
  • Sujintana Wongthong, Wichit Taron, Aroonwadee Chanawong, Patcharaporn Tippayawat, Paweena Pongdontri, Arpasiri Srisrattakarn, Pimchanok Panpru, Aroonlug Lulitanond. Effect of Vancomycin on Cellular Fatty Acid Profiles of Vancomycin-Susceptible and Nonsusceptible Staphylococcus aureus. Microbial drug resistance (Larchmont, N.Y.). 2022 Mar; 28(3):267-273. doi: 10.1089/mdr.2021.0055. [PMID: 34748415]
  • Yue Chen, Xudong Kong, Lei Liu. Therapeutic drug monitoring of vancomycin in neurosurgery patients, from trough concentration to area under the curve: a retrospective single center cohort study in a tertiary hospital. The Journal of international medical research. 2022 Mar; 50(3):3000605221083242. doi: 10.1177/03000605221083242. [PMID: 35264048]
  • Kai Tong, Jian Wei, Zhenyu Li, Hui Wang, Yinxian Wen, Liaobin Chen. Evaluation of the Efficacy of Vancomycin-Soaked Autograft to Eliminate Staphylococcus aureus Contamination After Anterior Cruciate Ligament Reconstruction: Based on an Infected Rat Model. The American journal of sports medicine. 2022 03; 50(4):932-942. doi: 10.1177/03635465211068114. [PMID: 35099312]
  • Yan-Xia Yu, Jian Lu, Hao-di Lu, Lan Li, Jing-Jing Li, Lu Shi, Lu-Fen Duan, Zhi-Wei Zhuang, Su-Dong Xue, Yi Shen, Lian Tang. Predictive performance of reported vancomycin population pharmacokinetic model in patients with different renal function status, especially those with augmented renal clearance. European journal of hospital pharmacy : science and practice. 2022 03; 29(e1):e6-e14. doi: 10.1136/ejhpharm-2020-002477. [PMID: 33414258]
  • Marc D Esquivel, Marguerite L Monogue, Greg S Smith, James D Finklea, James M Sanders. Ceftaroline versus vancomycin for treatment of acute pulmonary exacerbations of cystic fibrosis in adults. Journal of global antimicrobial resistance. 2022 03; 28(?):67-70. doi: 10.1016/j.jgar.2021.12.008. [PMID: 34936925]
  • Edwin Lam, Yi Ting Kayla Lien, Walter K Kraft, Douglas F Stickle, Beth Piraino, Jingjing Zhang. Intraperitoneal pharmacokinetics of vancomycin in patients on automated peritoneal dialysis. Clinical and translational science. 2022 03; 15(3):649-657. doi: 10.1111/cts.13182. [PMID: 34755479]
  • Michael B Stokes, Jacob S Stevens. Vancomycin-Associated Cast Nephropathy: Reality or Fantasy?. Kidney360. 2022 02; 3(2):372-375. doi: 10.34067/kid.0007282021. [PMID: 35373135]
  • Anam Rehan, Gilbert W Moeckel, Mark A Perazella. Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Kidney360. 2022 02; 3(2):405-406. doi: 10.34067/kid.0006102021. [PMID: 35373119]
  • Xin Wen, Cong Shen, Jinyu Xia, Lan-Lan Zhong, Zhongwen Wu, Mohamed Abd El-Gawad El-Sayed Ahmed, Nana Long, Furong Ma, Guili Zhang, Wenwei Wu, Jianlve Luo, Yong Xia, Min Dai, Liyan Zhang, Kang Liao, Siyuan Feng, Cha Chen, Yishen Chen, Wenji Luo, Guo-Bao Tian. Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study. Microbiology spectrum. 2022 02; 10(1):e0132221. doi: 10.1128/spectrum.01322-21. [PMID: 35019676]
  • Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang. Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. Toxicology. 2022 02; 467(?):153088. doi: 10.1016/j.tox.2021.153088. [PMID: 34979169]